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[Antitetanus vaccination in the adult: systematic offer in primary care as an effective approach].

OBJECTIVE: To establish the effectiveness of a broad offer for tetanus vaccination (ATT), to any person visiting his general practitioner, by evaluating its coverage, acceptance by patients and final vaccination figures. DESIGN: Intervention study of nonrandom type. SETTING: Primary care. PATIENTS: 1349 people aged > or = 24 registered with a general practitioner, of which 1048 were user's people. MEASUREMENTS AND MAIN RESULTS: Find out all people seeking primary care if they has been vaccinated against tetanus, recording the next token dosage or inoculating it, according to the recommendations of the Centers for Disease Control. We offered vaccination to 90.7% of the user's people, without significant difference as to age and sex groups, and to 70.7% of the registered population. The proposal was rejected by 8.9% of people who need to initiate vaccination. The 17.1% of the population stated that they had been inoculated the whole vaccination cycle, and after the treatment the rate rose to 81.5% of intervener's people. CONCLUSION: The broad offer for ATT vaccination to people seeking primary care, whatever the reason is, the final result is 8 patients vaccinated out of 10 of the offer's people. This is an easily measurable example of what can be achieved both with registered population and people seeking primary care if we include preventive programmes and health promotion in the daily medical attention demanded by patients who go to primary care centers.

Adult↗

Moving in a given year: a study in research design and data analysis.

"In this paper the distribution of the times between moves, or, equivalently, the relationship between duration of residence and the probability of moving [is examined]. Complete information on residence histories contained in the Population Register of Norway for the period 1965-1971 has been used to generate two data sets: the 'ideal' data set and the duration of residence at a specific point in time." The relationship between the probability of moving in a given year and stochastic models of mobility histories is then discussed. "In the subsequent section the feasibility of using the probability of moving in a given year, as measured by cross-sectional survey techniques, in lieu of complete residence histories, as contained in population registers, is evaluated. It could be demonstrated that cross-sectional data is sufficient for many purposes." In conclusion, "some comments are made regarding methodological problems arising out of the use of sparse tabular data, which is typical in socio-demographic studies where highly disaggregated projections are required."

Demography↗

Danish singles have a twofold risk of acute coronary syndrome: data from a cohort of 138 290 persons.

STUDY OBJECTIVE: Atherosclerosis of the coronary and other arteries is an important health problem in virtually all countries of the world, and thus there is a persisting need for the development of preventive programmes including population risk group identification. The aim of the study was to identify sociodemographic population risk indicators of an initial episode of acute coronary syndrome (ACS), including unstable angina pectoris (UAP), myocardial infarction (MI), and sudden cardiac death (SCD). DESIGN: Cohort study of 138 290 residents of the municipality of Aarhus, Denmark, aged 30-69 years. Information on population members' individual age, sex, social background, and eventual death was obtained from Danish Population Registers. SETTING: University hospital. PATIENTS: The study prospectively identified 646 victims of ACS from 1 April 2000 to 31 March 2002. MAIN RESULTS: Based on multiple logistic regression, age and single living were found to be positively associated with incident ACS in both sexes. Women >60 years living alone and men >50 years living alone were at especially high risk. They constituted only 5.4% and 7.7% of the source population, respectively, but they accounted for 34.3% and 62.4% of ACS patients dying within 30 days. CONCLUSIONS: Single living is associated with an increased risk of ACS. Thus, risk groups identified by use of information on their age and family structure may be targets for future more focused and cost effective preventive strategies. In Western populations, such high risk groups will constitute comparatively limited parts of the population, and in Denmark they are easily identifiable in routine population registers.

Acute Disease↗

Growing social inequalities in the occurrence of overweight and obesity among young men in Sweden.

