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At least 127 records · Page 7Linked to original sources
PubMed2000

Prognostic value of hemoglobin concentrations in patients with advanced head and neck cancer treated with combined radio-chemotherapy and surgery.

PURPOSE: Hemoglobin levels are currently the focus of interest as prognostic factors in patients with head and neck cancer. Most published clinical trials have confirmed hemoglobin to possess a significant influence on survival in patients treated with radiotherapy. In our study we have investigated the prognostic value of hemoglobin in a combined modality schedule. PATIENTS AND METHODS: Forty-three patients with advanced head and neck tumors were treated with combined radio-chemotherapy. The therapy comprised 2 courses of induction chemotherapy with ifosfamide (1,500 mg/m2, day 1 to 5) and cisplatin (60 mg/m2, day 5) followed by hyperfractionated accelerated radiotherapy with a total dose of only 30 Gy. Surgery involved tumor resection and neck dissection. RESULTS: The 1-year overall survival rate and the 2-year survival rate were 79% and 56%, respectively. The 1- and 2-year recurrence-free survival rates were 68% and 49%, respectively. Prognostic factors with an impact on survival were seen in tumor size (T3 vs T4, p = 0.0088), response to radio-chemotherapy at the primary site (no vital tumor rest vs vital tumor rest, p = 0.045), response to lymph node radio-chemotherapy (no vital tumor cells vs vital tumor cells, p = 0.013) and level of hemoglobin after radio-chemotherapy (Hb > or = 11.5 g/dl vs < 11.5 g/dl, p = 0.0084). CONCLUSION: In our study hemoglobin level after radio-chemotherapy was identified for the first time to be also a significant prognostic factor (univariate analysis) in head and neck cancer patients who underwent combined radio-chemotherapy. Besides chemotherapy plus low-dose irradiation achieved similar results in comparison with radical resection and high-dose radiotherapy at least for the first 2 years after therapy. Relapsing disease could be treated with 1 additional course of radiotherapy which is supposed to be well tolerated.

Adult↗
PubMed2000

Radio frequency heating of chronic ovine infarct leads to sustained infarct area and ventricular volume reduction.

OBJECTIVE: Myocardial infarct expansion and subsequent left ventricular remodeling are associated with increased incidence of congestive failure and mortality. Collagen is known to denature and contract when heated above 65 degrees C. We therefore tested the hypothesis that radio frequency heating of myocardial infarct tissue with application of a restraining patch causes a sustained reduction in myocardial infarct area and left ventricular volume. METHODS: Thirteen male Dorset sheep underwent surgical coronary artery ligation. At least 14 weeks later, animals were randomized to either radio frequency infarct heating (95 degrees C) with application of a restraining patch or a sham operation. Before treatment, after treatment, and 10 weeks later, left ventricular volume was measured with transdiaphragmatic echocardiography and myocardial infarct area was measured with an array of sonomicrometry crystals. RESULTS: Radio frequency infarct heating causes an acute decrease of 34% (-215 +/- 82 mm(2); P =.0002) in infarct area at end-diastole that is maintained at 10 weeks (-144 +/- 79 mm(2); P =.0002). Radio frequency infarct heating causes a downward trend in end-diastolic left ventricular volume measured by echocardiography of 20% (-15.7 +/- 6.3 mL; P = no significant difference) and end-systolic left ventricular volume of 32% (-17.1 +/- 9.8 mL; P =.09), which are significantly decreased at 10 weeks (-13.6 +/- 22.3 mL; P =.007 and -15.3 +/- 21.9 mL; P =.008, respectively). Radio frequency infarct heating causes an acute improvement in systolic function (P <.001), a sustained increase in left ventricular ejection fraction (+0.11%; P =.06), and preserved stroke volume. CONCLUSION: Radio frequency heating of chronic left ventricular myocardial infarct causes a sustained reduction in infarct area and left ventricular volume. This technique may beneficially reverse infarct expansion and left ventricular remodeling after myocardial infarction.

Animals↗
PubMed1999

The Radio Afterglow and the Host Galaxy of the X-Ray-rich GRB 981226.

