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At least 127 records · Page 7Linked to original sources

"Flower remedies": a systematic review of the clinical evidence.

BACKGROUND: Flower remedies (also called "Bach" flower remedies) are used by an increasing number of individuals, and many health claims have been made for them. No systematic review of flower remedies has so far been published. AIM: The aim of this systematic review is to summarise and critically analyse the data from all available controlled clinical trials of flower remedies. METHODS: Six databases were searched to identify all controlled clinical trials of flower remedies in humans for any medical condition. No language restrictions were applied. Key data were validated and extracted into table format according to pre-defined criteria. Statistical pooling was not possible, and results were evaluated in narrative form. RESULTS: Four studies met the inclusion/exclusion criteria. Two trials suggested a positive outcome. Those studies that controlled for placebo-effects and minimised selection bias through randomisation failed to demonstrate effects beyond a placebo response. CONCLUSION: The hypothesis that flower remedies are associated with effects beyond a placebo response is not supported by data from rigorous clinical trials.

Adult↗

Lead poisoning caused by Indian ethnic remedies in Italy.

BACKGROUND: Complementary or alternative medicine has become widespread in Western Countries and since the remedies are "natural" they are believed to be free of toxic effects and health risks. Ethnic remedies may contain lead, other metals and toxic substances. OBJECTIVES: To show how lead poisoning as a result of using ethnic remedies may be severe enough to cause serious damage to health, and to increase awareness among family doctors and occupational physicians of the risks associated with ethnic remedies. METHODS AND RESULTS: Description of ethnic remedy-related lead poisoning in 2 native Italian adults, with clinical, laboratory and toxicological data. CONCLUSIONS: When metal poisoning is diagnosed, ethnic remedies should be included among the putative sources so as to avoid erroneous attribution to workplace exposure and application of unneeded preventive measures.

Abdominal Pain↗

[The risks of combining medicine and herbal remedies].

The risks of using herbal remedies, considered 'natural', should not be disregarded, as some have serious side effects and some interact with and influence conventional medical therapeutics. The effect may be pharmacokinetic by altering absorption or metabolism, and may be pharmacodynamic, by changing the final effect of the drug. St. John's wort, for example, an antidepressant herbal remedy, may pharmacodynamically interact with specific serotonin reuptake inhibitors (SSRI's), causing a serotonin syndrome. St. Johns wort also causes serious pharmacokinetic interactions by activating the cytochrome CYP3A4, dangerously decreasing blood levels of cyclosporin, warfarin, and theophylline, and reducing the efficacy of contraceptive pills and AIDS therapy. The article presents a review of a number of herbal remedies, commonly used in Israel, that have documented drug interactions, providing details of common indications, adverse reactions and drug interactions of each herbal remedy. Physicians should recognize the fact that patients use herbal remedies, purchased directly at pharmacies or health stores, and be aware of the potential interactions of these remedies with conventional drugs.

Antidepressive Agents↗

[Value of the Remedi chromatography automate for the analytic diagnosis of drug poisoning].

The aim of this study was to evaluate the liquid chromatographic system Remedi (Biorad) in comparison with traditional immunological and colorimetric methods, for the diagnosis of acute drug overdose. 469 blood samples and 95 stomach cleaning liquid samples have been analysed during 1995. The usual toxicologic analysis was composed of the benzodiazepines, tricyclic antidepressants and barbiturates research. Ethanol, meprobamate and acetaminophen assays were performed only on physician's request. Only three pharmacological classes can be analysed both with immunological methods and Remedi: benzodiazepines, tricyclic antidepressants and barbiturates. Remedi has been found to be less sensitive than immunological method for benzodiazepines, it sometimes gave false negative results for barbiturates, but it was very efficient for antidepressants. Remedi often identified drugs other than the 3 previous classes: sedatives, antipsychotic, beta-blockers, antiarythmics. Furthermore these drugs are of clinical importance due to the fact that they are able to modify the symptomatology. In every case Remedi was able to give an estimation of the blood concentration of the toxic molecule matched. Remedi can not replace traditional methods but is a good complementary tool, available in emergency. This is particularly useful when clinical signs do not correspond to the toxics suspected by questioning the patient or relatives.

Antidepressive Agents, Tricyclic↗

Predictors of remediation success on a trained memory task.

