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Nonreproduction, homosexuality, transsexualism, and intelligence: I. A systematic literature search.

The relationship between various forms of nonreproduction (especially homosexuality) and intelligence (as measured by IQ and other tests) is investigated by a systematic review of the literature, selecting studies without regard to the direction of their findings. Most studies found the more homosexual subject groups' scores to be higher than those of the more heterosexual controls, and all exceptions to this trend are concentrated in one subgroup: prisoners. Moreover, the more representative the sample studied, and the less subject to challenge the methodology used, the clearer and more statistically significant was the superiority in intelligence of the more homosexual over the more heterosexual group.

Female↗

Artificial intelligence-assisted occupational lung disease diagnosis.

An artificial intelligence expert-based system for facilitating the clinical recognition of occupational and environmental factors in lung disease has been developed in a pilot fashion. It utilizes a knowledge representation scheme to capture relevant clinical knowledge into structures about specific objects (jobs, diseases, etc) and pairwise relations between objects. Quantifiers describe both the closeness of association and risk, as well as the degree of belief in the validity of a fact. An independent inference engine utilizes the knowledge, combining likelihoods and uncertainties to achieve estimates of likelihood factors for specific paths from work to illness. The system creates a series of "paths," linking work activities to disease outcomes. One path links a single period of work to a single possible disease outcome. In a preliminary trial, the number of "paths" from job to possible disease averaged 18 per subject in a general population and averaged 25 per subject in an asthmatic population. Artificial intelligence methods hold promise in the future to facilitate diagnosis in pulmonary and occupational medicine.

Artificial Intelligence↗

Development of a Computational Histology Artificial Intelligence-Powered Prognostic Biomarker in Colorectal Cancer in The Cancer Genome Atlas.

BACKGROUND: Risk stratification in colorectal cancer (CRC) plays an important role in treatment decision-making. As such, prognostic biomarkers that can augment risk stratification have clinical value. Quantitative histologic features from routine hematoxylin and eosin (H&E)-stained whole slide images (WSIs) provide a novel avenue for biomarker discovery. In this study, we explored the potential for a computational histology artificial intelligence (CHAI) platform to develop and validate a prognostic biomarker in CRC. METHODS: The Cancer Genome Atlas Colorectal Adenocarcinoma project was utilized for this study, with inclusion of all subjects (stage I-IV) with available digitized H&E specimens. The cohort was split into development and validation cohorts by a stratified random split. The previously developed CHAI platform was applied in the development cohort to construct a continuous risk score from histologic features associated with progression-free interval (PFI) that was dichotomized based on an optimized cutpoint for distinguishing PFI into a high risk CHAI (+) and lower risk CHAI (-). PFI was compared between CHAI (+) and CHAI (-) patients in the validation cohort in multivariable Cox proportional hazards models. Time-dependent area under the curve (tdAUC) and C-indices were also calculated for PFI. RESULTS: A total of 583 participants were included in the study, with 409 assigned to the validation cohort. The CHAI biomarker classified 229 participants (56%) as CHAI (+) and 180 (44%) as CHAI (-) in the validation set. CHAI (+) participants had worse PFI in a multivariable analysis adjusting for available clinicopathologic variables (hazard ratio (HR) = 2.65; 95% confidence interval (CI), 1.63-4.30). TdAUC for the CHAI biomarker was 0.60 (95% CI, 0.53-0.67) at 12 months, 0.62 (0.55-0.69) at 36 months, and 0.67 (0.55-0.79) at 60 months; the C-index was 0.62 (95% CI, 0.58-0.67). CONCLUSIONS: The CHAI platform was used to develop a prognostic digital pathology biomarker in CRC. This demonstrates the feasibility and potential to apply this artificial intelligence-based digital pathology biomarker platform for risk stratification in CRC and supports its further study.

Artificial intelligence↗

[Analytic design and clinical application of an intelligent control system for pharmacotherapy with insulin--1].

