Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “THROMBOPHLEBITIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1980

Infusion thrombophlebitis: the histological and clinical features.

Thrombophlebitis was induced in 8 greyhounds by intravenous infusion of naftidrofuryl (Praxilene), dextrose saline being used as a control. The histological features were the same in the treated and the control veins: circulating polymorphonuclear leucocytes became attached to and later infiltrated the vein endothelium. In more severe cases the deeper layers of the vein wall were affected. The clinical features in 97 patients receiving intravenous infusions of physiological saline, dextrose saline, 5% dextrose, or Hartman's solution are reviewed. Twenty-eight cases of thrombophlebitis were seen after an average of 54 h infusion; 22 presented with signs of inflammation and in 6 thrombosis occurred first. Thrombophlebitis occurs as a response to a number of different chemical and physical stimuli. The histological features are the same whatever the insult to the vein. It is an acute sterile inflammation without bacterial infection.

Animals↗
PubMed1979

Baker's cysts and true thrombophlebitis. Report of two cases and review of the literature.

We describe two patients who had knee pain and were found to have the unusual combination of a Baker's cyst and true thrombophlebitis. Since Baker's cysts can dissect along the gastrocnemius, they can cause leg pain and simulate thrombophlebitis, but they do not require anticoagulation therapy. Most of the literature implies that the two syndromes are mutually exclusive; however, our cases lend support to the fact that a dissecting popliteal cyst does not rule out the possibility of thrombophlebitis. Venography should be performed if there is any doubt as to the diagnosis.

Aged↗
PubMed1993

Massive septic pelvic thrombophlebitis.

BACKGROUND: Septic pelvic thrombophlebitis is a major complication of endometritis. The thrombi commonly occur in the uterine and/or ovarian veins and may extend into the inferior vena cava. CASE: Following vaginal delivery, a 19-year-old woman, gravida 2, developed postpartum septic pelvic thrombophlebitis extending from the right ovarian vein up to the diaphragm and down to the femoral vein. The patient was treated successfully with heparin and antibiotics, and eventually was discharged on oral anticoagulants for an extended period. Follow-up revealed complete resolution of the thrombus. CONCLUSION: Septic pelvic thrombophlebitis is not limited to the pelvis and lower abdominal vessels.

Adult↗
PubMed1977

A ten year study of heparin therapy for thrombophlebitis in ambulatory patients.

During the past ten years, we have observed 407 patients with thrombophlebitis using a standardized outpatient regimen including subcutaneously self-administered heparin therapy. A definite protocol for tapering and discontinuing anticoagulants was applied which allows a correlation between duration of heparin administration, decreasing heparin resistance and symptomatic improvement. In acute and subacute thrombophlebitis, this method induced symptomatic resolution within less than two months in half of the patients and within less than six months in 78%. The number of recurrences during the follow-up period was acceptable and the frequency of complications minimal. We conclude that, except in the most severe, toxic instances of thrombophlebitis or in suspected pulmonary embolism, hospitalization--complete bedrest and intravenously administered anticoagulants--is unnecessary and wasteful.

Acute Disease↗
PubMed1977

Differential diagnosis of the thrombophlebitis.

Thrombophlebitis is a disease which is increasing in incidence because of increased longevity and because the effect on the clotting factor by modern drugs is difficult to diagnose, and the rate of accuracy in clinical diagnosis seldom exceeds 50%. In this paper, the authors present a clinical review of thrombophlebitis and discuss clinical findings of other diseases which may mimic thrombophlebitis. It is their hope that their findings may help practitioners to diagnose the disease with a greater degree of accuracy.

Arthritis, Rheumatoid↗
PubMed1997

Ultrasonographic investigation of the pathogenesis of infusion thrombophlebitis.