Cognitive remediation has led to improvements for some but not all individuals with schizophrenia. The goal of the current investigation was to determine which variables predicted response to cognitive remediation training. In a sample of 58 patients with DSM-IV schizophrenia or schizoaffective disorder, normalization of performance on a trained memory task was selected as the criterion for successful remediation. The contribution of demographic, symptom, treatment process, and cognitive variables in predicting successful remediation was examined using a series of logistic regressions. A final regression evaluated the combined contribution of these variables. From among patients who were impaired before training, 43% reached normal levels of performance. Measures of attention, immediate verbal memory, hostility, and latency between last training and assessment were retained in the final step of the regression, resulting in 83% classification accuracy. Findings suggest that in addition to cognitive factors, motivational and training variables also significantly affect remediation outcomes.

Adult↗

Cognitive remediation for adolescents with early onset psychosis: a 1-year follow-up study.

OBJECTIVE: To investigate the long-term effects of a cognitive remediation programme for adolescents with early onset psychosis. METHOD: Twenty-five subjects (cognitive remediation, n=14; control, n=11) were assessed on cognitive, clinical and psychosocial measures 1 year after discharge. All patients had received a psychoeducational programme, while the experimental group received the addition of a 30-h cognitive remediation programme. RESULTS: A significant overall improvement for eight of 10 cognitive and three of four outcome measures was found. After controlling for IQ, there was a differential improvement in early visual information processing (P<0.05) in favour of the remediation group. No other between-group differences were found. CONCLUSION: The remediation programme may have a favourable long-term effect for early visual information processing. Improved cognitive functioning in both groups may be caused by beneficial elements in the psychoeducational programme. Because the study may be underpowered, the results should be interpreted with caution.

Adolescent↗

Putting struggling readers on the PHAST track: a program to integrate phonological and strategy-based remedial reading instruction and maximize outcomes.

PHAST (for Phonological and Strategy Training) is a research-based remedial reading program that attempts to capitalize upon current research on reading disabilities and their remediation. The focus of the program is on the primary obstacles to word identification learning and independent decoding that most disabled readers face and the steps necessary to help these children achieve independent reading skills. A framework of phonologically based remediation was used as a foundation upon which a set of flexible and effective word identification strategies were scaffolded in an integrated developmental sequence. The program uses a combination of direct instruction and dialogue-based metacognitive training, with the pedagogical emphasis shifting from an initial direct instruction, remedial focus to increasingly metacognitive-strategy-based methods. A continuum of intervention over 70 hours provides both (a) remediation of the basic phonological awareness and letter-sound-learning deficits of disabled readers and (b) specific training of five word identification strategies that offer different approaches to the decoding of unfamiliar words and exposure to different levels of subsyllabic segmentation. Explicit instruction in the application and monitoring of multiple word identification strategies and their application to text-reading activities continues throughout the PHAST Program. PHAST training provides the disabled reader with the opportunity to become a flexible reader who approaches new words in or out of context with multiple strategies and has the ability to evaluate the success of their application. The PHAST Program was developed following the controlled evaluation of its components in laboratory classroom settings and recent positive results from their sequential combination. PHAST represents a new integrated approach to programming in this area using instructional components that have already demonstrated their efficacy with children with severe reading disabilities.

Child↗

Unproved cancer remedies. A survey of use in pediatric outpatients.

Sixty-nine patients or parents of patients were interviewed during a five-week period. Each interviewee was given a questionnaire listing commonly recommended unproved drugs, diets, and miscellaneous treatments, and was instructed to respond to each remedy as follows: Have you tried it? Have you considered trying it? Has it been recommended by someone else? Six patients (8.7%) had tried at least one unproved remedy, four (5.8%) considered trying some other remedy, and recommendations to seek other remedies had been made to 17 patients (24.6%). Laetrile and assistance from faith healers were the remedies named most frequently.

Age Factors↗

Disopyramide analysis using REMEDi: comparison with EMIT and conventional high performance liquid chromatographic methods.

