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PubMed1978

Genetical distance and dermatoglyphic characters. III. Dermatoglyphic distances within twin pairs, between left and right sides and between normals and 21-trisomics.

The dermatoglyphic (genetical) distance coefficients have been estimated within monozygotic and dizygotic twin pairs, between left and right sides of the same individual and between normal subjects and 21-trisomics. All the coefficients have been based, in turn, on frequencies of fingertip, palmar and sole pattern elements, separately and for all characters combined. Quantitative variables (pattern intensities) have also been used for independent evaluation of the C2H distance coefficient in monozygotic and dizygotic twins, and in 21-trisomics as compared with normal individuals. The values of a distance have then been considered in relation to the degree of genetical likeness between the compared items as well as to the relative contribution of each pattern combination to the overall value of a distance. Some limitations in the interpretation of the results, connected mainly with statistical procedures, are also discussed.

Chromosomes, Human, 21-22 and Y↗
PubMed1984

Changes in the heritability components of anthropometric characters due to preselection and environment during migration.

Changes in the genetic and environmental components of the phenotypic variance of 20 morphological characters were studied in Mexican migrant and sedentary populations. As far as the changes in variance components and the average values of traits were concerned, it was found that some traits were subjected to different forms of selection pressure, some changed within the limits of the norm reaction, and some remained unchanged.

Adolescent↗
PubMed1991

Character phylogeny of the primate forelimb superficial venous system.

The ontogeny and comparative anatomy of the forelimb superficial veins were investigated in humans, non-human primates and other mammals. Adult humans and the orangutan (Pongo) possess two autonomous forelimb veins, one on the lateral (preaxial) margin of the limb, the other on the medial (postaxial) margin. All other adult primates and mammals examined possess a lateral vein alone. In African apes (Pan and Gorilla) and in 24% of human forelimbs the lateral vein is short, being essentially confined to the antebrachial region, whereas in other mammals and in 76% of human limbs the lateral vein runs from the carpus to the clavicular region. In humans the medial vein develops before the lateral vein, whereas in the rabbit and the pig the medial vein is present in early embryos but is subsequently lost. We propose that in humans, and probably also in the orangutan, the possession of a medial vein is a neotenic retention of a primitive tetrapod condition. These animals, which retain their medial vein, are united by losing a late stage in their ontogeny. Other animals subsequently pass through a stage in which the medial vein is lost, but Pongo and Homo retain this vein to adulthood. The loss of an ontogenetic stage can arise independently, and the presence of a medial vein therefore affords only weak evidence for a close phylogenetic relationship between humans and the orangutan. The polymorphic lateral vein of humans may be a character state that is intermediate between the derived (short) lateral vein of the African apes and the primitive long lateral vein of other non-human primates and mammals.

Animals↗
PubMedDate not supplied

Projections of sympathetic non-noradrenergic neurons to skeletal muscle arteries in guinea-pig limbs vary with the metabolic character of muscles.

This study set out to examine in detail the distribution of axons of sympathetic non-noradrenergic neurons innervating the arterial bed in skeletal muscles of the forelimb and hindlimb of guinea-pigs. The distribution of non-noradrenergic axons with immunoreactivity to vasoactive intestinal peptide (VIP) was examined in limb muscles of different histochemical character. The immunohistochemical demonstration of myosin heavy chain from fast-twitch muscle, and the histochemical demonstration of adenosine triphosphatase and succinic dehydrogenase, were used to determine the muscle fibre profile of 6 different limb muscles. Muscles included the oxidative type I muscle fibre-rich accessory semimembranosus muscle, the predominantly glycolytic type II muscle fibre-rich cranial gracilis and biceps brachii muscles and the plantaris, gastrocnemius medial head and triceps brachii long head of mixed muscle fibre composition. The frequency with which the VIP-immunoreactive (VIP-IR) axons innervated intramuscular arterial vessels was compared between categories of muscles defined by their muscle fibre profile. This study demonstrated that the projection of non-noradrenergic sympathetic neurons to skeletal muscle vasculature was widespread in guinea-pig limb muscles, but that it was not uniform. VIP-IR axons were more likely to innervate the arterial vasculature of muscles with a high proportion of type I and/or oxidative muscle fibres than of muscles with a large proportion of type IIb muscle fibres. This relationship between the distribution of sympathetic non-noradrenergic axons and the metabolic characteristics of muscle suggests that these presumed vasodilator neurons have an important role in matching blood flow to the particular metabolic demands of different limb muscles.