To determine whether insulin dosage recommendations provided by a computer system are as effective as those given by human experts, we developed an intelligent control system and prospectively studied its use in 42 type-1 diabetics attending a diabetes education center. Control algorithms were based on blood glucose self-monitoring and included parameter estimations to determine glucose metabolism. The algorithms were implemented in a vest pocket-sized system. Over a period of 32 days, 21 patients used the computer to determine the necessary dose of insulin, while a second group of 21 patients followed the recommendations of the diabetes specialists. Baseline HbA1 levels (9.8 +/- 1.6 vs 9.9 +/- 1.6%) were identical in the two groups. The mean serum glucose over the last two weeks of the study was lower in the computer group (151.3 +/- 25.2 vs 165.7 +/- 36.0 mg/dl; p < 0.01) although the rates of hypoglycaemic episodes were equal (1.7 vs 2.3%). Metabolic control, measured by the day-to-day standard deviation of the serum glucose (46.8 +/- 14.4 vs 50.4 +/- 16.2 mg/dl; p < 0.01), was more stable in the computer group. We conclude that metabolic control and safety were comparable in the two groups, and suggest that such an intelligent control system may be of benefit for use at home, when the help of doctors or diabetes educators is not available.

Artificial Intelligence↗

[Analytic design and clinical application of an intelligent control system for pharmacotherapy with insulin--2].

To determine whether insulin dosage recommendations provided by a computer system are as effective as those given by human experts, we developed an intelligent control system and prospectively studied its use in 42 type-1 diabetics attending a diabetes education center. Control algorithms were based on blood glucose self-monitoring and included parameter estimations to determine glucose metabolism. The algorithms were implemented in a vest pocket-sized system. Over a period of 32 days, 21 patients used the computer to determine the necessary dose of insulin, while a second group of 21 patients followed the recommendations of the diabetes specialists. Baseline HbA1 levels (9.8 +/- 1.6 vs 9.9 +/- 1.6%) were identical in the two groups. The mean serum glucose over the last two weeks of the study was lower in the computer group (151.3 +/- 25.2 vs 165.7 +/- 36.0 mg/dl; p < 0.01) although the rates of hypoglycaemic episodes were equal (1.7 vs 2.3%). Metabolic control, measured by the day-to-day standard deviation of the serum glucose (46.8 +/- 14.4 vs 50.4 +/- 16.2 mg/dl; p < 0.01), was more stable in the computer group. We conclude that metabolic control and safety were comparable in the two groups, and suggest that such an intelligent control system may be of benefit for use at home, when the help of doctors or diabetes educators is not available.

Adult↗

Mental, neuropsychic, and brain patterns of defense. Neuropsychic defense continua from psychopathology to the particularly human parallel networks that are problematic for artificial intelligence.

The synthesis of psychodynamic and neuroscientific data may be advanced by the study of similarly configured specific patterns of defense along continua from the normal and neurotic mental mechanisms of defenses, through what might be termed neuropsychiatric defenses influenced by the neurological state, to the more clearly neurological cortical reactions. These similar patterns and continua are the particularly human way brain adds its flavor of organism to mind, and the way in which all the psychodynamic mechanisms are specifically imbedded in brain. A purely psychological psychodynamics lacking this medical perspective fails to model human mental processes and reflects problems with artificial intelligence models that do not model brain. The pathological reactions that we address in psychiatry and neuropsychiatry interfere with and thereby reveal parallel processing features in (1) analogical and metaphorical thinking; (2) reduplication, redundancy, and repetitiveness; (3) self, person, and environmental recognition, including transference processes; (4) approximation and statistical inference; (5) spatiality and motor control; (6) affectivity, perception of sensations and sexuality; (7) projective mechanisms; and (8) problem solving by optimization, vectorial summation, and the mutual interaction of interconnected agencies. The new concepts in artificial intelligence built upon brainlike structures called neural nets portend great economies, emergent natural features that are more like human processes, and hierarchical and cyclic organizational demands. Medical psychoanalysts who comprehend dynamic and brain mechanisms and can describe them in terms that refer to both domains and their interaction should find increasing theoretical and practical convergence of their work with the emerging study and modeling of these processes by new forms of computers.

