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[Embolism at the iliac bifurcation secondary to an atrial myxoma].

A 73-year-old woman presented a clinical picture of bilateral acute ischemia of the lower limbs. After embolectomy, transthoracic echocardiography revealed left atrial tumor. The picture was complicated by the onset of compartment syndrome in the lower extremities requiring decompressive fasciotomy. The excised atrial tumor proved to be a cardiac myxoma. Atrial myxoma, the most common benign cardiac tumor, leads to systemic, cardiac and embolic sequelae. Transthoracic echocardiography is the main diagnostic technique available, proving more useful than transesophageal echocardiography for small tumors. Such techniques can also be used during surgery, particularly in cases where preoperative assessment has left doubts about tumor location. We also argue in favor of early use of transesophageal echocardiography when peripheral arterial embolism is the diagnosis, in order to locate a cardiac focus as the cause of the clinical picture.

Aged↗

[Atrial fibrillations: daily occurrence possibly leading to embolism in an extremity].

A 64-year old woman had been tired and short of breath for the previous few months. During the past few days she had experienced disruptions in the movement and feeling of the right arm and both feet as well as a loss of strength and a heavy feeling in her right leg. Due to atrial fibrillation she had recently started using digoxin and due to possible arterial embolisms in the extremities she had recently started using acenocoumarol. Further investigations revealed one large thrombus in the left atrium, two large thrombi in the left auricle and a serious constriction in the right iliac artery. The thrombi were treated with heparin and oral anticoagulants; the ischaemia which probably occurred as a result of this was successfully treated with embolectomy. After the cardiac thrombi had disappeared, the patient was electrically converted to sinus rhythm. One month later, the patient was still in sinus rhythm and her clinical picture had improved. As she does not feel the atrial fibrillation, she will be permanently maintained on oral anticoagulants. In patients with atrial fibrillations, the possibility of an embolisation towards the extremities deserves serious consideration.

Anticoagulants↗

[Apical ballooning by transient left ventricular dysfunction (so-called "ampulla" cardiomyopathy) associated with therapy for acute pulmonary thromboembolism: a case report].

An 86-year-old-woman presented with apical ballooning left ventricular dysfunction associated with therapy for acute pulmonary thromboembolism. She was referred to our hospital for advanced treatment for her shock state due to acute pulmonary embolism with normal left ventricular(LV) function. Her condition was stabilized using a percutaneous cardiopulmonary support system. Suction embolectomy was successfully carried out after pulmonary arteriography. After the therapy, echocardiography revealed apical ballooning and hyperkinesis of the base(LV ejection fraction = 28%), although coronary arteriography showed no fixed stenosis. LV wall motion significantly improved on day 3(LV ejection fraction = 45%). Pulmonary embolism relapsed on day 5 in spite of anticoagulation treatment. She died of multiple organ failure on day 9. Autopsy findings indicated no sign of myocardial infarction or myocarditis, patchy appearance of myocardial contraction band necrosis and few migrated lymphocytes. The mechanism for the flow mis-matched LV dysfunction remains unknown. The probable explanations include non-ischemic stress such as catecholamine or neurogenic stress, and possibly ischemic stress or ischemia/reperfusion injury.

Aged↗

Treatment of venous thromboembolism.

Venous thromboembolism (VTE) is a disease entity composed of pulmonary embolism (PE) and deep vein thrombosis (DVT). Anticoagulation, initiated as soon as the diagnosis is suspected, is the treatment of choice. Traditionally, anticoagulation is started with intravenous heparin, and changed to warfarin for long-term treatment. The introduction of unmonitored, subcutaneously administered, low molecular weight heparin has resulted in shorter hospitalizations, reduced the incidence of major bleeding as a complication, and shifted the treatment of VTE for selected patients to the outpatient setting. Thrombolytic therapy has been recommended for patients with life-threatening PE. Technologic advances in catheter embolectomy and fragmentation permit clot resolution in patients in whom thrombolytic therapy is contraindicated. Inferior cava filters can be placed percutaneously in patients at high risk for VTE or those in whom anticoagulation is contraindicated. Because VTE is often clinically silent, prevention of VTE is therefore the most effective means to reduce associated morbidity and mortality. Strategies to prevent VTE have been studied and validated for specific clinical circumstances.