AIMS: The aims of the present study are to investigate time trends and social inequalities in mean body mass index (BMI), overweight, and obesity among 18-year-old men in Sweden from 1970 to 2000 and to explore whether social inequalities in these conditions have increased. METHODS: A record linkage was made between the Military Service Conscription Register, Population and Housing Censuses, the Register of Education and the Register of the Total Population. All 1,748,800 males born in 1952-82 who were living in Sweden at the age of 17 years in 1969-99 were eligible for this nationwide study. The study population comprises 1,500,499 18-year-old men with information on BMI (86% of eligible subjects). RESULTS: During the study period from 1970 to 2000, mean BMI increased from 20.89 kg/m2 to 22.49 kg/m2, the prevalence of overweight increased from 6.6% to 13.6% and the prevalence of obesity increased from 1.0% to 3.8%. Mean BMI and the prevalence of overweight and obesity were higher among young men with low-educated mothers than among those with high-educated mothers. A noteworthy finding was that the socioeconomic gap increased over time. CONCLUSIONS: Between 1970 and 2000, the prevalence of overweight increased twofold and the prevalence of obesity increased fourfold in this study population. The social inequalities in overweight and obesity have steadily increased among young men in Sweden during the past three decades.

Adolescent↗

A pilot study of cervical screening in an inner city area--lessons for a national programme.

The objectives of this study were to examine aspects of organization of a proposed national screening programme based in general practice. The target population of women aged 25-59 years and their general practitioners (GPs), in a defined inner city area, was identified from a population register of persons eligible for free medical services; a computerized system was developed for invitations and record linkage of cytology results. Smears were examined in one laboratory and follow up of women with abnormal smears was undertaken by one gynaecologist. A random sample of non-responders was surveyed by questionnaire. Response following two invitations was only 20%. Practices with male doctors only had significantly lower response rates (P < 0.001) than those with a female doctor/nurse. A survey of non-responders showed that over 20% of addresses were incorrect and 16% of those interviewed were ineligible for smear tests. A preference for a female to undertake smears was expressed by 67%, and 77% believed that the purpose of the cervical smear was to detect cancer. An accurate population register, health promotion, support for GP practices, provision of alternative venues for smear tests, development of computer systems, accurate data entry and fail-safe follow up are aspects of a cervical screening service which must be addressed prior to setting up a national service.

Adult↗

Chemical shifts provide fold populations and register of beta hairpins and beta sheets.

A detailed analysis of peptide backbone amide (H(N)) and H alpha chemical shifts reveals a consistent pattern for beta hairpins and three-stranded beta sheets. The H alpha's at non-hydrogen-bonded strand positions are inwardly directed and shifted downfield approximately 1 ppm due largely to an anisotropy contribution from the cross-strand amide function. The secondary structure associated H alpha shift deviations for the H-bonded strand positions are also positive but much smaller (0.1-0.3 ppm) and the turn residues display negative H alpha chemical shift deviations (CSDs). The pattern of (H(N)) shift deviations is an even better indicator of both hairpin formation and register, with the cross-strand H-bonded sites shifted downfield (also by approximately 1 ppm) and with diagnostic values for the first turn residue and the first strand position following the turn. These empirical observations, initially made for [2:2]/[2:4]-type-I' and -II' hairpins, are rationalized and can be extended to the analysis of other turns, hairpin classes ([3:5], [4:4]/[4:6]), and three-stranded peptide beta-sheet models. The H alpha's at non-hydrogen-bonded sites and (H(N))'s in the intervening H-bonded sites provide the largest and most dependable measures of hairpin structuring and can be used for melting studies; however the intrinsic temperature dependence of (H(N)) shifts deviations needs to reflect the extent of solvent sequestration in the folded state. Several observations made in the course of this study provide insights into beta-sheet folding mechanisms: (1) The magnitude of the (H(N)) shifts suggests that the cross-strand H-bonds in peptide hairpins are as short as those in protein beta sheets. (2) Even L-Pro-Gly turns, which are frequently used in unfolded controls for hairpin peptides, can support hairpin populations in aqueous fluoroalcohol media. (3) The good correlation between hairpin population estimates from cross-strand H-bonded (H(N)) shift deviations, H alpha shift deviations, and structuring shifts at the turn locus implies that hairpin folding transitions approximate two-state behavior.

