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Coexisting alpha pattern coma, theta pattern coma and spindle coma.

Abnormal ectopic rhythms, such as alpha-theta activities and spindles, occur in comatose patients. A case is presented in which the EEG of a comatose patient showed coexisting alpha-theta pattern activities and spindles. It is concluded that the coexistence of these rhythmic patterns in the EEG of a comatose patient implies continued physiologic functioning of a thalamocortical system deafferented by brainstem dysfunction and a lesser degree of cortical dysfunction.

Alpha Rhythm

Maximal expiratory flow-volume patterns in allergic rhinitis. Characteristic flow-volume patterns of the lower airways.

On 37 patients with nasal allergy and 37 non-smoking healthy volunteers, maximal expiratory flow-volume curve and volume-time curve were obtained. To find the characteristic flow changes, the flow curves were classified into five patterns from type A to type E. The results showed that the incidence of type A was significantly lower in patients with nasal allergy than in the control group, while the rate of type E was significantly higher at 46% and the rate of type B was particularly high (32.4%) in the patient group. It was demonstrated that 77% of the subjects provided B or C flow-volume curves, while those with pale nasal mucous membranes developed D and E formats. In patients with nasal allergy, these patterns are useful in diagnosing remarkable differences in the lower airways.

Adolescent

The wide-angle pattern electroretinogram. Relation between pattern electroretinogram amplitude and stimulus area using large stimuli.

Pattern electroretinograms (PERGs) were recorded from two normal human subjects in response to various spatial frequencies and stimulus areas. The maximum stimulus area was 75 degrees x 86 degrees which was achieved by using a standard TV monitor and a reduced viewing distance. The amplitude of the PERG increased with area in an approximately logarithmic fashion over the range investigated. The explanation relates to non-linearities of the stimulus, the retinal image and neural processing. The wide-angle PERG may be useful in the assessment of retinal diseases affecting the mid-peripheral inner retina, such as diabetic retinopathy.

Electroretinography

Use of computerized pattern recognition in the study of the cuticular hydrocarbons of imported fire ants. I. Introduction and characterization of the cuticular hydrocarbon patterns of Solenopsis invicta and S. richteri.

A method is described in which gas chromatographic (GC) data obtained from cuticular hydrocarbons are treated by methods of pattern recognition. Based on a recently described sample preparation procedure, GC data are normalized to eliminate slight variations in chromatographic conditions and converted into the proper format for discriminant analysis by computer. The results of several methods of data treatment and display are discussed, based upon the chemometric system package, ARTHUR. The approach has the advantage of largely removing operator bias.

Animals

Use of computerized pattern recognition in the study of the cuticular hydrocarbons of imported fire ants. II. Comparison of the cuticular hydrocarbon patterns between different colonies of Solenopsis richteri.

Gas chromatography (GC) data obtained from the cuticular hydrocarbons of the black imported fire ants are treated by methods of pattern recognition. Based on a recently described sample preparation procedure, GC data are normalized to eliminate slight variations in chromatographic conditions, and converted to the proper format for discriminant analysis by computer. The results of several methods of data treatment and display are discussed, based on the chemometrics system package, ARTHUR.

Animals

Visual discrimination of simple geometrical patterns: II. Atypical responses in a subject suffering difficulties with pattern recognition.

We have applied the experimental methods described by Ike et al. (Spatial Vision, 1987, 2, 13-29) in the study of pattern discrimination by subjects who, during childhood, experienced severe difficulties with reading and spelling. Of the six subjects studied, one still suffers from such difficulties and we show that she performs atypically in certain of the discrimination tasks. In particular, her discrimination responses for elements such as delta are markedly different from those of all other subjects. We interpret these abnormal responses on the basis of the discrimination mechanisms for line orientation and rotation of the elements which were discussed by Ike et al. (1987).

Adult

Breast tissue classification using diagnostic ultrasound and pattern recognition techniques: I. Methods of pattern recognition.

This paper discusses the application of statistical pattern recognition techniques to problems in diagnostic ultrasound. Using our own system as an example, we describe the concepts and specific methods that we have applied to a problem involving the computer-aided classification of breast tissue in vivo. Topics include feature generation, feature selection and classification, as well as a method which estimates the probability of error on classifying future data. An accompanying paper applies these methods to the classification of backscattered RF signals from normal and diseased breast tissue.

Breast Diseases

[Pattern ERG in ocular hypertension and glaucoma. Effect of pattern size, contrast and retinal eccentricity].