REMEDi (Rapid EMErgency Drug identification; Bio-Rad) is an automated high performance liquid chromatographic (HPLC) system designed to detect, identify and measure a range of basic and neutral drugs in 0.5-1.0 mL of urine or plasma/serum. We have evaluated REMEDi in the analysis of the antiarrhythmic drug disopyramide in patient samples. The specimens were also analysed by a conventional HPLC method, based on solvent extraction and UV detection (254 nm), and by EMIT. There were good correlations between the results obtained with each method (r = 0.91 or greater). REMEDi gave a lower mean result than EMIT [means +/- SD (mg/L): REMEDi 2.64 +/- 1.10, EMIT 3.14 +/- 1.51; t = 4.0, p less than 0.01; n = 25], but there were no other significant differences in mean results. The principal disopyramide metabolite, mono-N-desalkyldisopyramide, did not interfere in any method. Clearly REMEDi can be used for therapeutic drug monitoring of disopyramide provided enough sample is available.

Autoanalysis↗

ReMeDy: A Flexible Statistical Framework for Region-Based Detection of DNA Methylation Dysregulation.

Region-based epigenome-wide association studies have demonstrated improved statistical power and biological interpretability compared with probe-wise analyses of DNA methylation data. However, most existing region-based methods characterize methylation dysregulation primarily through changes in mean methylation levels associated with a phenotype of interest. Substantial evidence indicates that phenotype-associated methylation alterations may also manifest through changes in methylation variability or through joint shifts in mean and variability. Despite this, no existing statistical framework jointly models mean-variance methylation changes in a region-based manner. We propose ReMeDy, a flexible statistical framework that uses a hierarchical likelihood approach within a generalized linear model setting to identify differentially methylated regions, variably methylated regions, and regions exhibiting joint differential and variable methylation at a genome-wide scale. Unlike existing models, ReMeDy operates directly on biologically defined co-methylated regions, allowing it to naturally capture spatial correlation inherent in DNA methylation array data, while avoiding reliance on heuristic, user-defined tuning parameters such as smoothing spans and kernel bandwidths that can substantially influence results and introduce subjectivity. Through extensive simulation studies and comprehensive benchmarking against popular models, we demonstrate that ReMeDy maintains false discovery and Type-I error rates at nominal levels while achieving consistently higher statistical power across a wide range of realistic scenarios. Application to population-level DNA methylation data further shows that ReMeDy identifies biologically meaningful regions and pathways implicated in complex human diseases that are not captured by conventional mean-based analyses alone. ReMeDy is implemented as an open-source R package and is freely available at https://github.com/SChatLab/ReMeDy.

DNA Methylation↗

Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation.

For the past several years we have been evaluating natural products as potential cancer chemopreventive agents in a short term in vitro assay involving Epstein--Barr virus early antigen (EBV-EA) activation in Raji cells promoted by phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). Because of the current interest in the use of herbal remedies, we considered examining them for their cancer chemopreventive activities, using their extracts with a view to uncovering such benefits (if any) these remedies might possess. Thirty-six extracts of 32 herbs belonging to 27 families in use as herbal remedies including those of gingko, black cohosh, echinacea, kava-kava, saw palmetto, turmeric, angelica, wild yam, cat's claw, passion flower, muira puama, feverfew, blueberry, chasteberry, licorice, nettle, golden seal, pygeum, ginger, valerian and hops were prepared and evaluated. Turmeric at a concentration of 10 microg x ml (-1)exhibited the most potent anti-EBV-EA activity, which is ten times more than passionflower, that is next in the order of activity. At the concentration level of 100 microg ml (-1), several of the herbal remedies tested inhibited the EBV-EA in Raji cells exposed to the tumor promoter TPA (32 pM) by more than 90%. We also report for the first time the activities of 16 new medicinal plants as potential cancer chemopreventive agents. Since inhibitors of EBV-EA promoted by TPA in vitro have been shown to be effective anti-tumor promoting agents in laboratory animal models, our results indicate new and potential applications of these herbal remedies as cancer chemopreventive agents since they are already in clinical use in the human population.

Antigens, Viral↗

Ecological benefits of contaminated sediment remediation.