We report the discovery of a radio transient VLA 232937.2-235553, coincident with the proposed X-ray afterglow for the gamma-ray burst GRB 981226. This gamma-ray burst (GRB) has the highest ratio of X-ray to gamma-ray fluence of all the GRBs detected by BeppoSAX so far, and yet no corresponding optical transient was detected. The radio light curve of VLA 232937.2-235553 is qualitatively similar to that of several other radio afterglows. At the subarcsecond position provided by the radio detection, optical imaging reveals an extended R=24.9 mag object, which we identify as the host galaxy of GRB 981226. Afterglow models that invoke a jetlike geometry for the outflow or that require an ambient medium with a radial density dependence, such as that produced by a wind from a massive star, are both consistent with the radio data. Furthermore, we show that the observed properties of the radio afterglow can explain the absence of an optical transient without the need for large extinction local to the GRB.

Journal Article↗
PubMed2003

Transvaginal radio frequency treatment of the endopelvic fascia: a prospective evaluation for the treatment of genuine stress urinary incontinence.

PURPOSE: We evaluate the safety and efficacy of a new treatment modality for genuine stress urinary incontinence which was a transvaginal radio frequency applicator to deliver radio frequency energy to the endopelvic fascia. The purported mechanism of effect for this therapy is shrinkage of the collagenated tissue which composes the endopelvic fascia that supports the bladder neck and proximal urethra, thus stabilizing the proximal urethra and bladder neck. In prior animal trials and early pilot studies this therapy was shown to cause a reproducible thermal effect manifested by fascial shrinkage. Preliminary human trials indicated a therapeutic benefit of this therapy for women with genuine stress urinary incontinence. MATERIALS AND METHODS: To our knowledge this is the first multicenter study of a transvaginal approach for radio frequency of the endopelvic fascia for treatment of genuine stress incontinence. Between June 1999 and June 2000, 120 consecutive women (mean age 49.9 years) at 10 sites underwent transvaginal radio frequency treatment in a prospective trial to evaluate the overall efficacy and safety profile of this therapy. All patients had preoperative urethral hypermobility (average cotton swab change 38 degrees). Detrusor instability was excluded by cystometry. In all procedures precisely controlled radio frequency energy was applied to the endopelvic fascia to heat and shrink the tissue. The patients were evaluated postoperatively at 1 week and at 1, 3, 6 and 12 months using objective and subjective measures. Primary end points consisted of physician assessment of continence, patient reported pad use and the number of patient reported episodes. Safety was determined for acute (immediate postoperative) and chronic time frames. RESULTS: Of the 120 patients 96 completed 1-year evaluation. Average operative time was less than 30 minutes, and all patients were treated as outpatients. Preoperatively 101 patients (84%) averaged 1 or more episodes of urinary incontinence per day. At 3, 6 and 12 months 57%, 66% and 59% of patients, respectively, averaged 1 or no daily episodes of urinary incontinence. At 12-month followup 79 of 109 patients (73%) reported being continent or improved. Preoperatively, 43% of patients reported using 1 or no pads daily. At 3, 6 and 12 months 69%, 70% and 72% of patients, respectively, required 1 or no pads daily. On urodynamic evaluation at 12-month followup 76.0% of the patients did not leak with a Valsalva maneuver. A total of 30 cases were classified as failures and 11 women were lost to followup. There were no intraoperative complications, 3 (4%) minor postoperative complications which resolved, and no device related complications. CONCLUSIONS: The transvaginal radio frequency applicator demonstrated good efficacy and excellent safety at 1-year followup. Ongoing analysis of the data has indicated opportunities for improvement of this new surgical technique that could result in higher efficacy rates without compromising safety. Further long-term evaluation is being conducted to assess chronic durability of the procedure.

Catheter Ablation↗
PubMed2002

Small hepatocellular carcinoma: therapeutic effectiveness of percutaneous radio frequency ablation therapy with a LeVeen needle electrode.

OBJECTIVE: To evaluate the therapeutic effectiveness of percutaneous radio frequency ablation of small (< or =3-cm) hepatocellular carcinoma with a LeVeen needle electrode. METHODS: Thirty patients (mean age, 65.7 years) with 32 hepatocellular carcinomas (range, 1.2-3.0 cm; mean, 2.3+/-0.5 cm) underwent percutaneous radio frequency ablation to the center of the hepatocellular carcinoma after expansion of the inner needles. The manufacturer's recommended radio frequency ablation protocol was used. Posttreatment contrast-enhanced color Doppler sonography, contrast-enhanced computed tomography, and fine-needle biopsy were performed to assess the radio frequency ablation-induced coagulated necrosis. RESULTS: Severe intratreatment pain made us abort radio frequency ablation in 2 patients. Complete tumor necrosis was achieved in 1 treatment session with 1 needle electrode insertion in 28 (93.4%) of 30 nodules (28 patients). We found no residual focus on both color Doppler sonography and computed tomography after any of the sessions. In follow-ups ranging from 3 to 15 months (mean, 8.4 months), no local recurrence was found in cases with complete tumor ablation. CONCLUSIONS: Radio frequency ablation with the LeVeen needle electrode was effective, obtaining complete coagulated necrosis with a safety margin when used for the treatment of small hepatocellular carcinomas.

