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Results for “Vivisection”

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At least 127 records · Page 7Linked to original sources
PubMed1991

Animal liberation or animal research?

The first wave of protest against animal research began over a hundred years ago and lasted for about 40 years. The present wave of protest has only existed for the past 20 years but it is already far more serious, and more violent, than the first. In this Special Feature, Mark Matfield reviews the history of the animal liberation movement, and predicts that unless the scientific community makes a greater effort to inform the public about why animal research is necessary and the humane way in which it is conducted, pharmacological and other areas of biomedical research could become seriously restricted.

Animal Welfare↗
PubMed2006

An in vivo technique for pharmacological manipulation of Drosophila brain during optical recording.

Drosophila melanogaster, an established model for genetic manipulation, has recently been used for studying olfactory perception, learning, and memory. Some of these important behavioral phenomena have been dissected with defined mutants, some to a single biochemical lesion, expressed in central brain structures known as the mushroom bodies. A previously introduced preparation used a window in the head capsule through which these structures could be imaged using genetically expressed fluorescent calcium sensors while applying physiological odorant stimuli. Unfortunately, technical constraints prevented direct manipulation of the mushroom bodies with this preparation. I describe here a preparation that will allow, for the first time, the direct pharmacological manipulation of these important structures during imaging in the living adult fly. Responses to discreet applications of acetylcholine were reversibly blocked with tubocurare and reversibly eliminated in calcium-free Ringers. This new technique will significantly enhance the usefulness of the Drosophila model system, allowing a more quantitative examination of the mechanisms involved in olfactory learning and memory.

Acetylcholine↗