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Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats.

In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, alpha-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.

Animals↗

Spatial memory and stereotypic behaviour of animals in radial arm mazes.

The symmetric radial arm maze, described by Olton in 1976, has developed into an important tool for the study of spatial memory. In a typical test an animal is placed in the centre of the maze, which contains some small piece of food at the end of each arm. The sampling behaviour of the animal is then recorded. In such studies the score (number of choices of arms which still contain food) of the animal is normally compared with the score of an imaginary animal which changes arms entirely at random. In a new method of analysis the non-random score of the animal is split into two parts, one depending on memory and one on stereotypic choice behaviour. Even mild departures from randomness are shown to alter considerably the expected 'random' score in an eight-armed maze. The part of the score claimed to depend on memory was shown to increase when the animals learn to search the maze, the stereotypic part did not. The general effect from stereotypic choice behaviour is shown to result, in most animals, in an increase in the total score. In an eight-armed maze this increase may amount to more than 20% of the total non-random score, even in a well-trained animal. The effect is less pronounced in mazes with 16 arms. It has been proposed that hippocampal lesions produce a stereotypic behaviour. We propose, based on our analysis, that the stereotypic behaviour is not produced but revealed by hippocampal lesions which destroy almost completely the memory-guided behaviour masking the stereotypic behaviour in the intact animal.

Animals↗

Interpretation of changes in apomorphine-induced stereotyped behaviour in rats receiving continuous administration of trifluorperazine for 15 months.

Rats treated continuously with trifluoperazine dihydrochloride (4.4-4.9 mg/kg per day) for 15 months showed an exaggerated stereotyped response to large doses of apomorphine (1.0 mg/kg, s.c.), but inhibition of stereotyped behaviour by a small dose of apomorphine (0.125 mg/kg, s.c.) as compared to responses obtained in age-matched control animals. Apomorphine (0.03-1.0 mg/kg, s.c.) produced more hyperactivity in trifluoperazine-treated rats than in control animals. After withdrawal of the drug for a period of 2 weeks or more, the stereotyped responses to all doses of apomorphine (0.0625-0.5 mg/kg, s.c.) were exaggerated in animals treated with trifluoperazine compared with age-matched control rats. Acute administration of trifluoperazine (4.5 mg/kg, p.o., 3 hr previously) to animals withdrawn from trifluoperazine abolished the stereotyped behaviour induced by a small dose of apomorphine (0.125 mg/kg) but a maximal response still was obtained with large doses (1.0 mg/kg). In contrast, acute challenge with trifluoperazine (4.5 mg/kg, p.o.) in control animals inhibited the stereotyped behaviour at virtually all doses of apomorphine, as compared with the responses to apomorphine in both animals withdrawn from trifluoperazine, given the same treatment, and naive control rats. Administration of trifluoperazine (0.28 and 0.56 mg/kg, p.o.) inhibited stereotypy induced by small doses of apomorphine (0.125 mg/kg, s.c.) in control animals but the response in animals withdrawn from trifluoperazine was exaggerated. Larger doses of trifluoperazine (1.125-4.5 mg/kg) totally inhibited apomorphine-induced (0.125 mg/kg, s.c.) stereotypy in both groups. These findings do not support the concept of separate mechanisms controlling low grade and high grade stereotyped behaviour during chronic treatment with neuroleptics.

Animals↗

Patient characteristics negatively stereotyped by doctors.

A variety of studies demonstrate the existence of prejudice in the manner and content of health care delivery. Alcoholics, attempted suicides, drug addicts, prostitutes, the mentally retarded or mentally ill, the aged and women have been found to receive less adequate health care. Previous studies have identified manifestations of prejudice in health care delivery but have generally failed to determine the prevalence of negative stereotypes in a sample comprising a cross section of medical practitioners. This study reviews the negative patient stereotypes reported by 2421 Victorian (Australia) and Michigan (U.S.A.) doctors. The characteristics of patients so stereotyped are found to be remarkably consistent. The most commonly held negative stereotypes (patients who abuse alcohol, unhygienic patients, abusive patients, substance abusers and those with minor mental disorders) appear to be determined by the social values which prevail in our society. Many negative stereotypes appear to reflect a response to patients who deviate from the sick role. Other stereotypes may involve reactions to patients or to the types of problems which raise important therapeutic dilemmas.

Adult↗

Stereotyping: the link between theory and practice.