We have previously shown that check-size-specific changes of the Pattern-Electroretinogram (PERG) can be used to detect early glaucoma. This time we conducted a study to determine whether different check sizes, contrasts and eccentricities can improve the diagnostic yield. We examined 15 normal eyes (15 subjects), 32 eyes (24 patients) in stage I or II glaucoma and 36 eyes (25 patients) with ocular hypertension (OHT). Visual acuity was always better than 0.8. The stimuli were checkerboards, phase-reversing at 16 rev/s. The check sizes were 0.8 degrees or 15 degrees with contrast at 60% or 98%. The stimulation area was either "full-field" (27 degrees x 30 degrees), "central" (less than or equal to 7 degrees) or "paracentral" (greater than 7 degrees). In the glaucoma group, all PERG amplitudes were significantly reduced compared to normals: maximally for stimuli of 0.8 degrees, 98% contrast, full-field to 51% +/- 18%, and least for stimuli of 15 degrees, 98% contrast, central (to 70% +/- 20%). Under paracentral stimulation, the amplitude was reduced to 55% and in the central condition to 64%. The single-most-sensitive stimulus to separate normal and glaucoma patients was 0.8 degrees, 60% contrast and full-field, as the variance was low for this condition. Only 4 patients (8.5%) were incorrectly classified using these parameters; when 8 different stimuli were entered into the discriminant analysis, the rate was marginally reduced to 3 patients (6.4%). Seventy-five percent of the OHT eyes were classified as pathological. These results confirm previous findings that in early glaucoma, PERG amplitudes are more reduced using check sizes of 0.8 degrees compared to 15 degrees.(ABSTRACT TRUNCATED AT 250 WORDS)

Electroretinography

Industrial rheumatology. Clinical investigations into the influence of the pattern of usage of the pattern of regional musculoskeletal disease.

Regional musculoskeletal diseases are exceedingly common in all segments of society, and dramatically so in industry. For generations, medicine has assumed that many such entities are use-associated. A critical review of several examples of back and upper extremity disease demonstrates that the literature supporting these assumptions is almost entirely anecdotal. It is argued that if defined patterns of usage were associated with defined clinical syndromes, such knowledge would have considerable therapeutic and prophylactic potential. Industrial rheumatology is proposed as an investigative discipline for the study of such relationships. The prerequisites in terms of assumptions and methods as well as potential fallacies and pitfalls are discussed.

Arm

Analysis of coat-color patterns in aggregation chimeras between BALB/cA and C3H/HeN mice with special reference to migratory patterns and clone number of epidermal melanoblasts.

Chimeras provide unique opportunities to study interactions between the phenotypically similar but genotypically allogeneic cell populations during embryogenesis in vivo. From the quantitative analysis of coat-color patterns in C3H/HeN----BALB/cA chimeras, a model was proposed stating that the aggregability of the C3H/HeN-derived melanoblasts in the chimeras was inversely related to the ratio between the mean free path of the epidermal melanoblasts in the normal C3H/HeN mouse and that in the chimeras. As a corollary, the possibility was suggested that during the migration of melanoblasts, mechanisms identical with or similar to contact inhibition of movement might operate after collision between the isogeneic, but not between the allogeneic melanoblasts. With regard to the number of melanoblast clones in the trunk region of the mouse, the present series of analyses yielded the value of 24-28 arranged unilaterally; the value closely approximated the number of the somites in that region and provided further support for the proposition made earlier by Tachi [Dev Genet 9: 121-154, 1988; "Development of Preimplantation Embryos and Their Environment." New York: Alan R. Liss, Inc., 1989, pp 263-274].

Animals

Early-phase physiological response patterns to psychosexual stimuli: comparison of male and female patterns.

The onset and sequential changes of psychosexual arousal for male and female were compared. During an erotic film presentation, genital hemodynamic and groin skin temperature measures of sexual arousal recorded moderate to large increases for both sexes. A sequential analysis revealed strikingly similar male-female response patterns for both the genital and groin measures of arousal. Thus, the commonly held view that males typically show a greater sexual responsivity to visual erotic stimuli than do females was not supported.

Adult

Clinical significance of fetal heart rate patterns during labor. I. Baseline patterns.

From a population of 2,774 high-risk patients monitored during labor, 1,304 single pregnancies in cephalic presentation and with direct monitoring for at least 1 hour before completion or cesarean-section were studied. The maternal and fetal clinical data and the tracings were hand reviewed, coded, and programmed for computer analysis. In the record were studied baseline, its changes (tachycardia, fixed, saltatory), the accelerations, and the decelerations (early, variable, late). Fifty-four per cent had some type of FHR deceleration. Accelerations were recorded in over 12 per cent of all cases and were associated with cord problems in 41 per cent. Subgrouping the patients by age of gestation (less than or equal to 36 weeks, 37 to 41 weeks, and greater than or equal to 42 weeks) revealed a 10 per cent prolonged gestation rate and only 6.8 per cent premature; these had a lower 5 minute Apgar score. Fetal weight and age were positively correlated with Apgar score. Baseline changes were much frequent among pre- and postmature infants, particularly tachycardia in the latter (40 per cent). The premature infants had a 25 per cent incidence of fetal distress and the postmature infants had 20 per cent. Neonatal morbidity and mortality rates were very high among premature infants and a mortality rate of 2.3 per cent was found among postmature infants. Saltatory pattern and particularly fixed baseline seem characteristic of prolonged gestation and placental insufficiency. With tachycardia, they constitute subtle symptoms of fetal distress.

