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Results for “developmental delay”

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PubMed1989

Prenatal ethanol and stress in mice: 1. Pup behavioral development and maternal physiology.

On days 12 to 17 of pregnancy, B6D2F1 mice were pair-fed liquid diets containing either 25% ethanol-derived calories or an isocaloric amount of maltose-dextrin. During this period, half the mice in each dietary condition also underwent two daily one-hour periods of restraint stress. A fifth group, given lab chow and water ad lib, was left undisturbed throughout gestation. Neither treatment affected offspring body weight on days 22 or 32 postconception, but undernutrition produced by the pair feeding procedure reduced day 32 body weight in all groups relative to the ad lib-fed group. Both prenatal ethanol and pair feeding led to delayed neurobehavioral development on day 32, while prenatal stress significantly reduced the degree of developmental delay caused by these factors. In a second study, restraint stress significantly reduced blood alcohol concentrations in pregnant dams on day 15 of gestation while elevating plasma corticosterone concentrations, and this elevation was consistent regardless of the dietary condition of the dam. The pair feeding procedure also produced corticosterone elevations but the effect of ethanol was not significant. These results suggest that prenatal stress in the presence of other physiological insults may act to counter the actions of those insults.

Animals↗
PubMedDate not supplied

Comparison of sight word training procedures with validation of the most practical procedure in teaching reading for daily living.

The effectiveness and efficiency (training trials and training errors through criterion) of stimulus fading, stimulus shaping, time delay, and a feedback only procedure were compared in teaching three adults with moderate developmental delays sight words encountered in activities of daily living. In Experiment 1, the four procedures were assessed during training in a controlled environment to identify the most effective and efficient procedure for each participant. All three adults acquired the target words, and the four procedures were found to be of comparable efficiency in total training sessions, whereas individual differences were found in training errors to criterion. In Experiment 2, the feedback only procedure was used to teach the three participants sight words in community settings. Participants learned new words in the community settings and used the previously trained words in daily living activities. The benefit of conducting a preliminary evaluation of instructional procedures during controlled training is discussed.

Activities of Daily Living↗
PubMed1998

Non-progressive congenital ataxias.

Congenital ataxias (CA) are rare, predominantly non-progressive syndromes characterized by marked hypotonia, developmental delay followed by the appearance of ataxia. Most children show marked speech and cognitive developmental problems. Non- progressive CA (NPCA) can be divided into pure CA without additional symptoms and syndromes with CA. Pure CA can be due to cerebellar malformations as (hereditary or non-hereditary) cerebellar hypoplasia, Dandy Walker syndrome, or occasionally supratentorial abnormalities. Ataxic syndromes are less frequent, but more distinctive. There are syndromes (e.g. Joubert syndrome) where ataxia is a cardinal feature and others where ataxia is only an occasional symptom. Acquired ataxias, due to congenital cytomegalovirus infection or perinatal problems, form a small third group. In about half of all cases with NPCA, aetiology and inheritance are still unknown. Diagnosis of NPCA is made by a typical history and careful clinical examination. Diagnosis of a more distinctive ataxic syndrome may be possible on clinical grounds. Neuroimaging with special attention to the posterior fossa will aid accurate clinical classification. Early progressive ataxias require careful differentiation from other types.

Ataxia↗
PubMed2004

A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R.