Administration, Cutaneous↗
PubMed2005

[Radio-chemotherapy for non-resectable primary esophageal malignant melanoma].

AIM: to demonstrate the simultaneous radio-chemotherapy of primary esophageal malignant melanoma on the basis of one case. PATIENT AND METHODS: 68-years-old male patient with malignant melanoma in middle part of the esophagus. The therapy was started with intraluminal high-dose-rate afterloading brachytherapy for the recanalisation of the esophagus (8 Gy in 0.5 cm deep), followed by percutaneous megavolt therapy two weeks after the last HDR AL session (50 Gy total dose, 5 x 2 Gy/week fractions for 5 week, 3D conformal planning). The chemotherapy was started simultaneously with the percutaneous megavolt irradiation (three courses of Cisplatin-5-Fluorouracil combination, repeated in four-week intervals). After the radio-chemotherapy a supraclavicular metastasis was verified, so the radio-chemotherapy was followed with megavolt therapy of the metastasis at 30 Gy dose (5 x 2 Gy/week fractions), and chemotherapy (Cisplatin-Dacarbazine combination in 6-session, four-week intervals) and after them immunotherapy was started. RESULTS: The swallow function has been improved, the supraclavicular metastasis was in partial remission. After the beginning of the radio-chemotherapy the swallow function was good for 16 months, and 18 months after the beginning of radio-chemotherapy the patient died due to pulmonary and hepatic dissemination. CONCLUSION: Radio-chemotherapy of esophageal malignant melanoma has favorable palliative effect with acceptable quality of life.

Aged↗
PubMed2000

A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors.

PURPOSE: Small renal tumors are frequently detected during the screening of patients with a hereditary type of renal cancer. The development of nonsurgical treatment modalities would greatly improve quality of life in these patients. We present our experience with radio frequency interstitial tissue ablation, a heating device approved by the Food and Drug Administration for treating soft tissue tumors. MATERIALS AND METHODS: Patients underwent radio frequency interstitial tissue ablation of small renal tumors just before surgical excision. Pathological examination of the renal tumors was done to evaluate the treatment effect. Computerized tomography and renal function testing were performed before and after therapy to evaluate toxicity. RESULTS: Four patients underwent treatment of a total of 14 tumors with the radio frequency interstitial tissue ablation device just before surgical removal of the tumors. All lesions were brown after ablation, in contrast to the normal pink appearance of untreated lesions that were resected. On color Doppler ultrasound blood flow to each tumor evident before was not visualized after treatment. The Wilcoxon rank sum test demonstrated no difference preoperatively and postoperatively in blood urea nitrogen, serum creatinine, creatinine clearance or differential renal function. We identified no toxicity associated with radio frequency interstitial tissue ablation. Of the excised tumors 11 were renal cell carcinoma and 3 fibrotic hemorrhagic cysts. For renal cell carcinoma the treatment effect involved the loss of nuclear detail and nonvisualization of nucleoli. These changes were not observed in any tumors resected without radio frequency interstitial tissue ablation. The treatment effect was noted in 10 of the 11 lesions, and in 1 case the treatment effect involved 35% of the tumor. CONCLUSIONS: No toxicity was associated with radio frequency interstitial tissue ablation. Percutaneous treatment of renal tumors is planned to evaluate the treatment effect better and further evaluate toxicity.

Adult↗
PubMed2002

Acute and long-term outcomes of radio frequency bladder neck suspension.