Amino Acid Sequence↗

[Computerized family reconstitution on a large data-base: the SOREP system].

This article outlines a new system for computerized family reconstitution. It has been developed in the last 10 years by a multidisciplinary team of Quebec researchers belonging to the Inter-University Research Center on Populations (SOREP). Basically, this system is characterized by 1) an attempt to computerize as much as possible every step involved in the process of reconstitution, 2) a set of tools devised for identifying and measuring all forms and degrees of similarity between names and surnames, 3) a technique to process cases of ambiguous links, 4) a set of programs used to assess the quality of the data and the strength of the links created, and 5) an attempt to maximize the performance of the linkage work in terms of both efficiency and accuracy. The system has been designed to support several kinds of analyses, from social history and demography to population genetics. The paper contains a brief overview of the current state of research in the field record linkage, an introduction to the Saguenay population register, and a description of the system itself which has utilized sucessfully in the last year on the 660,000 Saguenay parish records, covering the period 1842-1971.

Americas↗

Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.

AIM: Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare the teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) in monotherapy. METHODS: Infants exposed to AEDs (n = 1398) in early pregnancy were identified from the Swedish Medical Birth Registry. The number of infants with congenital malformations and exposed to AED was compared with the expected number estimated from all infants born (n = 582656). RESULTS: 90% (1256) of the AED exposed children were exposed to AEDs in monotherapy, 56% were exposed to CBZ and 21% to VPA. The odds ratio (OR) for having a malformation in the AED exposed group was 1.86 [95% confidence interval (95% CI) 1.42-2.44]. Exposure to VPA in monotherapy compared with CBZ in monotherapy gave OR = 2.51 (95% CI 1.43-4.68) for a neonatal diagnosis of malformations. However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups. CONCLUSION: There was a small increase in the risk of having a major malformation after exposure to AEDs in monotherapy. Exposure to VPA seems to carry a higher risk than exposure to CBZ.

Abnormalities, Multiple↗

Incidence of insulin-dependent diabetes mellitus (0-14 years) in the Abruzzo Region, Italy, 1990-1995: results from a population-based register.

OBJECTIVE: To provide incidence data of insulin dependent diabetes mellitus (IDDM) in the Abruzzo Region, Italy in 0-14 year-old children and contribute to a better understanding of IDDM geographical variability throughout Italy. SUBJECTS AND METHODS: All incident cases younger than 15 years first diagnosed with IDDM according to the WHO criteria between 1 January 1990 and 31 December 1995 and resident in the Abruzzo Region were recorded. The primary sources were divisions of pediatrics, endocrinology or medicine, diabetic centers for adult patients and the Regional Pediatric Diabetology Centre. Secondary independent sources included registered prescriptions for insulin in local district units of the National Health System and the regional IDDM association for children. RESULTS: During the six years, 117 new cases of IDDM in the age-group 0-14 were identified, with an overall standardized incidence rate of 9.34/100,000/year (95% C.I. 7.76-10.95). The crude incidence rate was highest in the 10-14 year age-group (10.64, 95% C.I. 7.66-13.62). Teramo province showed the highest standardized incidence rate, 10.30/100,000/year (95% C.I. 6.58-14.02); it is noteworthy that the IDDM rate in Teramo (15.40/100,000/year) was the highest in peninsular Italy in 1994. Abruzzo Region shows significantly higher rates than other central Italian regions. No significant difference in rates between males and females was observed. Seasonality was not observed from incidence data. CONCLUSIONS: We report the highest incidence rate for IDDM in children in the Italian mainland in the years 1990-95. Our findings confirm the need for epidemiological research to provide more information about the distribution of genetic markers and the etiologic role of environmental factors in Italian regions.

Adolescent↗

Towards regional equality in family planning: teenage pregnancies and abortions in Finland from 1976 to 1993.