BACKGROUND: Thrombophlebitis frequently complicates intravenous infusion, but its precise pathogenesis remains unclear. METHODS: Serial B mode ultrasonographic imaging was used to detect intraluminal thrombosis when intravenous nutrition was delivered via fine-bore catheters inserted into peripheral veins. RESULTS: Thrombus was detected in 14 of 22 catheterized veins. There were nine episodes of clinical phlebitis; each was associated with intravenous thrombosis. Venospasm was not observed. The time at which thrombus was first detected varied from within 24 h to more than 15 days after catheterization. Detection of intravenous thrombosis within 24 h of catheter insertion was associated with early catheter complications. Early thrombus tended to be found close to the site of venepuncture, whereas late thrombus was found at the catheter tip, where the hypertonic feed was delivered. DISCUSSION: Ultrasonographic imaging was a useful technique for investigation of infusion thrombophlebitis. Two patterns of thrombosis were observed: distal early thrombosis and proximal late thrombosis. Information acquired may help in the design of novel catheters and strategies to reduce the incidence of thrombophlebitis.

Aged↗
PubMed1998

[Postpartum cerebral thrombophlebitis. A case secondary to acquired antithrombin III deficiency].

The cerebral thrombophlebitis is a rare complication of the pregnancy and the postpartum. We report a case of a 21 year-woman presenting a post-partum cerebral thrombophlebitis, secondary to an acquired deficiency of antithrombin III. The clinical symptoms of cerebral thrombophlebitis can be misleading. The angiography and the magnetic resonance imaging permit the diagnosis. The treatment is relied on anticoagulating heparin therapy. This treatment will be adapted in case of coagulation's factors deficiency that must be searched in any thromboembolic accident having an unusual localization.

Adult↗
PubMed1998

[The treatment of acute thrombophlebitis in the varicose saphenous veins of the lower extremities].

682 patients underwent treatment for varicose veins of lower extremities (VVLE). 641 patients with thrombophlebitis of VVLE were operated: in 62.9% of patients urgent operation and in 37.1% delayed operation after conservative treatment were made. Operation procedure comprised removal of all thrombotic varicose veins and ligation of communicant veins. The treatment of acute thrombophlebitis affecting anatomically intact veins in 41 patients was conservative. Comparative evaluation of the results of treatment evidences, that active surgical policy is justified as it leads to a decrease of complication rate, shortening of hospital stay duration 2 times and reduction of disability period. Conservative treatment of acute thrombophlebitis in intact veins is advisable.

Acute Disease↗
PubMed1998

[Morphologic changes in the thrombus and venous wall in experimental phleobothrombosis and thrombophlebitis].

Phlebothrombosis and thrombophlebitis were induced in dogs by percutaneous intraoperative introduction of thrombotic mass, obtained in vivo (20-40 animal blood per 3-4 ml thrombin solution) into jugular vein and studied in postoperative days 1, 3, 5, 7, 10 and 14 through light microscope. The preparations were stained with hematoxylin and eosin and after Hart, Van-Gieson and MSB. Venous intima was established to alter already on the next day following thrombophlebitis modeling. On d 3 and 5 epithelium desquamation and moderate leukocytic infiltration of media between smooth myocytes were found. On d 7 signs of thrombus organization, i.e. invasion of fibroblastic series cells and small capillaries inside it, were demonstrated. Muscular layer and adventitia display leukocytic infiltration. Venous wall thickens due to disorders of blood passage in vasa vasorum. On d 10 the portion of the thrombus attached to the wall was essentially organized. Fibroblasts and capillaries invade inside the thrombus, connective tissue fibres are formed. Sclerotic changes were noted in adventitia. By the end of the 2nd week venous wall showed muscular layer atrophia and sclerosis. Middle portions of the thrombus were involved in organization, canals lined with endothelium are formed in it. In case of thrombophlebitis changes in thrombus and venous wall develop earlier and are more pronounced.

Acute Disease↗
PubMed1978

Renal allograft rupture with iliofemoral thrombophlebitis.

