Comprehensive diagnostic approach to breast cancer. November 1984-September 1988.
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In patients with isolated malignant tumoral hepatomegaly, the investigations performed should aim at excluding a primary carcinoma of the liver and concentrate on the search for primary tumours belonging to 2 main groups: tumours responsive to hormonal treatment or chemotherapy, and obstructive tumours amenable to local palliative measures. In all cases where simple, essentially clinical examinations fail to indicate the cause of the tumoral liver enlargement, further investigations should be based on the histopathological features of the metastases.
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As described in the above paragraphs, efforts in the areas of immunology, cytogenetics, molecular biology, and cytopathology have been applied to the problems urologists face in treating the individual patient with bladder cancer. It is hoped that continued investigations in these disciplines will not only lead to earlier diagnosis of bladder cancer and better prediction of tumor behavior but will further our understanding of the molecular basis of oncogenesis.
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Altogether 89 patients were examined using scintigraphy with 67Ga-citrate. Radiometric, scintigraphic, radioautographic and histological investigation of the operation material of 15 patients was conducted. The diagnostic accuracy was 92.1%, sensitivity 98.6%, specificity 75%. The investigation of the operation material showed that RP accumulation in the peripheral part of tumor was 4-4.5 times higher and in its central part 2-3 times higher than in the unaffected pulmonary tissue. Elevated RP accumulation was found in the capsular wall in inflammatory processes as well as in lymph nodes with anthracosis. Recovered silver grains on histoautoradiograms of tumor tissue zones were mainly localised around isolated cells and their groups in the intercellular space.
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