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PubMed1995

[The damped torsion swing test in guinea pigs].

The damped torsion swing test (DTST) was carried out for assessing the vestibular function in guinea pigs. Twenty guinea pigs which had normal pinna reflexes and normal tympanic membranes were used. In the formula, L represented the number of the left nystagmus, and R the right nystagmus during DTST. The symmetric rate [formula: see text] between left and right nystagmus was calculated. Then the animals were randomly divided into two groups: (1) Gentamicin group (n = 10): DTST was reexamined, Animals were injected with gentamicin (250 mg/kg) for three days. (2) Endolymphatic hydrops group (n = 10): Surgical obliteration of the right endolymphatic sac and duct was done, 30 days later DTST was carried out again. The results showed: (1) The normal value [formula: see text] of DTST in the 20 healthy guinea pigs is less than 8.25%. (2) Both of left and right nystagmus were reduced (P < 0.01) in gentamicin group. (3) The number of the right nystagmus was reduced in endolymphatic hydrops group (P < 0.01) and the symmetric rate of 6 animals was more than 8.25%. It is concluded that DTST is an important method of evaluating vestibular function in guinea pigs.

Animals↗
PubMed1989

[Differential heat diffusion as a factor in the etiology of the caloric nystagmus phenomenon].

Despite the significance of the caloric vestibular test in clinical practice, the origin of the caloric nystagmus phenomenon is still unclear. Several theories which try to explain the functional pathways have been published. However, the bandwidth of the reaction pattern and response times from the start of stimulation to the first responses question their plausibility. Therefore, the present investigation examines and analyses the specific reaction pattern and associated response times in 84 patients. On the basis of this information a simplified computer simulation model involving lumped tissue parameters has been created to study the heat diffusion process during stimulation. Consequently, an attempt was made to utilize the simulated diffusion times to identify those anatomical structures which could participate in the origin of the caloric nystagmus phenomenon and we developed a new hypothesis about its origin.

Body Temperature Regulation↗