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PubMedDate not supplied

Electrophysiology in pseudohistoplasmosis and chronic idiopathic retinal vasculitis.

We used computerized electroretinography (E.R.G.) flash to study 12 patients: five pseudohistoplasmosis (P.S.H.) and seven chronic idiopathic retinal vasculitis (C.I.R.V.), compared with 12 healthy controls. We found a moderate correlation in controls between white computer averaged b-wave amplitude and b-wave obtained with other wavelengths (over 600 nm red, over 550 nm orange, and under 500 nm blue), in scotopic (white/orange r = 0.41, P < 0.05; white/red r = 0.45, P < 0.05; white/blue r = 0.48, P < 0.02) and photopic conditions (white/orange r = 0.6, P < 0.01). For P.S.H. there was a highly significant correlation between white and all wavelengths in photopic (white/orange r = 1, white/red r = 0.96, P < 0.0001) and scotopic conditions (white/orange r = 0.97, P < 0.0001; white/red r = 0.96, P < 0.0001; white/blue r = 0.96). In vasculitis, as in controls, we found no white/red correlation and only in vasculitis we could not find a scotopic white/blue correlation. We conclude that these situations are electrophysiologically different. The closer correlation in P.S.H. suggests more efficient phototransduction and in C.I.R.V. there may also be a rod-selective dysfunction.

Adult↗
PubMed1990

Retinal vasculitis with multifocal retinochoroiditis.

We found a multifocal retinochoroiditis in 16 patients (13 female, 3 male). Patients also showed vitreous cells, in some cases pronounced retinal vasculitis, cystoid macular edema and papilledema. The patients ranged in age from 62 to 77 years. The anterior segment was involved in 13 cases. One patient demonstrated subretinal neovascularisation in both eyes. Fluorescein angiograms showed leakage from the retinal vessels, papilledema, macular edema and subretinal neovascularisation. A convincing classification of the described changes within any known disease entity was impossible. The findings most closely resembled a disease described by Dreyer and Gass in 1984 as 'multifocal choroiditis and panuveitis'.

Aged↗
PubMed1991

Birdshot retinochoroidopathy and HLA-A29+ and HLA-A29- idiopathic retinal vasculitis: comparative study of 56 cases.

We reviewed the records of 20 patients with birdshot retinochoroidopathy and 36 patients with idiopathic retinal vasculitis. The numbers of patients with the HLA-A29 phenotype were 19 (95%) and 22 (61%) respectively. Overall, similar findings were noted in the birdshot retinochoroidopathy group and the HLA-A29+ idiopathic vasculitis group: more posterior pole involvement, more severe course and poor visual prognosis despite intense corticosteroid therapy. In contrast, the patients with HLA-A29- idiopathic vasculitis showed more peripheral involvement, the course was less severe and the prognosis was better; smaller amounts of steroids were used. Only one patient with HLA-A29+ idiopathic vasculitis eventually presented with signs of birdshot retinochoroidopathy; complete cure was obtained in other cases. Our results suggest the existence of an HLA-A29 syndrome encompassing birdshot retinochoroidopathy as well as other conditions whose expression would be determined genetically.

Adrenal Cortex Hormones↗
PubMed2006

[Interferon and retinal vasculitis].

The treatment of noninfectious posterior uveitis can lead to severe vision loss, and the first-line conventional treatment includes systemic steroids. When the prednisone doses necessary to control intraocular inflammation are above 0.3mg/day, a therapeutic association is proposed in order to lower the daily prednisone dose. The combined drugs are immunosuppressive or immunomodulative. The side effects of immunosuppressive drugs are oncogenic, infectious, and hematological, and can involve reproductive troubles, associated with specific toxic effects depending on the drug used. Recently adding polyclonal or monoclonal antibodies and the interferons to immunomodulative drugs has been suggested. Interferon alpha has been shown to be effective in Behçet's disease. The efficacy of interferon needs to be evaluated in other etiologies of retinal vasculitis through randomized studies.

Humans↗
PubMed1987

Retinal vasculitis in Crohn's disease.

Although systemic vasculitis is a prominent part of the extraintestinal complications of Crohn's disease, the association of a retinal vasculitis with this chronic granulomatous disease of the gastrointestinal system is rare. We examined a 26-year-old woman with biopsy-proven Crohn's disease who developed a severe bilateral, obliterative retinal arteritis and phlebitis, leading to a marked loss of vision. Treatment with systemic corticosteroids and cyclophosphamide succeeded in halting progression of the disease.

Adult↗
PubMed1995

Retinal vasculitis associated with Crohn's disease.

Although systemic vasculitis can be a complication of inflammatory bowel disease at several locations (skin, eyes, brain, mesentery, and lung) the association of retinal vasculitis with Crohn's disease is rare. We studied a 26-year-old woman with biopsy-demonstrated Crohn's disease who developed a severe bilateral retinal arteritis and phlebitis, with acute loss of vision.

Adult↗
PubMed1992

Markers of vascular injury in Behçet's disease associated with retinal vasculitis.