BACKGROUND: Autism is a pervasive developmental disorder characterized by a triad of deficits: qualitative impairments in social interactions, communication deficits, and repetitive and stereotyped patterns of behavior. Although autism is etiologically heterogeneous, family and twin studies have established a definite genetic basis. The inheritance of idiopathic autism is presumed to be complex, with many genes involved; environmental factors are also possibly contributory. The analysis of chromosome abnormalities associated with autism contributes greatly to the identification of autism candidate genes. CASE PRESENTATION: We describe a child with autistic disorder and an interstitial deletion on chromosome 4q. This child first presented at 12 months of age with developmental delay and minor dysmorphic features. At 4 years of age a diagnosis of Pervasive Developmental Disorder was made. At 11 years of age he met diagnostic criteria for autism. Cytogenetic studies revealed a chromosome 4q deletion. The karyotype was 46, XY del 4 (q31.3-q33). Here we report the clinical phenotype of the child and the molecular characterization of the deletion using molecular cytogenetic techniques and analysis of polymorphic markers. These studies revealed a 19 megabase deletion spanning 4q32 to 4q34. Analysis of existing polymorphic markers and new markers developed in this study revealed that the deletion arose on a paternally derived chromosome. To date 33 genes of known or inferred function are deleted as a consequence of the deletion. Among these are the AMPA 2 gene that encodes the glutamate receptor GluR2 sub-unit, GLRA3 and GLRB genes that encode glycine receptor subunits and neuropeptide Y receptor genes NPY1R and NPY5R. CONCLUSIONS: The deletion in this autistic subject serves to highlight specific autism candidate genes. He is hemizygous for AMPA 2, GLRA3, GLRB, NPY1R and NPY5R. GluR2 is the major determinant of AMPA receptor structure. Glutamate receptors maintain structural and functional plasticity of synapses. Neuropeptide Y and its receptors NPY1R and NPY5R play a role in hippocampal learning and memory. Glycine receptors are expressed in very early cortical development. Molecular cytogenetic studies and DNA sequence analysis in other patients with autism will be necessary to confirm that these genes are involved in autism.

Autistic Disorder↗
PubMed1976

Predictive nursing: the baby and parents.

Predictive nursing as a health care strategy is not entirely new. What is new and emerging are means of sharpening our assessments of the events and conditions that support health, as well as specific models engaging the individual in assessing and altering or maintaining his position on the health continuum. This study has been shared with the readers to provide an encouraging direction toward new modes of health care delivery. We believe it is the most encouraging strategy for assisting families in promoting optimal health of infants from a very early point in the infant's life. The assessment techniques discussed in this paper relate to methods of identifying individual behavior patterns of newborn infants, behavioral interaction patterns of parents and infants during the early months and years of life, and the parents' perception of the infant. All of these measures are now being tested by the Nursing Child Assessment Project staff and will result in a systematic format of screening and assessing infants and families "at risk". With current knowledge, astoundingly correct predictions about cognitive development and achievement at school age of groups of children can be made with information about the mother's levels of education and the events of the perinatal periods. The measures discussed in this article concerning the infants' behavior, parent-child interaction, and the parents' perception of the child are factors which will go beyond our present ability to identify potential problems early. Predictive nursing of the infant and young child is our eventual goal. This means going a step beyond the current level of practice by beginning to systematically identify the proneness of individuals to good or bad health outcomes--specifically, the proneness of children to have developmental delays or problems--and to then provide a meaningful type of intervention before the developmental problem occurs.

Child Behavior↗
PubMed1994

Caregivers' expectations of future learning of dependents with a developmental disability.

Attitudes and expectations of caregivers affect the development of children, including those with a developmental disability. The purpose of this study was to examine caregivers' expectations of their dependent with a developmental disability and caregiver attributions in relation to these expectations. Primary caregivers (N = 35) were interviewed about their expectations and attributions related to the dependents' achievements. Expectations were measured by the Predictive Adaptive Ability Questionnaire (PAAQ). Expectations were significantly predicted by the degree of developmental delay and number of handicaps. Caregivers expected less of dependents who had a lower developmental age/chronological age ratio than for dependents whose developmental level more closely approximated the chronological age. Results suggest that nurses should assess caregivers' expectations for the future development of their dependent with a developmental disability and the basis for those expectations.

Adolescent↗
PubMed1995

Early childhood surveillance of developmental disorders by a birth defects surveillance system: methods, prevalence comparisons, and mortality patterns.

