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At least 127 records · Page 7Linked to original sources
PubMed2003

SEN virus infection--a new hepatitis virus: a review.

Approximately 10% of transfusion associated hepatitis and 20% of community acquired hepatitis cases do not have a defined etiology, suggesting the existence of an additional causative agent. The recent agents which have been detected in blood were Hepatitis G virus (HGV) and TT virus (TTV), members of the family Circoviridae. These viruses were initially thought to be associated with post-transfusion hepatitis but later studies negated this causal effect. Recently, a novel DNA virus at the moment designated as SEN virus (SEN-V) was discovered and is thought to be associated with post-transfusion hepatitis. This virus is related to the above two agents and belongs to the same family. Whether, like HGV and TTV causal relationship with hepatitis is finally confirmed only time will tell, but, at the moment the association appears to present. The present review summarizes the present available data on this new agent of hepatitis.

Hepatitis Viruses↗
PubMed2004

[Long-term results of valvular condition and clinical state in patients operated with the Senning method].

8 patients suffering transposition of the great arteries (d-TGA) aged from 8-17 years (mean 12.6 years) after Senning procedure performed were analyzed. Right atrium and right ventricle enlargement was detected in all patients. Small jet tricuspid valve regurgitation was confirmed in 5 patients, significant tricuspid valve insufficiency in 3 patients. 4 patients had presented with tricuspid valve, aorta valve and mitral valve insufficiency. In one patient insignificant pulmonary artery stenosis had been diagnosed. Chronic cardiac failure (NYHA III/IV) has been diagnosed in 2 patients, other patients from the analyzed group are in good clinical condition. All patients but 2 were diagnosed with arrhythmia using 24-hour Holter ECG. In 2 patients sinus node dysfunction was noted. Also supraventricular extrasystole, ventricular extrasystole, supraventricular tachycardia, ventricular salve, paroxysmal atrial fibrillation were described. No drug therapy in 4 patients is needed, one is treated with ACE-inhibitors, one with diuretic drugs. 2 patients suffering cardiac failure had been treated with 4 drugs, also temporary with intravenous dopamine. One death had been noted, caused by serious arrhythmia. One patient had been qualified for heart transplantation, there is no further data regarding this case. Senning procedure can be considered high risk for various problems, so patients who underwent this type of correction should be carefully observed.

Adolescent↗
PubMed2006

[Analysis of antineoplastic drugs used in Cancer Center, Sun Yat-sen University, during the period of 1996-2005].

BACKGROUND & OBJECTIVE: Lately, the prevention, treatment and research of cancer have developed rapidly. Antineoplastic drugs have become one of the major measures for cancer therapy. Many new antineoplastic drugs have been discovered and prepared, and used to treat tumors. Cancer Center of Sun Yat-sen University is one of the biggest cancer hospitals in South China. The use of antineoplastic drugs of this center can reflect changes in this area. This study was to analyze and evaluate the situation and trend of antineoplastic drugs used in Cancer Center, Sun Yat-sen University from 1996 and 2005, in order to provide references for the rational use of drugs in clinical application. METHODS: Consumption of antineoplastic drugs was analyzed by sum and defined daily dose (DDDs) ranking. RESULTS: The costs of antineoplastic drugs occupied 31.0%-48.8% of all drugs from 1996 to 2005; and the average increasing ratio is 21.5%. The cost rate of anti-cancer vegetable drugs and other genus increased the quickest, while the total costs of alkylate increased the slowest during the ten years. Some new monoantibodies and gene drugs were continuously applied in clinical use. CONCLUSION: The direction of the research and development of antineoplastic drugs is towards high efficiency, low toxicity and individualized use.

Antibodies, Monoclonal↗
PubMed1988

Senning repair for transposition of the great arteries without patch augmentation of the septum.

Forty-three consecutive patients with previous balloon atrial septostomy have undergone a Senning type repair of transposition of the great arteries without patch augmentation of the atrial septum. A technique was used that allows expansion of the atrial septum without the use of additional foreign or autogenous materials. The operative (30-day) mortality rate was 4.6% (2/43) with no late deaths. A mean follow-up of 20 months shows that 83% of the patients are in sinus rhythm and none of these patients have clinically detectable caval or pulmonary venous obstruction or baffle leaks. In patients selected for atrial switch, the Senning operation may be performed without patch augmentation of the septum. Performed by the method described herein, the operation provides predictable early and late results with a low prevalence of arrhythmias. Significant venous obstruction has not occurred.

