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At least 1,261 records · Page 70Linked to original sources
PubMed1986

Turnover of central biogenic amines in two-kidney, one-clip renal hypertensive rats.

Turnover rates, as estimated from the accumulation of the intermediates dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in 2-kidney, 1-clip renal hypertensive rats. Results indicated that at one week following clipping, DOPA accumulation was increased in the midbrain-pons. At 5 weeks no changes were observed. At 20 weeks a lower accumulation of both DOPA and 5-HTP was observed in the posterior hypothalamus while in the medulla oblongata DOPA accumulation was lower and in the midbrain-pons 5-HTP accumulation was reduced.

5-Hydroxytryptophan↗
PubMed1989

Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata.

The following monoamine transmitters and related neurochemicals were analyzed in hippocampus and substantia innominata from postmortem brain tissue of subjects with senile dementia of the Alzheimer's type (SDAT): tryptophan (TP), 5-hydroxytryptamine (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA), noradrenaline (NA), dopamine (DA) and homovanillic acid (HVA). The results were compared to those obtained in postmortem brain samples obtained from normal subjects matched for age, sex and time between collection of tissue and freezing. There were no significant differences in concentrations of TP, DA or HVA between normals and SDAT subjects in either brain region. While hippocampal 5-HT, 5-HIAA and NA concentrations were markedly reduced in SDAT patients relative to normals, the substantia innominata concentrations of these three were not significantly different between controls and SDAT patients, emphasizing the importance of detailed regional analyses when conducting neurochemical studies in SDAT.

Aged↗
PubMed1982

Biogenic amines and beta-endorphin responses in the rat vas deferens.

1. Recent studies have demonstrated that activation of opioid peptide receptor by beta-endorphin results in a change of bioamines in peripheral tissues. 2. The present results could be interpreted assuming that the action of beta-endorphin, on the smooth muscle of the isolated rat vas deferens, is independent of catecholaminergic, cholinergic and tryptaminergic neurotransmission. 3. There is evidence that it is through a specific opioid 'epsilon-receptor' which have been shown a high degree of affinity for beta-endorphin.

Animals↗
PubMed1983

Effect of biogenic amines reuptake inhibition on ethanol induced hypothermia.

The mechanism of ethanol induced hypothermia (EIH) was examined by the use of chemically related compounds which inhibit 5-hydroxytryptamine (5-HT) or norepinephrine (NE) reuptake. Desipramine, a tricyclic antidepressant drug (TCA) and NE reuptake inhibitor partially antagonizes EIH. However, Nisoxetine (NE reuptake inhibitor but not TCA) did not abolish EIH. Chlorimipramine, a TCA compound and 5-HT reuptake inhibitor abolishes EIH. Meanwhile, fluoxetine (5-HT reuptake inhibitor, but not TCA) potentiated ethanol induced hypothermia. It was concluded that the antagonism of EIH is probably related to the antidepressant effect of TCA compounds.

Animals↗
PubMed1990

The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain.

1. Two week chronic administration of trimipramine increased the brain concentration and metabolism of dopamine and 5-hydroxytryptamine. 2. The treatment also produced a reduction in dopamine D2 and 5-hydroxytryptamine 5-HT2 receptors but no change in tryptamine binding was observed. 3. These findings suggest that trimipramine induces adaptive changes in dopamine and 5-hydroxytryptamine neurotransmission.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1994

Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs.

1. In experiments on young (3-5-month-old), adult (10-11-month-old) and old (21-22-month-old) rats, it was found that significant age-related changes occurred in the high-affinity uptake of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) by cortical and striatal synaptosomes. 2. Changes in DA, NA and 5-HT uptake during aging are suggested to be neurochemical correlates of cognition and memory deficits that develops in senescence. 3. The in vitro effects of the nootropic drugs piracetam, aniracetam, meclofenoxate and adafenoxate on the DA, NA and 5-HT uptake by cortical and striatal synaptosomes from young rats were studied. Administered in increasing concentrations (1 x 10(-4) to 5 x 10(-3) M) these drugs inhibited monoamine uptake. 4. Adafenoxate proved to be a more potent monoamine uptake inhibitor than the other three drugs; it inhibited the uptake in the frontal cortex and striatum without selectivity for either monoaminergic system. It is suggested that adafenoxate affects cognition through the involvement of central neurotransmission and particularly through the inhibition of monoamine uptake systems.

Aging↗