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PubMed1994

[Testosterone levels in testicular and epididymal tissue during histopathologic changes in the testes in bulls].

A total of 42 sexual organs of bulls were used to study the relationship between the level of testosterone and the effect of histopathological changes. Genital organs were obtained immediately after slaughter at the Brno abbatoir. Bulls were 14 to 20 months of age and weighed 450 to 650 kg, they were of the Czech Pied, Black and White breeds and their crossbreds. After an assessment of testosterone contents in testicular and epididymal tissues and microscopic examination of organs the concentration of testosterone determined according to the histopathological findings were (Tab. I) as follows. The mean content of testosterone in testicular homogenates was 38.96 +/- 47.0 ng/g. The values for the head, corpus and cauda regions of the epididymal tissue were 5.7 +/- 4.7, 5.3 +/- 5.1 and 3.2 +/- 3.5 ng/g tissue, respectively. The mean level of testosterone in testicular homogenates in the group without histopathological changes of the spermatogenic epithelium was 9.2 +/- 6.77; 5.26 +/- 4.2. In this group the concentration of 5.3 +/- 4.2 from the head 5.4 +/- 5.3 from the corpus and 3.23 +/- 3.26 ng/g tissue were revealed in the cauda of the epididymis. In the group with oedematous infiltration of the interstitium the mean level of testosterone in testicular tissue was determined 16.2 +/- 24.6, in the head of the epididymis it was 6.2 +/- 3.59, in the corpus 4.6 +/- 3.3 and 2.07 +/- 1.2 ng/g of testosterone was obtained from the cauda of the epididymis.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1975

Spermiation and epididymal maturation of spermatozoa in the bonnet macaque (Macaca radiata) as viewed by scanning electron microscopy.

Spermiation and epididymal maturation of spermatozoa were studied in the bonnet monkey (Macaca radiata) by light and scanning electron microscopy. The morphology, location, and release of residual body were observed during spermiation. Along the epididymal duct, the shape of spermatozoa changed, the constriction at the anulus disappeared, the marginal thickening diminished in length, and the cytoplasmic droplet regressed and moved toward the posterior end of the middle piece. Mature spermatozoa were very similar to those of other Cercopithecidae, and they showed a forward motility and a drop in eosin stainability.

Animals↗
PubMed1993

[Pregnancy obtained by in vitro fertilization (IVF) with epididymal spermatozoa in obstructive azoospermia: report of two cases].

Epididymal spermatozoa aspiration was performed in two cases of obstructive azoospermia. After the procedure, in both cases, the patient's wives obtained twin pregnancies by this method in conjunction with in vitro fertilization (IVF) and embryo transfer (ET). The patient's wife in one case had a normal delivery. The patient's wife in the other case, however, aborted artificially because she had cerebral infarction. Epididymal spermatozoa aspiration proved efficacious for male sterility in cases of obstructive azoospermia.

Adult↗
PubMed1995

Testicular needle biopsy, open biopsy, epididymal aspiration and intracytoplasmic sperm injection in obstructive azoospermia.

Testicular or epididymal spermatozoa were obtained for in-vitro fertilization and intracytoplasmic sperm injection (ICSI) in 27 cycles out of 33 (in six men the azoospermia proved to have testicular causes). Testicular needle biopsy carried out in addition to surgical open biopsy proved to be an effective method to obtain spermatozoa for ICSI from patients with obstructive azoospermia. Thus it might be possible to replace scrotal operations by simple needle biopsies. Embryos resulting from ICSI with testicular spermatozoa were used in 19 transfers that resulted in six pregnancies. One pregnancy resulted from six embryo transfers from ICSI after microsurgical-epididymal sperm aspiration (MESA). The normal fertilization rates with testicular (37.3%) and MESA spermatozoa (53.7%) did not differ significantly from each other, but with testicular spermatozoa the rate was significantly lower than that obtained with ejaculated spermatozoa and ICSI (59.7%) in the matched couples. The abnormal fertilization of oocytes with one pronucleus was significantly higher with testicular spermatozoa than with ejaculated spermatozoa in the control couples.

Biopsy↗
PubMed1995

Electron-dense deposits in epididymal cells of rats chronically treated with lead acetate [Pb(II)].

Electron microscopic studies were performed to investigate the influence of chronic lead acetate treatment on morphology of rat epididymis. Dense, lead-loaded inclusions were found in the cytoplasm of epididymal principal cells, especially in the caput of epididymis. They were also present, but in smaller amounts, in smooth muscle cells. Usually, the inclusions were located in vacuoles, rarely without any surrounding membrane. Similar lead-containing structures were found in the epididymal lumen. The localization of lead deposits suggests the ability of lead to pass from blood vessels through the epithelial cells of the epididymis to its lumen. It can be therefore postulated, that lead can be eliminated from the male genital tract together with ejaculate.

