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At least 127 records · Page 7Linked to original sources

[Medical check-ups in childhood (author's transl)].

Eight year's experience indicates that medical check-ups in childhood have found a firm place in preventive medicine. The purpose of the examinations, the number of participants and the efficiency are dealt with and the importance of proceeding specifically emphasized. The special problems of early recognition of diseases which may lead to disability or chronic disease, e.g. cerebral motor disturbances, psychic handicaps, disturbances of vision, hearing and speech, and disorders of the hip joint are discussed. From the knowledge of risk factors, early symptoms and course of the disease, and the optimal beginning of treatment of each disease, the main point of attack for each age group emerges. An informative and instructive discussion with the parents is indispensable. Interdisciplinary cooperation is to be aimed at.

Child↗

Evaluation of specific pick-ups and preamplifiers for the recording of heart vibrations.

Experiments have shown that pick-ups used for the recording of heart vibrations (apexcardiography, phonocardiography) can influence the vibrations of the soft tissue chest wall to which they are applied. This influence is most pronounced in the medium and high frequency range (10 . . . . . 1000 Hz). Owing to the mechanical loading effect of the pick-up on the chest wall, the vibrations are attenuated and distorted. This is also shown with respect to pure mass loading of the chest wall. The loading effect on the chest wall (coupling function) has been studied by us in the frequency-domain as well as in the time-domain on 6 normal subjects who were in the recumbent position. Typical parameters of the coupling function have been established in relation to mass loading. An empirical formula has been found for the degree of attenuation of the vibrations caused by the load. In order to perform these investigations, a special seismic pick-up FYSPac2 has been constructed which will load the tissue to a slight degree only. Its mass is 1 g and it has a flat frequency response up to 1 kHz and a high sensitivity (12 pC m-1s2). The problem of the vibration measurement on soft tissue is discussed here in its whole context: the loading effect of the pick-up, the sensitivity (and bandwidth) of the pick-up as well as the quality of the preamplifier as regards its transfer characteristics and its electronic noise level.(ABSTRACT TRUNCATED AT 250 WORDS)

Amplifiers, Electronic↗

Factors to consider for predictable post and core build-ups of endodontically treated teeth. Part I: Basic theoretical concepts.

Post and core build-ups represent an important pre-prosthetic procedure prior to the restoration of an endodontically treated tooth. The dental practitioner is presented with the dilemma of selecting from an ever increasing variety of materials, techniques and designs related to this procedure, many of which are harmful and mired in controversy. Part I of this paper reviews some basic theoretical concepts for the dentist to consider when producing a predictable post and core build-up. An understanding of these basic concepts will assist the dentist in gathering data and establishing a risk/benefit equation, and will also provide an additional aid during the decision-making process for the restoration of an endodontically treated tooth.

Biomechanical Phenomena↗

[Relationship between medical expenditures and government-sponsored medical check-ups for the aged].

Japanese law provides for regular medical examinations for the aged. A simulation study to determine the relationship between medical expenditures of cardiovascular disease patients and government-sponsored health check-ups for the aged was conducted in a small community town in Kanagawa Prefecture. The results showed that medical expenditures decreased in accordance with an increase in health screening. However, medical expenditure for out-patients increased slightly with an increase in screening for those cardiovascular disease patients who had not received treatment prior to the government health checkup.

Adult↗

[Programmed complex for automated prophylactic check-ups of chronic outpatients. Communication 1. Tasks and fundamentals].

The authors present the fundamentals of making outpatient computer case histories for prophylactic check-ups of chronic outpatients with ocular diseases. They validate the necessity of creating mononosological versions of computer histories which should not only describe the underlying diseases in detail, but reflect any concomitant ocular disease as well. The basic criteria formulated by the authors helped create a computer history of a modulus type, which may be easily mastered by physicians within just 2-3 hours and be adapted to research of this or that patient population. The authors emphasize the importance of creating and wide use of software in everyday practical medicine.

Chronic Disease↗

[Results of 30 year follow-ups of pulmonary tuberculosis patients contingent with isolated drug resistant or sensitive strains].

The paper provides the results of follow-ups of 269 patients with pulmonary tuberculosis, 170 and 39 isolated drug-resistant or sensitive Mycobacteria tuberculosis (MT), respectively. Drug resistance to MT was found to lower the feasibility of curing the patients, to prolong their cure, and to slow down the rate of decreasing the cohort of tuberculosis patients registered at the dispensary. In the first 5-years of the follow-up, there were lower death rates due to tuberculosis in a group of patients with drug-resistant MT than in those with drug-sensitive one.

Antitubercular Agents↗

The ups and downs of oral lithium dosing.