Patient educators have long acknowledged the importance of individualizing educational interventions to the specific needs of individual patients. In this paper, we discuss ways in which stereotyping can interfere with this process. First, we examine stereotyping from the more general perspective of information processing. Biases introduced by stereotyping that affect the way individuals process information are discussed and the concepts of cognitive schemas and behavioral confirmation are described. We then briefly review selected studies that demonstrate stereotyping of patients by health care providers. The paper concludes with a discussion of the implications of stereotyping for patient education and the presentation of four strategies patient educators might employ either to decrease the occurrence of stereotyping or to avoid some of its detrimental effects.

Attitude of Health Personnel↗

Angel, handmaiden, battleaxe or whore? A study which examines changes in newly recruited student nurses' attitudes to gender and nursing stereotypes.

This article presents the findings of a comparative study, which investigated the attitudes of two groups of newly recruited student nurses to gender and nursing stereotypes. The 1992 sample (n=100) was a group of student nurses who were in their second day of studies of a Project 2000 type curriculum. The 2002 sample (n=96) were in their second month of studies of a "Fitness for Practice" curriculum [Fitness for Practice (the 'Peach Report'), UKCC, London, 1999]. Data were collected using a questionnaire, which utilised a Likert scale for measurement of attitudes to statements pertaining to gender and nursing stereotypes. The findings reveal significant differences between the characteristics of the two groups of students. For example, the 2002 group were generally older and had more healthcare experience. However, male representation in the sample groups was similar. The overall high scores and implied propensity towards beliefs in gender and nursing stereotypes in the 1992 study was found not to be the case for the 2002 sample. This is particularly true of most statements related to gender stereotypes, nursing as 'feminine', male nurse stereotyping and issues related to nurses' uniform. However, there is less evidence of changes in attitudes towards female nursing stereotypes with indecision being a general feature of both the 1992 and 2002 responses.

Female↗

Possible noradrenergic involvement in naloxone potentiation of apomorphine-induced stereotypic climbing in mice.

Apomorphine-induced stereotypic climbing behavior in mice was significantly potentiated by pretreatment with the opiate receptor blocker naloxone. In animals additionally pretreated with alpha-methyl-p-tyrosine, brain levels of norepinephrine (NE) and dopamine (DA) were markedly reduced and naloxone potentiation of apomorphine-induced stereotypic climbing was blocked. In mice pretreated with diethyldithiocarbamic acid, brain NE was slightly reduced, brain DA was slightly elevated but naloxone potentiation of apomorphine-induced stereotypic climbing was unaltered. In animals pretreated with reserpine, both brain NE and DA were significantly reduced by naloxone potentiation of apomorphine-induced stereotypic climbing was not affected. In other experiments, pretreatment with low doses of the alpha-adrenergic receptor blocker BE-2254 failed to suppress climbing activity induced by apomorphine alone but did successfully prevent naloxone potentiation of apomorphine-induced stereotypic climbing. These findings suggest the possibility that NE and alpha-adrenergic receptors might play a role in the potentiating influence of naloxone upon apomorphine-induced stereotypic climbing activity in mice.

Animals↗

Sensitization of stereotyped behavior to amphetamine is context and response dependent.

The present study was designed to determine whether the environmental context in which amphetamine is administered plays a role in the development of sensitization to the stereotyped behavioral effects of amphetamine in mice. In male CF-1 mice, the dose-response curve for stereotyped behavior elicited by amphetamine was shifted 1.9-fold to the left 48 h after pretreatment with 14 mg/kg amphetamine. Behavioral sensitization only developed in mice that were pretreated in the same or a similar environment as that of the test environment. In addition, when mice were placed in an environment that attenuated the acute expression of stereotyped behavior elicited by the pretreatment dose of amphetamine, sensitization never developed. A further experiment showed that 96% of the mice that expressed stereotypy after the ED50 pretreatment dose of 10 mg/kg amphetamine showed a stereotyped behavioral response to the lesser dose of 7 mg/kg 48 h later, indicating sensitization. In contrast, mice that did not express stereotypy after the ED50 dose of amphetamine failed to show a significant stereotyped behavioral response to amphetamine challenge compared to vehicle-pretreated controls. Therefore, the results indicate that preexposure to a single high dose of amphetamine produces context- and response-dependent sensitization to amphetamine-induced stereotyped behavior.

Animals↗

Association of stereotypes about physicians to health care satisfaction, help-seeking behavior, and adherence to treatment.

