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At least 127 records · Page 7Linked to original sources

The idealisation of therapy: fantasy versus reality in clinical practice.

In this paper, object-relations theory is used to illuminate problems encountered in the psychotherapeutic management of severely disturbed psychiatric patients. The hazards of idealisation of the psychiatrist by the patient are reported in four case histories. Attention is drawn to the subsequent breakthrough of negative feelings where idealisation had been unrecognised or unwittingly encouraged. Some implications for the more successful management of the transference in patients such as these are discussed.

Adult↗

Magnetic tracker calibration for an augmented reality system for therapy.

Magnetic trackers are widely used position/orientation measurement devices in interactive computer systems. These trackers output six-degree-of-freedom position and orientation of their receiver coordinates with respect to their transmitter coordinates. It is a potential solution for real-time position/orientation measurement in an augmented reality system for therapy (ART). However, an obstruction to be overcome is that a magnetic tracker is vulnerable to measurement inaccuracy caused by magnetic field distortions (including ferric and non-ferric distortions) when it is used in metallic environments. The purpose of this paper is to discuss calibration methods used to compensate distortions produced by metallic objects which are moving during the measurement procedure, but fixed with a receiver. Past work on the calibration of magnetic trackers has concentrated on static distortions, which are produced by stationary metallic objects in the environment. Compared with static distortions, in this paper a relatively dynamic situation is considered where the distortion is not constant with time. However, the location of the metallic objects is reflected in the outputs of the receiver so that the distortion can be compensated. This type of distortions, which is called 'quasi-static distortion' in this paper, is common in an ART. Compensation of quasi-static distortion is more complicated than that of static distortion and has not been mentioned in past publications. Some new compensation methods for quasi-static distortion will be introduced here. The results demonstrate that the methods are capable of significantly reducing quasi-static distortions.

Calibration↗

Gene therapy--when a simple concept meets a complex reality. Review on gene therapy.

In theory, gene therapy is a simple concept which holds great promise as a cure for disease. In practice, however, considerable obstacles have to be overcome, including problems with safe and efficient gene delivery and stable gene expression. This review gives an overview on the history of gene therapy and analyses some of the problems that have so far prevented the establishment of a successful clinical protocol. The future prospects of gene therapy are discussed.

Clinical Protocols↗

Electroshock therapy: myths and realities.

The methodology of the 1940s provided the data base for the myths that grew up around electroshock therapy. Since then indications have been refined and techniques drastically revised--as with many other medical treatments. When administered for carefully defined indications, in the proper setting by an experienced team, and with appropriate safeguards, EST is safe, effective, and often the treatment of choice.

Affective Symptoms↗

Molecularly targeted therapy for melanoma: current reality and future options.

Effective therapy for melanoma remains an unmet goal, with most traditional therapies representing inadequate trade-offs among the several goals of specificity, efficacy, and toxicity. Targeted molecular therapeutics are tailored to genetic abnormalities that are associated with tumor progression. Modulation of aberrant signaling pathways in cancer cells has the potential to provide more effective and potentially nontoxic therapy for a broad range of cancers, including melanoma. Among the possible targets in melanoma are the Ras-MAPK and PI3K/AKT signal transduction pathways, the proteasome, histone deacetylases, methyltransferases, and melanoma-induced angiogenesis.

Angiogenesis Inhibitors↗

[Satisfaction of geriatric patients with their pain therapy. Wish and reality].

AIM: The goal of this study was to determine the level of satisfaction of geriatric patients with their pain therapy, their wishes for improved treatment, and possible influencing factors. METHODS: From April to November 2002, all patients able to communicate ( n=1432) were included in the study if they had reported pain in the previous 7 days or were taking regular analgesic medication without specifying pain. RESULTS: Of the geriatric patients reporting from home, 36.4% were not satisfied with their pain therapy up to that time, and 25.4% of surgical patients were dissatisfied as were 28.5% of patients treated in other departments. A total of 93.3% desired better pain treatment. Independent predictors for dissatisfaction with their therapy or wish for improvement were increasing pain intensity, frequent concomitant complaints in addition to pain, and the objectively perceived everyday competence. CONCLUSION: This study supports the observation that competent pain therapy is necessary and that there is room for improvement in geriatric facilities. Measuring pain intensity, posing questions pertaining to satisfaction with pain therapy, and determining whether patients desire better pain treatment are all indispensable for optimal care. Pain therapy should equally address reduction of pain intensity and management of other complaints.

