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Pharmacy: a profession in transition or a transitory profession?

Areas in pharmacy that are in transition are described, and ways to prevent the perception of pharmacy as a transitory profession are detailed. Pharmacy has adapted itself over the past 75 years to changes in the health-care system and in societal demands of the profession. The evolution of pharmacy functions has included drug product preparation, establishment of standards, drug distribution, and clinical pharmacy. The profession is continuing to change in reaction to economic and social forces. Hospital pharmacy flourished when it shifted from a profit to a cost center because pharmacy practice researchers documented the contribution of clinical pharmacy to patient care and because hospital pharmacy administrators developed sound management procedures to maintain efficient inventories. Current controversies in pharmacy practice are discussed, including pharmacist prescribing, physician dispensing, and therapeutic substitution. These terms inadequately describe the concepts, especially when they are taken out of context of the total health-care process involving a physician-pharmacist team. Because of the success of this teamwork in acute-care institutions, ambulatory pharmaceutical services should involve cooperative activities of pharmacists in professional service administrative organizations (PSAOs) and physicians in independent practice associations. The cost-effectiveness of PSAOs is discussed. Marketing of drug products is changing as the physician-pharmacist interaction becomes integral to the drug therapy decision-making process. Drug distribution should not be viewed as less professional than clinical activities. Although the pharmacy profession is reorienting itself toward patient care and the rational use of drugs in society, it must maintain its authority over the drug distribution system.

Drug Prescriptions↗

Efficiency of different systems for medication distribution in an academic children's hospital in The Netherlands.

BACKGROUND: In the Sophia Children's Hospital, both a ward stock system and a decentralized, patient-orientated, ready-to-use drug distribution system (a 'satellite pharmacy system') exist. Hospital management considered expanding the concept of the satellite pharmacies. Little was known, however, about the efficiency of this drug distribution system, whereas there is increasing pressure to demonstrate the cost-effectiveness of pharmacy services. OBJECTIVE: To analyze the efficiency of satellite pharmacies compared with other medication distribution systems. METHODS: All medication orders and prepared doses were counted. The workload of the two current distribution systems was calculated using the direct time study method. Furthermore, the consequences of altering the distribution system were calculated by formulating nine variants in which certain activities surrounding the medication distribution were moved between nurses and pharmacy technicians. Moreover, we varied the degree of computerization of the medication order registration. RESULTS: The required working hours are the largest in the variants in which nurses do the preparation of the drugs. Moving the distribution of some drug categories, such as ready-to-use drugs, prepared oral drugs, and prepared inhalation drugs, from pharmacy technicians to nurses appeared not to produce noticeable benefits compared with the current distribution system. Expanding the concept of the satellite pharmacies involves a small rise in total working hours compared with the current situation, but does not raise personnel costs. The largest cost savings can be achieved by introducing an on-line computerized physician order-entry system. CONCLUSIONS: The concept of satellite pharmacies offers an efficient distribution system for the Sophia Children's Hospital.

Costs and Cost Analysis↗

Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.

Although the number of prescriptions for psychotropic drugs has decreased in recent years, prescriptions for antidepressants are still increasing (Fritze 2002). Hypericum perforatum (St John's wort) is the main psychotherapeutic herbal medicinal product used for treatment of mild-to-moderate depression. The lipophilic constituent hyperforin (2-5% of the extract) demonstrated, similarly to chemical antidepressants, a significant effect on the synaptosomal uptake inhibition of several neurotransmitters in in-vitro assays. In Germany, St John's wort products are distributed via two different markets: products that are pharmacy restricted are only allowed to be distributed in pharmacies; traditionally used products, which do not claim to have a curative character, are allowed to be sold in supermarkets. Depending on the market wherein a St John's wort product is offered, it needs to fulfill the legal requirements regarding pharmaceutical quality, safety and efficacy. Our goal was to compare the quality of St John's wort products distributed in pharmacies with that of those available from supermarkets. Therefore, the quantity of the pharmaceutical active ingredients (the phloroglucinol derivate hyperforin, the flavonoids rutin, hyperoside, isoquercitrin, quercitrin and the biflavonoid biapigenin) was determined by high-performance liquid chromatography (HPLC). The naphthodianthrones hypericines and pseudohypericines were quantified by differential pulse polarography (DPP). The efficacy of the products was investigated by measuring their activity to inhibit serotonin (5-HT) uptake in-vitro using a radio ligand uptake assay. It could be demonstrated that the products were different not only in the concentration of pharmaceutically relevant ingredients but also in showing individual IC50 values (concentration producing half-maximal inhibition) in the serotonin reuptake assay (IC50 values between 3.07 and 17.9 microg extract mL(-1)). The results of our study confirm the assumption that the potency of St John's wort products in inhibiting the uptake of serotonin depends on the amount of hyperforin in their dosage forms. St John's wort products having greater hyperforin content and potency on synaptosomal serotonin uptake inhibition are restricted to be sold only in pharmacies.

Animals↗

Drug utilization evaluation of nonprescription H2-receptor antagonists and alginate-containing preparations for dyspepsia.

