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Design and control optimization of microclimate liquid cooling systems underneath protective clothing.

The use of protective clothing, whether in space suits, hazardous waste disposal, or sporting equipment, generally increases the risk of heat stress and hyperthermia by impairing the capacity for evaporative heat exchange from the body to the environment. To date the most efficient method of microclimate cooling underneath protective clothing has been via conductive heat exchange from circulating cooling fluid next to the skin. In order to make the use of liquid microclimate cooling systems ((LQ)MCSs) as portable and practical as possible, the physiological and biomedical engineering design goals should be towards maximizing the efficiency of cooling to maintain thermal comfort/neutrality with the least cooling possible to minimize coolant and power requirements. Meeting these conditions is an extremely complex task that requires designing for a plethora of different factors. The optimal fitting of the (LQ)MCSs, along with placement and design of tubing and control of cooling, appear to be key avenues towards maximizing efficiency of heat exchange. We review the history and major design constraints of (LQ)MCSs, the basic principles of human thermoregulation underneath protective clothing, and explore potential areas of research into tubing/fabric technology, coolant distribution, and control optimization that may enhance the efficiency of (LQ)MCSs.

Cold Temperature↗

Dielectric measurements on electro-manipulation media.

The permittivity and conductivity of solutions of sugars and sugar alcohols, such as are suitable for electric-field work on cells, were measured. The range of concentrations was 0-3 M (subject to solubility), and the frequency range was that commonly used in dielectrophoresis prior to electrofusion (200 kHz-2 MHz). This was widened to 30 kHz-12 MHz, when dispersive behaviour was found. A parallel-plate impedance chamber with variable electrode-spacing, suited to stable measurements in these low-conductivity aqueous media, was used. Errors due to electrode polarisation were effectively removed by linear regression of the series parameters against electrode distance, as well as by subtraction of data obtained on KCl solutions of comparable conductivity. The permittivity of the sugar solutions decreased as only approximately linear functions of concentration, so that a description in terms of both first- and second-order molar dielectric increments (delta 1 and delta 2) provided a better description of the behaviour than a single linear increment (delta). Sugar solutions of concentration of 1.2 M or less showed no change in permittivity or conductivity over the measured frequency range (i.e., were dispersion-free). On the other hand, various high-density media showed dispersion. The stabilised silica sol 'Percoll' showed dispersion over the whole frequency range; solutions of sucrose (at above 1.2 M concentration), as well as of proprietary high-density solutes ('Metrizamide' at above 0.5 M and 'Nycodenz' at above 0.75 M) showed dispersion above 0.6 MHz. Although these media are of interest for electro-manipulation (they can be used to prevent sedimentation), their dispersive properties may make them unsuitable for use with radio-frequency fields.

Carbohydrates↗

Efficacy of the Steri-Shield filtered exhaust helmet in limiting bacterial counts in the operating room during total joint arthroplasty.

Filtered exhaust helmets (space suits) have been reported as efficacious in decreasing wound infections following joint arthroplasty procedures; however, strict experimental control of the many variables related to the incidence of clinical infection has been lacking in these studies, making support of such conclusions difficult. Any potential benefit of filtered exhaust helmets in the control of infection rates can be logically assigned to the reduction of airborne bacterial counts within the operating room. A study was done using the Steri-Shield helmet (Bio-Medical Devices, Irvine, CA) to define its efficacy in limiting airborne bacterial contaminates during total joint arthroplasty. Forty-eight paired prosthetic hip and knee cases were evaluated using a block experimentation design. One case of each pair was done with all surgical and scrub personnel cloaked in Steri-Shield filtered exhaust helmets and the other with the same personnel in conventional paper hoods and masks. Air samples were obtained with an Anderson two-stage viable particle sampler (Anderson Samplers, Atlanta, GA) placed immediately adjacent to the wound. Quantitative microbial cultures were obtained. The filtered exhaust helmet evaluated in this study provided no increased protection against bacterial contamination in the area of the surgical field than conventional paper hoods and masks.

Air Microbiology↗

The effect of simulated weightlessness on hypobaric decompression sickness.