Anticoagulants↗

[Acute ischemia of the extremities. As critical as a myocardial infarct].

Acute limb ischemia is a vascular-surgical emergency requiring immediate referral to a hospital provided with all the necessary therapeutic facilities. Essential initial measures are protection of the limb against continued cooling, management of pain, and bolus administration of heparin. For the physician providing further care, not only an accurate history, but, ideally, also the results of earlier investigations such as ECG, abdominal US or Doppler studies, provide useful information. In patients who have not undergone prior surgery vascular-surgical management, that is, embolectomy with a balloon catheter, is the treatment of choice. Furthermore, the patient requires continuing care after discharge; here, wound management and the supervision of anticoagulation measures that might be needed are important tasks for the general practitioner.

Acute Disease↗

Aortic dissection presenting as acute lower extremity ischemia: report of a case.

Although not common, acute leg ischemia is an important element in the clinical presentation of a patient with aortic dissection. This report describes a case of aortic dissection in which the main feature at presentation was acute right leg ischemia. The angiography showed right common iliac artery and external iliac artery occlusion. Diagnosis was made by clinical evaluation and angiography. Embolectomy was then attempted immediately but failed. Aortic dissection was highly suspected and confirmed by emergency computed tomography. Fortunately, the patient had good recovery. Aortic dissection is potentially lethal if misdiagnosed or if recognition is delayed. As such, aortic dissection should be considered in the differential diagnosis.

Adult↗

Emergent surgery for massive pulmonary embolism on the basis of clinical diagnosis.

We treated a 52-year-old man for a large pleural effusion that had occurred after he fell from a ladder. Upon discharge from the hospital, the patient collapsed and was nonresponsive and hypotensive. We suspected the cause to be pulmonary embolism. When it became evident that this patient would die without emergent intervention, he was taken to surgery. A massive clot was removed from the left pulmonary artery, and multiple smaller clots were removed from both pulmonary arteries. The patient recovered and was discharged from the hospital on the 11th postoperative day. To our knowledge, this is the 1st report of pulmonary embolectomy being performed on the basis of clinical diagnosis alone.

Accidental Falls↗

[The surgical treatment of acute ischemia of the lower limb].

OBJECTIVE: To analyze the surgical treatment strategy of lower limb acute ischemia and its results in the Department of Vascular Surgery of Kaunas University of Medicine Hospital in the period from 1999 to 2001. MATERIAL AND METHODS: While collecting the data retrospectively there has been determined, that due to the acute ischemia of the limbs there have been operated 244 patients (12.2% of all treated arterial patients). Because of the lower limb acute ischemia there have been operated 142 (7.1%) patients. All embolism and thrombosis have been approved with the operation findings. The comparison of quantitative values was done according to the Student parameter. RESULTS: The acute ischemia in the leg has been caused by: embolism - for 76 (53.5%) patients, acute thrombosis - for 66 (46.5%). Heart diseases have been ascertained in embolism group for 22.4% of patients, in acute thrombosis group - for 6.1%. The localities of embolism - the popliteal artery for 44.7% and femoral artery for 32.9%, acute thrombosis - in the femoral artery for 37.9% and iliac artery for 22.7%. Men experience the acute thrombosis more often (3.5:1), p<0.0001, and women - embolism (2.5:1), p<0.0001. Embolism has been treated with embolectomy, and acute thrombosis with thrombectomy, thrombendarterectomy and the bypass operations. There have been made 4.9% of great amputations, rescued 96.1% of lower limbs with the features of acute ischemia. Total death rate - 4.2%. CONCLUSIONS: The acute ischemia in the leg because of embolism was for 76 patients, the acute thrombosis - for 66 patients. Lower limbs embolism of arteries is more common for women, p<0.0001, acute thrombosis for men, p<0.0001. The death rate is higher in women group with acute ischemia than men, (p=0.1198) and in men group with acute ischemia in the lower limb there are made more great amputations (p=0.04250).