AIMS: To evaluate the use, efficacy and adverse effects of nonprescription H2-receptor antagonists and alginate-containing preparations obtained from community pharmacies. METHODS: Questionnaires were distributed to customers from 39 pharmacies in Scotland and Wales. RESULTS: Of 767 customers recruited, 608 (79.3%) returned an initial questionnaire and 472 (61.5%) customers a second questionnaire. The vast majority of respondents (424, 69.7%) had suffered their symptoms on three or more occasions and 369 (60.7%) had previously tried medicines to relieve their symptoms. Referrals to a doctor were less frequent than recommended in guidelines and few of those who were referred actually saw a doctor. Over a quarter of those returning the second questionnaire claimed to be taking more than one product simultaneously for symptom control. Eight customers who were taking prescribed ulcer-healing drugs obtained H2-receptor antagonists. The majority of respondents (355/472, 75. 2%) obtained some or complete symptom relief using the product obtained and 369/472 (78.2%) were completely satisfied with their product. H2-receptor antagonists were more likely to produce complete relief of symptoms than alginate-containing preparations (P < 0.05). Only 14 respondents (3.0%) reported side-effects from the product used which were mostly gastro-intestinal. CONCLUSIONS: The study demonstrated that drug utilization studies are feasible to carry out in a community pharmacy setting. While the results support published evidence of the efficacy and minimal toxicity of these products, they also highlight the possibility of H2-receptor antagonists being used outwith their licenced indications.

Adult↗

Drug information centers: ASHP's role and effect of clinical pharmacy.

The role of the American Society of Hospital Pharmacists in fostering the drug information movement is described, and the effects of clinical pharmacy practice on drug information centers are outlined. ASHP has been an early and consistent supporter of the pharmacists' role in providing drug information. In 1968 the Society adopted a statement that outlined the role and expected competencies of drug information specialists. Accreditation standards for specialized residencies in drug information practice were adopted in 1982. On a broad scale, drug information pharmacists foster rational drug therapy through input on pharmacy and therapeutics committees. In general, when decentralized drug distribution and clinical pharmacy services are implemented in a hospital, the number of questions asked of a drug information center decreases, but the type of question changes. Drug information pharmacists working with clinical pharmacists provide a communication system for providing other health-care practitioners with information necessary for optimal drug therapy in particular patients. To increase the efficiency of drug information centers, drug information pharmacists must incorporate computer technology into their practice sites.

Drug Information Services↗

Pseudomonas aeruginosa in hospital pharmacies.

The environments of hospital pharmacies and the preparations made in these pharmacies were examined for Pseudomonas aeruginosa. This organism was widely distributed in the pharmacies and was isolated from 9% of preparations. In 11 instances strains of Ps aeruginosa from the preparations bore a close resemblance to strains previously found in the pharmacy environments.

Drug Contamination↗

Analyzing pharmacy charges using DRGs.

Pharmacy charges at a 316-bed community hospital were analyzed using diagnosis-related groups (DRGs). All patients admitted to the hospital between January 1, 1983, and August 31, 1983, were retrospectively categorized by DRG. For the 20 most expensive DRGs for the pharmacy department in terms of pharmacy charges, the following data were compiled: number of patients, total pharmacy charges, mean hospital and pharmacy charges per patient, mean length of stay, pharmacy charges as a percentage of hospital charges, and DRG distribution and total pharmacy charges by major diagnostic category ( MDC ). A total of 10,550 patients were assigned to 390 DRGs. For the 20 most expensive DRGs, the mean total pharmacy charges and number of patients per DRG were $83,457 and 140, respectively. DRG 107 (coronary bypass) and MDC 5 (diseases and disorders of the circulatory system) had the highest pharmacy charges in the respective DRG and MDC categories. Pharmacy charges as a percentage of hospital charges ranged from 4.1% to 32% for the 20 most expensive DRGs. While there appeared to be a direct relationship between high hospital charges and length of stay for the most expensive DRGs, there did not appear to be a direct relationship between these two measures and high pharmacy charges. Until hospitals have data on actual cost per case and on cost per DRG for each department, analysis of pharmacy charge data by DRG for establishing pharmacy priorities may be a reasonable approach.

California↗

Automation in pharmacy: two institutions' experiences with novel distribution systems.

A computerized medication system, implemented at Rochester (MN) Methodist Hospital in 1987, has been adopted by the hospitals at the Mayo Medical Center, Rochester, MN. A key component of the medication system, which uses individualized patient medication envelopes, is the delivery of doses of medications to nursing units just before their administration time. The system has been shown to provide greater nursing support, increase patient safety by reducing medication errors, and decrease both full-time equivalent costs and operating costs. The immediate impact of the system has been to shift dose scheduling from a nursing to a pharmacy responsibility. At Duke University, an automated pharmacy system (APS) has been in operation since October 1993 and is used to dispense the majority of unit dose drugs. The APS provides up-to-the-minute information about the drugs that patients are receiving, which is used to fill each patient's unit dose drawer. It has not dispensed an incorrect drug since its installation and has allowed centralization of the unit dose cart system. Other benefits include decreased billing labor and increased drug usage reporting.