Spontaneous rupture of a renal allograft in the early posttransplant period is associated with tachycardia, hypotension, oliguria, swelling, pain, a falling hematocrit level, and tenderness at the transplant site. Occasionally, the ruptured allograft can be saved by control of the hemorrhage. Deep vein thrombophlebitis, a common occurrence after prolonged surgery and cortocosteroid therapy, is less common in renal allograft transplantation, but may be associated with renal vein thrombosis. The simultaneous occurrence of deep vein thrombophlebitis, renal vein thrombosis, and allograft rupture contraindicates anticoagulent therapy. We present a patient in whom ipsilateral deep vein thrombophlebitis developed eight days after a cadaveric renal allograft, followed in two days by hypotension, a falling hematocrit level, oliguria, and a painfall mass at the allograft site. Surgical exploration revealed a ruptured allograft with iliofemoral and renal vein thrombosis and profuse hemorrhage. A transplant nephrectomy was performed.

Female↗
PubMed1990

Septic cortical thrombophlebitis.

Thrombosis of cortical veins has been postulated as an important cause of seizures and focal neurologic deficits in patients with bacterial meningitis. Diagnoses from autopsies, angiograms, and medical records at Massachusetts General Hospital, 1960-1984, were reviewed to identify patients with septic cortical thrombophlebitis. Only 10 confirmed cases of septic cortical vein thrombosis without sagittal sinus thrombosis were found. Meningitis was present in nine patients; Streptococcus pneumoniae was isolated from the blood or cerebrospinal fluid of five patients. Common clinical manifestations included fever, seizures, and focal neurologic signs. Half the patients survived, but three had persistent disabilities. Cortical vein thrombosis could be documented in only approximately 1% of 790 cases of bacterial meningitis. In 97 patients with meningitis who died and had autopsies, cortical thrombophlebitis was identified in 5%. In autopsied patients, other pathologic processes including arteritis, ventriculitis, cavernous sinus thrombosis, and cerebral infarctions were usually more prominent than venous thrombosis. Cortical thrombophlebitis does not appear to be the major cause of seizures or focal neurologic signs during bacterial meningitis.

Adolescent↗
PubMed1988

Iliofemoral thrombophlebitis presenting as an acute abdomen: report and literature review.

Iliofemoral thrombophlebitis characteristically presents as acute inflammation and swelling of the affected extremity. We report a patient in whom the presenting complaints of high fever, nausea and left lower quadrant pain mimicked an acute abdomen. The diagnosis was confirmed by venogram after gallium scan and computer tomographic scan revealed abnormalities consistent with iliofemoral thrombophlebitis. This is the first report of abnormal gallium uptake in iliofemoral thrombophlebitis. Current methods of diagnosing this disorder are discussed and the literature reviewed.

Abdomen, Acute↗
PubMed1990

Jugular thrombophlebitis resulting from an anaesthetic induction technique in the horse.

Forty-eight hours after general anaesthesia was induced by glycerol guaiacolate and thiopentone sodium in 10 horses, the jugular veins were dissected out at post-mortem and examined visually and histologically. All veins showed a marked thrombophlebitis involving the media and intima at the site of injection. The influence of catheter composition, catheter placement and chemical composition on the occurrence of the thrombophlebitis is discussed. It is concluded that the thrombophlebitis was chemically induced.

Anesthesia, Intravenous↗
PubMed1993

The anti-inflammatory and analgesic action of transdermal glyceryltrinitrate in the treatment of infusion-related thrombophlebitis.

We have carried out a prospective double-blind randomized study in 40 patients with infusion-related thrombophlebitis. Twenty-two patients were included in the glyceryltrinitrate (GTN) ointment group and 18 patients in the control heparinoid group. Pain was assessed by an analogue scale. At 48 hours the analgesic index was 84.6 +/- 18 units with GTN and 49 +/- 45 units with heparinoid ointment (P < 0.01). Faster relief of oedema was also observed in the GTN-treated group. All signs of thrombophlebitis were relieved in less than 4 days in the GTN group compared with 9 days in the controls (P < 0.005). We conclude that transdermal GTN is useful therapy for infusion-related thrombophlebitis showing evidence of anti-inflammatory and analgesic effect.

Administration, Cutaneous↗
PubMed2002

[Conservative management of thrombophlebitis. Cooling, wrapping and mobilizing the patient].