Delivery, Obstetric

Anti-immunoglobulin analysis by diffusion patterns of inhibition and facilitation of complementary lysis in agar. I. Diffusion-lysis patterns of heterologous guinea pig anti-immunoglobulins.

Anti-rabbit immunoglobulin-containing sera were produced by immunizing guinea pigs with guinea pig red cells sensitized with rabbit-produced haemolysin against them. Such sera, and their 7S and 19S fractions, were radially diffused in agar containing sheep red cells sensitized with rabbit haemolysin and fractions thereof. After diffusion, the preparations were treated with guinea pig complement, which produced partial lysis in the background and a series of alternating rings of more and less lysis than that in the background. These were interpreted as a due to the presence of at least four anti-immunoglobulins (anti-Ig's) as follows: a 19S anti-Ig which inhibited lysis by 7S and 19S haemolysin; a 7S anti-Ig which facilitated lysis by 7S and 19S heamolysin; a 7S anti-Ig which inhibited lysis by 7S and 19S haemolysin; a 7S anti-Ig which facilitated lysis by 19S haemolysin. Similar patterns were obtained using correspondingly produced sera against mouse immunoglobulin, and sensitizing the sheep cells in the agar with mouse-produced haemolysin.

Animals

Bone trabecular pattern analysis in Down syndrome with the use of computed panoramic radiography. Part II: Visual pattern analysis with the frequency and gradational enhancement.

Visual pattern analysis of mandibular bone trabeculation of 51 patients with Down syndrome and 78 normal persons was performed by using rotational panoramic radiography with a laser scan system. The findings for patients with Down syndrome were consistent with geromorphism, one of the somatic characteristics of Down syndrome.

Adolescent

Species pattern of phosphatidylinositol from lung surfactant and a comparison of the species pattern of phosphatidylinositol and phosphatidylglycerol synthesized de novo in lung microsomal fractions.

1. Phosphatidylinositol (PI) is a minor component of lung surfactant which may be able to replace the functionally important phosphatidylglycerol (PG) [Beppu, Clements & Goerke (1983) J. Appl. Physiol. 55, 496-502] without disturbing lung function. The dipalmitoyl species is one of the main species for both PI (14.4%) and PG (16.9%). Besides the C16:0--C16:0 species, the C16:0--C18:0, C16:0--C18:1, C16:0--C18:2 and C18:0--C18:1 species showed comparable proportions in the PG and PI fractions. These similarities of the species patterns and the acidic character of both phospholipids could explain why surfactant PG may be replaced by PI. 2. PI and PG were radiolabelled by incubation of microsomal fractions with [14C]glycerol 3-phosphate (Gro3P). For 11 out of 14 molecular species of PI and PG we measured comparable proportions of radioactivity. The radioactivity of these 11 species accounted together for more than 80% of the total. The addition of inositol to the incubation system decreased the incorporation in vitro of Gro3P into PG and CDP-DG (diacylglycerol) of lung microsomes (microsomal fractions), but did not change the distribution of radioactivity among the molecular species of PG. These results supported the idea that both acidic surfactant phospholipids may be synthesized de novo from a common CDP-DG pool in lung microsomes.

Acylation

[Fatty-acid pattern of human fat and liver tissues in alcoholics and non-alcoholics: fatty-acid pattern as a measure of alcoholism (author's transl)].

Samples from the right lobe of the liver and from fat tissue of the abdominal wall were removed shortly after death from 116 persons. Fatty-acid pattern of both tissues (lauric, myristic, palmitic, palmitoleic, stearic, oleic, linoleic acids) was measured and compared with the degree of fatty infiltration of the liver. The data were also correlated with chronic excess alcohol consumption in the pre-terminal phase. It was found that with increasing fatty inflitration there was a rise in the relative proportion of palmitoleic acid in liver and subcutaneous fat tissues, with a fall in the relative proportion of stearic acid in the latter. Comparison of results in alcoholics (19 subjects) and non-alcoholics (91) showed the expected higher fatty infiltration of the liver in the former (x equal 13.4% and 5.6%, respectively). Both in liver and subcutaneous fat tissues the relative proportion of palmitoleic acid was significantly higher in alcoholics. But while in these the proportion of palmitoleic acid in the liver was higher than in subcutaneous tissue, the relationship was the converse among the non-alcoholics.

Abdominal Muscles

Foot-ground pressure pattern of standing hemiplegic patients. Major characteristics and patterns of improvement.

The study was designed to examine major weight-bearing characteristics of hemiplegic patients receiving physical therapy and to assess the usefulness of the Foot Print apparatus as an objective, clinical measurement tool of these characteristics. Measurements of the foot-ground pressure pattern of 23 patients were taken two times, three weeks apart. The results confirmed the clinical impression of lesser weight bearing by the patient on the affected leg, especially on the heel of that leg, compared with weight bearing on the contralateral leg. Consequently, stance stability was impaired. The difference between the foot-ground pressure of the two measurements indicated improvement in the stance characteristics of these patients after treatment. The Foot Print apparatus seems to be an objective measurement tool of assistance both to the patient and the physical therapist in execution of a treatment.

Aged