Aged↗

Esophageal perforation--associated risk with balloon tamponade after endoscopic therapy. Myth or reality?

BACKGROUND/AIMS: Variceal bleeding is still associated with high mortality and balloon tamponade may be a lifesaving measure when endoscopic therapy is not available or feasible. The risk of esophageal perforation with balloon tamponade after endoscopic therapy is still uncertain. The aims of the study were to investigate balloon tamponade effectiveness and safety after endoscopic therapy. METHODOLOGY: Retrospective analysis of 100 consecutive episodes of acute variceal bleeding treated with the Sengstaken-Blakemore tube. RESULTS: Balloon tamponade had an overall effectiveness of 61%. The Child-Pugh score was significantly higher in patients who failed balloon tamponade. In 48 cases balloon tamponade was preceded by failure of endoscopic therapy. Balloon tamponade was more effective if a previous attempt to perform endoscopic therapy happened (75% vs. 48%; p = 0.006). Aspiration was the most frequent complication. No cases of esophageal perforation were registered. CONCLUSIONS: Currently balloon tamponade is only used as a temporary bridge to other strategies, when other forms of hemostatic therapies do not succeed. Balloon tamponade was more effective in patients with less severe hepatic dysfunction. Previous attempts to perform endoscopic therapy may augment tamponade effectiveness without increasing the risk of esophageal perforation.

Adult↗

[Reality approach in senile dementia. Fundamental methodologies of occupational therapy in psychogeriatrics].

Occupational therapy in psychogeriatrics has always been practiced empirically, aimed mainly at merely occupying patients. In the light of recent findings from the old age psychological research, a specific method should cope with certain forms of lost intellectual capacities. The purpose of this work is to define as accurately as possible the field of occupational therapy in psychogeriatrics. Three main concepts towards a systematic approach can be proposed: a) Those related to a careful observation of spontaneous activities dealing with the relationship between the patient and the world around him, and which lead to a classification of these activities. b) Concepts related to the most elementary level of intervention in occupational therapy termed as "objective relationship", in other words the construction of the external objective world as opposed to the world of phantasms or magical thought. c) Concepts, at a more sophisticated level, related to the instrumental aspects of traditional occupational therapy. An important distinction should thus be made between local and inclusive constituent parts of an activity.

Aged↗

Exploring the use of computer games and virtual reality in exposure therapy for fear of driving following a motor vehicle accident.

Specific phobia, situational type-driving, induced by accident (accident phobia) occurs in 18-38% of those involved in a vehicular accident of sufficient severity to warrant referral to the emergency departments of a general hospital. The objective is to investigate, in an open study, the effectiveness of the combined use of computer generated environments involving driving games (game reality [GR]) and a virtual reality (VR) driving environment in exposure therapy for the treatment of driving phobia following a motor vehicle accident (MVA) program. Fourteen subjects who met DSM-IV criteria for Simple Phobia/Accident Phobia and were referred from the emergency department of a general hospital were exposed to a Virtual Driving Environment (Hanyang University Driving Phobia Environment) and computer driving games (London Racer/Midtown Madness/Rally Championship). Patients who experienced "immersion" (i.e., a sense of presence with heightened anxiety) in one of the driving simulations (defined as an increase in SUD ratings of 3 and/or an increase of heart rate > 15 BPM in a 1-h trial session of computer simulation driving) were exposed to a cognitive behavioral program of up to 12 1-h sessions involving graded driving simulation tasks with self-monitoring, physiological feedback, diaphragmatic breathing and cognitive reappraisal. Subjects were assessed at the beginning and end of therapy with measurements of: physiological responsivity (heart rate), subjective ratings of distress (SUD), rating scales for severity of fear of driving (FDI), Posttraumatic Stress Disorder (CAPS) and depression (HAM-D) and achievement of target behaviors. Of all patients 7/14 (50%) became immersed in the driving environments. This immersed group (n = 7) completed the exposure program. Pre- and post-treatment comparisons showed significant post treatment reductions on all measures SUDS (p = 0.008), FDI (p = 0.008), CAPS (p = 0.008), HR (p = 0.008), CAPS (p = 0.008), HAM-D (p = 0.031). Further analysis of the FDI showed significant reductions in all three subscales: travel distress (p = 0.008), travel avoidance (p = 0.008), and maladaptive driving strategies (p = 0.016). The findings of this study suggest that VR and GR may have a useful role in the treatment of driving phobia post-accident even when co-morbid conditions such as post-traumatic stress disorder and depression are present.