As the name implies, thrombophlebitis superficialis affects superficial extrafascial veins, and is thus to be differentiated from phlebothrombosis (thrombosis in the deep venous system). Special manifestations are varicophlebitis arising out of a varicosis, thrombophlebitis migrans or saltans as recidivating inflammation of non-varicose veins, and the rare Mondor's disease. On the basis of the typical clinical presentation with tenderness, reddening and warming of the skin over the hardened (palpation) vein, thrombophlebitis is relatively easy to diagnose. In uncertain cases, duplex ultrasonography serves to exclude involvement of the deep venous system. The leading therapeutic measure is compression. Whenever possible, the patient should be mobilized. Cold dressings, anti-inflammatory medication and, if indicated, a stab incision, help ameliorate pain.

Bandages↗
PubMed1992

Postpartum ovarian vein thrombophlebitis: etiology, diagnosis, treatment, and nursing implications.

This article presents a review of the literature on postpartum ovarian vein thrombophlebitis with special emphasis of nursing implications. The technology of real time ultrasound, duplex Doppler ultrasound, computerized axial tomography, and magnetic resonance imaging now offer reliable methods for confirming a suspected diagnosis of postpartum ovarian vein thrombophlebitis. However, it may well be nurses in clinical settings who assess the often vague signs and be the first to alert the physician. Nurses have an important role in the prevention of postpartum ovarian vein thrombophlebitis. Prevention may be successful by teaching women holistic prenatal care including how to avoid infections during pregnancy and postpartum, and by practicing meticulous technique during pregnancy, labor and delivery, and postpartum.

Female↗
PubMed1963

Fibrinolysin therapy of thrombophlebitis and pulmonary embolism--a double-blind study.

Thrombophlebitis and pulmonary embolism are major causes of disability and death in both medical and surgical patients. Etiological factors are still poorly understood. Preventive measures as currently practised are non-specific and based on questionable premises. Diagnostic measures to predict the silent fatal embolus are inadequate. Currently accepted treatment measures are designed to prevent extension of the thrombus but have no effect on the existing clot. Theoretically, thrombolytic preparations now being marketed offer some hope for dissolution of preformed thrombi. An experimental study was carried out on artificially induced thrombi in jugular and femoral veins of mongrel dogs. Human fibrinolysin (Actase, Ortho) was infused locally and systemically in varying doses. No thrombi were successfully lyzed by either method. Thirty-six cases of acute deep thrombophlebitis in the leg, one of axillary thrombosis, three of chronic postphlebitis of a lower limb with massive edema and eight of pulmonary emboli were observed and carefully documented clinically. All these patients received anticoagulants unless there was a contraindication. Fibrinolysin infusions in varying dosages were administered to 27 patients; 10 served as controls. The observers were unaware of the identity of those receiving the actual drug or of those given the placebo until completion of the study. Progress of the disease was judged by the rate of dis-appearance of symptoms and signs. No significant benefit could be noted in the treated as compared to the control group, in terms of rate of recovery or incidence of embolus.

Acute Disease↗
PubMed2007

Acellular dermal matrix grafts for prevention of microarterial thrombophlebitis.

OBJECTIVE: To examine the role of acellular dermal matrix grafts for prevention of microarterial anastomotic thrombophlebitis. DESIGN: Bilateral femoral artery microvascular anastomoses were created in the field of established wounds infected with Staphylococcus aureus in 12 rats. In each animal, 1 femoral microarterial anastomosis was wrapped with an acellular dermal matrix graft, and the contralateral femoral anastomosis was left unprotected. The incidence of femoral artery thrombosis was determined after 4 days by wound reexploration. SETTING: David Geffen School of Medicine, University of California, Los Angeles. MAIN OUTCOME MEASURE: The patency of femoral artery anastomoses was determined after 4 days by wound reexploration. RESULTS: The incidence of femoral artery thrombosis in vessels wrapped with acellular dermal matrix grafts was 17%. The incidence of femoral artery thrombosis in unprotected vessels was 100%. This difference was statistically significant (P<.05). CONCLUSION: Acellular dermal matrix grafts seem to have a protective effect in the prevention of acute thrombophlebitis when arterial microvascular anastomoses are performed in infected surgical fields.

Anastomosis, Surgical↗