BACKGROUND: A discrepancy exists between the incidence of ground-based decompression sickness (DCS) during simulated extravehicular activity (EVA) at hypobaric space suit pressure (20-40%) and crewmember reports during actual EVA (zero reports). This could be due to the effect of gravity during ground-based DCS studies. HYPOTHESIS: At EVA suit pressures of 29.6 kPa (4.3 psia), there is no difference in the incidence of hypobaric DCS between a control group and group exposed to simulated weightlessness (supine body position). METHODS: Male subjects were exposed to a hypobaric pressure of 29.6 kPa (4.3 psi) for up to 4 h. The control group (n = 26) pre-oxygenated for 60 min (first 10 min exercising) before hypobaric exposure and walking around in the altitude chamber. The test group (n = 39) remained supine for a 3 h prior to and during the 60-min pre-oxygenation (also including exercise) and at hypobaric pressure. DCS symptoms and venous gas emboli (VGE) at hypobaric pressure were registered. RESULTS: DCS occurred in 42% in the control and in 44% in simulated weightlessness group (n.s.). The mean time for DCS to develop was 112 min (SD +/- 61) and 123 min (+/- 67), respectively. VGE occurred in 81% of the control group subjects and in 51% of the simulated weightlessness subjects (p = 0.02), while severe VGE occurred in 58% and 33%, respectively (p = 0.08). VGE started after 113 min (+/- 43) in the control and after 76 min (+/- 64) in the simulated weightlessness group. CONCLUSIONS: No difference in incidence of DCS was shown between control and simulated weightlessness conditions. VGE occurred more frequently during the control condition with bubble-releasing arm and leg movements.

Adolescent↗

Staged decompression to 3.5 psi using argon-oxygen and 100% oxygen breathing mixtures.

INTRODUCTION: The current extravehicular activity (EVA) space suit at 4.3 psia causes hand and arm fatigue and is too heavy for Martian EVA. A 3.5 psia EVA pressure suit requires increased preoxygenation time but would reduce structural complexity, leak rate, and weight while increasing mobility, comfort, and maintainability. On Mars, nitrogen and argon are available to provide the inert gas necessary for a fire-resistant habitat atmosphere, eliminating need for transport. This study investigated breathing argon/oxygen and 100% oxygen gas mixtures during staged decompression prior to exposure to 3.5 psia. METHOD: During this study, 40 subjects each completed 3 hypobaric exposures to 3.5 psia for 3 h in a reclined position: (A) a 4-h 25-min 14.7-psia (ground level) denitrogenation (100% oxygen breathing) prior to exposure to 3.5 psia; (B) the same as A, utilizing a 7.3-psia stage denitrogenation; and (C) the same as B, with 62% argon-38% oxygen (ARGOX) during the stage. Venous gas emboli (VGE) were monitored with echocardiography. RESULTS: Decompression sickness (DCS) incidence at 3.5 psia with ARGOX at 7.3 psia (C) was significantly higher than with oxygen breathing with or without staged decompression: there was 78% DCS for C compared with 33% and 55% DCS, respectively, for A and B. The corresponding VGE incidences were 73% (C) compared with 33% (A) and 45% (B). CONCLUSION: Preoxygenation at a 7.3-psia stage resulted in a higher DCS risk at 3.5 psia than ground level preoxygenation. It is suggested that an 8.0-psia stage pressure could eliminate this difference. Unfavorable results after preoxygenation with ARGOX indicate argon on-gassing was significant.

Adolescent↗

[Changes in the maximum permissible supersaturation coefficient in altitude decompression].

This paper presents experimental data obtained during 383 altitude chambers tests in which 70 subjects participated. The purpose of the tests was to verify experimentally the safety of altitude decompression regimens that simulated transition from the orbital station atmosphere at a normal barometric pressure to the space suit oxygen atmosphere at a lowered pressure. The results help better understand correlations between the maximal allowable super-saturation coefficient and total postdecompression pressure.

Adult↗

A comparison of three liquid-ventilation cooling garments during treadmill exercise.

Tests were performed on five male subjects to compare the heat transfer performance and physiological effects of three different cooling garments when used under a sealed, impermeable garment which simulated a space suit. The mean exercise metabolic rate while walking at 0.9 m/s (2 mph) was 464 +/- 33 W. An equilibrium condition was never reached during the uncooled suited control runs and the subjects lost a mean of 1.12 +/- 0.15 kg (2.5 +/- 0.3 lb)--approximately 2% of body weight--during exercise. The mean weight loss was 0.35 +/- 0.10 kg (0.8 +/- 0.2 lb) with an Apollo-type garment; 0.26 +/- 0.11 kg (0.57 +/- 0.24 lb) with the full-body cooling patch (garment 2); and 0.52 +/- 0.12 kg (1.15 +/- 0.26 lb) with the partial-coverage cooling patch (garment 3). Impedance plethysmography data showed an increase in leg blood flow when the working muscles were not cooled by liquid flow (garment 3), and the arm blood flow remained unchanged whether or not there was liquid cooling to the arms.

