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PubMedDate not supplied

[Effect of testosterone propionate on the lymphoid system and antibody-producing capacity in golden hamsters].

The effect of testosterone-propionate on the lymphoid tissue and humoral immunological response to SRBC was studied in 224 golden hamsters of both sex. The hormone was injected intramuscularly in a dose of 1 and 5 mg every other day (a total of 10 injections). Testosterone caused thymus atrophy, hypoplasia of the spleen, reduction of the absolute B lymphocyte count in the bone marrow, forming cell count and a fall of the serum hemolysin titre in the immunized animals. The detected changes were found to be more pronounced in female animals.

Animals↗
PubMed1992

[Clinical trial on termination of early pregnancy by using dl-15 methyl prostaglandin F2 alpha methyl ester in combination with testosterone propionate. Report of 244 cases].

244 subjects with amenorrhea < or = 56 days were given intramuscular injection of testosterone propionate 100 mg per day for 3 days, and in the morning of day 4, 1 mg dl-15 methyl prostaglandin F2 alpha methyl ester (PG05) suppository was inserted in the posterior fornix of the vagina every 2 hours up to the pass-out of the villi and sac for utmost 5 mg. At the same time 1-2 tablets of diphenyloxylate Co. were taken. The complete-abortion rate was 83% (191/231), the incomplete abortion rate was 13% (30/231), the total efficacy rate was 96% (221/231), and the failure rate was 4% (10/231).

Abortion, Induced↗
PubMed1990

Synergism of testosterone propionate with growth hormone in promoting growth of hypophysectomized rats: effect of sexual differentiation.

The effect of testosterone propionate (TP), alone and in combination with porcine GH, on the growth of hypophysectomized rats was investigated. An initial study determined doses of TP and GH which would result in a synergistic response. Hypophysectomized male rats, approximately 40 days of age, received GH at doses of 5, 25 and 62.5 micrograms/day administered in two injections/day at 08.00 and 16.00 h. At all doses of GH, administration of TP at 100 micrograms/day significantly enhanced the GH-stimulated rate of growth. This growth enhancement by TP was greatest in combination with GH at 25 micrograms/day. In a subsequent study, growth responses to 25 micrograms GH/day and 100 micrograms TP/day were examined in animals with differing degrees of sexual differentiation. Sex groups were: intact males, males castrated at 11 days of age and females administered 100 micrograms TP at 3 days of age (masculinized rats), and males castrated at 2 days of age and normal females (non-masculinized rats). In all sex groups, growth of hypophysectomized rats was stimulated by GH. Genetic sex and masculinization did not influence the response to GH. Masculinized hypophysectomized rats exhibited significantly greater rates of growth and final live, empty body, liver and kidney weights than non-masculinized hypophysectomized rats. All sex groups other than normal females responded synergistically to the combination treatment of GH plus TP. Rats that experienced neonatal exposure to testosterone became programmed to respond to testosterone and demonstrated greater rates of growth and body and organ weights when administered the combination of GH plus TP. These data indicate that TP synergizes with GH to promote growth of hypophysectomized rats appropriately programmed to respond.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Influence of castration and testosterone propionate on prostatic and seminal vesicular lipids in mature monkeys.

The effect of castration and administration of testosterone propionate (TP) has been studied in mature monkeys in relation to prostatic and seminal vesicular lipids to castrates on prostatic and seminal vesicular lipids were studied in mature monkeys. Castration decreased prostatic total lipid, total phospholipids and total glyceride glycerols. Among neutral lipid classes only diacyl glycerol was decreased due to castration. Similarly among phospholipid classes, phosphatidyl choline and ethanolamine were decreased. A marked decrease in the seminal vesicular total lipid, total phospholipids, total cholesterol and total glyceride glycerol were observed due to castration. Mono and diacyl glycerols and phosphatidyl choline and ethanolamine also registered a significant decrease after castration. Administration of TP to castrates brought back all the lipid classes to normal level which showed a decrease due to castration. However, TP treated to castrates on both seminal vesicles and prostates had no effect on other classes of lipids which were unaltered by castration. The present study reveals that lipid metabolism in the male accessory sex organs is under androgenic control. Nevertheless, the influence of testicular androgen is specific to different classes of lipids as a number of phospholipids and neutral lipid classes were resistant to castration or administration of TP.

