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[Role of radiotherapy in esthesioneuroblastoma].
A case report on a locally advanced inoperable esthesioneuroblastoma in a patient of 65 years of age is presented. Chemotherapy (CYVADIC) resulted in a slight reduction of tumour mass and was followed by rapid tumour regrowth. By megavoltage radiotherapy (65 Gy) with shrinking field technique a clinically complete remission was achieved. The role of radiotherapy in long-term local tumour control in combination with surgery is discussed, taking into account the few date reported in literature. Depending on the tumour stage at diagnosis, a graduated strategy combining surgery and radiotherapy is recommended as the treatment of choice. The value of adjuvant chemotherapy has not yet been clearly established, not even in locally progressing or advanced stages of tumours or in metastasizing tumours.
[Cytogenetic data on sarcomas of the bone and soft tissue].
Cytogenetic data are now available in most bone and soft tissue sarcomas. The characteristic chromosomal rearrangements observed are of great importance for the diagnosis, the classification and the comprehension of these cancers at the molecular level.
[Operative approach to a dumbbell-shaped tumor in the anterior cranial fossa. A case of olfactory neuroblastoma].
We present a case of giant olfactory neuroblastoma with special reference to a new operative approach in cases of dumbbell-shaped tumor in the anterior cranial fossa. Our new approach is characterized as follows: resection of the bilateral orbital roof and frontal sinus en bloc, following bifrontal conventional craniotomy. Accordingly, retraction of the frontal lobe is minimized and it is possible to obtain, with ease, a good operative field extending to the region adjacent to the tuberculum sellae. Using this technique combined with the transsphenoidal approach, even in the case of marked extracranial downward extension of a dumbbell-shaped tumor, it should be possible to remove the tumor totally. This approach should open a way to a wide range of application.
[Esthesioneuroblastoma: a comparative study of tumor and matrix tissue with derived histogenesis].
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[Esthesioblastoma].
Histological appearance of esthesioblastomas shows wide-range variations contributing to difficulties in diagnosis. Five cases of the tumor analysed by the authors provided evidence on ultrastructural signs of the tumor cells neuroblasts-oriented differentiation, permitting ultrastructural differential diagnosis of esthesioblastoma with tumors of another histogenesis.
[A case of yolk sac tumor of the eye].
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Primary primitive neuroectodermal (neuroepithelial) tumor of ovary.
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[Olfactory neuroblastoma. Review of the Spanish literature and presentation of 2 cases].
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Hyperostotic esthesioneuroblastoma: CT and MR findings.
Olfactory neuroblastoma is a malignant, slow growing, neurogenic tumor that originates in the olfactory mucosa of the upper nasal cavity. Its CT appearance, i.e., a soft tissue mass adherent to the cribriform plate usually with bone lysis, has been described. Two cases are presented in which this entity was associated with exuberant bony hyperostosis, a feature not previously reported. The differential diagnosis of nasoethmoid soft tissue masses with associated hyperostosis is reviewed.
[Radiation and combined therapy of esthesioneuroblastomas].
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Pathologic quiz case 1. Olfactory neuroblastoma.
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Cytologic appearance of esthesioneuroblastoma in a fine needle aspirate.
Esthesioneuroblastoma (olfactory neuroblastoma) is a rare malignant neoplasm derived from the olfactory epithelium. It was diagnosed by cytologic study of fine needle aspiration biopsy smears of a tumor situated in the nasopharynx in a 57-year-old man.
[Contribution of immunology and molecular biology].
Recent technical advances in immunology and molecular genetics have allowed to better delineate Ewing sarcoma among other small round cell tumors of bone and soft tissues. Ewing cells present with a characteristic translocation t (11;22) (q23-24; q11-12) shared with neuroepithelioma. They express a series of cell-surface antigens associated with the neuroectodermal differentiation lineage. These data open new avenues for exploring the origin and the mechanism of transformation of these tumors and to conceive new therapeutical approaches.
N-myc protein expression in small round cell tumors.
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[Olfactory neuroblastoma of the olfactory sinuses of the middle concha in a 9-year-old girl].
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Treatment of colloid cysts of the third ventricle by stereotactic aspiration.
Four patients are described with a colloid cyst in the anterior part of the third ventricle, causing obstruction of the foramina of Monro. Stereotactic aspiration of the cyst was performed after exact neuroradiological localization, including CT scan. The great advantages of the technique presented are discussed.
[Olfactory esthesioneuroma. Clinical, histological and therapeutic aspects; apropos of 6 cases].
On the basis of 6 cases, the authors review the clinical, histological and therapeutic aspects of olfactory esthesioneuromas. These rare tumours, showing varying rates and degrees of progression from one patient to another, generally have a severe prognosis. Diagnosis is based upon precise histological criteria which may be clarified by electromicroscopic data. In difficult cases it may be useful to seek the aid of immuno-histochemical techniques in order to demonstrate the presence in tumour cells of specific neuronal enolase and the labelling of such cells by anti-protein S-100 antibodies. The treatment of choice would appear to be radio-surgical completed by chemotherapy similar to that used in neuroblastomas.