Adult↗

[Dynamic proprioceptive correction in the rehabilitation of patients with a late residual stage of stroke].

Space gravity suit has been used for over 20 years in Russian space stations to prevent harmful consequences of being in zero gravity (osteoporosis, muscle atrophies, etc.). The space suit is designed in such a way that it enables to create a payload on muscles, temporarily out of function, which is adequate to the natural one. Stroke patients with motor defect of hemiparesis are quite limited in their movement. To develop walking and self-serving skills we conducted 2-hour sessions of treatment using space gravity suit. Neuro-physiological and psychological methods confirm the positive effect of treatment. The predictors of positive effect of treatment were also observed. Our experience has shown that the method is simple to use, very effective and can be applied in both clinics and home conditions.

Acute Disease↗

Cardiovascular effects of anti-G suit and cooling garment during space shuttle re-entry and landing.

BACKGROUND: Many cardiovascular changes associated with spaceflight reduce the ability of the cardiovascular system to oppose gravity on return to Earth, leaving astronauts susceptible to orthostatic hypotension during re-entry and landing. Consequently, an anti-G suit was developed to protect arterial pressure during re-entry. A liquid cooling garment (LCG) was then needed to alleviate the thermal stress resulting from use of the launch and entry suit. METHODS: We studied 34 astronauts on 22 flights (4-16 d). Subjects were studied 10 d before launch and on landing day. Preflight, crewmembers were suited with their anti-G suits set to the intended inflation for re-entry. Three consecutive measurements of heart rate and arterial pressure were obtained while seated and then again while standing. Three subjects who inflated the anti-G suits also donned the LCG for landing. Arterial pressure and heart rate were measured every 5 min during the de-orbit maneuver, through maximum G-loading (max-G) and touch down (TD). After TD, crew-members again initiated three seated measurements followed by three standing measurements. RESULTS: Astronauts with inflated anti-G suits had higher arterial pressure than those who did not have inflated anti-G suits during re-entry and landing (133.1 +/- 2.5/76.1 +/- 2.1 vs. 128.3 +/- 4.2/79.3 +/- 2.9, de-orbit; 157.3 +/- 4.5/102.1 +/- 3.6 vs. 145.2 +/- 10.5/95.7 + 5.5, max-G; 159.6 +/- 3.9/103.7 +/- 3.3 vs. 134.1 +/- 5.1/85.7 +/- 3.1, TD). In the group with inflated anti-G suits, those who also wore the LCG exhibited significantly lower heart rates than those who did not (75.7 +/- 11.5 vs. 86.5 +/- 6.2, de-orbit; 79.5 +/- 24.8 vs. 112.1 +/- 8.7, max-G; 84.7 +/- 8.0 vs. 110.5 +/- 7.9, TD). CONCLUSIONS: The anti-G suit is effective in supporting arterial pressure. The addition of the LCG lowers heart rate during re-entry.

Adult↗

Bhageerath: an energy based web enabled computer software suite for limiting the search space of tertiary structures of small globular proteins.

We describe here an energy based computer software suite for narrowing down the search space of tertiary structures of small globular proteins. The protocol comprises eight different computational modules that form an automated pipeline. It combines physics based potentials with biophysical filters to arrive at 10 plausible candidate structures starting from sequence and secondary structure information. The methodology has been validated here on 50 small globular proteins consisting of 2-3 helices and strands with known tertiary structures. For each of these proteins, a structure within 3-6 A RMSD (root mean square deviation) of the native has been obtained in the 10 lowest energy structures. The protocol has been web enabled and is accessible at http://www.scfbio-iitd.res.in/bhageerath.

Computational Biology↗

The Chameleon Suit--a liberated future for space explorers.