Animals↗
PubMedDate not supplied

Quantitative maintenance of spermatogenesis in cyclosporine-treated rats by exogenous administration of testosterone propionate.

The authors had previously shown that the subcutaneous administration of cyclosporine (CsA) resulted in an impairment of spermatogenesis. Testosterone levels declined and gonadotropin levels increased, suggesting that CsA primarily affects the synthesis and secretion of testosterone. In this study, the authors attempted to determine whether the exogenous administration of testosterone would maintain spermatogenesis in animals treated with a very high dose of CsA. Sexually mature, male Sprague-Dawley rats were treated subcutaneously with CsA (40 mg/kg per day) alone, or in combination with testosterone propionate (TP; 2 and 5 mg/d per rat), for 14 days. As expected, CsA reduced the body and reproductive organ weights and the levels of serum testosterone, while elevating the levels of follicles-stimulating hormone (FSH) and luteinizing hormone (LH). Quantitative analysis of spermatogenesis revealed a decline in all the different types of germ cells in tubules at stage VII of the cycle of the seminiferous epithelium. Administration of TP in 2 and 5 mg/d per rat doses restored the body and reproductive organ weights and the circulating levels of FSH. The serum levels of LH were below the assay's minimum level of detectability. Analysis of spermatogenesis revealed a dose-dependent increase in the germ cell counts after the administration of 2 and 5 mg of TP. The circulating levels of CsA were also significantly reduced after TP administration. These results revealed that CsA-induced alteration in spermatogenesis can be prevented by the exogenous administration of testosterone.

Animals↗
PubMed1979

"In vivo", testosterone propionate induced aberrations in Notopterus notopterus.

Germ cell chromosomes of N. notopterus responded ot the higher doses of testosterone propionate peculiarly. Emergence of anomalies like agglutination at terminal ends, clumping and precocious despiralization was evident. The stickiness, breaks, laggard and a few achromatic lesions also appeared. Effect up to 72 hrs stages was evincible and varying occurrences of chromosomal irregularities.

Animals↗
PubMedDate not supplied

Testosterone propionate induced changes in testicular phosphatases of musk shrew (Suncus murinus L.).

In order to investigate the role of testosterone (TP) on the physiology of the testis of the musk shrew, activities of acid phosphatase, alkaline phosphatase and adenosine triphosphatase, and DNA, protein and phospholipid contents ot the testis were compared under high and suppressed testosterone conditions. The result indicates that testosterone propionate administration to intact shrews resulted in a significant increase in the activities of testicular enzymes. Following TP the testis phospholipid: DNA ratio increased, whilst no change was observed in the enzyme activities in response to aminoglutethimide phosphate. The role of testosterone in regulating testis function of this non-scrotal primitive eutherian mammal is discussed.

Acid Phosphatase↗
PubMed1975

The behavior of chickens following embryonic treatment with testosterone propionate.

This study was designed to investigate an initial response and the flocking behavior of chicks treated embryonically with testosterone propionate (TP). The high (1.28 gm. %) and low (0.32 gm. %) levels of TP interfered with the response of these chicks to a specific stimulus. However, only the high level TP depressed the flocking response. TP administered prior to day 13 of embryonic development will depress sexual behavior in the chicken. These data suggest that TP influences a variety of behavioral patterns in the chicken.

Animals↗
PubMed1984

Effect of blinding on the growth of reproductive organs in male rats treated neonatally with testosterone propionate.

