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Ulcerative colitis in Zagreb, Yugoslavia: incidence and prevalence 1980-1989.

We present a ten-year incidence of ulcerative colitis in Zagreb, Yugoslavia. The study included both outpatients and inpatients regardless of the extent and severity of the disease. The mean annual incidence rate was 1.5 per 100,000 inhabitants for the period of 1 January 1980 through 31 December 1989. There was no increase in the incidence of ulcerative colitis during the study period. A prevalence rate estimate of 21.4 per 100,000 inhabitants was based on July 1985 official estimated population. The results confirm the low frequency of ulcerative colitis in central Europe.

Adult↗

Belgrade virus: a new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia.

Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1-3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia.

Adult↗

Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome.

An outbreak of severe hemorrhagic fever with renal syndrome (HFRS) occurred in 1988 in Pozarevac, Serbia, Yugoslavia. The disease was diagnosed in 4 children and 1 adult, and 1 of the children died. Rodents were captured from the same area and virus isolation attempted. A hantavirus, POZ-M1, was isolated from lung tissues of hantavirus antigen-positive Mus musculus. Serology and restriction enzyme digestion of polymerase chain reaction-amplified segments from this virus showed that it was a strain of Puumala (PUU) virus, the causative agent of nephropathia epidemica. While Clethrionomys glareolus is the major rodent host for PUU virus, these results suggest that M. musculus may also play an important role in harboring and transmitting PUU-like viruses. The serologic association of this virus with patients with severe HFRS reaffirms that PUU-like viruses may cause severe disease in addition to the generally mild form normally associated with nephropathia epidemica.

Animals↗

Selected aspects of the epidemiology of psychoses in Croatia, Yugoslavia. IV. Representative sample of Croatia and results of the survey.

This is the fourth paper in a series on the epidemiology of psychoses in Croatia, Yugoslavia. Data collected from 1960-1975 on a representative sample of the population of the study area, including the Istrian Peninsula and the northern Adriatic littoral, and the control area, the rest of Croatia, indicate that functional psychotic illnesses are more frequent in the study area, with the highest rates in older population groups. The finding is not associated with coastal or inland residence, with educational level, or with occupational group. Other diseases in excess in the study area are diabetes mellitus, psoriasis, and alcoholism. Nutritional disorders are about equally distributed between study and control areas. Data on extent of cigarette smoking was more prevalent in the study area, cases of functional psychoses smoked no more than the general population.

Adult↗

Did NATO attacks in Yugoslavia cause a detectable environmental effect in Hungary?

Because of the intensive NATO bombardment of the neighboring region to Hungary, i.e., Vojvodina, North Yugoslavia, air monitoring for detection of depleted uranium particles supposed to be used as a component of bullets was extended to the Southern region of the country. Alpha spectrometry was applied as a sensitive analytical technique able to detect uranium. Though no depleted uranium was detected in air by the sensitive technique of alpha-spectrometry, the increased uranium content in natural ratio as a component of normal soil, natural gas, etc., is suggested to originate from well dispersed dust (2.5 microm size) emitted to the atmosphere by explosions during bombing. This observation is supported by the geographical distribution and the relatively rapid decrease of pollution after the bomb attacks ceased.

Air↗

Depressive symptoms among hospitalized and posthospitalized alcoholics in Yugoslavia.

Two clinical samples of male and female alcoholics undergoing inpatient hospital and posthospital treatment in Zagreb, Yugoslavia, were evaluated for depressive symptomatology and extent of alcoholism, using self-report measures (Zung Self-Rating Depression Scale and Michigan Alcohol Screening Test). Higher levels of depressive symptoms and lower alcoholism scores were reported for the hospital group, in comparison with the posttreatment "Clubs of Treated Alcoholics" group. In the hospital, no significant relationships were found between levels of depression and extent of alcoholic indicators. In the club group, however, those alcoholics who remained depressed (at minimal or mild levels) are also those who perceived themselves as having greater consequences from the alcoholism. The cultural context and psychosocial drinking and postdrinking environments of the alcoholics and their families appear to be important factors in the decline of depressive symptoms among treated, abstinent alcoholics, as well as in the retention of such symptoms among a subset of the sober alcoholics. This suggests that treatment should place a high priority on reordering the social and personal life of the alcoholic and his or her family while also retaining whatever nondrinking social ties that the alcoholic had developed and valued before treatment.

Adult↗

Oral health in Slovenia, Yugoslavia.

An oral health epidemiological survey using WHO assessment forms was conducted in the Republic of Slovenia (Yugoslavia) in 1987. The study population consisted of 1623 persons aged 6, 12, 15, 18, 35-44 and over 65 yr. The survey included 10 towns in 9 geographical areas of Slovenia. The results showed the prevalence of dental caries in the Slovenian population to be very high (93.6% in 12-yr-olds). The mean decayed, missing, and filled teeth (DMFT) scores were as follows: 5.1 at age 12 yr, 10.2 at 15 yr, 12.9 at 18 yr, 20.5 at 35-44 yr, and 27.0 in persons aged over 65 yr. Assessment of the periodontal status showed calculus to be the predominant disorder in the age groups 18 and 35-44 yr, while shallow pockets prevailed in persons aged over 65 yr.

Adolescent↗

Epidemiology of hepatitis D virus (delta) infection in Yugoslavia.