The prevalence of developmental disabilities in early childhood is not well documented. An established birth defects registry extended surveillance to identify cases of developmental disorders in early childhood by adding all known sources of diagnosis and service to case-finding methods. Residents of a northwest Arkansas region born during 1985 to 1987 and diagnosed with either a birth defect or a developmental disorder by the 4th birthday comprised the studied cohort. Case records were linked with death certificates to examine the influence of mortality on prevalence ratios. Prevalence ratios estimated were 64.5/1000 resident live births (60.9/1000 among survivors to age 4 years) for either birth defect or developmental disorder, 33.4/1000 for developmental disorder, 37.0/1000 for birth defect, and 9.5/1000 for both developmental disorder and birth defect. Prevalence ratios of specific developmental disorders and the role of mortality in decreasing population prevalence are reported. The most common diagnostic categories in this age group were developmental delay, seizures, and failure to thrive. Overlap of birth defect categories with a diagnosed developmental disability was examined; 68.8% of children diagnosed with neural tube defects and 45.5% of those with chromosomal abnormalities who survived to age 4 years had clinically diagnosed developmental disorders. An anticipated high degree of overlap (77%) for other central nervous system defects was found. For other birth defect categories, developmental disorder diagnosis was present in 20 to 30% of the study group. Death before age 4 years occurred most often when the diagnosis was newborn seizures (17.1%) or "conditions of the brain" (13.6%); the mortality rate was 6 to 8% for epilepsy or seizure disorders, mental retardation, and vision loss. The large number of developmental diagnoses among this cohort indicates that surveillance of these disorders in early childhood, even with tentative diagnoses, is feasible. Data obtained indicate that many birth defects are associated with developmental disorders; potentially, this association can contribute to earlier identification of developmental disorders in childhood.

Arkansas↗
PubMed2005

Developmental screening by the Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) in HIV- infected children.

Bayley Scales of Infant Development (BSID) is considered to be a standard test for child development. The test requires experienced evaluator and is time consuming; therefore, it is not easy to apply in busy clinic. The Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) is an easy assessment method that has been demonstrated to correlate with BSID in many studies among normal and developmental delayed children, including in HIV-infected infants. We created a pilot system of CAT/CLAMS assessment applied to 16 HIV-infected infants ages 12-34 months. They were all in the normal range score of developmental quotient (DQ). However, longitudinal follow-up by CAT/CLAMS assessment is needed in these HIV-infected children. When DQ score is below 70 (assuming to be delayed development), the child should be evaluated by BSID. In this way delayed development can be screened easily and early developmental stimulation program can be implemented appropriately.

Child Development↗
PubMed2003

Early intervention after universal neonatal hearing screening: impact on outcomes.

This article summarizes the developmental outcomes of Colorado children with significant hearing loss. Some of the research compares children born in hospitals that have implemented universal newborn hearing screening programs for newborns. Other research compares the developmental outcomes of children who have been early-identified with hearing loss. Early-identification is defined as identification of hearing loss within the first six months of life. Late identification in the Colorado studies is defined as age of identification of hearing loss after the age of six months. In a few of the Colorado studies, age at initiation of intervention was used. Within the Colorado system, age of identification can be interpreted as almost synonymous with age of intervention, as the vast majority of children enter intervention services with two months after the identification of the hearing loss. Children who were early-identified and had early initiation of intervention services (within the first year of life) had significantly better vocabulary, general language abilities, speech intelligibility and phoneme repertoires, syntax as measured by mean length of utterance, social-emotional development, parental bonding, and parental grief resolution. Two other studies (Nebraska and Washington state) of early- versus later-initiation of intervention services report findings similar to the Colorado studies. Direct comparisons with the historical literature are not possible because the developmental delays of what would now be termed "later-identified" were too low to report developmental ages for the birth through five-year-old population.

Child, Preschool↗
PubMed1992

Serial MRI in Fukuyama type congenital muscular dystrophy.

Serial MRI of the brain of a female infant with Fukuyama type congenital muscular dystrophy (FCMD) is presented. Initial MRI revealed diffuse abnormal signal in the cerebral white matter extending peripherally. On follow-up studies, the abnormal signals disappeared or decreased from the posterior to anterior, and from central to peripheral. These changes in signal intensity correlate well with the process of myelination as demonstrated in histochemical studies. It appears that the abnormal signals in FCMD are caused by delayed myelination. When abnormal signal intensity is seen in the cerebral white matter of a developmentally delayed infant, serial MRI may be used to follow the course of the illness.

