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At least 127 records · Page 7Linked to original sources
PubMed2001

Modified cross-pin femoral fixation using long needles, polydioxanone suture, and traction suture for hamstring anterior cruciate ligament reconstruction.

The use of cross-pin femoral fixation in anterior cruciate ligament (ACL) reconstruction using semitendinosus and gracilis (ST/G) tendons has been shown to be biomechanically sound. As a result of some technical problems that we encountered, we modified the technique of the DePuy OrthoTech Xact ACL Graft Fixation System (DePuy, Warsaw, IN) using No. 2/0 polydioxanone suture (PDS) with long needles normally used for inside-out meniscal repair. In addition, a No. 5 Ethibond suture loop (Ethicon, Somerville, NJ) is used for traction of the ST/G graft up the femoral tunnel. Using a 2-suture loops technique, the traction suture loop offers a more effective in-line pull for the graft and it pulls the ST/G loops slightly higher than the alignment PDS. By so doing, it lessens the chance of kinking the alignment guidewire or even amputating the graft. Although not reported in literature, this type of graft complication is possible in other single-alignment suture or guidewire techniques.

Journal Article↗
PubMed1989

A comparison of scar quality in wounds closed under tension with PGA (Dexon) and Polydioxanone (PDS).

Wounds closed under tension have a tendency to stretch. To assess whether this stretching can be limited by inserting absorbable subcuticular sutures, 28 wounds, which involved elliptical excisions, were closed with PGA and PDS sutures in opposite halves of the same wound. PGA scars were found to be significantly wider than their PDS counterparts and were associated with greater hypertrophy at 6 months.

Adolescent↗
PubMed2005

Biodegradable polydioxanone and poly(l/d)lactide implants: an experimental study on peri-implant tissue response.

Several implants for orbital wall fracture treatment are available at the present, but they have drawbacks: resorption, risk for migration and foreign body reaction. Alloplastic resorbable implants would be advantageous: no removal operation and no donor side morbidity. The purpose of this study was to evaluate the foreign body reaction, capsule formation and mechanical properties of two bioresorbable implants. PDS and SR-P(L/DL)LA mesh sheet (70/30) with solid frame (96/4) implants (SR-P(L/DL)LA 70,96) were placed into subcutaneous tissue of 24 rats. Immunohistochemistry was used to evaluate reactivity for Tn-C, alpha-actin, type I and III collagens and two mononuclear cells: T-cells and monocyte/ macrophage. GPC, DSC and SEM were performed. Student's t-test or nonparametric Kruskall-Wallis test were used for statistical analysis. Histology of peri-implant capsule exhibited an inner cell-rich zone and an outer connective tissue zone around both materials. Tn-C reactivity was high in the inner and alpha-actin in the outer zone. At the end of the study, the difference of type I collagen versus type III collagen reactivity in inner zone was statistically significant (P<0.0001) as was the difference of type I collagen versus type III collagen reactivity in outer zone (P<0.0001). Immunohistochemistry did not reveal any statistical differences of T-cell and monocyte/macrophage reactivity around PDS versus SR-P(L/DL)LA 70,96 implants, nor any differences as a function of time. PDS were deformed totally after 2 months. SR-P(L/DL)LA 70,96 implants were only slightly deformed during the follow up of 7 months. PDS degraded rapidly in SEM observation. Particles were detaching from surface. SEM observation revealed that polylactide implant was degrading from the surface and the inner porous core became visible. The degradation came visible at 7 months. There were cracks in perpendicular direction towards to the long axis of the filaments. M(w) of PDS decreased fast compared to the polylactide implant. Foreign body reaction was minimal to both materials but continued throughout the whole observation period. Mechanically PDS was poor, it looses its shape totally within 2 months. It cannot be recommended for orbital wall reconstruction. New mesh sheet-frame structure (SR-P(L/DL)LA 70,96) approved to be mechanically adequate for orbital wall reconstruction. It seems not to possess intrinsic memory and retains its shape. The resorption time is significantly longer compared to PDS and is comparable to other studied P(L/DL)LA copolymers. Thus, the new polylactide copolymer implant may support the orbital contents long enough to give way to bone growth over the wall defect.

Absorbable Implants↗
PubMed1986

The use of synthetic absorbable suture materials (polyglycolic acid and polydioxanone) in the low pressure circulatory system of growing organisms.

Synthetic absorbable sutures were used for surgery in the cardiovascular low pressure system of growing beagle dogs. Right atrial incisions were closed with this material in 20 dogs. In another 20 dogs caval anastomoses were performed in continuous suture technique. Repeated angiographies and histological examination were performed after observation periods between 5 and 180 days. No clinical complications occurred. Postoperatively patent anastomoses grew with the surrounding tissue, while stenotic anastomoses attained normal luminal diameter after suture absorption. Synthetic absorbable suture materials are recommended for use in the cardiovascular low pressure system, especially in the correction of congenital anomalies.