Mankind's spacefaring future demands the ability to work freely and frequently in space. Traditional spacesuit systems burden both the spacefarer and the mission, limiting the extent to which this is possible. The spacefarer is burdened by a pressure suit designed for isolation from the environment and a life support system designed to replace everything our environment normally provides. The space mission is burdened by this equipment and the expendable materials to operate and maintain it. We aren't free to work in space as frequently, as long, or in all of the locations envisioned. The NASA Institute for Advanced Concepts (NIAC) has sponsored research on an alternative concept, the "Chameleon Suit", that seeks to liberate future explorers and missions from these limitations. The Chameleon Suit system works with the environment in an adaptive fashion to minimize hardware and expendable materials. To achieve this, functions of the life support system are integrated with the pressure suit using emerging materials and design technology. Technologies under study include shape change polymers and electroemissive materials to modify heat transfer characteristics of the spacesuit "skin" achieving thermoregulation analogous to that in natural biological systems. This approach was shown to be feasible for many space missions during the Phase 1 study program. The current Phase 2 program is investigating more aggressive concepts aimed at eliminating most of the hardware currently included in the spacesuit's life support backpack. This paper describes the concept, study results to date, and possible impacts on future human space exploration.

Biomimetic Materials↗

Advanced Crew Escape Suit.

Design of the S1032 Launch Entry Suit (LES) began following the Challenger loss and NASA's decision to incorporate a Shuttle crew escape system. The LES (see Figure 1) has successfully supported Shuttle missions since NASA's Return to Flight with STS-26 in September 1988. In 1990, engineers began developing the S1035 Advanced Crew Escape Suit (ACES) to serve as a replacement for the LES. The ACES was designed to be a simplified, lightweight, low-bulk pressure suit which aided self donning/doffing, provided improved comfort, and enhanced overall performance to reduce crew member stress and fatigue. Favorable crew member evaluations of a prototype led to full-scale development and qualification of the S1035 ACES between 1990 and 1992. Production of the S1035 ACES began in February 1993, with the first unit delivered to NASA in May 1994. The S1035 ACES first flew aboard STS-68 in August 1994 and will become the primary crew escape suit when the S1032 LES ends its service life in late 1995. The primary goal of the S1035 development program was to provide improved performance over that of the S1032 to minimize the stress and fatigue typically experienced by crew members. To achieve this, five fundamental design objectives were established, resulting in various material/configuration changes.

Astronauts↗

Life in extreme environments: how will humans perform on Mars?

This review of astronaut extravehicular activity (EVA) and the details of American and Soviet/Russian spacesuit design focuses on design recommendations to enhance astronaut safety and effectiveness. Innovative spacesuit design is essential, given the challenges of future exploration-class missions in which astronauts will be called upon to perform increasingly complex and physically demanding tasks in the extreme environments of microgravity and partial gravity.

Extravehicular Activity↗

Work and fatigue characteristics of unsuited and suited humans during isolated isokinetic joint motions.

The effects of a pressurized suit on human performance were investigated. The suit is known as an Extra-Vehicular Mobility Unit (EMU) and is worn by astronauts while working outside their spacecraft in a low earth orbit. Isolated isokinetic joint torques of three female and three male subjects (all experienced users of the suit in 1G gravity) were measured while working at 100% and 80% of their maximum voluntary torque (MVT, which is synonymous with maximum voluntary contraction (MVC)). It was found that the average decrease in the total amount of work (the sum of the work in each repetition until fatigue) done when the subjects were wearing the EMU were 48% and 41% while working at 100% and 80% MVT, respectively. There is a clear relationship between the MVT and the time and amount of work done until fatigue. Here, the time to fatigue is defined as the ending time of the repetition for which the computed work done during that repetition dropped below 50% of the work done during the first repetition. In general the stronger joints took longer to fatigue and did more work than the weaker joints. It was found that the EMU decreases the work output at the wrist and shoulder joints the most, due to the EMU joint geometry. The EMU also decreased the joint range of motion. The average total amount of work done by the test subjects increased by 5.2% (20.4%) for the unsuited (suited) case, when the test subjects decreased the level of effort from 100% to 80% MVT. Also, the average time to fatigue increased by 9.2% (25.6%) for the unsuited (suited) case, when the test subjects decreased the level of effort from 100% to 80% MVT. It was also found that the experimentally measured torque decay could be predicted by a logarithmic equation. The absolute average errors in the predictions were found to be 18.3% and 18.9% for the unsuited and suited subjects, respectively, when working at 100% MVT, and 22.5% and 18.8% for the unsuited and suited subjects, respectively, when working at 80% MVT. These results could be very useful in the design of future EMU suits and the planning of Extra-Vehicular Activity (EVA) for the future International Space Station assembly operations.

Female↗

Displays in space.

This chapter describes the human and environmental factors that dictate the way that displays must be designed for, and used in space. A brief history of the evolution of such display systems covers developments from the Mercury rockets to the International Space Station.

Astronauts↗