Prepubertal blinding slightly retards the growth of seminal vesicles and prostate in male Wistar rats. Neonatal administration of testosterone propionate (TP) increases the susceptibility of rats to light deprivation. The growth of testes, seminal vesicles and prostate is markedly retarded in TP-treated rats blinded at 30 days of age. However, prepubertal blinding does not inhibit the tissue growth completely since even in TP-treated animals steady growth of reproductive organs occurs. Blinding of TP-treated adult rats induces involution of seminal vesicles and prostate although it has no effect on testis weight. The weight of testes can thus be influenced by light deprivation only during its growth in maturing animals, whereas the weights of seminal vesicles and prostate may be affected even in adult animals.

Age Factors↗
PubMedDate not supplied

Effects of short-term high-dose testosterone propionate administration on medium molecular-weight proteins of human seminal plasma.

Effects of short-term high-dose testosterone propionate treatment on medium molecular-weight proteins (lactoferrin, albumin, prostatic acid phosphatase, prostate specific antigen) and on zinc and fructose levels were investigated in the seminal plasma of seven normal volunteers. A significant reduction in levels of prostatic-acid phosphatase, zinc and, to a lesser degree, prostate-specific antigen, lactoferrin and fructose was observed on the 14th day of androgen treatment, concomitantly with the maximal increase in free androgen-circulating levels. The data obtained suggest that testosterone administration may induce a reduction in the sex accessory-gland secretion. Indeed, this effect tends to disappear with withdrawal of hormone treatment. Therefore, the authors suggest a close follow-up of prostatic and vesicular function during the long-term high-dose testosterone intake, used frequently as anabolic treatment by athletes and body builders.

Acid Phosphatase↗
PubMed1984

Topical testosterone propionate in the therapy of vulvar dystrophies.

187 patients with atrophic, hypertrophic and mixed vulvar dystrophy were treated with 2% testosterone propionate ointment from 18 months to 7 years. Symptoms, macroscopic, and histologic picture were evaluated before and during treatment. About 75% of the patients achieved good and excellent symptom relief. Treatment efficacy differentiates according to the type of dystrophy, and in relation to the lesion's extension and the duration of symptoms, which consist mostly of pruritus. Side effects from therapy were negligible.

Administration, Topical↗
PubMedDate not supplied

Changes in serum alpha2u-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay.

The Hershberger assay has been proposed as a candidate screening test method for the detection of androgenic and anti-androgenic chemicals and is being validated presently under the test guideline programme of the Organization for Economic Cooperation and Development (OECD). Rat alpha2u-globulin is male rat-specific protein appearing in their serum and urine, and the protein is known to be induced by androgens. We investigated the usefulness of measuring serum alpha2u-globulin levels as a parameter for the androgenic activity of chemicals tested in the Hershberger assay. The serum alpha2u-globulin level was measured after the administration of testosterone propionate at dosages of 0, 20, 100 or 500 microg kg(-1) day(-1) for ten consecutive days in the castrated male rats. The ventral prostate, balbocavernosus/levator ani muscles, glans penis and Cowper's gland were collected and weighed. Although all the androgen-responsive organ weights were increased significantly at dosages of 100 and 500 microg kg(-1) day(-1), the serum alpha2u-globulin level was increased significantly only at a dosage of 500 microg kg(-1) day(-1). These results show that the serum alpha2u-globulin level may be a useful biomarker for detecting androgenic activity caused by test chemicals, but it is less sensitive than the organ weights of androgen-responsive tissues in the Hershberger assay.

Alpha-Globulins↗
PubMed1989

Effect of active immunization against estrogen on gonadotropin response to testosterone propionate treatment in ovariectomized pony mares.