In 614 HBsAg-positive Yugoslavian patients, radioimmunoassay testing for anti-delta showed the presence of this antibody in serum in 11.2%. Of the patients, 213 belonged to a risk group (i.v. drug users, hemophiliacs, hemodialysed patients and patients with posttransfusion hepatitis); a significant number of these patients (63; 29.6%) were found to have anti-delta. A second group was composed of 401 HBsAg-positive patients from the general population (patients with acute hepatitis B, with fulminant hepatitis B and patients with chronic HBV infection); delta infection was found only in six (1.5%). Immunohistochemical methods failed to demonstrate the delta antigen in the livers of 73 patients with chronic HBV infection. Testing the liver of 36 patients with fulminant hepatitis B for delta antigen demonstrated this reactivity in only one (2.8%) liver sample. Delta antigen was also found in the liver of a female patient who underwent biopsy in 1972. The results of this study suggest the HDV is not endemic in Yugoslavia; however, it is frequently found in patients at risk of blood exposure, primarily i.v. drug users.

Adult↗

Some experiences with the F scale in Yugoslavia.

Two studies in which the original F scale (Adorno, Frenkel-Brunswik, Levinson & Sanford, 1950) has been used in Yugoslavia are reported. The first one considers inter-item correlations whereas the second rates total score to several personality variables. It has been found that these studies provide evidence for the existence of several hard-to-interpret first-order factors which do lead to one higher-order factor. The F scale measures anxiety, independence (dominance) and also unexpected social adjustment second-order personality factors. Both political and cultural influences could be considered as explanations for these results but the latter seem to be more pronounced. That being the case, revisions of the scale have been suggested.

Adolescent↗

Pre-existing disease in British Army patients aeromedically evacuated from the former Republic of Yugoslavia.

A questionnaire study was carried out on 74 British Army patients who were awaiting aeromedical evacuation from the Former Republic of Yugoslavia. The study confirmed previous unpublished reports that 41% of patients were being repatriated for exacerbation of pre-existing disease. Of these, 78% had disease known to their medical officer, were considered to be outside limits for full fitness, according to accepted military standards, but had not been downgraded. Only 34% of these patients had been reviewed prior to deployment to assess their fitness. Assessment of fitness to deploy was in some cases based on inaccurate information about in theatre living and working conditions, and the medical support available. In conclusion it would appear that medical officers should be more diligent in downgrading unfit personnel to prevent their deployment on operations thereby reducing the burden on the medical evacuation chain. Medical officers need up-to-date information on operational areas in order to make appropriate decisions on fitness of personnel to deploy.

Confidence Intervals↗

Trauma related symptoms in British soldiers 36 months following a tour in the former Yugoslavia.

This paper measures the prevalence of psychological symptoms in two British Infantry battalions, 36 months after being involved in peace keeping operations in the former Yugoslavia during November 1992-April 1993. Those deployed had a high level of post traumatic stress disorder (16%) compared to (9%) in the control group. However, there was a high level of probable psychiatric disorder in both the Bosnia and control group of around 25%. The possible explanations for these findings are discussed.

Adult↗

Epidemiology of Huntington's disease in Rijeka district, Yugoslavia.

Epidemiologic study of Huntington's disease (HD) in the Rijeka district represents the first research of its kind carried out in Yugoslavia. After a detailed investigation of all available sources of health information, ten families, with a total number of 24 HD patients, were found. The prevalence rate of HD on March 31, 1981, was 4.46/100,000 population. Most of the patients involved were members from the second or third familial generation. The age at recognition of disease was 41.6 years, with earlier onset among the males. Involuntary movements frequently appeared as the initial symptomatology (45.8%). Duration of the disease from initial symptomatology to death averaged at 10.6 years. Six of nine patients who died had committed suicide. It took physicians of primary care, neurologists, and psychiatrists 5.3 years (1-12 years) to make a definite diagnosis. Nine of the affected families from Rijeka district were autochthonic households. Six of these families immigrated from Saxony, Slovakia and Upper Carinthia during the reign of the Habsburg dynasty (1619-1780).

Adult↗

Human red cell adenylate kinase polymorphism in Srbija, Yugoslavia.

Red cell adenylate kinase (AK) phenotypes were determined in 283 unrelated adults in Srbija (Yugoslavia). The gene frequencies observed were: AK1 0.961 and AK2 0.039. The adenylate kinase activity was estimated in all haemolysates; no significant differences were found between individuals of different phenotypes.

Adenylate Kinase↗

Human red cell glutamic-pyruvic transaminase polymorphism in Serbia, Yugoslavia.

The polymorphism of red cell glutamic-pyruvic transaminase (GPT) was studied in 277 unrelated voluntary blood donors from the population of Serbia (Yugoslavia). The following phenotype frequencies were observed: GPT 1 0.309, GPT 2-1 0.454 and GPT 2 0.206, while gene frequencies were: GPT1 0.556 and GPT2 0.454.

Alanine Transaminase↗

Esterase D polymorphism in Serbia (Yugoslavia).

Phenotypes of human red cell esterase D (EsD) were determined in 351 unrelated adults from Serbia (Yugoslavia). The calculated allele frequencies were 0.911 for EsD1 and 0.089 for EsD2. The phenotype distribution was in good agreement with the Hardy-Weinberg equilibrium.

Carboxylesterase↗

An outbreak of acute hemorrhagic conjunctivitis in Yugoslavia in 1973.

An outbreak of approximately 200 cases of acute hemorrhagic conjunctivitis is described in Prekmurje, a northern province in Yugoslavia. The epidemic was caused by enterovirus type 70, serologically identical with the causative agents of similar outbreaks in London and Japan. The origin of the outbreak could not be elucidated but a link was seen between this case and a small outbreak in Veenendaal in the Netherlands.

Acetates↗