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At least 1,261 records · Page 70Linked to original sources
PubMed2004

[Antimetastatic effects of genistein on salivary adenoid cystic carcinoma in vivo].

OBJECTIVE: To study the antimetastatic effects of genistein on salivary adenoid cystic carcinoma (ACC-M) in vivo. METHODS: ACC-M cells were exposed to genistein for 3 days. The treated cells and control cells were then injected into the tail vein of 20 nude mice, which were randomized into 2 groups. The mice were sacrificed at the sixth week after implantation. The lung metastasis rates and the number of metastases were detected. Apoptosis index (AI), the expression of VEGF and MMP-9 of the lung metastases were also observed. RESULTS: Compared to the control groups, the number of metastases was significantly reduced in genistein treated group (P < 0.05). The AI of ACC-M cells was higher in the treated group than in the control group (P < 0.05). The level of VEGF and MMP-9 expression were decreased in the treated groups (P < 0.05). CONCLUSIONS: Genistein has a moderate inhibitory effect on metastasis of ACC. Inducing apoptosis, inhibiting the expression of VEGF and MMP-9 are the mechanisms of antimetastatic effects of genistein on ACC-M in nude mice.

Animals↗
PubMedDate not supplied

Adenoid cystic carcinoma of trachea.

A 20-year-old male, presented with cough, haemoptysis, breathlessness and wheezing for the past one month. Contrast enhanced computerised tomographic (CECT), scan of chest and fibreoptic bronchoscopy revealed an endotracheal mass that on histopathological examination showed adenoid cystic carcinoma of trachea. Magnetic resonance imaging (MRI) scan of chest confirmed involvement of adjacent prevertebral, para-oesophageal and subcarinal lymph nodes rendering the tumour inoperable.

Adult↗
PubMed2005

Changes of histological and biological features by serial passages in a human adenoid cystic carcinoma line transplantable in nude mice.

The basic histologic patterns of adenoid cystic carcinoma (ACC) are classified into three types (tubular, cribriform and solid), but clinical significance of the histological type is unclear. We have successfully established a human tumor line derived from ACC that is serially transplantable in nude mice. This tumor showed an increased growth rate as the passage levels proceeded, and the histological type was changed from a cribriform pattern in the initial stage to a solid one. In this study, we investigated the relationship between histological type and biological characteristics by analyzing the serially transplantable ACC tumor model. As a result, the tumor growth rate at the 15th passage level was increased approximately 5-fold compared with that at the initial passage level. In the histological type, approximately 30% of the cribriform pattern in the initial level was changed to a solid one at the 15th passage level, and the PCNA labeling index was elevated 4-fold. Concomitant with this, expression of Ki-67, p53 and bcl-2 proteins was increased, and apoptotic cells were decreased as demonstrated by the TUNEL method. From these findings, it was suggested that cell proliferation and histological change of this ACC tumor are related to the inhibition of apoptosis. This tumor line would provide a useful model for investigating the biological behavior of ACC.

Animals↗
PubMed2001

[Double adenoid cystic and squamous cells carcinoma of the hypopharynx and larynx. A contribution to the issue of multicomponent neoplasms].

Bicomponent cancer of the piriform fossa and larynx of 55 years old man has been described. The patient was treated surgically and by radiotherapy. The performance of laryngectomy and partial pharyngectomy with conservative bilateral neck dissection was used as surgical treatment. In histopathological findings of postoperative specimens two types of neoplasms: squamous cells and adenoid-cystic cancers were stated. The authors presented opinions on the affection arising of multicomponent tumours of the aerodigestive truct.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

Neutron therapy, prognostic factors and dedifferentiation of adenoid cystic carcinomas (ACC) of salivary glands.

PURPOSE: Analysis of the efficacy of fast neutron radiotherapy in the treatment of adenoid cystic carcinomas (ACC) of the salivary glands, identification of prognostic variables and dedifferentiation after radiotherapy. PATIENTS AND METHODS: Histological slides of primary and recurrent lesions of 71 patients were reviewed to confirm the diagnosis and to analyse subtypes. Median follow-up was 52 months. Local control rate and overall survival were analysed in multivariate analysis. Complications are also described. RESULTS: Primary vs. recurrent therapy (p=0.001), margin-status (p=0.01) and subtype (p=0.019) influenced overall survival. Primary vs. recurrent therapy (p=0.001), margin-status (p=0.018) and T-stage (p=0.043) influenced local control rate. Dedifferentiation was seen in only 1/17 cases. CONCLUSION: The calculated prognostic factors illustrate the importance of a radical primary therapy. Histological subtype is a significant additional factor for overall survival and, in case of dedifferentiation, it is a strong predictor of a detrimental outcome.

Adult↗
PubMed2005

Expression of beta-catenin, E-cadherin and cyclin D1 in adenoid cystic carcinoma of the salivary gland.