Female↗
PubMed1987

Long-term follow-up of the Senning operation for transposition of the great arteries in children under 3 months of age.

Twenty-six patients aged 6 days to 3 months (mean 57 days) underwent a Senning procedure for transposition of the great arteries. Twenty-two had intact ventricular septum and four had a small ventricular septal defect. They were followed up for 1 month to 8 years (mean 4 years). There were no late deaths. At late examination, 25 patients were asymptomatic and there was no clinical or echographic evidence of caval or pulmonary venous obstruction. Growth was normal in all but two patients. Neurologic assessment was abnormal in eight patients. The electrocardiogram showed sinus rhythm in 22 patients and asymptomatic arrhythmias in four. Twenty-three patients underwent cardiac catheterization and angiographic studies 2 to 72 months postoperatively (mean 15 months), which demonstrated effective left and right atrial contraction. An atrial shunt was noted in one patient and a ventricular shunt in one. Two infants (8%) had a residual left ventricular outflow tract obstruction (gradients of 26 and 37 mm Hg). Two had mild superior vena caval obstruction (gradients of 4 and 5 mm Hg). We conclude that the Senning procedure can be performed in early infancy with good results and a low incidence of late complications.

Cardiac Catheterization↗
PubMedDate not supplied

[Current status of Senning's physiologic correction of transposition of the great vessels. Personal experience].

From January 1978 to December 1985, 70 children affected by TGA have been operated with the Senning operation. Among the 70 cases, 64 were simple TGA and 6 were TGA + VSD. The mean age at operation was 6 months (range 2 day - 3 years). Of 64 cases with simple TGA, two (respectively of 2 days and 40 days) died with an operative mortality rate of 3.1% of 6 cases with TGA and VSD, one died with a mortality rate of 16.6%. The total mortality was 4.2%. Since 1981 in a continuative series of 47 patients there were no deaths. Our current policy is now the following: after the diagnosis of simple TGA by ECHO, if the Rashkind septostomy is successful, we perform Senning operation over 3 months; if the Rashkind is unsuccessful, we give prostaglandin (PGE1) for a long period (25-30 days) and in case we do a Blalock-Hanlon septectomy. In conclusion we think that in our hands, the policy followed in the treatment of simple TGA is justified by the results achieved but this policy does not prevent us from using different techniques if the results are better.

Follow-Up Studies↗
PubMed1978

[The Senning operation for correction of transposition of the great arteries (author's transl)].

The reported incidence of the main complications related to the Mustard operation for correction of transposition of the great arteries seems to be quite high: more than half patients develop arrhythmias and about one third develop venous (pulmonary or sistemic) obstructions. For these reasons we have reconsidered the type I (1959) Senning operation. Ten children below two years of age (body weight ranging from 3.9 to 12 Kg) have been operated on with this technique at our Institution. Nine were D-TGA and one L-TGA. One patient had a small VSD and three had mild pulmonary outflow stenosis (p less than 30 mmHg). All patients survived operation and none suffered from complications. At the time of the discharge from the Hospital all were in sinus rhythm. Late evaluation (24 hours EKG, cardiac catheterization, etc.) is in course. We believe that the Senning operation is easier to perform than the Mustard operation because of its more standardized technique which respects the internal geometry of the heart. Additional advantages are: 1) the intra-atrial conducting pathways are less likely to be damaged; 2) there is a minimal or no need for artificial tissues.

Child, Preschool↗
PubMed1984

Results of the Senning operation for transposition of the great arteries with intact ventricular septum in neonates.

In spite of an adequate balloon atrial septostomy, some neonates (less than 28 days of age) with transposition of the great arteries and intact ventricular septum (TGA, IVS) remain hypoxemic and acidotic and require operative treatment. Our entire experience with the Senning operation in neonates with TGA, IVS is reviewed. From March 1978 to March 1983 there were 104 infants who underwent the Senning operation for TGA, IVS. Of these, 19 were neonates (18%). The mean age at operation was 12 days (2 to 24) and mean weight was 3.52 kg (3 to 4.38). Two died early (10%) and one died late (5%). The last 16 are alive and well. Causes of early mortality were sepsis and severe obstruction of the superior vena cava. The cause of late mortality was severe pulmonary venous obstruction. Among the 16 survivors, postoperative courses, both early and late, have been remarkably benign. Ten patients have undergone postoperative cardiac catheterization (mean follow up 17 months). Two (12%) had severe pulmonary venous obstruction (one diagnosed by two-dimensional echocardiography), but both were successfully repaired. Atrial shunt was noted in two patients (12%), one of which underwent elective repair. Five infants have dynamic subvalvular pulmonary stenosis of various gradients (9 to 93 mm Hg). One infant has mild tricuspid regurgitation. There are no cases of superior vena caval obstruction or right ventricular dysfunction. Twenty-four hour electrocardiographic monitoring (mean follow-up 25 months) showed predominant normal sinus rhythm in 15 infants and predominant junctional rhythm in one.(ABSTRACT TRUNCATED AT 250 WORDS)

