Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “THYMUS GLAND”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1991

Ontogeny of the thymus gland of a marsupial (Monodelphis domestica).

The gray short-tailed opossum (Monodelphis domestica) has recently been established as a laboratory animal; consequently, its utility as an animal model is enhanced as more of its basic biologic characteristics become defined. To this end, we studied the ontogeny of the thymus gland in M. domestica ranging in age from the day of birth to over three years. In contrast to most Australian marsupials, M. domestica possesses only a thoracic thymus. The thymus is large in neonates and remains large until young adulthood (six months of age). It has a well-defined cortex, medulla and Hassall's corpuscles. At about six months of age, the thymuses of most animals begin to atrophy, the cortex and medulla being replaced by fat. By 28 months of age, about 50% of animals have thymuses that are completely atrophied. Thus, the ontogeny of the thymus of M. domestica appears to be similar to that of eutherian mammals.

Adipose Tissue↗
PubMed1973

The incidence of germinal centres in thymus glands of patients with congenital heart disease.

The incidence of thymic germinal centres in normal individuals is disputed by various authors. The present study gives the results of a detailed histological assessment of 75 thymic biopsies obtained during operations to correct congenital heart lesions. Serial sectioning showed structures previously of disputed significance to be obliquely sectioned germinal centres. Comparison with the data of Hammar (1926) showed that there was some stress involution of the glands studied. Despite this 40% of the subjects had thymic germinal centres. Germinal centres were not detected in subjects under 4 years of age and there were insufficient subjects over 16 years of age to allow assessment of the frequency in adult thymus glands.

Adolescent↗
PubMed1975

The thymus gland in elderly patients with myasthenia gravis.

This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On microscopic examination, 11 patients had no thymic tissue. The other nine patients, including the one with thymectomy, all showed marked involution of the thymus. No germinal centers were seen. The thymus glands of two additional patients, still alive after thymectomy at ages 62 and 70, showed similar findings. Marked involution of the thymus also was found in each of six elderly controls. Thymectomy is not likely to be effective treatment of the elderly myasthenic patient.

Aged↗
PubMed1983

[Selective phlebography of the thymus gland with pneumomediastinum in patients with myasthenia gravis].

The authors describe the technique of selective phlebography of the thymus under conditions of pneumomediastinum. The investigation of the thymus in 40 patients with myasthenia enabled the authors to conclude that a preliminary administration of gas into the fatty tissue of the anterior mediastinum facilitated catheterization of the thymus veins and favoured a success of selective phlebography, elevated the reliability of differential diagnosis of tumorous and involutional changes of the thymus as well as tumors and portions of a dense fibro-fatty tissue of the anterior mediatinum. The method is characterized by a lower radiation load on the patient and is more economical.

Adolescent↗
PubMed1983

[Hypoplasia of the thymus gland in children].

Morphological changes of the thymus, tonsils, lymph nodes, spleen, and other organs in two observations of severe combined insufficiency (SCIN) in infants of the first year of life are described. In both cases there was hypoplasia of the thymus with the lack or occasional thymic bodies and poor content of thymocytes in the lobules. In one infant, hypoplasia of the thymus was combined with intestinal angiomatosis which suggested the syndrome of ataxia-teleangiectasia. In the other infant, SCIN was associated with severe granulocytopenia of the Kostman type. In this case epithelial cells of the lobules formed adenomatous structures. Both infants died with sepsis developing against the background of SCIN.

Agranulocytosis↗
PubMedDate not supplied

[The development of the thymus gland in rat embryogenesis with progesterone administration].

Thymus structure was studied in 16 and 20-days-old embryos after everyday administration of 0,3 microgram (treatment doze) and 3,0 micrograms/100 g body weight of progesterone. It was established by morphologic methods that on 16th day blast forms amount in experimental animals is significantly lower than that in control animals. Amount of the hormone, 10 times exceeding the previous ones was administered in the same terms and caused reduction of the mitotic activity. The data on the cell by that time were absent. Progesterone administration during placenta forming does not change neither does thymus location nor its structure in 20-days-old foetuses. Treatment doze causes increase of the share of the section area occupied with the cortical matter. 10-times exceeding doze results in more significant decrease of the lymphoid cells number than those caused by treatment doze. Progesterone dissolvent (apricot oil) does not cause significant changes in thymus structure indexes studied. Thus, changes in the thymus structure observed result from progesterone effect on the thymus rudiment during placenta forming.

Animals↗
PubMed1986

Myasthenia gravis: 75seleno-methionine scanning of thymus gland.

The 75Se-seleno-methionine isotope thymus scanning was examined in a series of patients with myasthenia gravis. The method proved useful and informative in the diagnostics of myasthenia. Prior to thymectomy, the thymic tumour or a large gland could be observed and some hints could be gained concerning the biological activity of the gland. After the operation, the success of thymectomy could be checked and later a possible recidive could be shown or excluded. In non-operative cases the change in thymic activity could be followed which is an important sign of a malignant or tumorous growth of the thymus.

Adult↗