An experiment was conducted to determine whether partial neutralization of estrogens via active immunization alters testosterone propionate (TP)-induced increases in FSH secretion after GnRH administration in ovariectomized pony mares. Twenty mares were used in a 2 X 2 factorial arrangement of treatments (n = 5/group). Factor 1 was long-term active immunization against either bovine serum albumin (BSA) or estrone-17-oxime-BSA. Factor 2 was 11-d administration of either vehicle (vegetable oil) or TP (175 micrograms/kg BW). Plasma concentrations of FSH were not affected (P greater than .1) by either factor. As expected, the FSH response to exogenous GnRH was threefold greater (P less than .05) in BSA-immunized mares treated with TP than in BSA-immunized mares receiving oil. However, immunization against estrogens reduced (P less than .05) this TP-induced increase in FSH response by 52%. Plasma concentrations of LH were decreased (P less than .08) by TP; this effect was not altered (P greater than .1) by immunization against estrogen. The LH response to exogenous GnRH was not affected (P greater than .1) by either factor. We conclude that aromatization of testosterone to estrogen is partially responsible for the increased FSH response to exogenous GnRH in TP-treated mares. In contrast, suppression of LH concentrations by TP appears to involve only the androgenic effect of TP.

Animals↗
PubMed1988

Sexual interactions between estrous female rats and castrated male rats treated with testosterone propionate or estradiol benzoate.

Estrous female rats display 'precopulatory behaviors' such as ear wiggling and hopping/darting when castrated males treated with testosterone propionate (TP) are placed in their vicinity and before copulatory interactions have taken place. Castrated males treated with estradiol benzoate (EB) do not elicit these precopulatory behaviors in advance of copulatory interactions. It therefore seemed of interest to study females' sexual behavior with castrated males treated with TP or EB when males or females had primary control over the temporal patterning of the behavior. Unrestrained sexual behavior (= male control) with EB-treated males was characterized by large numbers of intromissions and long periods of time preceding ejaculation, as compared with interactions with TP-treated males. The temporal pattern of sexual behavior did not change importantly when the males were tethered (= sexual behavior controlled by females). When given a choice between two sexually active castrated and tethered males, one treated with TP and the other with EB, estrous females 'preferred' EB-treated animals in various respects. Fewer interactions occurred with, and less time was spent in the vicinity of, TP-treated males over prolonged observation periods (115-135 min). The preference for EB-treated males disappeared, and TP- and EB-treated animals became equally attractive, when the vaginal opening of the female animals was covered with adhesive tape to prevent the occurrence of penile intromissions during mounting. It is concluded that female control over copulatory behavior does not necessarily change the females' sexual behavior.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1995

Diurnal sensitivity of the testes to exogenous testosterone propionate in sexually regressed whitethroated munia Lonchura malabarica.

The testes in different groups of whitethroated munia (Lonchura malabarica) were studied following exogenous treatment of testosterone propionate (1 mg/100 g body wt./day) at 06.00 h or 14.00 h or 22.00 h for 15 consecutive days during the quiescent phase of the annual testicular cycle. The testicular conditions in each group of testosterone treated and appropriate control (administered only with the vehicle of hormone at corresponding time-points) group of birds were analyzed by the studies of paired testicular weight, seminiferous tubular diameter, spermatogenetic index, and cytology of the testicular germ cells. The results of the study revealed that exogenous testosterone was stimulatory to the testicular functions irrespective of the time of treatment. The gametokinetic response of the testes to exogenous testosterone also did not show any statistical difference among the birds treated at different hours of the day. The present study demonstrates for the first time that the responses of the testes to exogenous testosterone during the post-breeding phase in an annual testicular cycle of a wild bird does not vary with the time of administration.

Animals↗
PubMed1990

Chronic testosterone propionate treatment decreases the concentration of [3H]quipazine binding at 5-HT3 receptors in the amygdala of the castrated male rat.

Chronic administration of testosterone propionate (TP) was found to decrease the concentration of [3H]quipazine binding at 5-HT3 receptors in the lateral and basal amygdaloid nuclei of the brains of castrated male rats. TP had no effect on the binding of [3H]quipazine at 5-HT3 receptors in the posterolateral or posteromedial cortical amygdaloid nuclei, or in the amygdalohippocampal areas. It is suggested that the effects of testosterone on sexual and other social behaviors in male rats may be mediated, at least in part, by decreases in the activation of 5-HT3 receptors in the amygdala.