Accidents, Traffic↗

Virtual reality-based multidimensional therapy for the treatment of body image disturbances in obesity: a controlled study.

The main goal of this paper is a preliminary evaluation of the efficacy of a virtual reality VR-based multidimensional approach to the treatment of body image attitudes and related constructs. The female obese patients (n = 28) involved in a residential weight control treatment, including low-calorie diet (1,200 kcal/day) and physical training, were randomly assigned either to the VR treatment or to psychonutritional groups based on the cognitive-behavior approach. Patients were administered a battery of outcome measures assessing eating disorders symptomatology, attitudes toward food, body dissatisfaction, level of anxiety, motivation for change, level of assertiveness, and general psychiatric symptoms. In the short-term, the VR treatment was more effective than the traditional cognitive-behavioral psychonutritional groups in improving the overall psychological state of the patients. In particular, it was more effective in improving body satisfaction, self-efficacy, and motivation for change. The improvement was associated with a reduction in problematic eating and social behaviors. The possibility of inducing a significant change in body image and its associated behaviors using a VR-based short-term therapy can improve body satisfaction in traditional weight reduction programs. However, given that this research that does not include a follow-up study, the obtained results are preliminary.

Adolescent↗

The virtual aneurysm. Virtual reality in endovascular therapy.

Image guided therapies, such as new endovascular procedures for treating brain aneurysms are now in clinical use. To plan these procedures, physicians currently use angiography to view projectional images of anatomy and blood flow. There are currently no available tools for visualizing the details of complex blood flow or predicting the effects of specific treatments. To address this problem, we have created a virtual environment for the visualization of blood flow and the simulated effects of therapy in brain aneurysms. The "Virtual Aneurysm" is composed using a combination of image processing, flow simulation, scientific visualization, and virtual reality techniques.

Angiography, Digital Subtraction↗

Virtual-reality-based multidimensional therapy for the treatment of body image disturbances in binge eating disorders: a preliminary controlled study.

The main goal of this paper is to preliminarily evaluate the efficacy of a virtual-reality (VR)-based multidimensional approach in the treatment of body image attitudes and related constructs. The female binge eating disorder (BED) patients (n = 20), involved in a residential weight control treatment including low-calorie diet (1200 cal/day) and physical training, were randomly assigned either to the multidimensional VR treatment or to psychonutritional groups based on the cognitive-behavior approach. Patients were administered a battery of outcome measures assessing eating disorders symptomathology, attitudes toward food, body dissatisfaction, level of anxiety, motivation for change, level of assertiveness, and general psychiatric symptoms. In the short term, the VR treatment was more effective than the traditional cognitive-behavioral psychonutritional groups in improving the overall psychological state of the patients. In particular, the therapy was more effective in improving body satisfaction, self-efficacy, and motivation for change. No significant differences were found in the reduction of the binge eating behavior. The possibility of inducing a significant change in body image and its associated behaviors using a VR-based short-term therapy can be useful to improve the body satisfaction in traditional weight reduction programs. However, given the nature of this research that does not include a followup study, the obtained results are preliminary only.

Adolescent↗

A step forward in research on psychotherapy of schizophrenia.

The Boston group have devoted 10 years to a thoughtful, comprehensive, and much needed study that will undoubtedly become a classic reference in the field. If the emphasis is placed on differences that reached statistical significance, the major finding is minimal outcome differences between exploratory, insight-oriented (EIO) and reality-adaptive, supportive (RAS) therapies with, if anything, significant advantages to RAS in recidivism and performance. Selective beneficial effects for EIO gain only very weak support. The results should contribute to a climate wherein we may move on to study how psychotherapy and pharmacotherapy can be combined to achieve optimal results and minimize toxic effects.

Clinical Trials as Topic↗