Contaminated sediment has been identified as a source of ecological impacts in marine and freshwater systems throughout the world, and the importance of the contaminated sediment management issue continues to increase in all industrialized countries. In many areas, dredging or removal of sediments contaminated with nutrients, metals, oxygen-demanding substances, and persistent toxic organic chemicals has been employed as a form of environmental remediation. In most situations, however, the documentation of the sediment problem has not been quantitatively coupled to ecological impairments. In addition, the lack of long-term, postactivity research and monitoring for most projects has impeded a better understanding of the ecological significance of sediment contamination. Establishing quantitatively the ecological significance of sediment-associated contamination in any area is a difficult time- and resource-consuming exercise. It is, however, absolutely essential that it be done. Such documentation will likely be used as the justification for remedial and rehabilitative action(s) and also as the rationale for proposing when intervention is necessary in one place but not another. Bounding the degree of ecological impact (at least semiquantitatively) provides for realistic expectations for improvement if sediment remediation is to be pursued. It should also provide essential information on linkages that could be used in rehabilitating other ecosystem components such as fish or wildlife habitat. The lack of information coupling contaminated sediment to specific ecological impairments has, in many instances, precluded a clear estimate of how much sediment requires action to be taken, why, and what improvements can be expected to existing impairment(s) over time. Also, it has likely resulted in either a delay in remedial action or abandonment of the option altogether. A clear understanding of ecological links not only provides adequate justification for a cleanup program but also represents a principal consideration in the adoption of nonintervention, alternative strategies. In developing this understanding, it is important to know not only the existing degree of ecological impairment associated with sediment contaminants but also the circumstances under which those relationships and impacts might change (i.e., contaminants become more available and more detrimental). Because contaminated sediment remediation often costs millions of dollars per area, adequate assessment, prediction, and monitoring of recovery would seem obvious. However, experience has shown that this is not always the case, particularly for prediction and monitoring of ecological recovery. This scenario would never happen in the business world and should not occur in the environmental management field.

Animals↗

Temperature-sensitive, osmotic-remedial mutants of Neurospora crassa: osmotic pressure induced alterations of enzyme stability.

Three temperature-sensitive, adenine-requiring mutants of Neurospora crassa were found to be osmotic-remedial when non-penetrating solutes were used to increase the osmolarity of the growth medium. The affected enzyme (adenylosuccinase) from one of the mutants (ad-4, 44206t) was found to have higher levels of activity when the organism was grown at non-permissive temperatures under osmotic-remedial conditions than when it was grown with adenine as a nutritional supplement. The enzyme synthesized at 30 degrees C in the presence of adenine exhibited increased sensitivity to inhibition by high salt concentrations and a lowered stability toward heat denaturation, indicating that the remedial effect may be the result of changes in the physical properties of the enzyme molecule. Temperature shift experiments indicate that the enzyme which is synthesized at permissive temperatures or under osmotic-remedial conditions is also stable in vivo under non-permissive conditions. This suggests that the critical period for temperature sensitivity, and conversely osmotic remediability, may be during protein synthesis or during the conformational folding of the protein.

Adenine↗

Heavy metals in traditional Indian remedies.

The growing popularity of traditional Indian remedies necessitates a critical evaluation of risks associated with their use. This systematic review aims at summarising all available data relating to the heavy metal content in such remedies. Computerised literature searches were carried out to identify all articles with original data on this subject. Fifteen case reports and six case series were found. Their collective results suggest that heavy metals, particularly lead, have been a regular constituent of traditional Indian remedies. This has repeatedly caused serious harm to patients taking such remedies. The incidence of heavy metal contamination is not known, but one study shows that 64% of samples collected in India contained significant amounts of lead (64% mercury, 41% arsenic and 9% cadmium). These findings should alert us to the possibility of heavy metal content in traditional Indian remedies and motivate us to consider means of protecting consumers from such risks.

Adult↗

A framework for net environmental benefit analysis for remediation or restoration of contaminated sites.

Net environmental benefits are gains in value of environmental services or other ecological properties attained by remediation or ecological restoration minus the value of adverse environmental effects caused by those actions. Net environmental benefit analysis (NEBA) is a methodology for comparing and ranking net environmental benefits associated with multiple management alternatives. A NEBA for chemically contaminated sites typically involves comparison of several management alternatives: (1) leaving contamination in place; (2) physically, chemically, or biologically remediating the site through traditional means; (3) improving ecological value through onsite and offsite restoration alternatives that do not directly focus on removal of chemical contamination; or (4) a combination of those alternatives. NEBA involves activities that are common to remedial alternatives analysis for state regulations and the Comprehensive Environmental Response, Compensation, and Liability Act, post-closure and corrective action permits under the Resource Conservation and Recovery Act, evaluation of generic types of response actions pertinent to the Oil Pollution Act, and land management actions that are negotiated with regulatory agencies in flexible regulatory environments (i.e., valuing environmental services or other ecological properties, assessing adverse impacts, and evaluating remediation or restoration options). This article presents a high-level framework for NEBA at contaminated sites with subframeworks for natural attenuation (the contaminated reference state), remediation, and ecological restoration alternatives. Primary information gaps related to NEBA include nonmonetary valuation methods, exposure-response models for all stressors, the temporal dynamics of ecological recovery, and optimal strategies for ecological restoration.

