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Results for “SALICYLIC ACID”

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PubMed1986

Effects of salicylic acid on the permeability of the plasma membrane of the small intestine of the rat: a fluorescence spectroscopic approach to elucidate the mechanism of promoted drug absorption.

The effects of sodium salicylate on the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH), 2-hydroxyoctadecanoic acid, 9-anthroate (2-AS), 12-hydroxyoctadecanoic acid, 9-anthroate (12-AS), 8-anilino-1-naphthalenesulfonic acid (ANS) and 2',4',5',7'-tetrabromo-5-maleimidofluorescein, disodium salt (EM), with which rat small intestinal brush border membrane vesicles were labeled, were examined. Salicylate ion decreased the fluorescence polarization of ANS and EM in these vesicles, however, it had no influence on the fluorescence polarization of DPH, 2-AS and 12-AS-labeled vesicles. It also released trapped 6-carboxyfluorescein (3',6'-dihydroxy-3-oxospiro-[phthalan-1,9'-xanthene]-6-carbo xylic acid) (CF) from the vesicles, but caused no leakage of trapped CF from liposomes. These results indicate that salicylate ion increases the plasma membrane permeability by effecting the plasma membrane proteins rather than directly interacting with the membrane lipids. The action of salicylate ion on these vesicles could possibly promote nonabsorbable drug absorption in vivo.

Animals↗
PubMed1988

Salicylic acid causes a diuresis and natriuresis in normal and common bile-duct-ligated cirrhotic miniature swine.

In patients with liver disease, or in normal subjects who are sodium-depleted, the administration of either a nonsteroidal anti-inflammatory drug or acetylsalicylate (aspirin) has a detrimental effect on the kidney; profound renal vasoconstriction and the retention of sodium and water may occur. We observed recently that salicylate (SA), in contrast to meclofenamate (MECLO) or aspirin, caused a diuresis and natriuresis in the sodium-depleted dog. To determine if SA would similarly affect the kidneys in a cirrhotic subject, the effects of SA (40 mg/kg) and subsequent MECLO treatment (2 mg/kg) were evaluated in five normal and six common bile-duct-ligated (CBDL) miniature swine. All six CBDL animals showed signs of biliary cirrhosis and four of the six were ascitic at the time of study. SA did not significantly alter renal blood flow or glomerular filtration rate in either the normal or CBDL animals. In both groups, SA caused a significant diuresis and natriuresis. MECLO, given after SA, caused a reduction in renal blood flow in the normal but not in the CBDL animals, but did not alter glomerular filtration rate in either group. In the CBDL animals, when MECLO was given alone a significant decrease in renal blood flow occurred. MECLO abolished the SA-induced diuresis and natriuresis in the normal swine but only affected the SA-mediated natriuresis in the CBDL animals. SA significantly reduced renal prostaglandin E2 excretion in both groups. With MECLO, prostaglandin E2 excretion was reduced further in the normals but not in the CBDL animals. These data demonstrate that SA does not produce detectable renal vasoconstriction in the cirrhotic pig.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1962

Antimicrobial activity of 8-quinolinols, salicylic acids, hydroxynaphthoic acids, and salts of selected quinolinols with selected hydroxy-acids.

Seventy-seven compounds were screened by the disc-plate method against strains of five bacteria and five fungi. A new constant was proposed to describe the antimicrobial activity of a compound in a defined system of organisms. This constant includes not only the inhibitory level of activity of the material but also the number of organisms inhibited. This constant, the antimicrobial spectrum index, was compared with the antimicrobial index of Albert.

Anti-Infective Agents↗