Animals↗
PubMed1994

The effect of site of implantation and animal age on properties of polydioxanone pins.

Absorbable polymeric orthopaedic pins (Orthosorb) of 2.0 mm diameter were implanted at different sites in mature (3.5 kg, > 5 months) and immature (5 weeks old) rabbits (total 36) for 2, 4, and 5 weeks. The sites of implantation were the medullary canal of the femur, muscles of the thigh and subcutaneous tissue of the dorsum. In mature rabbits, 1.3 mm diameter pins were also implanted in the medullary canal of the femur. The shear strength of the pins harvested from the rabbits, was measured at each time period using a fixture that shears the pins into three parts symmetrically about the load axis. In both mature and immature rabbits the rate of degradation in mechanical properties was higher in the medullary canal of bone than in the muscle and in the subcutaneous tissue (p < 0.05). The strength retention was lower in immature than in mature rabbits after 4 and 5 weeks. The 1.3-mm pins had higher initial strength (174.7 +/- 7 MPa), higher strength retention and slower degradation within the medullary canal of femur of mature rabbits as compared to the 2.0-mm pins (157.5 +/- 4.8). DSC and X-ray diffraction results of control and implanted pins showed higher initial crystallinity and a wider range of crystallite size in the 1.3-mm pins. After 5 weeks in vivo, the crystallinity increased indicating degradation within the amorphous phase. The smaller crystallites underwent recrystallization to form larger crystallites. The results indicate that site of implantation and age of recipient influence the degradation and associated effects on mechanical properties of absorbable implants. The size of the implant, though important in determining its properties, should be considered in association with its microstructure, which also plays an important role in determining strength and strength retention of absorbable polymeric systems.

Aging↗
PubMed2001

Single absorbable polydioxanone pin fixation for distal chevron bunion osteotomies.

The distal chevron osteotomy is a well-established technique for correction of symptomatic mild to moderate metatarsus primus varus with hallux valgus deformity. Fixation of the osteotomy ranges from none to bone pegs, Kirschner wires, screws, or absorbable pins. We evaluated one surgeon's (J.K.D.) results of distal chevron osteotomy fixation with a single, nonpredrilled, 1.3-mm poly-p-dioxanone pin and analyzed any differences in patients with unilateral or bilateral symptomatic metatarsus primus varus with hallux valgus deformities. All osteotomies healed without evidence of infection, osteolysis, nonunion, or necrosis. Equal correction was achieved in unilateral and bilateral procedures. The technique is quick and easy, and adequate fixation is achieved.

Adult↗
PubMed1992

[Ligament repair with PDS (polydioxanone) in chronic insufficiency of the fibular ligament of the upper ankle joint: experimental and clinical experiences].

From September 1988 till February 1989, 14 patients with chronic ligamentous rupture of the ankle had been operated on using PDS-plasty. Of 12 patients checked in follow-up examination (mean postoperative period 45 weeks), only two showed good or very good results. Most patients had the same signs of chronic instability as preoperatively. Two patients had been reoperated on. Intraoperatively we did not find a biological substitute along the PDS guide line. In an experiment on the rat we examined histological changes and tensile strength at appointed times. Histological data showed no biological substitute of PDS. We also found residues of PDS even after 300 days. After a short time loss of tensile strength occurred. In view of an aseptical necrosis that occurred in our experiments, we must point out the risk of foreign body granulomas.

Adolescent↗
PubMed1989

[Use of a cup-shaped implant of polydioxanone in orbital-malar fractures].

Treatment of orbito-malar trauma has two priorities; restoration of the pelvi-orbital integrity and recovery of malar stability. Numerous techniques using various materials, whether or not of autologous origin, have been developed with this aim in mind. The authors report their experience with the PDS bioresorbable orbital prosthesis within the framework of orbito-malar trauma.

Biocompatible Materials↗
PubMed1989

[Postoperative continuous passive motion following augmentation of anterior cruciate ligament ruptures with polydioxanone ligaments. Early results of a prospective study].

During a period of six months 30 patients underwent surgery at the St. Vincenz and Elisabeth Hospital at Mainz (Germany) because of a rupture of the anterior cruciate ligament (ACL). 26 persons could be examined three and six months after surgery. The surgical technique was the PDS augmented suture or the PDS augmented central third of the patellar tendon depending on the age of the rupture. All patients were rehabilitated with early exercises including CPM during the stationary phase. The influence of CPM on swelling, effusion, mobility, muscle atrophy, stability and time of after-treatment will be presented. The findings lead to the conclusion that CPM has great influence on prevention of muscle atrophy and early, unlimited mobility.

Adult↗