Conservation of Natural Resources↗

Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy.

Traditional remedies have been a source of important antimalarial drugs and continue to provide novel and effective treatments, both where pharmaceuticals are not available and where the disease is increasingly resistant to commonly prescribed drugs. The Kenyah of the Apo Kayan, a remote forested plateau in Indonesian Borneo, use 17 malaria remedies derived from natural sources. A quantitative analysis of the relationship between a 'local importance value' index for each malaria remedy (IVmal) and inhibition of cultured Plasmodium falciparum by ethanolic extracts supports the hypothesis that the degree of local consensus about a given remedy is a good indicator of its potential biological efficacy. Our results confirm the rational selection and use of traditional remedies for malaria by the Kenyah. We have identified target species for further research directed toward safe and effective treatments for malaria.

Antimalarials↗

Environmental features of two commercial surfactants widely used in soil remediation.

One of the main limitations for a wider application of surfactants in soil remediation is the lack of knowledge about environmental fate and toxicity of surfactant itself especially for in situ application. Sorption behaviour, biodegradability, toxicity of parent compound and its metabolites are important processes that affect environmental fate of surfactants in site remediation applications. Tween 80 (poly(oxyethylene)(20)-sorbitane monooleate) and Aerosol MA+80 (dihexyl sodium sulfosuccinate) are surfactants that have been tested in laboratory and field scale remediation of soil and groundwater. In this work, the sorption and biodegradability of these surfactants were assessed to provide conditions and limitations for their use. The soil used in this experimentation was analysed for organic carbon content, soil bacteria, and size fraction and resulted to be a good model because is characterised by mean values for almost all considered parameters. Tween 80 showed high degree of biodegradability but a high affinity for soil matrix. Results suggest that Tween 80 could find its best application in ex situ solid phase remediation like ex situ bioremediation; its high affinity to soil could limit in situ applications. Biodegradation tests for Aerosol MA+80 show low degree of biodegradability and mineralisation. Biodegradation experiments, coupled with analysis of toxicity, could support the hypothesis that degradation of Aerosol MA+80 is not complete and leads to an accumulation of intermediates with at least the same toxicity of the parental compound. Therefore, aquifer remediation application with Aerosol MA+80 has to be conducted with necessary precautions to avoid product loss and excess surfactant should be flushed from the soil.

Adsorption↗

Soil remediation time to achieve clean-up goals II: Influence of natural organic matter and water contents.

This work reports a relatively rapid procedure for the forecasting of the remediation time (RT) of sandy soils contaminated with cyclohexane using vapour extraction. The RT estimated through the mathematical fitting of experimental results was compared with that of real soils. The main objectives were: (i) to predict the RT of soils with natural organic matter (NOM) and water contents different from those used in experiments; and (ii) to analyse the time and efficiency of remediation, and the distribution of contaminants into the soil matrix after the remediation process, according to the soil contents of: (ii1) NOM; and (ii2) water. For sandy soils with negligible clay contents, artificially contaminated with cyclohexane before vapour extraction, it was concluded that: (i) if the NOM and water contents belonged to the range of the prepared soils, the RT of real soils could be predicted with relative differences not higher than 12%; (ii1) the increase of NOM content from 0% to 7.5% increased the RT (1.8-13 h) and decreased the remediation efficiency (RE) (99-90%) and (ii2) the increase of soil water content from 0% to 6% increased the RT (1.8-4.9 h) and decreased the RE (99-97%). NOM increases the monolayer capacity leading to a higher sorption into the solid phase. Increasing of soil water content reduces the mass transfer coefficient between phases. Concluding, NOM and water contents influence negatively the remediation process, turning it less efficient and more time consuming, and consequently more expensive.

Adsorption↗