BACKGROUND: A major goal of Finnish family planning policy since the 1970s has been to minimize unintended pregnancies by providing equal contraception and abortion services throughout the country. This report looks at how this policy has succeeded among teenagers. METHODS: The data on childbirths, induced abortions and mean populations were collected from the national abortion and population registers. Regional and age-specific rates were calculated for fertility, abortions and pregnancies in girls aged 15-19. RESULTS: In 1993, the teenage pregnancy rate was 20/1000 and the abortion rate 9.5/1000 in the whole country. Although the pregnancy rate had dropped by half since the 1970s, the regional differences were still there: the lowest rate was 18/1000 and the highest 29/1000 (in Lapland) in 1991-93. The abortion rate ranged from 8/1000 to 14/1000. Childbirths decreased, particularly at the beginning of the study period, while abortions declined sharply towards the end of the period. In 1986-88, the abortion ratio exceeded 100 in all provinces except two. In the 1990s, it dropped below 100 again except in the capital province. In 16-17 year-olds, the trends were quite equal in different provinces. In 18-19 year-olds, pregnancies remained more frequent in the north and were more often carried to term, while the choice of abortion was more likely in the south. CONCLUSIONS: Equally declining trends in pregnancies in all provinces suggest that teenage family planning services have a comprehensive coverage. However, regional differences still remain and imply a detailed analysis of their reasons.

Abortion, Induced↗

New parents and mental disorders: a population-based register study.

CONTEXT: Studies on postpartum mental disorders among mothers have primarily focused on either depression or psychoses and have generally not included the broader spectrum of mental disorders. A few studies have found that some men have symptoms of depression after becoming fathers, but these studies have not documented whether this exceeds the morbidity among men in general. OBJECTIVES: To estimate the risk of postpartum mental disorders necessitating hospital admission or outpatient contact for mothers as well as fathers during a 1-year postnatal follow-up period after birth of first live-born child and to investigate whether parents in general differ from nonparents in the risk of admission with a mental disorder and how this difference varies with age. DESIGN, SETTING, AND PATIENTS: Register-based cohort formed by linking information from Danish health and civil service registers. A total of 2,357,942 Danish-born persons were followed up from their 15th birthday or January 1, 1973, whichever came later, until date of onset of the disorder in question, date of death, date of emigration from Denmark, or July 1, 2005, whichever came first. From 1973 to 2005, a total of 630,373 women and 547,431 men became parents for the first time, and during the first year after childbirth, these parents contributed 1,115,639 person-years at risk. MAIN OUTCOME MEASURE: First-time psychiatric hospital admission or outpatient contact 0 to 12 months after becoming a parent. RESULTS: A total of 1171 mothers and 658 fathers were admitted with a mental disorder to a psychiatric hospital during the first 12 months after parenthood, and the corresponding prevalence of severe mental disorders through the first 3 months after childbirth was 1.03 per 1000 births for mothers and 0.37 per 1000 births for fathers. Compared with women who had given birth 11 to 12 months prior, primiparous women had an increased risk of incident hospital admission with any mental disorder through the first 3 months after childbirth, with the highest risk 10 to 19 days postpartum (relative risk [RR], 7.31; 95% confidence interval [CI], 5.44-9.81). Among mothers, risk was also increased for psychiatric outpatient contacts through the first 3 months after childbirth, also with the highest risk occurring 10 to 19 days postpartum (RR, 2.67; 95% CI, 1.99-3.59). Unlike motherhood, fatherhood was not associated with any increased risk of hospital admission or outpatient contact. CONCLUSION: In Denmark, the risk of postpartum mental disorders among primiparous mothers is increased for several months after childbirth, but among fathers there is no excess of severe mental disorders necessitating admission or outpatient contacts.

Adult↗

Population and registered vehicle data vs. road deaths.

