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At least 1,261 records · Page 70Linked to original sources
PubMed1982

Epidermal growth factor in the healing of second degree burns: a controlled animal study.

The effects of the topical application of epidermal growth factor (EGF) on the healing of partial-thickness scald burns in rats was evaluated. Time to complete healing, the rate of healing, daily percentage weight change, and cell growth were the measured parameters. We were able to demonstrate an insignificant healing advantage with the topical application of EGF, by itself or in combination with silver sulphadiazine. This insignificant healing advantage does not warrant clinical evaluation.

Administration, Topical↗
PubMed1983

Topical silver sulphadiazine: side effects and urinary excretion.

Silver sulphadiazine has been used as a topical antimicrobial agent in a large group of children with burns and scalds. Four developed neutropenia and two an erythema multiforme rash which were thought to be due to sulphadiazine sensitivity. To assess the extent of sulphadiazine absorption in children, the urinary excretion was measured in a group of 8 patients with a mean area of injury of 13 per cent BSA. The mean urinary concentration of sulphadiazine was 31.8 mg/l.

Administration, Topical↗
PubMed1984

The haematopoietic response to burning: studies in an animal model.

Changes in haematopoiesis which occur in humans after burning injury may have important effects on morbidity and mortality. Because of the heterogeneity of burn patients we studied the regulation of blood cell formation which occurs in an animal using an established mouse model. Mice received a 20 per cent third degree scald injury on the back. Serial studies of a variety of haematopoietic parameters including stem cell, bone marrow and peripheral blood findings were done post burn. Although anaemia occurred frequently after injury red blood cell survival studies and examination of the stool for occult blood showed that neither haemolysis nor blood loss were primary causes of the anaemia. Bone marrow erythroid stem cells fell markedly post burn and this was associated with the development of a substance in serum capable of inhibiting red cell colony formation but not white cell colony formation of normal marrow cells. Reticulocytosis occurred but was mild and the anaemia was primarily of the aregenerative type. Partial compensation for the depressed marrow erythropoiesis occurred in the spleen with an increase in erythroid colony-forming cells and erythroblasts. Marked granulocytosis occurred in the peripheral blood and bone marrow. There was an increase in splenic granulocytic stem cells post burn. Megakaryocytosis was striking in the bone marrow and spleen and there was an increase in peripheral blood platelet count. Evidence of immune stimulation included an increase in the size of the spleen and an increase in peripheral blood and splenic lymphocytes. Correlations of many of these findings suggested that the events were not occurring at random but that the changes in haematopoiesis were linked together. We speculate that the anaemia was the result of the increase in granulopoietic and thrombopoietic effort seen post burn.

Anemia↗
PubMed1984

Mortality of burn injuries in Jordan.

Three hundred and ninety patients who died following fire burns and scalds between 1973 and 1982 were subjected to autopsy examination at the departments of Forensic Medicine in the Ministry of Health and Jordan University Hospital. Flame burns caused 82 per cent of the deaths. Most of the burn injuries occurred at home and most of the accidents may have been avoidable. Seventy-six per cent of the patients were children and young adults (0-29 years). Suicide caused 13.5 per cent of the deaths. The most common causes of death were septicaemia and hypovolaemia.

Adolescent↗
PubMed1985

The electric kettle flex--a cause for concern.

A study of 153 preschool children admitted to a subregional burns unit over a 4-year period revealed 23 who had sustained scalds by pulling on kettle flexes. The dangers of dangling kettle flexes have been noted in the past. However, identifying problems and undertaking education programmes to warn against them has a limited effect on accident prevention. The recent introduction of 'curly' cables makes the prospect of active prevention considerably simpler.

Accident Prevention↗
PubMed1985

Survival of an extensively burned infant following purulent pericarditis.

This is a report of the treatment and survival of an extensively burned infant following purulent pericarditis with massive pericardial effusion due to Staphylococcus aureus. A 2-year-old boy fell into a bathtub and suffered scalds covering at least 70 per cent of the body surface area. Pericarditis with massive pericardial effusion was diagnosed on post-burn day 36. As conservative treatment was ineffective pericardiotomy and pericardial drainage were carried out. Whole body oedema disappeared promptly and entirely and the patient was discharged from hospital with healed burns and free of cardiac symptoms.

Burns↗
PubMed1985

Children's burns due to cresol.

A total of 213 burns were admitted to the Burns Unit at the Royal Children's Hospital, Brisbane, during the 2 year period 1982-1983. Of these 118 were due to scalds and 33 were due to flame burns. However, one patient was admitted following burning with cresol after inhalation. We have had several such injuries in previous years. Two such patients are discussed and the problems of cresol burns are briefly discussed. Such injuries pose a problem inasmuch as while not frequent, they are injuries that could probably be prevented.