Adult↗

[Evaluation of intelligence with non-verbal tests in aphasic patients].

Eight patients with cerebral vascular disease and aphasia were studied just after the stroke. The clinical, neuropsychiatric, EEG and neuro-radiological aspects were evaluated. The patients were submitted to the psychological and phonoaudiological studies. The authors correlated the neurological lesions to the structural alteration of the intelligence, to the praxic and estheognostic alterations and also to the language disturbances. The criterions adopted by the World Health Organization and the genetics classification of Jean Piaget were used for the intellectual level classification. The results suggest that the intelligence evaluated through Leither's non-verbal test is better preserved in some asphasics.

Adolescent↗

Wisdom and intelligence: the nature and function of knowledge in the later years.

Intelligence can be defined as the ability to think logically, to conceptualize and abstract from reality. Wisdom can be defined as the ability to grasp human nature, which is paradoxical, contradictory, and subject to continual change. These two constructs hold potential for highlighting positive and adaptive features of development in the later years. both are considered to increase with age, and both provide for life-long acquisition of knowledge. Despite these phenotypic similarities, this paper attempts to illustrate that the nature of wisdom and its function in the developmental process differs sufficiently from cognitive ability to warrant separate scrutiny. These two constructs are compared with respect to the domains of behavior they represent, the operational tasks used to assess them, and the relationship of logic and time in their development. The function of intelligence is characterized as focusing on questions of how to do and accomplish necessary life-supporting tasks; the function of wisdom Is characterized as provoking the individual to consider the consequences of his actions both to self and their effects on others. Wisdom, therefore, evokes questions of should one pursue a particular course of action.

Aged↗

Social ecology of intelligence and suicide in the United States.

Two proxy variables for regional intelligence, state-level mean scores of 1994-2004 on the American College Test and of 1982, 1993, 1994, and 1998-2004 on the Scholastic Assessment Test, were consistently positively correlated with the averaged regional U.S. suicide rates of 1990-1994. The effects observed in these ecological (group-level) analyses were of small size, with correlation coefficients ranging from .05 to .25, thus mostly falling below the nominal statistical significance level. The present evidence nevertheless adds to several recent findings from international geographical studies by Lester and by Voracek of a positive association of intelligence and suicide mortality by indicating that this pattern may also exist on the within-nation level.

Humans↗

Regional intelligence and suicide rate in Germany.

Regional intelligence proxies (intranational average domain scores from the PISA 2000 and 2003 studies) were not reliably associated with the suicide rate across the states of Germany, thereby not replicating findings of a positive ecological correlation of regional intelligence and suicide prevalence from other within-nation studies (Austria, Belarus, the British Isles, Denmark, The Netherlands, and the USA).

Cross-Sectional Studies↗

Auditory discrimination, intelligence, and reading achievement at grade 1.

To determine the relations of auditory discrimination and intelligence to reading achievement in first grade the California Test of Mental Maturity, the California Achievement Test (reading), and the Buktenica Modification of the Wepman Auditory Discrimination Test were administered to 78 first grade students. Correlations suggested a stronger relation between auditory discrimination and reading than between IQ and reading as measured here; however, range of reading scores were restricted. Results support Wepman's developmental theory. The methodological approach includes simultaneous consideration of effects of auditory discrimination and intelligence.

Achievement↗

Human intelligence and power spectral analysis of visual evoked potentials.

The relationship between intelligence and power spectra of visual evoked potential was investigated using 8 normal and 8 mentally retarded children as subjects. The results showed the power spectrum of mentally retarded has a peak at 4 to 6 Hz, whereas that of normal has two apparent peaks at 4 and 12 Hz. It appears the peak at 12 Hz reflects the difference of intelligence.

Adolescent↗

The paradoxical relationship between intelligence and reading disability.

