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PubMed1982

[Medical treatment of calcium nephrolithiasis (author's transl)].

Calcium calculi are by far the most frequent of urinary stones. In many cases their formation is enhanced by lithogenetic abnormalities, including idiopathic calciuria. The basis of the treatment is to promote diuresis by absorbing for an indefinite period a mineral water containing less than 100 mg/l of calcium. There is no evidence that drugs reducing calciuria (thiazides, phosphorus) or uraturia (allopurinol) are effective, and they should be reserved to cases of rapidly progressive lithiasis. A long-term strategy for the prevention of lithiasis is discussed.

Calcium↗
PubMed1982

[Concentrically layered microconcrements in the renal medulla of nephrolithiasis patients. A contribution to the renal stone pathogenesis (author's transl)].

The electron microscopic investigation of the renal medulla in calcium oxalate stone patients has shown the frequent occurrence of globoid microconcrements in the basal laminae of the collecting ducts and of the thin limbs in Henle's loop. They have a concentrically layered structure, the diameter is usually below 1.5 microns, rarely more than 3 microns. Some of these objects were also seen in the interstitial connective tissue. Tissue of stone-free patients exhibited either no or only few such microconcrements which were usually located in the interstitial space. Histochemical tests and energy dispersive microprobe analysis suggest that calcium phosphate and acid mucopolysaccharides are principal components of the microconcrements. There are indications that some microconcrements might be expelled from the basal laminae into the urinary space and may form agglomerations. They might then furnish nuclei for heterogeneous crystallization especially in cases without hypercalciuria or hyperoxaluria.

Calcium Oxalate↗