Acidosis↗
PubMed1978

The Senning operation for transposition of the great arteries.

The original Senning technique of interatrial transposition of venous return was selectively employed for physiological correction in 24 patients with transposition of the great arteries (TGA) ranging in age from 74 days to 26 months (median 7 months). Twenty-three had intact ventricular septum and one had a large ventricular septal defect and diaphragmatic subpulmonary stenosis. There were no hospital or late deaths, and at follow-up examination 1.5 to 12 months postoperatively, each patient was asymptomatic, in normal sinus rhythm, and had no clinical evidence of caval or pulmonary venous obstruction. Nine patients underwent cardiac catheterization and angiocardiographic studies between 1.3 and 9 months postoperatively which demonstrated widely patent venous pathways and effective "left" and "right" atrial contraction. This experience lends support to the continued use of the Senning technique for interatrial transposition of venous return.

Angiocardiography↗
PubMed1983

Dysrhythmias following the Senning operation for dextro-transposition of the great arteries.

Twenty-nine patients have undergone the Senning operation for repair of dextro-transposition of the great arteries (TGA) since 1979 at St. Louis Children's Hospital. The early mortality has been comparable to that reported for the Mustard operation (10%). Electrocardiograms (ECGs) following the Senning operation reveal abnormalities similar to those noted after the Mustard operation; 63% of survivors were in normal sinus rhythm 1 week postoperatively, and 86% demonstrated normal sinus rhythm at a mean of 15 months after operation. Twenty-four hour ambulatory monitoring revealed normal sinus rhythm in 35% and occasional premature atrial or ventricular contractions in another 30%. No cases of sudden unexpected death have been noted, and no pacemakers have been inserted. Possible mechanisms for rhythm disturbances following venous transposition operations are discussed.

Arrhythmias, Cardiac↗
PubMed1980

Reintroduction of the Senning operation for transposition of the great arteries.

At the Royal Children's Hospital, Melbourne, since November, 1978, the Senning operation has become the operation of first choice, in place of the Mustard procedure, for transposition of the great arteries. In total of 22 patients, there have been three hospital deaths, two of which were attributable to severe pulmonary vascular disease. There have been no deaths. Because the Senning procedure is based on the use of living tissue, it may provide better long-term results, by permitting growth and thus avoiding late systemic or pulmonary venous obstruction, than the Mustard procedure which employs extensive use of prosthetic material or graft.

Child, Preschool↗
PubMed1981

Reconstruction of the new atrial septum in the Senning operation. New technique.

A new technique incorporating the left atrial appendage for the reconstruction of the new atrial septum is described as a modification of the original Senning operation for transposition of the great arteries. In reconstruction of the atrial septal flap, the balloon septostomy defect is closed by approximating the inverted left atrial appendage to the anterior margin of the flap. This technique completely eliminates the necessity for foreign material in the repair of the new atrial septum of the Senning operation and has been used in 21 patients with good results.

Cineangiography↗
PubMed1994

The modified Senning operation for cavopulmonary connection with autologous tissue.

UNLABELLED: A modified Senning technique was used for intraatrial channeling of the systemic venous blood into the pulmonary arteries to create a Fontan circulation in 26 children, six with tricuspid atresia and 20 with complex congenital heart disease. In this technique a flap of atrial free wall tissue is used to create an atrial tunnel without artificial material. Eight patients had subaortic stenosis and required a Damus-Kay-Stansel procedure, in addition. Early mortality was two of 26 and late mortality one of 26. Pleural effusion was encountered in 17 of 26 patients, of whom four had a pericardial effusion, in addition. One patient required pacemaker implantation for complete atrioventricular block. Follow-up ranged from 2 months to 5 years. In this period the ability level index rose by one level. No thrombi were encountered in the right atrium/cavopulmonary tunnel. One patient required antiarrhythmic medication. Protein-losing enteropathy was diagnosed in one patient. CONCLUSION: This modified Senning technique has the advantage of avoiding the use of prosthetic material in the creation of a Fontan circulation and the potential for fewer long-term complications.