Specific reading disability or developmental dyslexia is a condition wherein an individual with average or superior intelligence does not acquire normal reading skills. This paper provides a tentative explanation of the paradoxical relationship between the reading disability and intelligence. Study of 15 dyslexic college students showed that they were deficient in grapheme-phoneme conversion and that the decoding skill could be an autonomous, specific ability that is independent of the "g" factor as expressed in terms of IQ. The decoding skill appears to be a subroutine and may, in dyslexia, operate as a limiting factor that affects reading comprehension.

Dyslexia↗

Magnitude-estimation scaling of speech intelligibility: effects of listeners' experience and semantic-syntactic context.

Fifteen speech-language pathologists with extensive experience judging speakers' intelligibility and 15 control subjects with no such previous experience provided magnitude-estimation responses for two sets of nine audiotaped speech samples. These samples were three utterances composed of a group of 17 words that contained all the consonant phonemes of English. These words were arranged to form a set of either meaningful or nonsense utterances. Nine separate versions of both the meaningful and nonsense utterances were created by systematically increasing the number of phonemes produced incorrectly on each of the nine recordings. The analysis indicated no significant difference between the magnitude-estimation scaling responses of experienced and inexperienced listeners. A significant over-all difference was found for listeners' responses to meaningful versus nonsense utterances. The advantages of magnitude-estimation scaling as a measure of speakers' intelligibility are discussed.

Adult↗

Correlations of the Kahn Intelligence Test and the WAIS--R IQs among mentally retarded adults.

Correlations of scores on the WAIS--R and Kahn Intelligence Test: Experimental (KIT) were examined. The 21 subjects were moderately and severely adaptively impaired adults. The WAIS--R is frequently included in the evaluation of moderately and severely retarded adults but its use has been questioned given the problem of statistical floor because institutionalized mentally retarded adults were excluded from the standardization sample. Tasks demand verbal communication and timed performance. The KIT is utilized as a test of intelligence that requires limited verbal skills, is less influenced by cultural/educational factors, and has an adequate statistical floor. Results suggested significantly lower mean scores on the KIT than on WAIS--R. If further evidence supports these conclusions, the KIT may be a valuable instrument in the assessment of moderately and severely retarded adults.

Adult↗

Intelligence and motor skill acquisition by discrimination learning.

This experiment investigated the relation between intelligence and acquisition of motor skill using predictions from Zeaman and House's 1963 attention theory. 20 undergraduate students and 20 subjects of low IQ (WAIS-R Full Scale IQ range 50 to 73, M = 60) made linear positioning movements of long and short amplitude to the left and right of a central starting position. Four conditions (right-long, right-short, left-long, left-short) were created by specifying the corresponding target area on the positioning apparatus. One or both of the paired cues were varied, i.e., left, right, long, or short, while the dimensions of direction and amplitude remained unchanged across conditions. A shift from one condition to the next followed a criterion response of four consecutive movements to the target area. Results supported the hypothesis that subjects of low IQ would require more trials to criterion than subjects of normal IQ across all conditions of direction and extent. There was qualified support for the hypothesised interaction between intelligence and cue shifts. The practical implications and theoretical significance of these findings are discussed.

Adolescent↗

Correlations of scores on the Kaufman short neuropsychological assessment procedure and the Kaufman Adolescent and Adult Intelligence Test for a hospitalized depressed sample.

Scores on the K-SNAP, a new brief cognitive measure designed to assess neuropsychological functioning in adolescents and adults, were correlated with KAIT IQs, a comprehensive test that measures fluid and crystallized intelligence. The sample included 33 adolescent and adult patients hospitalized for depression. The K-SNAP correlated significantly higher with fluid than crystallized intelligence.

Adolescent↗

Measured intelligence of problematic patients with chronic pain.

100 patients with chronic pain judged "problematic" by their referring physicians were administered the Wechsler Adult Intelligence Test-Revised. 38 obtained IQs of 85 or less while only 11 earned IQs of 101 or higher. While a number of confounds may have influenced these results, low intelligence appears to be a marker for negative treatment prognosis, at least as perceived by physicians, and its influence would seem to merit further investigation and clarification.

Adult↗