As a mood-stabilizing agent, lithium has a long history of documented efficacy as well as risks associated with its use. Relative to other psychiatric medications, lithium exhibits a number of unique pharmacokinetic properties. The use of in vivo nuclear magnetic resonance spectroscopy of the 7Li isotope has immense potential to provide an improved understanding of the pharmacokinetic basis of lithium response and nonresponse. The conventional use of orally administered immediate-release preparations of lithium salts in psychiatry is associated with high postabsorptive blood lithium concentrations and trough lithium concentrations in later phases of lithium elimination. These ups and downs of blood lithium concentrations are associated with acute lithium toxicity and symptomatic states, respectively. The use of slow-release lithium formulations represents a long available means of diminishing the postdose variation in serum lithium concentrations. A significant need exists for head-to-head comparisons of the pharmacokinetics and clinical response relationships for slow-release and immediate-release lithium formulations.

Administration, Oral↗

The ups and downs of anorexia nervosa.

OBJECTIVE: We updated our incidence study by identifying Rochester, Minnesota, residents diagnosed with anorexia nervosa during 1985 through 1989. METHOD: From a community-based epidemiologic resource, 2,806 medical records with diagnoses including anorexia nervosa, eating disorder, bulimia, amenorrhea and other conditions were screened to identify new cases of anorexia nervosa. RESULTS: Two hundred eight (193 females and 15 males) residents fulfilled standard diagnostic criteria for anorexia nervosa. The overall age-sex-adjusted incidence rate was 8.3 per 100,000 person-years. The age-adjusted incidence among females was 15.0 per 100,000 person-years compared to 1.5 per 100,000 among males. The long-term linear increase for 15 to 24-year-old females noted during the first 50 years of the study continued. The disorder remained less frequent among older females. DISCUSSION: Anorexia nervosa remains a relatively common disorder among young females. While there are short-term fluctuations in incidence, the long-term increasing trend for 15 to 24-year-old females has continued.

Adolescent↗

The ups and downs of daily life: profiling circadian gene expression in Drosophila.

Circadian rhythms are responsible for 24-hour oscillations in diverse biological processes. While the central genes governing circadian pacemaker rhythmicity have largely been identified, clock-controlled output molecules responsible for regulating rhythmic behaviors remain largely unknown. Two recent reports from McDonald and Rosbash(1) and Claridge-Chang et al.2 address this issue. By identifying a large number of genes whose mRNA levels show circadian oscillations, the reports provide important new information on the biology of circadian rhythm. In addition, the reports illustrate both the power and limitations of microarray-based methods for profiling mRNA expression on a genomic scale.

Animals↗

Ups and downs of tissue and planar polarity in plants.

The polar orientation of cells within a tissue is an intensively studied research area in animal cells. The term planar polarity refers to the common polar arrangement of cells within the plane of an epithelium. In plants, the subcellular analysis of tissue polarity has been limited by the lack of appropriate markers. Recently, research on plant tissue polarity has come of age. Advances are based on studies of Arabidopsis patterning, cell polarity and auxin transport mutants employing the coordinated, polar localization of auxin transporters and the planar polarity of root epidermal hairs as markers. These approaches have revealed auxin transport and response, vesicular trafficking, membrane sterol and cytoskeletal requirements of tissue polarity. This review summarizes recent progress in research on vascular tissue and planar epidermal polarity in the Arabidopsis root and compares it to findings on planar polarity in animals and cell polarity in yeast.

Animals↗

Experience of boron-neutron capture therapy for malignant brain tumours--with special reference to the problems of postoperative CT follow-ups.

Boron-neutron capture therapy (BNCT) is theoretically a highly selective treatment of infiltrating tumours, in that the tumoricidal heavy particle radiation is limited to a sphere of 10 microns around a tumour cell which is loaded with non-radioactive boron-10 atoms. There were 73 gliomas among the 83 cases treated by boron-neutron capture therapy. For grade III-IV cerebral gliomas, 5 and 10 year survival rates were an unimpressive 19 and 10% respectively. This was the result of technical problems such as unsatisfactory reactors and inadequate craniotomies for the majority of the patients. If the analysis was limited to those whose tumours had been irradiated with more than 2.5 x 10(12) neutrons/cm2 (yielding more than 3,000 rem or more), the 5 and 10 year survival were almost 100 and 50%. The longest surviving glioblastoma (grade IV) patient has lived in a satisfactory manner for the past 15 years. For the cases who had been treated with borderline doses (lethal or sublethal), interpretation of the postoperative CTs was frequently intriguing. Several cases had to undergo re-opening and occasionally even another BNCT, only to find no viable tumour tissue. Death occurred in some, either due to discontinuation of supportive treatments by local physicians, or due to excessive therapies by the author directly involved in the patient's care, both of whom had erroneously believed in recurrence. At autopsy, residual tumour cells were recognized only in the areas where the above-mentioned neutron fluence had not been delivered at the time of the treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