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PubMed1982

Role of anchorage in the expression of tumorigenicity of untransformed mouse cell lines.

Cultured mouse cells were tested for tumorigenicity in nude mice with both a conventional assay (injection of cell suspensions) and a new test involving implantation of cells grown on gelatin sponges. Sublines of Balb/3T3 cells, obtained from different sources, varied in their tumorigenic potential with either assay. One subline (A) formed distinctive precancerous nodules only in the sponge assay; these nodules often became progressive after a latent period of 3-4 months. However, suspensions of cells of this subline also caused tumors after a similar latent period, but no nodular phase preceded tumor formation. Another subline of Balb/3T3 (M) has failed to form tumors in either assay. The Balb/3T3 sublines did not differ in vitro properties, such as low saturation density, failure to grow in methylcellulose, and monolayer morphology. A second experimental approach involved tests on nude BALB/c mouse-embryo fibroblasts at various passage levels. The cells were passaged from primary culture, through crisis, to heteroploid, established cell lines. Tumorigenicity was demonstrable earlier in the sponge assay, at which time in vitro parameters putatively associated with malignant behavior were unchanged. Possible relationships with the in vivo phenomenon of solid-surface sarcomagenesis are discussed.

Animals↗
PubMed1980

Control of gastroesophageal bleeding varices by percutaneous transhepatic portography.

We used the transhepatic approach to the portal system to obliterate bleeding gastroesophageal varices as an alternative to portosystemic shunt performed as an emergency. In eight of 13 patients, we obtained complete arrest of bleeding, while rebleeding was observed in five patients. The shunt was performed upon six patients, and only one patient died. Transhepatic obliteration of varices seems to be the more useful method for the control of untractable hemorrhage and to prepare the patient for an elective operation.

Adult↗
PubMed1980

Embolization of pelvic arteries for control of postpartum hemorrhage.

Two cases are presented in which postpartum hemorrhage was controlled by Gelfoam embolization via an angiographic catheter. The advantages of embolization over surgery are discussed. It is suggested that an attempt be made to control severe postpartum hemorrhage by this means before resorting to surgery.

Adult↗
PubMed1981

Arterial embolisation in the treatment of malignant tumours.

Arterial embolisation is performed in order to interfere with the blood supply and growth of tumours and also to palliate the pain produced by them. In the present study 5 patients with liver metastases, 6 patients with renal tumours and 1 patient with bleeding from the rectum were treated by arterial embolisation with gelatin (Gelfoam). Before embolisation angiography was performed in all and computerized tomography in some of the patients. The control examinations and repetitive procedures were performed 2-4 weeks afterwards and there after according to the response. The effectiveness of the embolisation was assessed by angiography as good in 70% of the cases. Out of 5 patients examined with CT in 4 the tumour was found to have become smaller. The procedure eliminated pain caused by the enlarged liver in all 5 patients, stopped the rectal bleeding, and the subjective condition of all patients improved. Pain produced by the postembolisation syndrome occurred in all cases, but repeated embolisations did not result in further pain. Serious complications did not occur.

Adenocarcinoma↗
PubMed1980

Tympanoplasty--25 years later.

The surgical details of tympanoplasty, the importance of the pathology, the proper selection and preparation of the patient have been emphasized. The results of the procedure have been discussed. While at times disappointing, the operation tympanoplasty as viewed over 25 years has been established in the armamentarium of the otologic surgeon.

Adult↗
PubMed1980

Management of rupture in allografted kidneys.

Allograft rupture is a rare but serious complication in renal transplantation, occurring in 3 to 8.5% of the transplanted kidneys. The consequences for the recipients are fatal in 6% of the cases and graft loss is the outcome in another 53%. Clinical features and treatment of renal allograft rupture are discussed and illustrated by a case history, in which successful management of this complication resulted in salvage of the graft and patient. A literature study with the purpose of determining the pathogenesis of graft rupture revealed that rejection plays a major role.

Adolescent↗
PubMed1980

Ultrastructural observations on the three-dimensional reorganization and growth of newly-formed candidate stromal cells and residual hemopoietic cells in culture.

Gelfoam sponges were used as three-dimensional culture supports to allow the migration, reorganization and growth of regenerative cells derived from bone fragments previously depleted of marrow by curettage. The explants and sponges, cultured in 0.3% agar-medium, were analysed ultrastructurally throughout a 14 day culture period. By day 5 the gelfoam sponge was infiltrated by large cells with extensive cytoplasmic processes (stromal cells) and primitive round cells. The stromal cells were pleomorphic and varied in their content of rough endoplasmic reticulum, mitochondria, cytoplasmic granules, microfilaments, lipid droplets and glycogen. The cytoplasmic processes made multiple intercellular contacts with other stromal cells thereby forming a stromal network. Close and direct associations of stromal cells with primitive hemopoietic cells and various stages of myeloid cells were identified. The identification of proliferating granulocytes and mononuclear phagocytes on days 7--14 in these unstimulated cultures suggests that the organization of stromal cells is able to maintain primitive cells and supports the proliferation and differentiation of myeloid cells. It is proposed that this three-dimensional culture technique (i) allows the development of primitive stromal precursors and primitive residual hemopoietic cells; (ii) provides a model for the analysis of early stromal cell-hemopoietic cell interactions.

Animals↗
PubMed1982

Gelfoam powder embolization of the hepatic artery in liver metastases of carcinoid tumors.

Five patients with liver metastases of carcinoid tumors were treated with transcatheter embolization of the liver arteries with gelfoam powder. In three of four patients with flushing symptoms, these symptoms disappeared immediately after the treatment. One patient remained free of symptoms for 6 months. Another patient was free of symptoms at 1-month control but 1 year later he again had slight symptoms. The third patient had slight recurring symptoms at 1-month control. Liver angiograms performed on four patients 1 month after the embolization showed recanalized arteries and reduced vascularity of the tumors.

Aged↗
PubMed1982

Control of postoperative renal hemorrhage by embolization with a Gianturco coil.

A 35-year-old woman underwent a left pyelonephrolithotomy for removal of a staghorn calculus. Blood loss was minimal for 5 days. Then there was profuse bleeding from the left kidney that did not respond to conservative management. Angiographic examination demonstrated extravasation of contrast medium from a minor intrarenal artery in the lower pole of the kidney directly into the pelvicalyceal system. An attempt was made to embolize the bleeding vessel with Gelfoam particles but this failed because the Gelfoam passed directly into the collecting system. A Gianturco coil, however, occluded the vessel and immediately the hemorrhage ceased; the patient had no further complications. The authors emphasize that the introduction of a steel coil to control bleeding is advocated only when the use of temporary occlusive agents is unsuccessful.

Adult↗
PubMed1980

A pathological study following bronchial artery embolization for haemoptysis in cystic fibrosis.

A detailed post-mortem study is reported on an adult with cystic fibrosis who died in respiratory failure three weeks after selective bronchial artery embolization with gelatin sponge to treat severe haemoptysis. Bronchial arteriography during the procedure showed complete occlusion of the vessel supplying the righ upper lobe and following this the bleeding stopped. However, post-mortem angiography of the same vessel demonstrated disappearance of much of the injected material with contrast bypassing the remaining gelatin to fill the peripheral bronchial arterial bed. This report therefore adds pathological evidence to previous clinical reports which have suggested that this procedure may not produce permanent occlusion of the embolised bronchial artery.

Adult↗