Burns, Chemical↗
PubMed1986

The total number of burn injuries in a Scandinavian population--a prospective analysis.

During the period 1 September 1982 to 31 August 1983 the total number of burn injuries in the municipality of Copenhagen was recorded prospectively. The social changes and the constitution of the population are illustrated. The total number of burn injuries showed a decrease of 33 per cent compared to the investigation in 1974/75. Scalds are still the most frequent cause of burn accidents, small children are especially vulnerable. Seventy-two per cent of all accidents occurred at home. Only a few patients required 'antishock' therapy. No patients with work-related burn injuries died. Preventive measures have eliminated or reduced the number of some types of thermal injury.

Accidents, Home↗
PubMed1986

Epidemiology of industrial burns in Brisbane.

A retrospective epidemiological study of industrial burns admitted to the Royal Brisbane Hospital was conducted over a period of 7 years. A total of 182 patients were included in this survey--173 males (95 per cent) and 9 females (5 per cent). The proportion of industrial burns has decreased from 31.5 per cent to 18.5 per cent of total admissions to the burns unit over the past 10 years. Fifty per cent of the burns occurred in males less than 30 years old. The average age was 31 years. Two-thirds of the burns covered less than 10 per cent of the body and 84 per cent covered less than 20 per cent. While scalds were the commonest cause of industrial burns in our study (19.4 per cent), flame burns with clothing ignited caused the most extensive burns. Face and hands were the most common sites involved. Burns to these regions were mainly caused by flame and electrical burns. Eye burns comprised 5.5 per cent of the sample and were due to chemicals, gas explosions and electric flash. Twenty-six patients (14 per cent) suffered respiratory injury. Only one patient out of our series of 182 died. Progress has been made in industrial safety in the past few years but carelessness and human error still take their toll.

Accidents, Occupational↗
PubMed1986

Effect of Dazmegrel (UK-38,485) on immune function in a burned guinea-pig model.

We investigated the effects of Dazmegrel, a highly effective and selective thromboxane synthetase inhibitor, on the immune system in a bilateral 5 per cent total body surface area (TBSA) deep partial thickness scald in a guinea-pig model. The animals were randomized into two groups: one received Dazmegrel at 3.4 mg kg-1 day-1 by i.m. injection; the other received the same volume of saline. Cell-mediated immunity was evaluated by the response to the hapten dinitrofluorobenzene (DNFB), as measured by ear swelling in response to cutaneous application. The ear swelling of the Dazmegrel-treated group was 52.8 +/- 3.8 per cent, compared to 41.4 +/- 2.4 per cent for the control group (P less than 0.02). Neutrophil bactericidal function was determined on post-burn day (PBD) 7 and opsonic function on both post-burns days 7 and 22. The serum opsonic indices were nearly identical at both times, but the Dazmegrel-treated animals had a significantly improved neutrophil bactericidal index (1.15 +/- 0.05 v. 1.68 +/- 0.17, P less than 0.01). Dazmegrel exerted a stimulating effect on the immune system in this burn model, improving neutrophil antibacterial function and cell-mediated immunity.

Animals↗
PubMed1986

Conservative treatment of 725 burned children hospitalized in 10 years.

Seven hundred and twenty-five children were hospitalized in the paediatric burn unit of Brugmann University Hospital during the past 10 years. The majority of the patients were under 5 years of age and presented with scalds on less than 10 per cent of the body surface area. As burn depth was difficult to assess on admission, a conservative form of treatment was performed including a daily bath containing chlorhexidine and silver sulphadiazine dressings. Contamination of the wounds was observed in 80 per cent of the larger than 20 per cent surface burns but only 18 cases (2.4 per cent) of the series needed administration of systemic antibiotics for repeated contamination. No lethal septicaemia was observed. Mean inpatient time ranged between 16 days for ungrafted patients to 69 days for over 20 per cent surface grafted patients. The lower iatrogenic risks (anaesthesia and donor site morbidity) seemed important enough to justify conservative treatment in children despite a slightly longer hospitalization time.

Administration, Topical↗
PubMed1987

Evaluation of topical therapy with silver-kaolin (Argostop) in an experimental model of burn wound sepsis.