PURPOSE: A new treatment modality for women with stress urinary incontinence secondary to urethral hypermobility is radio frequency bladder neck suspension. Radio frequency energy is a form of electromagnetic energy that is reliable and highly controllable. This thermal therapy can produce well-defined areas of tissue heating. The technology has been used extensively in dermatological and orthopedic surgery for tissue shrinkage and ablation. Radio frequency thermal therapy is now being applied to the endopelvic fascia at the bladder neck and urethra for treating hypermobility in patients with stress urinary incontinence. The purported mechanism is shrinkage of the collagenated tissue that supports the bladder neck and proximal urethra. We report our acute and long-term experience with laparoscopic radio frequency bladder neck suspension for stress urinary incontinence. MATERIALS AND METHODS: Enrolled in this prospective multicenter trial were 94 women with a mean age of 48.4 +/- 7.6 years who had urethral hypermobility with an average cotton swab angle change of 41 degrees and Valsalva leak point pressures greater than 90 cm. water at 250 ml. bladder capacity. Detrusor instability was excluded by cystometry. In all cases precisely controlled radio frequency energy was applied to the endopelvic fascia to heat and shrink the tissue. The primary end points were physician assessment of continence, patient reported pad use and the number of patient reported episodes of urinary incontinence daily 1, 3, 6 and 12 months after surgery. RESULTS: Average operative time was less than 60 minutes and 98% of the patients were discharged home from the recovery room. Treatment surface area decreased an average of 17% in length and 21% in width. Preoperatively 78% of patients had an average of 1 or more episodes of urinary incontinence daily. At 1, 3, 6 and 12 months there was an average of 1 or fewer episodes of urinary incontinence daily in 84.7%, 85.6%, 85.9% and 77.4% of patients, respectively, and at 12 months 83.5% reported being continent or improved. Preoperatively 41.2% of patients reported using 1 pad or less daily, while at 1, 3, 6 and 12 months 85.6%, 90.4%, 87.2% and 86.9%, respectively, required 1 pad or less daily. Urodynamic evaluation at 12 months showed no leakage during the Valsalva maneuver in 78% of cases. There were no major postoperative complications and the minor complication rate was 5.3%. CONCLUSIONS: Early results of thermal treatment of the endopelvic fascia indicate that radio frequency bladder neck suspension is safe and effective for improving stress urinary incontinence in women. The improvement in symptomatology appears to be durable in most patients at the 1-year followup. Longer followup is needed to assess the durability of results and it is currently in progress.

Catheter Ablation↗
PubMed2002

Hemodynamic changes in hepatic cancer before and after cluster electrode radio-frequency ablation.

OBJECTIVE: To evaluate the hemodynamic changes of hepatic artery (HA), portal vein (PV) and tumors in hepatic cancer patients treated by cluster electrode radio-frequency ablation with the aid of color Doppler flow imaging (CDFI). METHODS: The hemodynamic changes of HA, PV and 42 tumors in 30 cases of hepatic cancer were investigated by CDFI one week before and after cluster electrode radio-frequency ablation. RESULTS: One week after radio-frequency ablation, the velocity of HA decreased (P<0.05), but the diameter and velocity of PV unchanged. Before radio-frequency ablation, blood signals were observed in 35 cancer nodes (83.0% of all 42 nodes). After radio-frequency ablation, blood signals were reduced in 15 nodes and disappeared in 14 nodes. Early investigation implied that the decrease of blood supply was parallel with the reduction of node size. However, the outcome in case of huge nodes with double blood supply was not as promising as those small nodes. CONCLUSION: CDFI is useful to assess blood supply in ablation of hepatic cancer by using cluster electrode radio-frequency therapy.

Adult↗
PubMed2006

[Radio wave and cryodestruction in the complex therapy of cervical lesions].

We have determined the effectiveness of cryodestruction and radio wave surgery during the treatment of background diseases of cervical lesions. To 52 patients with background diseases of cervical lesions the radio wave surgery has been performed and for 81 patients cryodestruction has been carried out, 65 patients got laser, anti-virus and immunomodulating therapy after cryosurgical treatment. The usage of radio wave surgery and cryodestruction helps to avoid unpleasant postoperative consequences such as pain, edema, infection and postoperative shock from loss of blood, which quite often arise after application of traditional methods of surgical operation. The advantage of cryodestruction and radio wave surgery at treatment of background diseases of cervical lesions in comparison with other invasive methods of treatment of given pathology is the absence of scars and preservation of cervical lesions' reproductive function. During the radio wave surgery operation the depth of destruction of tissues are being controlled by the adjustment of the device's capacity, which in our opinion is an advantage of radio wave method of treatment of cervical lesions' pathology in comparison with the method of cryodestruction.

Cervix Uteri↗
PubMed1970

[Further facts in pleural recurrence prevention by radio-colloidal gold in operated breast cancer].