We evaluated the expression of beta-catenin, E-cadherin, and cyclin-D1 in 23 cases of adenoid cystic carcinoma (ACC) of the salivary gland. We detected beta-catenin on the cell membranes in all ACCs, but its distribution was irregular, as compared to that on normal structures. In three out of the 23 cases, beta-catenin was detected in the nuclei, as well as on cell membranes. Polymerase chain reaction (PCR) and direct sequencing revealed a missense mutation in one case in which beta-catenin had been detected in the nuclei of tumor cells. We also detected E-cadherin on cell membranes with a similar irregular distribution to that of beta-catenin. In 11 cases (almost 48%) of ACC, cyclin D1 was localized in cell nuclei but there was no correlation with the nuclear staining of the beta-catenin. Our results suggest that disturbances in the distribution of beta-catenin and E-cadherin might affect the morphology ofACC and that a small fraction of cases of ACC are characterized by a mutation in the beta-catenin gene, which is associated with the nuclear accumulation of the product of this gene but does not affect the transcription of the gene for cyclin-D1.

Base Sequence↗
PubMed2005

[Sinonasal cystic adenoid carcinoma with epiphora and orbital involvement. Report of a case and review of the literature].

We report the clinical case of a 41 years old male with nasal obstruction of 1 year, epistaxis and epiphora. The ENT exam showed a bleeding red mass in left nasal fossa and CT joint to IRM revealed a tumoral process on that level and informed about its extension to adyacents structures (cavum, ethmoides, sphenoids and maxillary sinus). The biopsy was positive for cystic adenoid carcinoma. Our patient was operated by paralateronasal rhinotomy with removal of the tumor. One year later we found recurrence on the left orbital floor and maxilar sinus. The Oncology Department informed that it was not possible a treatment with radiotherapy or chemotherapy because the low sensitivity of that lesion those treatment.

Adult↗
PubMed2005

Adenoid cystic carcinoma of the trachea: a report of seven cases and literature review.

BACKGROUND: Adenoid cystic carcinoma (ACC) of the trachea is rare. The clinical manifestations, natural history, and responses to therapy differ from those of other malignant tracheal tumors. METHOD: In this retrospective study, we examined pathological records of patients in the Department of Pathology at Chang Gung Memorial Hospital from 1990 through 2002. There were five male patients and two female patients with ages that ranged from 21 to 55 years. For these seven patients the clinical manifestations and period from initial symptoms to diagnosis, treatment and outcome are presented. RESULTS: Hemoptysis, nonproductive cough, dyspnea, chest pain and weight loss were the frequent early manifestations. Five patients had tumors in the lower area of the trachea, two had tumors in the upper area of the trachea. In a patient with the tumor in the upper area of the trachea, the tumor involved the cricoid ring, larynx, and subglottic area. In one patient with the tumor in the lower area of the trachea, the tumor invaded the right lower lobe of the lung. The longest survival time was more than 10 years. CONCLUSIONS: ACC is a rare primary tracheal malignancy. The time from first symptoms to diagnosis varied, ranging from weeks to more than 1 year. Complete surgical resection provides the patient with the best chance of prolonged survival or even complete remission.

Adult↗
PubMedDate not supplied

Effects of imatinib mesylate on adenoid cystic carcinomas.

BACKGROUND: Adenoid cystic carcinomas (ACCs) are rare tumors which most often arise in the salivary glands. They have a propensity for local relapse and tend to metastasize, frequently with a protracted clinical course. A substantial fraction of the tumors expresses c-Kit or the platelet-derived growth factor receptor beta (PDGFRbeta), both targets for imatinib mesylate. No standard systemic therapy is known for these neoplasms. PATIENTS AND METHODS: c-kit and PDGFRbeta-expression were determined by immunohistochemistry. Four patients with distant metastases and with at least one positive result were treated with 400 mg imatinib mesylate once daily and their response assessed. RESULTS: c-Kit and PDGFRbeta expressions were variable among the tumor samples. Toxicity was mild. No remissions were observed. CONCLUSION: These data support that c-Kit or PDGFRbeta expression per se are not prognostic for the therapeutic response of metastasized ACCs to imatinib mesylate.

Adult↗
PubMed2005

[The relation of nuclear factor kappa B to angiogenesis and clinical outcomes in adenoid cystic carcinoma of salivary glands].

