Proceedings: A controlled prospective trial of the effect of multiple exposures to halothane on liver function.
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In order to study the chronic form of decompression disease, clinical and physiological examinations of 38 test subjects were carried out. They participated in 133 chamber experiments and were exposed to an altitude of 11,000--12,000 m for 2--3 to 20--24 hours after desaturation of different duration. Besides, histological and histochemical examinations of organs and tissues of 3 dogs were performed. During 70, 110 and 140 days the dogs were exposed 20, 33 and 35 times to an altitude of 12,000 m for 2--2.5 hours without preliminary desaturation. No persistent pathological changes were found in the animal or human body.
Rats behaviour in the "open field" changed in 2 hrs after a single episode of hypoglycaemia was abolished with glucose whereas no changes occurred in their stereotyped behaviour and intraspecies interaction. In 24 hrs quantitative parameters of the "open field" behaviour normalised although the behaviour still had an altered structure. At the same time, amphetamine-induced stereotyped behaviour's indices became reduced. These and other findings suggest some deeper behavioural changes in rats during their recovery from repeated hypoglycaemic episodes and absence of synchronisation of the insulin effects.
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The lysosomes of neutrophils and system influenced by the Hageman factor were shown to take part in adaptation of the body to manyfold stress. The data obtained show that manyfold stress (immobilization) led to adaptation of the neutrophil lysosomes so as no need occurred in the lysosome enzymes to take part in the humoral regulation.
For 30 days rats were exposed daily 3 hrs a day to a constant magnetic field of 1.6 T. The time within which the rats were swimming with a load until they were fatigued was measured and the concentration of catecholamines in blood and adrenals was determined. Two stages of the response to the magnetic field were identified. During the first stage (1-15 days) physical work capacity increased and the reactivity and reserve ability of the sympatho-adrenal system (SAS) grew. During the second stage (30th day and early recovery period) work capacity returned to normal and the SAS reactivity decreased, although the catecholamines stored in the adrenals remained unchanged. These findings indicate that the SAS is involved in mechanisms underlying changes in work capacity and adaptation processes during exposure to a constant magnetic field.
C57BL/6 male mice were every day exposed to stressing influence. The liver was examined on day 4, 10, 21 after the start of the experiment and 3 days after the exposure was discontinued. These periods were characterized by increased concentration of ultrastructure membranes and intensified autophagocytosis. The volume changes in glycogen and autophagic vacuoles have been characterized by a strong correlation ratio. These changes were most prominent on day 10 of observation. The adaptive nature of changes is suggested.
Blood bed and structure of the compact substance of the cat tibial diaphysis have been studied at normal conditions and after repeated effect of gravitational overloadings. Hypergravitation produced a noticeable rearrangement in the microcirculatory bed and in histoarchitectonics of the bone compact substance. The date obtained demonstrate that the changes produced depend on the number of parameters participating in the gravitational effect and on the position of the animal in the container, as well as on the time when the animal falls ill after the experiment.
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