The communication deals with endoscopical facts making recognizable that the intrapleural incorporation of colloidal radio-gold after the so-called radical mastectomy corresponds to a preventive-curative act. There is an analysis and proof of lymphogenous nature of the threatening, in it's manifest stage always lethal early and late pleural metastasis. The special and various features of the pleural cavity in postoperative endoscopy are demonstrated as a basis for the following dosage of radio-gold in a preventive-curative sense. Original, spectacular pictures are represented. On the basis of an experience for decades and because of the insufficient results of surgical therapy and conventional radiotherapy, unsatisfactory quoad sanationem et vitam, it must be pointed out that an additional, intrapleural radio-gold therapy is imperative. The application must be done early after operation. The effectiveness of this application is beyond question, since the pioneer-work of J. H. Müller and the ten years results with his preoperative radio-gold infiltration of the breast and my own endoscopically developed intrapleural radio-gold infusion. Both methods make possible true healing and ten years survival. For this reasons I recommend the employ of the more practicable intrapleural infusion on a big collective. The question of a long-term effectiveness of the therapy with fast electrons (betatron) is still to be decided on the ten years parameter. But I don't doubt that radio-gold is superior to all kind of radiotherapy controlling the contralateral pleural dissemination.

Adenocarcinoma, Scirrhous↗
PubMed1980

[Differences in the levels of serum immunoglobulin E determined by the competitive radio-immuno-sorbent and the paper-radioimmuno-sorbent methods: Removal of these differences by pretreatment of sera with polyethylene glycol (author's transl)].

The serum IgE of patients with chronic nonspecific lung diseases was determined with the competitive radio-immuno-sorbent and the paper-radio-immuno-sorbent methods (Phadebas). Some samples showed markedly higher values with the competitive radio-immuno-sorbent than with the paper-radio-immuno-sorbent method. These discrepancies were abolished by pretreatment of the sera: polyethylene glycol 6000 (final concentration 35 g/l) was added, followed by centrifugation at 0 degrees C for 30 min at 20 000 g, and IgE was determined in the supernatant. This treatment had no effect on the values of the paper-radio-immuno-sorbent method, but the values of the competitive radio-immuno-sorbent method were decreased so that the two values agreed within the experimental confidence limits.

Binding, Competitive↗
PubMed1991

Astrometry of southern radio sources.

An overview is presented of a number of astrometry and astrophysics programs based on radio sources from the Parkes 2.7 GHz catalogues. The programs cover the optical identification and spectroscopy of flat-spectrum Parkes sources and the determination of their milliarc-second radio structures and positions. Work is also in progress to tie together the radio and Hipparcos positional reference frames. A parallel program of radio and optical astrometry of southern radio stars is also under way.

Astronomical Phenomena↗
PubMed1993

The effect of hand-held radio operation on audio dosimeters.

Six models of audio dosimeters from five manufacturers were tested to determine the effect of radio frequency (r-f) interference caused by the operation of hand-held radios near the dosimeters on the measured average sound pressure level in a controlled noise field. Exposures were in a reverberant chamber at levels of 36, 80, and 92 dBA to an octave of noise centered at 1 kHz. Two walkie-talkie type radios, one operating at 160 mHz and the other operating at 460 mHz were used to generate the r-f field. The radios were operated on two duty cycles (2 or 3 cycles/min) during the recording period. Reported measures, such as average sound pressure level and peak sound pressure level, were compared for each noise exposure condition with and without operation of the hand-held radio. The results indicate that all makes and models of the dosimeters that were tested gave false readings under some conditions. These values always exceeded the reading in the noise alone control condition and varied by as much as 45 dB above the "true" level. Because each dosimeter behaved differently--including different samples of identical models--it was not Rather, steps are recommended to help users identify potential r-f contamination on dosimeter performance in the field.

Bias↗
PubMed2002

Adult and childhood leukemia near a high-power radio station in Rome, Italy.

Some recent epidemiologic studies suggest an association between lymphatic and hematopoietic cancers and residential exposure to high-frequency electromagnetic fields (100 kHz to 300 GHz) generated by radio and television transmitters. Vatican Radio is a very powerful station located in a northern suburb of Rome, Italy. In the 10-km area around the station, with 49,656 residents (in 1991), leukemia mortality among adults (aged >14 years; 40 cases) in 1987-1998 and childhood leukemia incidence (eight cases) in 1987-1999 were evaluated. The risk of childhood leukemia was higher than expected for the distance up to 6 km from the radio station (standardized incidence rate = 2.2, 95% confidence interval: 1.0, 4.1), and there was a significant decline in risk with increasing distance both for male mortality (p = 0.03) and for childhood leukemia (p = 0.036). The study has limitations because of the small number of cases and the lack of exposure data. Although the study adds evidence of an excess of leukemia in a population living near high-power radio transmitters, no causal implication can be drawn. There is still insufficient scientific knowledge, and new epidemiologic studies are needed to clarify a possible leukemogenic effect of residential exposure to radio frequency radiation.