This paper discusses the use of rates to evaluate the effectiveness of countermeasures and to compare the safety of different countries and of different periods of time. The use of a rate requires an understanding of the shape of the curve relating the two variables. The use of the rates "death per registered vehicle" or "death per vehicle-kilometer" does not provide a consistent measure across time when there is a nonlinear relationship between number of deaths and number of vehicles. Predictive equations with one variable forming both part of the independent and dependent variable will suffer from spurious correlation. Smeed's equation does not predict the number of deaths in the original data set with any degree of overall accuracy, and cannot be assumed to predict accurately the number of deaths in other countries. The use of the number of persons killed rather than the number of fatal accidents might be questioned as one is the outcome of the other. More subdivisions of the total would be of more interest such as the numbers of different road user types within age groups. While deaths might be one of the common currencies of road injuries for comparing countries, there is little excuse for using them for examining trends within one country. Some performance measures that use the number of accidents and the number of persons (injured and uninjured) that are involved in them would be more meaningful than using deaths per vehicle.

Accidents, Traffic↗

Low 5-minute Apgar score: a population-based register study of 1 million term births.

OBJECTIVE: To determine the rate of 5-minute Apgar scores below 7 in term infants (at least 37 weeks) in Sweden during 1988-1997, evaluate the influence of obstetric risk factors on low 5-minute Apgar scores, and to study the infant prognosis regarding infant mortality, neonatal neurologic morbidity, and outcome. METHODS: Data were collected from the Swedish Medical Birth Registry 1988-1997, and the National Hospital Discharge Registry. Odds ratios (OR) and risk ratios were calculated. RESULTS: Among 1,028,705 term newborns, 7787 (0.76%) had 5-minute Apgar scores below 7. The annual rate of low Apgar scores decreased from 0.77% in 1988 to 0.63% in 1992, but thereafter increased to 0.82% in 1998. The highest OR was found for vaginal breech delivery (OR 6.7), birth weights above 5 kg (OR 6.3), and second born twins (OR 4.1). Primiparity, maternal age, smoking, post-date pregnancy, epidural analgesia, male infant gender, and being born at night, were also significant risk factors for Apgar below 7 at 5 minutes. The infant mortality rate was 48 per 1000 (OR 14.4), and the ORs were 31.4 for a diagnosis with cerebral palsy, 7.9 for epilepsy, and 9.5 for mental retardation. CONCLUSION: Several obstetric risk factors are associated with low 5-minute Apgar score in term infants. Mortality and the risk of severe neurologic morbidity are increased in these infants.

Apgar Score↗

Morbidity in responders and non-responders in a register-based population survey.

BACKGROUND: Non-response analysis is often restricted to the influence of age, sex and socio-economic status on response status. In this study the health status of responders and non-responders was also compared. RESULTS: Responders were comparable to non-responders with regard to the number of diagnosed disorders as well as to the prevalences of disorders within body systems. Non-responders only showed psychological disorders more often. CONCLUSION: It is useful to assess the relation between non-response and morbidity patterns in other studies as well, in order to detect selective non-response and bias.

Adult↗

Maternal age and fetal loss: population based register linkage study.

OBJECTIVE: To estimate the association between maternal age and fetal death (spontaneous abortion, ectopic pregnancy, stillbirth), taking into account a woman's reproductive history. DESIGN: Prospective register linkage study. SUBJECTS: All women with a reproductive outcome (live birth, stillbirth, spontaneous abortion leading to admission to hospital, induced abortion, ectopic pregnancy, or hydatidiform mole) in Denmark from 1978 to 1992; a total of 634 272 women and 1 221 546 pregnancy outcomes. MAIN OUTCOME MEASURES: Age related risk of fetal loss, ectopic pregnancy, and stillbirth, and age related risk of spontaneous abortion stratified according to parity and previous spontaneous abortions. RESULTS: Overall, 13.5% of the pregnancies intended to be carried to term ended with fetal loss. At age 42 years, more than half of such pregnancies resulted in fetal loss. The risk of a spontaneous abortion was 8.9% in women aged 20-24 years and 74.7% in those aged 45 years or more. High maternal age was a significant risk factor for spontaneous abortion irrespective of the number of previous miscarriages, parity, or calendar period. The risk of an ectopic pregnancy and stillbirth also increased with increasing maternal age. CONCLUSIONS: Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. This should be taken into consideration in pregnancy planning and counselling.

Abortion, Spontaneous↗