Animals↗
PubMed1996

Pregnancy following in vitro fertilization and embryo transfer by microsurgical epididymal sperm aspiration from a patient with congenital absence of the vas deferens: a case report.

Congenital absence of the vas deferens (CAVD) has been considered a virtually untreatable cause of male infertility. Men with this condition have been shown on testicular biopsy to have adequate spermatogenesis, and are theoretically producing sperm capable of fertilizing an oocyte. Yet epididymal transit was thought to be essential for the maturation of spermatozoa and development of their fertilizing ability since the characteristics of sperm motility improve as the sperm passes through the cauda. However recent studies in man have shown that spermatozoa aspirated from the obstructed caput epididymis and ductuli efferentia are, in fact, capable of fertilization in vitro. Microsurgical epididymal sperm aspiration (MESA) from the proximal region (caput) of the epididymis, obtained 0.5 x 10(6) sperm per ml, following washing and direct swim-up. Twelve oocytes were inseminated and three embryos were generated for transfer. The patient conceived and delivered a healthy female baby weighting 2838 gm, on March 3, 1994. This is the first documentation in Taiwan of live birth resulting from MESA from a patient with CAVD combined with in vitro fertilization and embryo transfer.

Adult↗
PubMed1996

[Epididymal leiomyoma. Report of 2 cases].

At present, the paratesticular tumors are not frequent, but when they appear, the most common location is on spermatic cord and epididymis. Within the epididymal tumors the most frequent (75%) are benign tumors, been the second one the leiomyoma after the adenomatoid tumor. We want to show two clinical cases about epididymal leiomyoma in patients who had different ages. We achieve the definitive diagnostic after the tumor removed by histological analysis. We also checked the medical literature.

Adult↗
PubMed1995

In vitro fertilization pregnancy achieved with epididymal caput sperm of a patient with obstructive azoospermia.

A successful epididymal sperm aspiration, in vitro fertilization and embryo transfer in a woman whose husband had previously undergone extensive attempts at recanalization of the spermatic ducts is reported. A twin pregnancy was achieved using sperm obtained from the husband's epididymal caput. This case demonstrates that pregnancy can be achieved by this reproductive technique in cases of obstructive azoospermia, even after extensive surgery.

Adult↗
PubMedDate not supplied

Mouse epididymal sperm contain active P450 aromatase which decreases as sperm traverse the epididymis.

Recently we reported that mouse germ cells in the testis contain active P450 aromatase (P450arom), the enzyme that converts androgens to estrogens. This finding suggested that germ cells have the ability to produce estrogen. Further studies have shown that germ cells in the testis of several species contain P450arom. The goal of this study was to determine if epididymal sperm contain P450arom and if P450arom activity in sperm changes during traversion of the epididymis in the adult mouse. P450arom was localized in sperm present in the efferent ductules and epididymis by immunocytochemistry using an antiserum generated against purified human placental cytochrome P450arom. P450arom immunostaining in sperm was most prominent in sperm located in the proximal caput epididymis, decreased as sperm traversed the corpus epididymis, and was only slightly apparent in sperm in the cauda epididymis. The immunolocalization of P450arom in epididymal sperm was supported by the measurement of P450arom activity in sperm by the 3H2O assay. We found that P450arom activity in sperm significantly decreases as sperm traverse the epididymis. Based upon these observations, we conclude that sperm can synthesize estrogen and that the synthesis of estrogen by sperm present in the efferent ductules and caput epididymis could be important in the process of sperm maturation.

Animals↗
PubMed1996

Seasonal variation in the correlation of testicular and epididymal weight-dimensions in the red Sokoto goat and white Yankassa ram.

A correlative study of testicular weight (TW), length (TL), diameter (TD), epididymal weight (EW) and cauda epididymal weight (CEW) in adult red Sokoto goat and white Yankassa ram during the dry and wet seasons in Kano City, Nigeria was undertaken. The data was analyzed by Pearson's product of moment correlation coefficient and the results showed that TW maintained a highly significant correlation with TL, TD, TW and CEW in the ram, and goat during the wet season (p < 0.01), but non-significant correlation with TL and TD during the dry season (p > 0.05). This suggests that there is a seasonal variation in the dimensions of the reproductive organs of the animals and that during the breeding season (wet season) testicular size and weight are intimately correlated. During the wet season, the reproductive performance of these animals may be assessed by measuring their testicular size and will be very useful in animal husbandry.