Burn wound therapy with silver-kaolin, a topical agent applied as an aerosol spray, was evaluated in male rats given a 20 per cent total body surface area, full thickness dorsal scald burn. Burn wounds treated with silver-kaolin healed at rates comparable to untreated wounds. No significant differences were noted in the numbers or types of organisms colonizing the wounds of treated and untreated rats at 5, 12 and 19 days post-burn. To evaluate the effectiveness of silver-kaolin in treating burn wound sepsis, rats were inoculated on the wound surface with 2.5 x 10(8) Pseudomonas aeruginosa. This inoculum resulted in 100 per cent mortality in untreated rats. Rats treated with silver-kaolin had a mortality rate of 71 per cent, compared to a 9 per cent mortality rate in rats treated with 1 per cent silver sulphadiazine. When silver-kaolin was applied to the wound prior to bacterial inoculation, the mortality rate was reduced to 6 per cent. When wounds were treated with kaolin alone and then inoculated with bacteria, the mortality rate was 50 per cent, indicating that part of the effectiveness of silver-kaolin appeared to be due to a barrier effect. These results indicate that silver-kaolin may be useful for preventive topical antimicrobial therapy of acute burns or after wound debridement or excision, but is not suitable for therapy of wounds previously colonized by microorganisms.

Administration, Topical↗
PubMed1987

Occupational burn injuries.

The epidemiology of occupational burns injuries in a well-defined population is analysed. Although a total of 371 persons sustained an injury, only a few were inpatients and just one required anti-shock treatment. The mean burn surface area was 0.66 per cent and 14 patients had full thickness burn injuries. There were no deaths. Men were found to be more prone than women to injury, especially young workers. The distribution by categories of work and causes of burn are illustrated. Scalds and contact burns were dominant, particularly in restaurants. The work by the National Labour Inspection is acknowledged.

Adolescent↗
PubMed1987

Childhood burns in Zaria, Nigeria.

From 1971 to 1980, 429 children with burn injuries were admitted to the Ahmadu Bello University Hospital, Zaria. These were major burns in 275 patients, moderate in 82 and minor in 72. Fourteen of the patients were neonates, 102 infants, 228 were 5 years old or younger and 85 were older. Socioeconomic factors contributing to the injuries included the use of firewood for cooking at ground-level and for warming the house and body during the cold season; loose indigenous garments; thatch-roofed huts and the post-partum rituals of mud-bed heating and hot baths. Flame burns exceeded scalds with a seasonal frequency which peaked during the harmattan. In the absence of a 'burn's unit', burned children were nursed on the general ward together with other sick children by the same nursing personnel supervised by general surgeons. Complications included wound infection, respiratory distress, measles, malnutrition and tetanus. One-fifth of the patients absconded. Overall mortality was 13 per cent but 29 per cent of the neonates died. Preventive strategy should include public information, nursery school supervision, economic development and architectural improvements.

Adolescent↗
PubMed1988

With or without? A cooling study.

The cooling characteristics of a variety of hot-water receptacles have been tested to provide a guide to the temperatures involved in a scald.

Cooking and Eating Utensils↗
PubMed1988

Epidemiology of burns in Kuwait.

A prospective study of 765 burns cases treated as inpatients at the Burns Unit, IBN Sina Hospital and the Plastic Surgery Unit, Mubarak Al Kabeer Hospital from January 1984 to December 1986 is presented. Hot water scalds were the commonest type of injury. Most of the burns occurred at home but coinciding with standard working hours. Children up to 5 years old were commonly affected, but most of the fatal burns were among adults. The overall mortality rate was 7.2 per cent with a male to female ratio of 1.1:1. Our survival rate from burn injuries is improving due to advances in treatment, but prevention remains the best cure. We consider our epidemiological survey to be important as the basis for a preventive programme in Kuwait's extremely heterogeneous society.

Accidents, Home↗
PubMed1988

Systemic effects of single hindlimb burn injury on skeletal muscle function and cyclic nucleotide levels in the murine model.

This study tested the hypothesis that a single hindlimb burn has both local and distant effects. Male CF1 anaesthetized mice were given a full thickness scald burn of 3 per cent total body surface area (BSA) by immersion of their left hindlimb in water at 95 degrees C for 5 s. Muscle tension was measured through twitch analysis. Levels of cyclic adenosine 3'-5' monophosphate (cAMP) and cyclic guanosine 3'-5' monophosphate (cGMP) were analysed by 125I-radioimmunoassay. Measurements were made in gastrocnemei of the ipsilateral burned and contralateral unburned limbs over a 28-day postburn period. Within 1 week the burned limb showed an increase in both tension and a 100-fold increase in levels of cAMP. However, by the end of the second week muscle tension in the burned limb dropped to one-seventh of control values despite persistence of high levels of cAMP. In contrast, the systemic effects were manifested in the unburned contralateral limb which showed tension to undergo a six-fold compensatory increase at the end of the second week with a 75-fold increase in cAMP. By the end of 4 weeks, tension levels of both burned and unburned limbs were attenuated to one-half control values indicating neuromuscular (NM) dysfunction. Nevertheless, cAMP levels remained elevated in both limbs. Levels of cGMP were reduced throughout the 4-week postburn period. Subsequent to the single hindlimb injury both ipsilateral and contralateral gastrocnemei muscles showed elevated levels of total protein content.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