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PubMed1986

[Ovarian stimulation by a new therapeutic principle for the treatment of complications of the climacteric. Results of a double-blind crossover study with a defined spleen dialysate].

In a placebo-controlled double-blind cross-over study (test period 8 weeks) the spleen dialysate Solcosplen is tested for effectiveness and tolerance in 40 women, i.e. 14 pre- resp. 26 postmenopausal women in two consecutive periods (test periods I and II). The treatment begins in the first week of each test period with 2 ampoules i.m. t.i.d. and is to be continued for the following 7 weeks with 2 dragees b.i.d. Besides the incidence of clinical symptoms there intensity is summarized in a graded form to the Kupperman index. For further objectifying the therapeutic results vaginal-cytological examinations and radioimmunological analyses of estradiol (E2), LH, FSH and DHEA-S are carried out. The courses of therapy are frequented on a balanced basis. The progress of clinical symptoms shows in respect of incidence of appearance and intensity measured in Kupperman index in Phase I as well as in the cross-over statistically clear reciprocity, which demonstrates - with homogeneous prefindings - significantly differing results of treatment in favour of the dialysate. In the intraindividual comparison of judging the effectiveness by the physician and patient yields significant preferences for the verum. Side-effects were not observed. The proven effectiveness of the spleen dialysate within this study is explained by the stimulation of the ovarian residual function during menopause. It is discussed and compared to the presently applied monotherapeutic E2-substitution.

Adult↗
PubMed1987

[Changes in urinary NAG activity in patients with climacteric syndrome treated with estrogens].

The behaviour of urinary NAG activity was studied in patients during menopause, some of whom were given estrogen therapy due to severe vasomotor symptoms (hot flushes etc.). One group of these patients revealed slightly higher than normal blood pressure. A second group had slight arterial hypertension and pancreatic diabetes. The third group consisted of apparently healthy menopausal women. The significant increase in enzymuria in the first two groups suggests that blood pressure should be carefully checked before starting estrogen therapy. Furthermore this treatment should be given very cautiously and under constant surveillance in the presence of slight hypertension. In patients with diabetes or more severe hypertension, estrogens should never be given.

Acetylglucosaminidase↗
PubMed1987

[Configuration frequency analyses of psychiatric symptoms in climacteric females].

Configurational frequency analysis according to Krauth and Lienert is a multivariant no-parametric statistical test method to identify types and syndromes. It was used in an attempt to disclose combinations of symptoms by which the various forms of climax of women could be typed. The point is made that outcome of this study should be evaluated in terms of heuristics, with further studies being necessary.

Adaptation, Psychological↗
PubMed1987

[Sex behavior and vaginal flora in climacteric and postmenopausal females].

515 menopausal or postmenopausal women visiting the gynecologic clinic of a university hospital and having received no hormonal replacement therapy were screened for frequency of sexual intercourse and clinical symptoms typical for this period in life by a questionnaire. We found that a high percentage of women are still sexually active even with advanced age. It appeared that sex life is more intensive right after the menopause. A decrease of sexual intercourse after an age of 66 years and older seems to be secondary to the lack of a partner. Older women who remained sexually active had significantly more often a pathologic vaginal smear. We conclude that even in older women, when seen for consultation, it remains important to take into account possible sexual activity in regard to the diagnosis and therapy of vulvovaginitis.

Aged↗