Animals↗
PubMed1996

[Epididymal adenomatoid tumor. Review of the national literature and report of a case].

Benign epididymal epithelial tumours are very uncommon. Their frequency rating is as follows: adenomatoid tumour, leiomyoma and papilliferous cystoadenoma. This paper contributes a new case of epididymal adenomatoid tumour in a 29-year old male who presented with testicular pain. Diagnosis was achieved through physical examination and echography. A simple tumourectomy was performed. As a result of this case, a review was made of the Spanish literature.

Adenomatoid Tumor↗
PubMed1997

Glycoconjugates during the annual sexual cycle in lizard epididymal ductuli efferentes: a histochemical study.

The epididymal ductuli efferentes of the lizard Podarcis sicula campestris De Betta are lined with simple, columnar, nonciliated and ciliated cells. The use of lectin histochemistry has provided information about changes of sugars associated with glycoconjugates of epithelial cells and intraluminal spermatozoa which are conveyed from the longitudinal canal to the cranial region of the ductus epididymis. Epithelial cells exhibited residues of alpha-D-mannose, N-acetylglucosamine, and beta-D-galactose-(1-4)-N-acetylglucosamine as revealed with lectins Con A, WGA and RCA120, respectively, throughout the sexual cycle. An increase of RCA120 staining was observed on microvilli of nonciliated cells and in the cytoplasm of ciliated cells during the reproductive period. However, during the following refractory period, when the organ was in regression, there was a decreased staining with Con A on microvilli and the absorbent surface of nonciliated cells, with WGA in nonciliated cells and the cytoplasm of ciliated cells, and with RCA120 on microvilli and the cytoplasm of both cell types. Terminal alpha-D-galactose residues were increasingly stained from autumn up to the reproductive period with BS I-B4 on microvilli, the absorbent surface and cilia, whereas they were entirely lacking during the refractory period. UEA I revealed alpha-L-fucose residues on the absorbent surface of nonciliated cells during the abortive and reproductive periods, increasing in the latter period when cilia also expressed this sugar. Terminal alpha/beta-D-N-acetylgalactosamine was evidenced with SBA on the absorbent surface of nonciliated cells during the reproductive period. The terminal beta-D-galactose-(1-3)-N-acetylgalactosamine dimer was never found with PNA, whereas O- and N-linked sialoglycoconjugates were present only during the reproductive period. The spermatozoa head exhibited N-linked glycans with high-mannose content, and beta-D-galactose-(1-4)-N-acetylglucosamine as well as O- and N-linked sialoglycoconjugates throughout the year. During the reproductive period, oligosaccharides with alpha-D-mannose residues increased, and oligosaccharides with terminal alpha-D-galactose, alpha-L-fucose and sialic acid-N-acetylgalactosamine dimer were also present. Unlike spermatozoa of seminiferous tubules, the spermatozoa head of the lizard epididymal ductuli efferentes exhibited seasonal variability in the lectin binding pattern which may be related to time-dependent changes in the glycoconjugate profiles of epithelial cells.

Animals↗
PubMed1997

[Epididymal adenomatoid tumors. 2 new cases].

OBJECTIVE: To review the different aspects of epididymal tumors, with special reference to adenomatoid tumor of the epididymis (mesothelial neoplasm). Two such cases are reported herein. METHODS: Two cases of adenomatoid tumor of the epididymis are described. The clinical features, diagnosis and treatment are discussed, within the context of the algorithm recently presented by Pellicé and co-workers. RESULTS/CONCLUSION: Most of the epididymal tumors are benign and treatment using a scrotal approach will suffice. However, inguinotomy should be performed when the benign nature of the tumor cannot be established unequivocally.

Adult↗
PubMed1997

[Epididymal sarcoidosis: a case report].

A rare case of epididymal sarcoidosis is reported. A 52-year-old man was admitted with a painless mass in the left scrotum. An operation revealed that a 1-cm mass was located at the epididymal head and well demarcated from the testis and the surrounding tissue. Epididymectomy was performed. Histopathological diagnosis was noncaseating granulomas consistent with sarcoidosis. Systemic examination showed bilateral hilar lymphadenopathy and bilateral peripheral anterior synechiae, but these lesions were diagnosed as inactive. Serum level of angiotensin-converting enzyme was normal.

Epididymis↗
PubMed1996

[Calcium distribution changes during epididymal maturation of mouse and guinea pig sperms].