Adolescent↗
PubMed1994

Budd-Chiari syndrome with extensive portal thrombosis: treatment with Senning's procedure.

A patient with Budd-Chiari syndrome and associated extensive portal thrombosis, precluding any kind of portosystemic shunt, was treated with Senning's procedure. This technique, which includes dorsocranial hepatic resection and direct hepatoatrial anastomosis under total vascular exclusion of the liver, resulted in prompt recovery from acute hepatic failure and esophageal bleeding. Peroperatively, the hemodynamic status was secured with a venous cavo-caval bypass. This observation suggests that Senning's procedure is strongly indicated in the case of Budd-Chiari syndrome with extensive portal thrombosis.

Adult↗
PubMed1993

[Successful two-staged Jatene operation for severe right ventricular dysfunction and tricuspid regurgitation after Senning operation--a case report].

We report a seven-year-old boy who underwent a successful Jatene procedure seven years after Senning procedure. The modified Senning operation was performed for the treatment of transposition of the great arteries with intact ventricular septum at three years of age. However, he gradually showed the progressive right ventricular failure with tricuspid regurgitation after operation. When he was referred to our hospital, he was in severe right ventricular failure and showed massive tricuspid regurgitation simultaneously with the moderate degree of left ventricular failure. Staged pulmonary artery banding was applied to prepare the left ventricle for Jatene procedure in spite of the presence of left ventricular failure. The systolic pressure ratio of left ventricle to right ventricle was elevated to 0.91 by this banding although the left ventricular ejection fraction decreased from 43% to 30%. And Jatene procedure was successfully performed after three months of preparation period. Catheterization study after Jatene procedure revealed improved right and left ventricular functions with decrease of tricuspid regurgitation. We conclude that the Jatene procedure should be an ideal alternative in patient with right ventricular failure and/or tricuspid regurgitation after an atrial switch operation; the left ventricle could be prepared by an effective pulmonary banding in most instances.

Child↗
PubMed1993

[The Senning procedure in Budd-Chiari syndrome associated with complete portal vein thrombosis].

The authors report their experience of one case of Budd-Chiari syndrome with total thrombosis of the portal vein. The patient was undergoing hepatico-atrial anastomosis with Senning's procedure. The original technique utilised extracorporeal circulation with hypothermia; the authors utilised venovenous bypass from femoral vein to axillary vein. Anastomosis function is proved with nuclear magnetic resonance and echo-Doppler on year after operation. Senning's procedure is feasible in the case of Budd-Chiari syndrome with total portal thrombosis with venovenous bypass without extracorporeal circulation with hypothermia.

Adult↗
PubMed2004

PCR-probe capture hybridization assay and statistical model for SEN virus prevalence estimation.

SEN viruses (SENV) are newly discovered blood-borne single-stranded circular DNA viruses that may play a role in liver disease. To date, no serologic assays are available for the detection of SENV antigens or antibodies. We report on a rapid and sensitive molecular assay for the detection of four SENV strains (SENV-A, -C, -D, -H). This method uses PCR with universal primers and microwell capture hybridization with type-specific probes. Cut-off points to define "infected" based on chemiluminescence readings were determined from a statistical mixture model applied to samples from 300 injection drug users (IDUs) in San Francisco. Based on the estimated cut-off points, we examined the prevalence of SENV infection among 232 healthy US blood donors and assessed sensitivity and specificity of the assay in a small validation sample of infected individuals with partial sequence information.

Base Sequence↗
PubMed2002

Transmission of SEN virus from mothers to their babies.

Sera from 30 women at high risk for infection, one half of which were SEN virus positive (SENV(+)), were collected at delivery to study SENV mother-to child transmission. Thirteen of their babies were positive for at least one SENV strain: one baby was SENV(+) at birth, eight became positive within 6 months from delivery, and four became positive in the following months. Our data indicate that vertical transmission of SENV does occur, presumably, at delivery, but it may not induce persistent viremia. This is supported by the fact that, generally, SENV is not detected at birth, by the high SENV homology in the sequences found in the mothers and in their children, by a lack of other risk factors for infection of the babies, and by the irregular detection of SENV in the follow-up. No clinical events surely linked to SENV infection were found, but transient elevations of alanine aminotransferase were observed in babies followed for a long period of time.

DNA Virus Infections↗