OBJECTIVE: To evaluate the expression of nuclear factor kappa B (NF-kappaB) p65 in relation to angiogenesis microvessel density (MVD) and clinical outcomes in adenoid cystic carcinoma of salivary glands (ACCs). METHODS: Immunohistochemical staining method was used to quantify the protein expression levels of NF-kappaB p65 in 80 surgically resected salivary gland ACC and normal salivary tissues. In all cases of ACCs, microvessel density was evaluated by counting any CD(34)-reactive endothelial cell or endothelial-cell cluster. The patients with ACCs were followed up from 1992 to 2002. RESULTS: NF-kappaB p65 was detected in the cytoplasm of normal and ACC cells, but was only in the nucleus of tumor cells; while there was no NF-kappaB p65 nuclear staining in all the controls. The mean value of MVD was (47.07 +/- 13.44), which had significant correlations with NF-kappaB p65 expression (P < 0.01). In three histological types of salivary gland ACC, the expressions of NF-kappaB and MVD were significantly higher in solid type than in cribriform type and tubular type (P < 0.01). NF-kappaB p65 expression and MVD were significantly correlated to clinical stage, tumor size, perineural and vascular invasion, recurrence and metastasis (P < 0.05), but there were no correlations between those three factors and patient age, gender and tumor site (P > 0.05). Multivariate analysis showed NF-kappaB (P < 0.05) expression, MVD (P < 0.01), histotypes (P < 0.01), and perineural invasion (P < 0.05) had an independent prognostic impact on overall survival. CONCLUSIONS: The expression of NF-kappaB p65 was related to MVD, and the correlation between those two factors and clinico-pathological factors and prognosis of ACCs are significant.

Carcinoma, Adenoid Cystic↗
PubMed2005

[Treatment of patients with chronic adenoiditis and abnormal coagulation].

Chronic adenoiditis (CA) prevails among ENT diseases in children. It often demands surgical intervention. Frequent hemorrhagic complications during adenotomy necessitate assessment of the patient's hemostasis. A preoperative examination of 43 children has detected primarily dysaggregation thrombocytopathies. Streptococcus pneumoniae is a dominating etiological agent. Chronic focal infection is involved in pathogenesis of systemic disorders in CA including those provoking coagulatory disturbances. An algorithm of hemostatic disorders diagnosis in CA children is proposed as well as an effective program of targeted pre- and intraoperative hemostatic therapy.

Adenoidectomy↗
PubMed2005

Adenoid cystic carcinoma of the salivary glands: a 20-year review with long-term follow-up.

The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpredictable in terms of local and distant spread and mortality. We retrospectively studied 35 operations in 34 patients who had had a pathologic diagnosis of ACC of the salivary glands and who had been treated over a 20-year period and followed for a minimum of 10 years. We analyzed the effect that different factors had on outcomes. The site of origin appeared to be an important factor in survival rates; survival among patients with tumors that had originated in the parotid gland was fairly good, while survival among those with tumors that originated in the minor salivary glands was significantly worse. TNM staging was another significant factor in survival. Other poor prognostic indicators were local spread, nodal positivity, distant metastasis, and local and regional recurrence. Radiation and chemotherapy did not appear to be beneficial for patients with advanced disease. We recommend radical surgery with complete resection for all patients with ACC of the salivary glands and a careful assessment of the neck in patients with minor salivary gland tumors.

Adenoma↗
PubMedDate not supplied

Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.

BACKGROUND: p27(kip1), a universal cyclin-dependent kinase inhibitor, is a useful marker for predicting clinical aggressiveness with various human tumors. In this study, p27 expression was investigated in pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs) of minor salivary glands to evaluate its utility for differentiation purposes. At the same time, the correlation between p27 and ACC grading was evaluated. MATERIALS AND METHODS: Clinicopathological features of 22 patients (11 ACCs, 11 PAs), including age, sex and size of tumor were obtained from medical records. Immunohistochemical staining with p27(kip1) was performed for each specimen and p27 labelling indices were determined with a computer-assisted image-analyzing system (CAS 200). Pearson's correlation coefficient, Spearman's correlation coefficient, Students t-test, Kruskal-Wallis test and ANOVA were applied for statistical analyses using SPSS 11.5. RESULTS: p27 LIs for all PAs were above 25% whereas for ACCs they were under 25% (except one case). p27 expression (LI and intensity) was significantly lower in ACCs than PAs. The correlation between p27 expression and ACC grading was not significant. CONCLUSION: Overall, these findings suggest that reduced expression of p27 might be correlated with the development of ACC and could be an indicator of malignant behavior.

Adenoma, Pleomorphic↗
PubMed1991

[A case of adenoid cystic carcinoma of the esophagus].