Adolescent↗
PubMed1985

The admittance of the squid giant axon at radio frequencies and its relation to membrane structure.

The admittance of the squid giant axon membrane has been measured, using an intracellular electrode, at frequencies up to 40 MHz. The existence of a radio frequency dispersion, previously detected with extracellular electrodes (Cole, 1976) and attributed to the Schwann cell layer, has been confirmed and followed to higher frequencies. For a comparable method of analysis, membrane parameters similar to those given by Cole (1976) have been calculated. The radio frequency dispersion has a centre frequency at approximately 1.8 MHz, and the properties of a parallel combination of a 28 nF cm-2 capacity and a 3.3 omega cm2 resistance. When the axon membrane capacity is calculated, taking into account the radio frequency dispersion, as described above, the capacity remains frequency dependent throughout the range studied. If it is assumed that at high frequencies the axolemma capacity becomes constant at approximately the value for a lipid bilayer, a radio frequency dispersion is found which cannot be accounted for in terms of a simple equivalent circuit with two passive components, but appears to arise from a network with a distribution of relaxation times. This result could be consistent with the morphology of the Schwann cell layer. The radio frequency dispersion referred to in (4) can be described reasonably well by a circuit with two dispersions having centre frequencies of 250 kHz and 3.2 MHz respectively. The corresponding axolemma capacity (100-500 kHz) would be approximately 0.6 microF cm-2. It is argued that between 50 and 100 kHz the geometrical capacity arising from the non-polar regions of the membrane is a major contributor to the axon membrane capacity, and that capacity variations arising from compositional changes in the lipid bilayer are best monitored in this frequency range.

Action Potentials↗
PubMed1988

Radio-frequency vs. electrolytic VMH lesions: differential effects on plasma hormones.

Electrolytic lesions of the ventromedial hypothalamus (VMH) result in marked hyperphagia and obesity, but several studies have found the excess food intake and weight gain to be greatly reduced when lesions are produced by electrocauterization with radio-frequency current. Unlike electrolytic lesions, radio-frequency lesions leave few or no deposits of metallic ions that can potentially stimulate adjacent tissue. In the present experiment, weight gain and several endocrine responses previously associated with the VMH syndrome were compared in female rats given either electrolytic, radio-frequency, or sham VMH lesions. Both groups with VMH lesions became obese, but rats with radio-frequency lesions displayed only 63.2% of the weight gain of animals with irritative lesions (120.0 vs. 189.8 g in 20 days). Only rats with electrolytic lesions displayed elevated plasma insulin levels during an initial period of food restriction, but both groups with lesions were hyperinsulinemic when allowed to overeat. Plasma growth hormone levels were decreased by electrolytic lesions but unaffected by radio-frequency lesions. Morning corticosterone levels were elevated in both VMH groups, but only the rats with electrolytic lesions were found to have elevations in plasma adrenocorticotropin. It is concluded that some of the endocrine dysfunctions resulting from electrolytic VMH lesions are due to irritative stimulation rather than to tissue ablation.

Animals↗
PubMedDate not supplied

[Evaluation of two strategies for nutritional education using radio programs in Guadalajara, Mexico].

Modifying knowledge and attitudes through persuasive communication in health via radio has produced encouraging results for public health planners. This study's objective was to measure the effect of an educational strategy on knowledge and attitudes towards nutrition in two marginalized communities in Guadalajara, Mexico. Two communities were randomly selected. In each community a group of individuals was invited to be exposed to radio broadcasts. Using a coded and structured instrument, knowledge and attitudes towards the contents of nutritional education for health were measured before and after the intervention in both groups. Group A (n = 37) was organized and exposed to the dynamics of the radio forum throughout the 4 months during which the project lasted. Group B (n = 33) was not organized, and listened to the radio program according to its own cultural dynamics. Median knowledge and attitudes (KA) for group A was 56.8 in the pre-test and 74.1 in the post-test (W: p = -0.05). In group B the KA results were 53.0 and 59.2, respectively (W: p = -0.05). The results emphasize the advantages of the radio forum as a health communications strategy for human nutrition.

Case-Control Studies↗