Calcium was localized by in situ precipitation with potassium antimonate during epididymal maturation of the mouse and guinea pig sperms. In caput epididymis the calcium in mouse sperm head was mainly localized on the inner surface of tha outer acrosomal membrane (OAM) in preacrosomal region. During the passage from the caput epididymis to the cauda epididymis the calcium amount of mouse sperm did not undergo apparent changes. In comparison with mouse sperm, there were a few fine calcium deposite granules on the inner surface of the guinea pig sperm OAM on the abdomen side at the caput epididymis stage, but these granules disappeared at the cauda epididymis stage. The microvilli of columnar cell in columnar epithlium lining the epididymal duct are probably involved in regultion of Ca2+ concentration of the intraluminal fluid. The calcium precipitation granules distributing in the microvilli were observed. An abundance of Ca2+ were present in the intraluminal fluid of the corpus epididymis and they might have some important functions during the process of sperm maturation. Calcium in sperm tail was mainly distributed in the mitochondria. Compared with the mouse sperm, the mitochondria of guinea pig sperm possessed more calcium.

Animals↗
PubMed1998

Epididymal sperm aneuploidies in three strains of rats detected by multicolor fluorescence in situ hybridization.

A multicolor fluorescence in situ hybridization (FISH) method was developed to detect aneuploidy and diploidy in epididymal sperm of rats using DNA probes specific for chromosomes 4 and Y. Fourteen healthy young-adult rats from three strains were evaluated: inbred Fisher 344/N/ehs, outbred Sprague-Dawley, and outbred WU Wistar/CPB. The hybridization efficiency of the FISH procedure was > 99.9%, the sex-ratio in sperm was approximately 1 as expected, and there was no significant variation among two independent scorers. No significant variations were detected within or among strains in the frequencies of sperm disomy for chromosome 4 (1-6.5 per 10,000 cell per animal) or the Y chromosome (0-2.5 per 10,000 cells per animal). There was a trend toward increased variation among Wistar rats. The frequencies of sperm-carrying hyper- and hypohaploidy for chromosome 4 were similar, suggesting a symmetrical mechanism of chromosome gain and loss during meiosis. The frequencies of Y-Y-4-4 sperm, which represent genomic meiosis II errors, did not differ significantly across strains (0.1-0.7 per 10,000 cells per strain). This FISH method for detecting aneuploidy in rat epididymal sperm provides a promising interspecies biomarker of male germ cell aneuploidy and introduces the rat as an animal model for investigating the heritable risk to offspring associated with paternal genotype, physiology, and exposure to environmental mutagens. There appear to be no significant differences among young healthy rats, mice, and men in the baseline frequencies of sperm with Y chromosomal disomy, the only chromosome for which data currently exists for all three species.

Aneuploidy↗
PubMedDate not supplied

[Paratesticular adenomatoid tumor, presentation as epididymal pain].

OBJECTIVE: To describe an additional case of adenomatoid tumor of the epididymis. METHODS/RESULTS: A 55-year-old man consulted for epididymal pain. Palpation and ultrasound evaluation disclosed an epididymal tumor. The patient underwent orchidectomy; histological examination of the surgical specimen confirmed an adenomatoid tumor. CONCLUSIONS: Adenomatoid tumor of the epididymis is an uncommon tumor of the paratesticular tissue. Although its etiopathogenesis remains unclear, there appears to be a mesothelial involvement. Ultrasound evaluation and clinical examination are essential in making the preoperative diagnosis. It is a benign tumor and surgical excision can achieve cure. If the intraoperative frozen section is found to be benign, the tumor can be excised or enucleated without semicastration.

Adenomatoid Tumor↗
PubMed1998

Successful pregnancy in a case of azoospermia from congenital bilateral absence of vas deferens (CBAVD) using percutaneous epididymal sperm aspiration (PESA) and intracytoplasmic sperm injection (ICSI).

In men with obstructive azoospermia, bypass surgery would obviously be the most acceptable form of treatment as it gives the couple an opportunity to conceive naturally. However, when this has failed to restore patency or when surgery is not feasible (congenital absence of vas), fertility treatment using spermatozoa aspirated from the epididymis should be considered. Percutaneous epididymal sperm aspiration (PESA) is more acceptable to patients than micro epididymal sperm aspiration (MESA) because it eliminates the requirement for a general anaesthetic, post-operative pain, and the risk of haematoma formation, thus allowing a rapid return to normal activity of the husband. To our knowledge, this is the first reported case in Thailand where a pregnancy resulted in a couple whose infertility was due to azoospermia from the congenital absence of vas deferens. Spermatozoa collected through PESA were used in ICSI to achieve fertilization. The PESA technique, due to its simplicity is the choice of treatment for obstructive azoospermia.

Adult↗