Acute Disease↗

[Analysis of factors influencing on the surgical results of arterial embolism in the lower extremities].

130 patients with arterial embolism in the lower extremities underwent surgical treatment. The curative rate was 66.9%, amputation rate-19.2% and the mortality rate-13.8%. Statistical study showed that sex, age and recurrent embolism had few effects on the surgical results (P < 0.05). One of the influencing factors was the ischemic time of the lower extremities. The mortality rate was 33.3% in the distal abdomen with aortic embolism and 8.7% in the lower extremities (P < 0.005). The mortality rate and amputation rate were significantly higher in embolic patients with atherosclerotic stenosis and occlusion (9% and 17%). The mortality rate and amputation rate were 2.3% and 3.4% in patients with good blood flow and were 42.1% and 57.9% in patients without good blood flow uspectively. Reembolectomies showed no satisfactory effect. The results indicated that embolectomy combined with other necessary operations did not increase the mortality rate and amputation rate (P < 0.05). Postoperative anticoagulation therapy is extremely important.

Adolescent↗

MESENTERIC ARTERY INSUFFICIENCY.

The syndromes of superior mesenteric artery insufficiency are briefly reviewed. Three cases associated with infarction of bowel which were treated with restoration of arterial flow and resection of residual irretrievable bowel are reported. In two patients an embolectomy and in one patient a bypass graft were used to restore arterial continuity. The importance of the recognition and removal of irretrievable bowel at the time of vascular reconstruction is emphasized. Success is not necessarily predicated by the time factor alone, although the importance of early diagnosis and surgical intervention cannot be denied.

Embolectomy↗

PREVENTING, RECOGNIZING, TREATING PULMONARY EMBOLISM.

PULMONARY EMBOLISM OCCURS IN THREE FORMS: (1) Asymptomatic "silent" embolization of lungs; (2) pulmonary infarction; and (3) massive pulmonary embolization leading to acute cor pulmonale. The commonest source of emboli are veins of the lower extremities and of the pelvic organs. The prevention and the treatment of pulmonary embolism overlap, for except for the heroic procedure of pulmonary embolectomy, treatment is equivalent to the prevention of further emboli. The diagnosis may be easy in typical cases and very difficult in others.

Acute Disease↗

Thromboembolectomy in geriatric patients from long-stay wards.

The results of arterial embolectomy with the Fogarty balloon catheter in patients over 70 years of age with acute ischaemia of the lower limbs were evaluated. Twenty-three geriatric patients from long-stay wards, median age 81 years, range 70-92, were compared with 45 independent patients, median age 81 years, range 70-91, living in their own homes. The period of ischaemic symptoms before admission was on average shorter for patients coming from long-stay wards, but the outcome was less successful. Recurrent occlusion during the first postoperative month took place in 12 patients (52%) from long-stay wards as compared to eight (18%) among independent patients (p < 0.01). The mortality was 35% and 18% respectively (p > 0.2). After six months, only 35% of patients from geriatric institutions were alive with a functional extremity as compared to 62% in the independent group (p > 0.01).

Aged↗

[Acute pulmonary embolism--are vena cava interruption procedures and extracorporeal circulation always necessary?].

Between 1983 und 1991, emergency pulmonary embolectomy with the aid of extracorporeal circulation was performed in 13 patients. Ten patients were in class IV according to Greenfield, seven came into the operating theater with external cardiac massage. The 30-day mortality was 46%. In the same period, 15 venous interruption procedures were performed (three Adams de Weese Clip, ten Greenfield-Filter, and two femoral vein ligations). Eight times the venous interruption procedure was done prophylactically. The acute pulmonary embolism of class III and IV according to Greenfield is an indication for lytic therapy. We operate only if there is a contraindication to lytic therapy or if there is deterioration of the clinical state.

Combined Modality Therapy↗

[Surgical treatment of pulmonary embolism].

