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At least 1,261 records · Page 70Linked to original sources
PubMed2003

Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp.

AIMS: To investigate the levels of the capsaicin or vanilloid receptor-1 (VR1) and the ATP-gated purinoceptor P2X3 in painful and nonpainful human tooth pulps. METHODS: Immunohistochemistry with specific antibodies and image analysis was used to quantify VR1- and P2X3-positive nerve fibers in painful (n = 13) and nonpainful (n = 33) human tooth pulps, and VR1 immunoreactivity was compared with immunoreactivity for the structural neuronal marker peripherin. RESULTS: Strong VR1-like immunoreactivity was documented for the first time in dental pulp neurons. Weaker P2X3-like immunoreactivity was also detected in fewer nerve fibers. The ratio of VR1 to peripherin immunoreactivity was not significantly different between nonpainful and painful tissues (mean +/- SE% area of VR1 to peripherin; nonpainful 53.4 +/- 4.7%, n = 33; pulpitis 35.1 +/- 7.1%, n = 13; P = .07). CONCLUSION: The presence of VR1 and P2X3 in fibers of human tooth pulp suggest that they may play a role in perception of dental pain, but further studies, including quantitation of their ligands, are necessary to elucidate any role they may play in pathophysiologic states.

Capsaicin↗
PubMed2003

Sinusitis as a source of dental pain.

Sinusitis is a common medical problem that can occasionally manifest as dental pain. If the patient is experiencing dental pain in the maxillary posterior teeth, then it is appropriate for the dentist to rule out sinusitis as a source of the problem before proceeding with definitive dental treatment. Often there is an obvious odontogenic source of the pain, and this should be resolved first, but in other situations it is difficult to determine the cause of the symptoms. In some patients, the source of the pain is so equivocal that it may be necessary to treat the patient for sinusitis to eliminate this as the source of the dental pain (Table 7). In this process, the dentist has one of 2 options: either refer the patient to a physician or treat the sinusitis. The option chosen regarding patient management is made by the dentist and depends on the particular clinical situation and the dentist's training and experience.

Amoxicillin-Potassium Clavulanate Combination↗
PubMedDate not supplied

Early childhood caries and quality of life: child and parent perspectives.

PURPOSE: The purpose of this study was to investigate the effects of early childhood caries (ECC) on children's oral health-related quality of life (QOL) before and 4 weeks after its treatment, as assessed by the children themselves as well as by their parents/guardians. METHODS: This study had a longitudinal intervention design. Sixty-nine children diagnosed with ECC and 43 children without caries (combined children's mean age=50.4 months; range=22 to 70 months) and their parents/guardians responded to face-to-face administered surveys before a dental treatment was started (baseline assessment). Thirty-seven children with ECC completed dental rehabilitation. Four weeks after the treatment was completed, these 37 children as well as their parents/guardians responded to a second survey (follow-up assessment). RESULTS: The results show that children with ECC have significantly lower oral health-related QOL than children without ECC as assessed both by the children and the parents/guardians at baseline. The children with ECC who received dental treatment had a significantly improved oral health-related QOL at the follow-up assessment when compared with their baseline measurement as measured both with the children's self-ratings of oral health-related QOL and the parents'/guardians' perception of their child's oral health-related QOL. CONCLUSIONS: ECC and its treatment affect children's oral health-related QOL in a significant way. Oral health-related QOL can be assessed validly and reliably both in self-reports from children as young as 36 months of age as well as by asking parents/guardians about their perceptions of their child's oral health-related QOL.

Adult↗
PubMed2003

Fixed drug eruption to ibuprofen in daughter and father.

Fixed drug eruption (FDE) is a common cutaneous reaction which may be seen in reaction to several medications. The usual etiologic agents associated with FDE are phenazones, sulfonamides, and tetracyclines. Often the causative agent is made out from the patients history; in some cases, oral challenge or topical testing may be required. The pathophysiology of FDE is unclear. Cell-mediated, rather than humoral immunity is thought to be involved. Herein we report a case of FDE in a daughter and father.

Adolescent↗