Ankle Joint↗
PubMed1996

Neurobehavioral development of neonatal rats after in-utero hypothyroxinemia: efficacy of prenatal thyroxine treatment.

The aim of this study was to assess the impact on neonatal neurobehavioral development of methimazole (MMI)-induced in-utero hypothyroxinemia and of correction by maternal-fetal thyroxine (T4) transfer in the rat. Two groups of pregnant Sprague-Dawley rats received MMI as drinking water from gestation day 10 until birth. From day 16 until parturition, one of these groups received daily intraperitoneal injections of L-T4 and the other received saline injections. A third (control) group drank tap water and received saline injections. From day of birth, offspring from all groups were raised by untreated foster dams. Their neurobehavioral development was monitored, on postnatal days 5-14 (N = 3/litter, from 30 litters) by experimenters blind to treatment group. Prenatal T4 treatment resulted in correction of MMI-induced delayed appearance of three different reflexes. Body-weight gain of treated pups was similar to that of controls and more rapid than development of rats treated with MMI-alone. T4 treatment did not prevent, however, MMI-induced delay in maturation of physiological landmarks (e.g. ear opening). At least a portion of the developmental delay resulting from prenatal (maternal) MMI administration may be reversed by maternal-fetal transfer of T4 administered to the gravid dam.

Administration, Oral↗
PubMed2001

Malformations of cortical development and epilepsy.

Although once thought to be rare, malformations of cortical development are being increasingly recognized as the underlying cause of developmental delay in children and of epilepsy in children and young adults. Advances in neuroimaging and developmental neurobiology have created the tools by which these important malformations have been investigated. Through a symbiotic type of relationship, these investigations, and the search for a better understanding of these malformations, have led to advances in neuroimaging techniques and better understanding of both normal and abnormal brain development. In this review, the most common malformations or cortical development associated with epilepsy are discussed in regard to their clinical manifestations, classification, imaging appearance and basic neurobiology.

Cell Movement↗
PubMed2002

Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly).

Pelger-Huët anomaly (PHA; OMIM *169400) is an autosomal dominant disorder characterized by abnormal nuclear shape and chromatin organization in blood granulocytes. Affected individuals show hypolobulated neutrophil nuclei with coarse chromatin. Presumed homozygous individuals have ovoid neutrophil nuclei, as well as varying degrees of developmental delay, epilepsy and skeletal abnormalities. Homozygous offspring in an extinct rabbit lineage showed severe chondrodystrophy, developmental anomalies and increased pre- and postnatal mortality. Here we show, by carrying out a genome-wide linkage scan, that PHA is linked to chromosome 1q41-43. We identified four splice-site, two frameshift and two nonsense mutations in LBR, encoding the lamin B receptor. The lamin B receptor (LBR), a member of the sterol reductase family, is evolutionarily conserved and integral to the inner nuclear membrane; it targets heterochromatin and lamins to the nuclear membrane. Lymphoblastoid cells from heterozygous individuals affected with PHA show reduced expression of the lamin B receptor, and cells homozygous with respect to PHA contain only trace amounts of it. We found that expression of the lamin B receptor affects neutrophil nuclear shape and chromatin distribution in a dose-dependent manner. Our findings have implications for understanding nuclear envelope-heterochromatin interactions, the pathogenesis of Pelger-like conditions in leukemia, infection and toxic drug reactions, and the evolution of neutrophil nuclear shape.

Cell Line↗
PubMed1993

Unique hereditary sensory and autonomic neuropathy with growth hormone deficiency.

The proband, a French-Canadian white boy, presented with congenital sensory polyneuropathy, moderate to severe sensorineural hearing loss, infantile cataracts, nystagmus, esotropia, unusual facies, hypotonia, bilateral congenital hip dysplasia, delayed ossification of the femoral heads, scoliosis, short stature secondary to growth hormone deficiency, and developmental delay. His parents are consanguineous. His maternal first cousin, a 16-year-old girl, has congenital sensory polyneuropathy, infantile cataracts, unusual facies, scoliosis, short stature secondary to growth hormone deficiency, late-childhood-onset arthritis, and hypoglycemia. Reportedly, she has no hearing difficulties and has normal intelligence. Her parents are third cousins. These children appear to have a distinct variant of hereditary sensory and autonomic neuropathy with infantile cataracts, unusual facies, skeletal dysplasia, short stature secondary to growth hormone deficiency, and other features, with probable autosomal recessive inheritance.