The authors describe the pathology and the symptoms of pulmonary embolism with possible therapies, including thrombolysis and suction extraction. We performed two successful operations and after the examination of the data of the literature we think that in most patients the conditions for immediate surgery are not present. After the acute period, when the cardio-respiratory status is stabile, pulmonary embolectomy can result in complete recovery. Extracorporeal circulation and cardiac surgical background are necessary for the intervention. The seven Hungarian adult cardiac surgical centers could save the life of many patients.

Adult↗

Epidemiology, diagnosis, and therapy of pulmonary embolism.

Pulmonary embolism is a frequently observed clinical symptom. Its mortality rate is ca. 10 % und occurs mainly in the acute phasis. Immobilization, surgery, old age, malignancies, hormonal factors as well as inherited or acquired thrombophilia are important risk factors. Spiral computed tomography and ventilation-perfusion-scintigraphy are the decisive imaging methods. Pulmonary angiography is still the gold standard. The risk of pulmonary embolism could be lowered by 50 % through prophylaxis with unfractioned or low-molecular-weight heparin. The therapy of pulmonary embolism stratifies the clinical grade and reaches from ambulant therapy with low-molecular-weight heparin to thrombolysis or embolectomy in massive pulmonary embolism. Long-term anticoagulation, usually with vitamin-K-antagonists, should be applied according to the individual risk profile of the patient.

Angiography↗

[Recurrent systemic embolisation in a patient with a large thrombus in left ventricular aneurysm--case report].

A case of a 47-year-old female with the aneurysm of the left ventricle is presented. Several days prior to the hospitalization signs of femoral embolism emerged, which was treated with embolectomy. Echocardiographic examination revealed large thrombus in the cavity of the aneurysm with pedunculated surrounding echo. On the second day after the admission the symptoms of renal artery embolism occurred. Due to recurrent symptoms of peripheral emboli and the lack of a consent for the interventional treatment, fibrinolysis (Actilyse) was applied resulting in the reduction of the thrombus mass in the left ventricle. Subsequent Doppler ultrasound of the renal arteries showed normal flow pattern. During hospitalization general condition has gradually improved and the patient was discharged.

Echocardiography↗

The role of intraoperative angiography in arterial thromboembolectomy for non-traumatic acute upper limb ischaemia.

The aim of the study was to investigate the influence of intraoperative arteriography on the outcome of upper limb acute arterial thromboembolectomy. In a retrospective study, 63 thromboembolectomies were analysed in 59 patients with acute ischaemia of the upper limbs (51 embolectomies and 12 thrombectomies). In 19 interventions, intraoperative angiography was performed either routinely or because of difficulty in passing the Fogarty catheter and/or absence of backflow. No angiography was performed in 44 interventions because the surgeons were dubious as to the benefits of the procedure. In 6/19 cases (32%) intraoperative angiography led to an extension of the intervention, with 1 intraoperative transluminal angioplasty, 2 patchplasties, 4 distal thromboembolectomies and 2 thromboendarterectomies. In patients with embolic occlusion, the adoption of routine intraoperative angiography resulted in a significantly lower re-occlusion rate at 6 months in comparison with patients who were not submitted to angiography (P<0.05). Also in patients with thrombotic occlusion, the adoption of angiography resulted in a lower re-occlusion rate at 6 months compared to patients not submitted to angiography (P<0.05). There were no amputations at 1 month. We recommend intraoperative arteriography as a routine procedure due to its positive influence on the outcome of thromboembolectomy for acute upper limb ischaemia.

Adult↗

Surgical treatment of pulmonary embolism with recent intracranial hemorrhage.

Massive pulmonary embolism (PE) with concomitant intracranial hemorrhage (ICH) has a high mortality rate. Although thrombolytic therapy is generally accepted as emergent treatment for massive PE, the risk of bleeding complications are significant. A 69-year-old woman presented with acute PE 11 days after onset of ICH. Thrombolysis was deferred, and emergent surgical embolectomy with cardiopulmonary bypass (CPB) was elected. Patient outcome was favorable without recurrence of ICH.

Aged↗