Animals↗
PubMedDate not supplied

Character defenses and biofeedback. The problems of symptom chronicity and symptom removal.

One aspect of biofeedback treatment with chronically incapacitated persons concerns their resistance to getting better. In effect, the removal of their symptom is equivalent to undercutting a characteristic way of relating to themselves and to the world, and hence, is opposed. Even though many biofeedback procedures are impressively effective, the therapist must watch for another symptom reemerging in the place of the older somatic complaint, or for psychologically regressive attempts to preserve one's character defenses.

Adolescent↗
PubMed1989

Risk of schizophrenia in character disordered patients.

Inpatients from the Chestnut Lodge follow-up study diagnosed with character disorder were studied to predict future schizophrenic decompensation. Individually, three DSM-III criteria for schizotypal personality disorder predicted schizophrenia at long-term follow-up: magical thinking, suspiciousness or paranoid ideation, and social isolation. Additionally, lower IQ, poorer premorbid quality of work, and transient delusional experiences were predictive. No borderline personality disorder criterion was predictive. This suggests that schizotypal but not borderline personality disorder belongs in the schizophrenic spectrum. Within schizotypal personality disorder, criteria from both familial and clinical traditions appear to be dimensions of vulnerability to psychosis.

Adult↗
PubMed1979

Management of character disorders in a hospital setting.

Management of the character disorders in a hospital is synonymous with the therapeutic process itself. No single mode of therapy is the answer. The key seems to be a structured social setting, a therapeutic milieu involving an interdisciplinary team approach in which harmony, mutual trust and relative agreement about patient goals prevail.

Antipsychotic Agents↗
PubMed1979

Heredity and character disorders.

The role of heredity in personality development and character disorder has been studied by a variety of means. These include investigation of twins and/or families, using clinical ratings, personality scales, or psychological tests; observation of neonates and infants; and longitudinal description of discordant pairs of twins. Attention to the interaction of heredity and environment provides new strategies for prevention and treatment.

Adult↗
PubMed1979

Character disorders in traumatized and handicapped children.

Character disorders in children may arise from abuse or neglect by the family or from stresses of the broader social environment. Physically handicapped and mentally retarded children have innate disabilities that predispose them to problematic interaction with their surroundings. Early professional multidisciplinary intervention can often avert future psychopathy.

Cerebral Palsy↗
PubMed1979

Symptom formations and character changes due to upheavals of war: examples from Cyprus.

This article offers a review of the psychoanalytic and psychiatric literature on symptom formation and individual and collective character changes triggered by war or by similarly violent civil upheaval. It is suggested that each such event should be studied by itself since many different circumstances can bring man to acts of aggression. The effects of the war on Cyprus, where group narcissism developed to compensate for hurt, constitute a case example of such focused study.

Aggression↗
PubMed1983

The impact of patients with chronic character pathology on a hospital inpatient unit.

Inpatient psychiatric facilities are admitting an increasing number of young patients with chronic character pathology. Hospitals must explore the impact these patients have on the treatment facility and the risks inherent in their treatment, including the possibility of decreased milieu specificity, increased staff regression, and loss of cost-effectiveness. These risks are system responses that go beyond individual staff countertransferences. Possible remedies include refined indications for inpatient psychiatric treatment, tailoring of milieu functions to fit individual patient needs, explicit accountability of administrative and supervisory structures, and involvement of families in the formation of the initial treatment alliance.

Acting Out↗
PubMed1992

Paranoid character and the intolerance of indifference.

This paper suggests that aspects of paranoid character are structured around fantasies of magical and concrete connectedness to objects; these fantasies serve to avoid the terrors of object inconstancy. The authors describe how these fantasies are expressed in the psychoanalytic situation and explore their relation to common paranoid phenomena. The paranoid person must maintain these fantasies of connectedness at all cost or risk experiencing unbearable indifference between self and object. Paradoxically, the sacrifice of self and object boundaries inherent in these fantasies makes object constancy even more difficult to achieve because of the secondary defensive use of anger mobilized to protect the boundaries of the self.

Ego↗
PubMed1983

The multi-dimensional inpatient treatment of severe character disorders.