The present research consists of three studies examining the role of patients' stereotypes about health care providers in the health care decision process. Study 1 examined the association of stereotypes to health care satisfaction and help-seeking behavior among a low-income clinic sample; Study 2 examined the relationship of stereotypes to satisfaction and adherence to treatment among low-income individuals living with HIV; and Study 3 examined the association of stereotypes to satisfaction and help-seeking among a sample of homeless individuals. Overall findings indicate that individuals who held more negative stereotypes about physicians sought care less often when sick, were less satisfied with the care that they did obtain, and were less likely to adhere to physician recommendations for treatment. Moreover, African Americans, but not Whites, with more positive stereotypes reported better adherence in Study 2 and were more satisfied with their health care in Study 3. Our findings point to the need to better understand the role of patients' beliefs about health care in predicting health care satisfaction and health behaviors.

Adult↗

Selective self-stereotyping.

In an examination of group members' responses to the threat of negative in-group characterizations, sorority/fraternity members were asked to rate themselves, their own sorority/fraternity, sororities/ fraternities in general, and students in general on attributes that were stereotypic of sororities/ fraternities. Results showed that individuals selectively self-stereotyped-they embraced positive stereotypes as highly descriptive of themselves and their closest in-groups but rejected negative stereotypes. They did not, however, deny that negative stereotypes were accurate or valid-they continued to accept them as typical of sororities/fraternities in general. This represents a protective, creative response to the threat posed by exposure to negative group attributes, in which self-stereotyping as a result of self-categorization is selective rather than complete.

Analysis of Variance↗

Stigma consciousness: the psychological legacy of social stereotypes.

Whereas past researchers have treated targets of stereotypes as though they have uniform reactions to their stereotyped status (e.g., J. Crocker & B. Major, 1989; C. M. Steele & J. Aronson, 1995), it is proposed here that targets differ in the extent to which they expect to be stereotyped by others (i.e., stigma consciousness). Six studies, 5 of which validate the stigma-consciousness questionnaire (SCQ), are presented. The results suggest that the SCQ is a reliable and valid instrument for detecting differences in stigma consciousness. In addition, scores on the SCQ predict perceptions of discrimination and the ability to generate convincing examples of such discrimination. The final study highlights a behavioral consequence of stigma consciousness: the tendency for people high in stigma consciousness to forgo opportunities to invalidate stereotypes about their group. The relation of stigma consciousness to past research on targets of stereotypes is considered as is the issue of how stigma consciousness may encourage continued stereotyping.

Adolescent↗

Strategies for social inference: a similarity contingency model of projection and stereotyping in attribute prevalence estimates.

Most models of how perceivers infer the widespread attitudes and qualities of social groups revolve around either the self (social projection, false consensus) or stereotypes (stereotyping). The author suggests people rely on both of these inferential strategies, with perceived general similarity moderating their use, leading to increased levels of projection and decreased levels of stereotyping. Three studies featuring existing individual differences in perceived similarity as well as manipulated perceptions supported the predictions, with similarity yielding increased projection to, and decreased stereotyping of, various in-groups and out-groups. Evidence that projection and stereotyping may serve as inferential alternatives also emerged. The model and accompanying results have implications for research on social comparison and projection, stereotyping and prejudice, and social inference.

Adult↗

Distinguishing stereotype threat from priming effects: on the role of the social self and threat-based concerns.

It has been argued that priming negative stereotypic traits is sufficient to cause stereotype threat. The present research challenges this assumption by highlighting the role of the social self and targets' concerns about confirming a negative group-based stereotype. Specifically, in 3 experiments the authors demonstrate that stereotype threat adversely affects the test performance and threat-based concerns of targets (but not nontargets) because only targets' social self is linked to the negative group stereotype. Trait priming, however, harms the test performance of both targets and nontargets but has no effect on their threat-based concerns because trait priming does not require such a link between the social self and the group stereotype. Moreover, the authors show that merely increasing the accessibility of the social self in nonthreatening situations leads to the underperformance of targets but has no meaningful effect on nontargets' test performance.

Adult↗

Definition and assessment of accuracy in social stereotypes.

A perennial issue in the study of social stereotypes concerns their accuracy. Yet, there is no clear concept of the various ways in which stereotypes may be accurate or inaccurate and how one would assess their accuracy. This article is designed to rectify this situation. Three forms of stereotype inaccuracy are identified: stereotypic inaccuracy, valence inaccuracy, and dispersion inaccuracy. The implications of each form are discussed, along with how each can be assessed using a full-accuracy design. Past research that has attempted to examine stereotype accuracy is reviewed, and new data on the issue are presented. Although of perennial interest, the theoretical and methodological difficulties of assessing stereotype accuracy are substantial. The goal in this article is to alert the researcher to these difficulties and point toward their solution.