A 64-year-old male admitted with feeling of a foreign body at the esophagus in swallowing. Esophageal radiologic findings showed a serrated type shadow defect 6 cm in diameter at the middle thoracic esophagus. Endoscopic findings revealed a elevated type tumor at a site 32 cm from the incisor dentition. The biopsy specimens showed squamous cell carcinoma. The operation was performed with right thoracotomy, subesophagotomy, and reconstruction of gastric tube via substernum. Macroscopically, a elevated type tumor of 5.5 x 4.0 x 2.0 cm covered by normal esophageal mucosa at the periphery was recognized. Histologically, most of the tumor was adenoid cystic carcinoma differentiating to squamous cell carcinoma in the epithelium. Immunohistological stain of actin, S-100 protein indicated that the tumor may have originated from an esophageal gland. Histologic stage was mp, ly(-), v(-), n(-), stage I. Surgical curability was CIII. Postoperative irradiation for prevention of recurrence has been conducted. The patient survives without tumor at present 4 months later.

Carcinoma, Adenoid Cystic↗
PubMed2005

[Clinical analysis of 38 patients with cephalic and cervical adenoid cystic carcinoma].

OBJECTIVE: To assess the clinical features and the treatment result of cephalic and cervical adenoid cystic carcinoma (ACC). METHOD: A retrospective analysis was performed on 38 patients with cephalic and cervical ACC by their clinical manifestation, the therapy and follow-up results. RESULT: We had 38 patients of operation. All patients followed up from 3 years to 13 years. The overall 3-year survival rate of patients was 71.1%, the overall 5-year survival rate of patients was 63.2%. CONCLUSION: Cephalic and cervical ACC is not easy to exact diagnosis in early stage. It progresses slowly. It also has the tendency of recurrence and cancerous metastasis. Thus it, is necessary to do both thorough surgery.

Adolescent↗
PubMed2005

Detection of cancer cells in the peripheral blood and lung of mice after transplantation of human adenoid cystic carcinoma.

Polymerase chain reaction (PCR) targeting human beta-globin gene has been reported to be able to detect micrometastasis in an animal model. We attempted to detect cancer cells from the lung and peripheral blood in nude mice, into which a human adenoid cystic carcinoma (ACC) line (KOA-1 and KOA-1L3) had been transplanted. Positive PCR reaction was observed in the lung of a total of 19 of 47 (40.4%) mice into which KOA-1 tumor cells had been transplanted: none of 10 after 1 month, seven of 18 after 2 months, and 12 of 19 after 3 months or later. The KOA-1L3 tumor showed earlier lung metastasis, that is, two of 24 after 7 days and two of 12 after 14 days. Positive PCR reaction was confirmed in the blood samples of three of 19 mice. The lungs of these mice were positive PCR results after subcutaneous transplantation of the KOA-1 tumor. Three of four mice in these blood samples were confirmed in Positive PCR reaction after subcutaneous transplantation of the KOA-1L3 tumor similarly. The lungs of these mice were PCR positive reaction as well as the lungs of transplantation KOA-1 tumor mice. On the other hand, negative PCR reaction was showed these lungs of 60 mice after subcutaneous transplantation of the KOA-1 or KOA-1L3 tumor. All of them were showed negative PCR results in the blood samples. This experimental model can be expected to provide a more detailed understanding of ACC, as well as help to develop a therapy for metastasis of ACC.

Animals↗
PubMedDate not supplied

[Treatment of laryngeal adenoid cystic carcinoma].

Laryngeal localization (nearly always hypoglottic) of adenoid cystic carcinoma is quite rare (0.6% of all malignant laryngeal tumors). In most cases the local development of the neoplasm is slow, of an infiltrating and highly invasive nature (affecting the cartilage, thyroid gland, esophagus). On the other hand in some cases, particularly in the laryngeal-tracheal localization, the tumors take on an exophytic, sessile, polypoid aspect. Although the evolution is quite slow prognosis is poor due to the latent spreading of distant metastasis (average survival is 8 years). Prognosis is further worsened by delay in diagnosis due to the poor, aspecific initial symptoms. C.A.T. and N.M.R. have made a marked contribution to improved diagnostic definition, especially in terms of tumor extension, which is of great importance in therapeutic staging. Given the poor results obtained with radiotherapy and chemotherapy the only possible treatment is surgery which, in most cases, must be quite radical. Only in those forms which are still localized (with endoluminal exophytic development) is it possible to perform conservative surgery. Two paradigmatic cases are reported here indicating two different tumor extensions: in the first case total laryngectomy was performed and extended to the thyroid gland and the upper portion of the trachea; in the second, a partial glottic-subglottic laryngectomy was performed with functional restoration of laryngeal function. Conservative surgery is only possible if the hypoglottic neoformation is limited to the larynx, if it is mainly exophytic in nature and if histological examination reveals a low degree of malignancy (a high degree of cell differentiation). Since this type of carcinoma tends to give rise to latent distant metastases prognosis is, in all cases, poor no matter what surgical technique is employed for the primary tumor. Therefore it is imperative that a conservative laryngectomy be performed in all cases where it proves oncologically possible and particular attention should be paid to the quality of the patient's post-surgery life.

Carcinoma, Adenoid Cystic↗