The pathogenesis of vascular damage in Behçet's disease (BD) is still unknown. We investigated anticardiolipin antibodies (AC) in a genetically homogeneous group of Italian patients with BD and retinal vasculitis. In a subset, we examined the level of factor VIII-related antigen and antiendothelial cell antibodies (AECA). We found a high prevalence of AC; AECA were not found in most of our patients. Only three patients had raised levels of factor VIII-related antigen, all of whom had systemic involvement. We believe BD may be considered as a vasculitis of unknown origin in which several and different pathogenetic factors may play a role.

Adolescent↗
PubMed2002

Role of computed chest tomography (CT scan) in tuberculous retinal vasculitis.

AIM: To compare computed chest tomography (chest CT) and routine chest X-rays for the detection of pulmonary tuberculosis in patients with presumed tuberculous retinal vasculitis. MATERIALS AND METHODS: Case reports. RESULTS: Three patients underwent a detailed workup for uveitis. Routine chest X-rays showed normal lung fields in all cases with abnormal hilar shadows in one case. Chest CT revealed the presence of active tuberculous mediastinitis in all three patients. CONCLUSIONS: Chest CT revealed the presence, dimensions, and activity of tuberculous mediastinal lymphadenopathy which routine chest X-rays were unable to detect. Thus, chest CT may be the preferred modality for pulmonary evaluation in these patients.

Adult↗
PubMed1990

[Retinal vasculitis with multifocal chorioretinitis].

Multifocal retinochoroiditis was diagnosed in 16 patients (13 female, 3 male). The patients also had cells in the vitreous, and in some cases pronounced retinal vasculitis, cystoid macular edema and papilledema. The patients' ages ranged from 62 to 77 years. There was anterior segment involvement in 13 cases. One patient had subretinal neovascularization in both eyes. Fluorescein angiograms revealed leaks from the retinal vessels, papilledema, and macular edema. So far, the authors have not succeeded in classifying the changes described as belonging to a known disease entity. The findings most closely resembled a disease described by Dreyer and Gass in 1984 as "multifocal choroiditis and panuveitis". Similar changes were seen by Tiedemann in 1987, in patients with Epstein-Barr viral antibodies.

Aged↗
PubMed1991

A case of progressive hemifacial atrophy with uveitis and retinal vasculitis.

Parry Romberg syndrome is a rare disorder characterised by progressive hemifacial atrophy that is usually unilateral, involving the skin, subcutaneous tissue, and subsequently the muscle, cartilage and bone. Previous cases with various ocular manifestations have been reported. A case of Parry Romberg syndrome with retinal vasculitis is reported.

Alopecia↗
PubMed1978

Juvenile retinal vasculitis of the central variety.

Central retinal vasculitits of the type reported herein occurs monocularly in young males. The presenting symptom is always a massive vitreous hemorrhage with gross visual loss, which tends to persist indefinitely. Vitrectomy through the pars plana is followed by complete visual recovery; the condition becomes quiescent, although recurrent hemorrhages may occur. Other complications seen after surgery are glaucoma and retinal detachment. 6 cases were seen in a period of 11/2 years.

Adolescent↗
PubMed1990

Bilateral spontaneous dislocated lenses, retinal vasculitis and progeria-like changes.

Findings are reported for a 70-year-old man with a progeria-like syndrome consisting of premature aging (per history), diffuse wasting, skin atrophy, disseminated skeletal osteoporosis (documented for at least 25 years), especially in the vertebral column and metacarpal joints with short stature, beaked nose and high-pitched voice, The ocular findings include: spontaneous bilateral dislocation of spherophakic mature cataracts into the vitreous together with bilateral retinal vasculitis, characterized by venous congestion, tortuosity and occlusion, To the best of our knowledge, there is no case report with all the above features in one person, Hence, the differential diagnosis will also be discussed.

Aged↗
PubMed1995

Retinal vasculitis caused by rubella.

A patient with vasculitis apparently caused by rubella and diagnosed during her life-time is here presented. The girl showed optic neuritis and large vascular changes in the eye fundi (retinal vasculitis). High intrathecal antibody production against rubella but little or none against other viruses was found in the cerebrospinal fluid. This study suggests that immunoactivation after rubella vaccination may remain and lead to vascular changes.

Adolescent↗
PubMed1985

Alpha 1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis.

alpha 1 antitrypsin is an important immunoregulatory protein, the serum level of which is genetically determined. Deficient phenotypes of this ubiquitous protease inhibitor are associated with a variety of inflammatory diseases including anterior uveitis. In order to investigate the role of this protease inhibitor in the pathogenesis of retinal vasculitis (RV) 25 patients were investigated. Diseases associated with RV included Behcet's syndrome (8), SLE (2), and sarcoidosis (1). Deficient phenotypes of alpha 1 antitrypsin were not associated with RV. However, the serum alpha 1 antitrypsin level was significantly increased in patients with active RV and paralleled disease activity in patients studied prospectively.

Adolescent↗
PubMed1998

Association of temporal arteritis, retinal vasculitis, and xanthomatosis with multiple myeloma: case report and literature review.

Bone pain, anemia, renal failure, and paraproteinemia are common manifestations in patients with multiple myeloma. In this article, we describe an elderly woman with multiple myeloma who had unusual manifestations of cutaneous xanthomatosis, temporal arteritis, and retinal vasculitis. The literature of the dermatologic, ocular, and rheumatologic manifestations of multiple myeloma is reviewed, and the clinical significance of vasculitis in multiple myeloma is discussed.

Aged↗