Adolescent↗
PubMed1996

[Developmental status at 12 months of age in a cohort of children in southern Brazil: differences according birthweight and family income]

This study evaluated all children born in 1993 in hospitals from Pelotas, Rio Grande do Sul, Brazil. Besides a perinatal study, a sample of 20% (1400 children) was followed through home visits during the first year. During these visits the nutritional status was assessed and a screening test for development (Denver II Test) was performed. Thirty-four per cent of the children assessed at 12 months failed this screening. Failure was associated with socioeconomic status, with low-income children presenting twice the risk of those from more affluent families (p<0,001). Failure in the screening test was also associated with birthweight, and children weighing less than 2,500 g showed three times the risk of those with a birthweight equal to or greater than 2,500 g (p<0,001). In addition, children weighing less than 2000 g at birth were at three times the risk of failing the test as compared to those weighing between 2000g and 2499g. Results suggest that birthweight and family income are strongly related to the potential risk of developmental delays at the age of 12 months. It also points to the need for systematic developmental screening and early intervention programs in children at risk.

Journal Article↗
PubMedDate not supplied

Promoting the overall development of infants and young children receiving home health services.

Because of medical conditions and/or as a result of prolonged hospitalization, many children receiving home health services demonstrate developmental delays. Home health personnel can play an important role in promoting a young child's developmental progress by being informed of the early intervention services available in the community, facilitating referral to needed developmental services, and incorporating developmentally appropriate strategies into their every day care.

Child, Preschool↗
PubMed2000

Parental and professional agreement in developmental assessment of very-low-birthweight and term infants.

The aim of this prospective follow-up study was to evaluate the accuracy of a parent-completed questionnaire compared with professionally detected developmental delay. Parents of 108 very-low-birthweight (VLBW) infants and parents of 279 term control infants completed the German version of the Revised Prescreening Developmental Questionnaire (R-PDQ) at the corrected age of 12 months. Simultaneously, infants underwent developmental examination using the Griffiths Developmental Scale. Sixty-nine VLBW infants were classified as not delayed, 16 as delayed by both methods (conegativity 76% and copositivity 94%), as compared to 240 and six term control infants (conegativity 88%, copositivity 94%). The questionnaire suggested delay in 22 VLBW infants and 32 control infants, which was not substantiated by professional examination (P=0.006). In contrast, examination-diagnosed delay was missed by the questionnaire in one infant in each group. The R-PDQ is a reliable monitoring instrument for both VLBW and term infants at the age of 12 months. Parents of VLBW infants tend to underestimate their infants' development.

Child Development↗
PubMed1993

Uterine histology of the dasyurid marsupial, Antechinus stuartii: relationship with differentiation of the embryo.

Uterine samples from Antechinus stuartii on days 1, 4, 6, 8, 11, 13, 15, 18, 21 and 23 after ovulation were examined histologically. Animals were pregnant, nonpregnant and unmated, or nonpregnant and mated but found to have only unfertilized eggs on autopsy. The histological parameters used were thickness of the myometrium, endometrial stroma, and endometrial epithelium, and density of uterine stromal glands and of lymphocytes at the endometrial basal lamina. Overall, the fluctuation patterns of these parameters were superficially similar between pregnant and nonpregnant animals (mated or unmated). However, statistically significant differences were detected between pregnant and unmated nonpregnant animals in every parameter examined at nearly every time point except day 13. Comparison of these results with known data on embryonic stages, corpus luteum development and plasma progesterone concentrations revealed that the gravid uterus underwent histological changes co-incident with changes in both progesterone concentration and developmental delay or embryonic arrest. It was concluded that the uterus mediates progesterone-driven changes in embryonic developmental rate. Although determination of number of lymphocytes provided inconclusive evidence of cellular immunity against embryos, the possibility that embryonic signalling to the uterus occurs is discussed.

Animals↗