Humans↗

Basic rest activity cycle and stereotyped behavior of a mentally defective child.

Stereotyped acts of a mentally defective girl, 6 1/2 years old, were observed from 6 a.m. til 8 p.m. during 16 days. Alternating phases of more or less frequent hand waving showed intervals of about 1 1/2 hours. Sleep stages were also determined by polygraphic recordings during 10 nights. As statistically proved the mean peak-to-peak interval of stereotyped activity at days corresponded with the mean REM-to-REM period of consecutive nights. This suggests, that the stereotyped hand waving of this child was driven by the BASIC REST ACTIVITY CYCLE (BRAC) already described by Kleitman. The mean periodicity of sleep cycles was represented by model rhythms adapted to the scored sleep stages. If the model rhythms of all 10 nights were extended backward to the preceding days, they paralleled the stereotyped activity. Thereby half periods found in phase with REM-stages approximatly corresponded to maxima of stereotyped activity. It will be discussed that the BRAC triggers motor and sensory mechanisms characterizing both the phases of enhanced stereotyped activity at day and REM stages at night.

Activity Cycles↗

Will opposites attract? Similarities and differences in students' perceptions of the stereotype profiles of other health and social care professional groups.

The extent to which health and social care (HSC) students hold stereotypical views of other HSC professional groups is of great potential importance to team working in health care. This paper explores students' perceptions of different HSC professional groups at the beginning of their university programmes. Findings are presented from an analysis of baseline data collected as part of the New Generation Project longitudinal cohort study which is assessing the impact of interprofessional education over time on a range of variables including stereotyping. Questionnaires were administered to a cohort of over 1200 students from 10 different HSC professional groups entering their first year of university. Stereotypes were measured using a tool adapted from Barnes et al. (2000) designed to elicit stereotype ratings on a range of nine characteristics. The findings confirm that students arrive at university with an established and consistent set of stereotypes about other health and social care professional groups. Stereotypical profiles were compiled for each professional group indicating the distinctive characteristics of the groups as well as the similarities and differences between groups.Midwives, social workers and nurses were rated most highly on interpersonal skills and on being a team player whilst doctors were rated most highly on academic ability. Doctors, midwives and social workers were perceived as having the strongest leadership role, whilst doctors were also rated most highly on decision making. All professions were rated highly on confidence and professional competence and, with the exception of social workers, on practical skills. A comparison of profiles for each professional group reveals that, for example, pharmacists and doctors were perceived as having very similar characteristics as were social workers, midwives and nurses. However, the profiles of nurses and doctors were perceived to be very different. The implications of these similarities and differences are discussed in terms of their potential impact on interprofessional interactions, role boundaries and team working.

Health Personnel↗

The activation of aging stereotypes in younger and older adults.

The activation of ageism and aging stereotypes in younger and older adults was investigated by manipulating both the valence and the stereotypicality of trait stimuli. Participants completed a lexical decision task in which the stimulus onset asynchronies (SOAs) between the prime and target stimuli were varied to examine the effects of automatic and controlled processing (300 and 2,000 ms, respectively). Both younger and older adults demonstrated strong stereotype activation for elderly stereotypes but relatively weak activation for young stereotypes. Both younger and older adults also demonstrated a positive bias toward older people, which was not moderated by SOA. These findings suggest that younger and older adults do not differ in their accessibility to aging stereotypes or to their age-based biases, which appear to be positive toward elderly people.

Adolescent↗

Knowing is half the battle: teaching stereotype threat as a means of improving women's math performance.

We tested whether informing women about stereotype threat is a useful intervention to improve their performance in a threatening testing situation. Men and women completed difficult math problems described either as a problem-solving task or as a math test. In a third (teaching-intervention) condition, the test was also described as a math test, but participants were additionally informed that stereotype threat could interfere with women's math performance. Results showed that women performed worse than men when the problems were described as a math test (and stereotype threat was not discussed), but did not differ from men in the problem-solving condition or in the condition in which they learned about stereotype threat. For women, attributing anxiety to gender stereotypes was associated with lower performance in the math-test condition but improved performance in the teaching-intervention condition. The results suggest that teaching about stereotype threat might offer a practical means of reducing its detrimental effects.

Adolescent↗