Amygdala↗
PubMed1983

Regulation of luteal activity in adult female rats treated neonatally with testosterone propionate.

The present study was concerned with the control of luteal activity in female rats which had been treated neonatally with 1.25 mg testosterone propionate (TP). Treatment of such rats in adulthood with 15 i.u. human chorionic gonadotrophin induced ovulation followed by a period of luteal activity. The two daily surges of prolactin secretion, typical for a period of luteal activity in the normal female rat, were not observed in TP-treated females. Instead, higher basal levels of prolactin were observed in TP-treated females than in normal female rats. Furthermore, uterine traumatization at 5 days after ovulation did not result in the formation of decidual tissue. In intact TP-treated females luteal activity, induced and temporarily sustained by an ectopic pituitary transplant, persisted after removal of the pituitary graft. In contrast, in TP-treated females which had been ovariectomized on day 25 of age and had received an ovarian transplant before induction of the luteal phase, luteal activity ended within a week after removal of the ectopic pituitary gland. Females treated with TP which had been ovariectomized on day 25 of life had lower plasma levels of prolactin and higher levels of dopamine in hypophysial stalk plasma than intact TP-treated females when measured at 4 months of age. Treatment of ovariectomized rats with oestradiol-17 beta increased levels of prolactin in plasma and lowered levels of dopamine in hypophysial stalk plasma. It is concluded that the control of luteal activity in TP-treated females shows 'male' characteristics. However, the presence of the ovaries in such rats leads to decreased hypothalamic release of dopamine and increased plasma levels of prolactin, probably due to increased oestrogen levels. These increased levels of prolactin are sufficient to maintain luteal activity.

Animals↗
PubMed1992

Induction of proliferative lesions of ventral prostate, seminal vesicle, and other accessory sex glands in rats by N-methyl-N-nitrosourea: effect of castration, pretreatment with cyproterone acetate and testosterone propionate and rat strain.

Wistar (Cpb:WU), F344 or Sprague-Dawley rats were sequentially treated with cyproterone acetate (CA) for 21 days, testosterone propionate (TP) for 3 days, followed by a single i.v. injection of N-methyl-N-nitrosourea (MNU). One group of Wistar rats was castrated 4 weeks after MNU injection, and another group 58 weeks after MNU, when the first prostatic carcinoma was detected. Control groups received only CA + TP, CA, MNU, or they remained untreated. Early or late castration inhibited the development of atypical hyperplasia of the ventral prostate in Wistar rats. This lesion was induced by the CA + TP + MNU treatment in F344 rats, but not Sprague-Dawley rats; in Wistar rats, it was induced by CA + TP treatment, irrespective of whether MNU was given. Hypertrophic-hyperplastic lesions of the seminal vesicle were induced by MNU, irrespective of pretreatment, and their development was prevented by early castration and inhibited by late orchiectomy. Dorsolateral prostate carcinomas and preneoplasia occurred only in low incidence in Wistar and Sprague-Dawley rats. These lesions were absent in F344 rats that had received treatment with CA + TP + MNU. No dorsolateral prostate (pre)neoplasia was found in Wistar rats subjected to early orchiectomy, but rats castrated at 58 weeks had an incidence similar to that for the intact group treated with CA + TP + MNU. This finding supports the contention that androgens are required for the development of MNU-induced prostatic cancer in rats but that advanced carcinomas are androgen insensitive. Differences in incidence and localization of prostatic proliferative lesions between F344 and Wistar rats and between dorsolateral and ventral prostate could not be explained by differences in epithelial cell proliferative responses to CA + TP treatment at the time of MNU injection, since they were similar in ventral and dorsolateral prostate and were more prominent in F344 rats than in Wistar rats. DNA damage as estimated by MNU-induced unscheduled DNA synthesis also did not differ between dorsolateral and ventral prostate.

Androgens↗