Patients with severe character disorders present a special challenge to the clinician. Many can be helped with outpatient psychotherapy, often with the adjunctive use of medication. Some cannot, and need intensive inpatient treatment. An inpatient psychiatric unit in a general hospital is described which has been designed to treat such patients. The treatment makes use of a variety of therapeutic modalities. Psychotherapy is central and essential to the successful functioning of this therapeutic instrument.

Adolescent↗
PubMed2001

Evaluation of the All Stars character education and problem behavior prevention program: effects on mediator and outcome variables for middle school students.

The effects of All Stars, a character education and problem behavior prevention program, on variables theorized to mediate problem behaviors and on the problem behavior variables of substance use, sexual behavior, and violence among middle school students are reported. In an independent, randomized, single-cohort, longitudinal evaluation of the program, 1,655 students completed pretest, posttest, and 1-year follow-up surveys measuring demographics, mediating variables, and behavioral outcome variables. Results indicate that the All Stars program, when administered by teachers, had an immediate effect on mediating variables that did not persist over time. Inclusion of ethnicity in the design showed that the program, when administered by specialists, had delayed effects on mediating variables for African American and Hispanic students. However, no consistent effects were found for student problem behaviors in either condition. Implications for prevention practice and directions for future research are discussed.

Adolescent↗
PubMed1998

ERPs of characters of Chinese words compared with tone and picture stimuli in adolescents and aged persons.

ERPs to target stimulation with tone, picture and characters of Chinese words ([symbol: see text] CCW were target stimulus) were studied in adolescents group and aged persons group. The age of the adolescent group ranged from 15-17 years, with 30 males and 30 females; the age of the elderly persons group ranged from 60-79 years with 29 males and 18 females. The latencies of N2 of aged persons in tone stimulus and in picture stimulus among males were longer than those of adolescents. The latencies of P3 and RT of aged persons were longer than those of adolescents in three stimulus models. The gender differences of latencies of N2 and RT were not obvious in two groups, but were apparent in P3 in adolescents. The latencies of N2, P3 and RT of CCW stimulus were longer compared to those of picture stimulus in the adolescent group, but not in the aged persons group.

Adolescent↗
PubMed2005

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.

Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9, Meis1 accelerates leukemogenesis. Because Hoxa9 immortalizes myeloid progenitors in the absence of Meis1 expression, the contribution of Meis1 toward leukemia remains unclear. Here, we describe a cultured progenitor model in which Meis1 programs leukemogenicity. Progenitors immortalized by Hoxa9 in culture are myeloid-lineage restricted and only infrequently caused leukemia after more than 250 days. Coexpressed Meis1 programmed rapid AML-initiating character, maintained multipotent progenitor potential, and induced expression of genes associated with short-term hematopoietic stem cells (HSCs), such as FLT3 and CD34, whose expression also characterizes the leukemia-initiating stem cells of human AML. Meis1 leukemogenesis functions required binding to Pbx, binding to DNA, and a conserved function of its C-terminal tail. We hypothesize that Meis1 is required for the homing and survival of leukemic progenitors within their hematopoietic niches, functions mediated by HSC-specific genes such as CD34 and Fms-like tyrosine kinase 3 (FLT3), respectively. This is the first example of a transcription factor oncoprotein (Meis1) that establishes expression of a tyrosine kinase oncoprotein (FLT3), and explains their coexpression in human leukemia. This cultured progenitor model will be useful to define the genetic basis of leukemogenesis involving Hoxa9 and Meis1.

Acute Disease↗
PubMed2007

Character process model for semen volume in AI rams: evaluation of correlation structures for long and short-term environmental effects.

The objective of this study was to build a character process model taking into account serial correlations for the analysis of repeated measurements of semen volume in AI rams. For each ram, measurements were repeated within and across years. Therefore, we considered a model including three environmental effects: the long-term environmental effect, which is a random year(*)subject effect, the short-term environmental effect, which is a random within year subject(*)collection effect, and the classical measurement error. We used a four-step approach to build the model. The first step explored graphically the serial correlations. The second step compared four models with different correlation structures for the short-term environmental effect. We selected fixed effects in the third step. In the fourth step, we compared four correlation structures for the long-term environmental effect. The model, which fitted best the data, used a spatial power correlation structure for the short-term environmental effect and a first order autoregressive process for the long-term environmental effect. The heritability estimate was 0.27 (0.04), the within year repeatability decreased from 0.56 to 0.44 and the repeatability across years decreased from 0.43 to 0.37.

Animals↗