Automation↗

Drug distribution: a philosophy.

Hospital pharmacy has made significant progress in the last two decades by any of a number of program evaluation methods. However equally apparent are our current deficiencies in the level of service provided in our drug distribution systems in Canadian hospitals. It is apparent that we will not be allowed to abrogate our responsibility any longer in that it is becoming recognized in medical, nursing and administrative circles that compounding and dispensing functions are clearly in the realm of a pharmacist's responsibility and these issues must be addressed if we can truly claim to be part of a world class health care system. Hospital pharmacists must take the initiative in accepting responsibility for chemotherapy preparations, I.V. additives and compounding as well as the adoption of a unit dose drug distribution system as a positive means to reduce medication errors. The report of the Hospital for Sick Children Review Committee makes it equally clear that society has expectations of an institutional pharmacy service that are considerably beyond that which we are accustomed to providing. The recommendations relating to pharmacy provide adequate support to facilitate the establishment of a contemporary drug distribution system in Canadian hospitals. Similarly the C.S.H.P. Standards of Pharmacy Practice and the Canadian Council on Hospital Accreditation Guidelines for Pharmacy Service offer additional "ammunition" for us individually and collectively to change the face of hospital pharmacy practice. The profession must take stock of its responsibilities before society insists that someone else take over where pharmacists have failed.

Canada↗

Operating room satellite pharmacies: demographics, services and implementation.

OR (operating room) satellite pharmacies are still a relatively new addition to the system of pharmacy-coordinated drug distribution. For the last ten years, however, hospitals creating OR satellite pharmacies have found that they provide improved service, reduced inventory, better narcotic control and more efficient drug delivery. Hospital Pharmacy and the OR Satellite Pharmacy Bulletin published a questionnaire to obtain information about OR satellite pharmacies from those actively involved in their planning, implementation, and operation. The questionnaire covered three major areas: demographics, functions and services. This article summarizes the results.

Centralized Hospital Services↗

Pharmaceutical services in rural hospitals in Illinois--2001.

The results of a survey characterizing pharmaceutical services in rural hospitals in Illinois are reported and compared with results of a similar survey conducted in 1991. A questionnaire was developed and mailed to pharmacy directors at rural hospitals in Illinois to obtain information about product-related services, the use of technology, clinical pharmacy services, and human resources data (including vacancies) for 2001. Of the 71 surveys that were mailed, 47 pharmacy directors (66%) responded. Respondent hospitals were smaller compared with those responding in 1991 (mean average daily census, 41.0 versus 51.2, respectively). As in 1991, nearly all respondents reported the provision of unit dose services and complete and comprehensive i.v. admixture programs (100% and 83%, respectively, for 2001). Three respondents (6%) reported having a cleanroom facility. The most commonly used technology reported was nursing-unit-based automated drug dispensing cabinets (35%). Nearly all hospitals reported providing drug therapy monitoring, patient education and counseling, pharmacokinetic consultations, and nutritional support. Consistent with national reports, staffing levels and vacancies increased between 1991 and 2001. In 2001, the mean number of full-time equivalents was 7.1, with a pharmacist to technician ratio of 1.0:1.08 and a ratio of pharmacists to occupied beds of 1.0:22.6. The overall vacancy rate was 8%, with a vacancy rate of 14% and 5% for pharmacists and pharmacy technicians, respectively. A 2001 survey of pharmacy departments in rural hospitals in Illinois showed progression in the provision of distributive and clinical pharmacy services since 1991. Employee vacancy rates in pharmacy departments were high in 2001, especially among pharmacist positions, but were lower than those reported for the general population of hospitals.

Automation↗

Survey of Canadian oncology pharmacy services--the emergence of a specialty.

The provision of pharmacy services to oncology is a substantial component of hospital pharmacy practice at several Canadian hospitals. To determine the scope of such pharmacy services a survey was developed and distributed to 103 hospital pharmacies and 11 ambulatory oncology pharmacies in 1988. There were 72 responses (65%), although only 96 centres were known to offer oncology services (adjusted response = 72 of 96 = 75%). Surveys were distributed and returned in reasonable proportion across the country. Inpatient and outpatient services were reported separately, for size of service offered, and categories of work in which staff were employed. Twenty-four of fifty-seven centres report large inpatient pharmacist services, and 21 of 57 had large inpatient technician services. The ratio of pharmacists to technicians appeared to be about equal, but technicians were less likely than pharmacists to be permanently assigned (one-third vs. one-half permanently assigned). About one-half of both large and small services indicate a desire for increased time for both pharmacists and technicians. Outpatient services were reported by fewer respondents, and the job assignments in this setting were mostly permanent. Manpower usage in both settings is primarily dedicated to drug preparation and distribution, although two-thirds of centres report small clinical services (most centres desired increased clinical services). Future planning topics ranked improved clinical services and standardization of practice highest. A 91% majority agree that there should be standards for pharmacy practice in oncology pharmacists in Canada. Many factors, including insufficient clinical services, impede specialty development and recognition, but are priority areas for future development.

Canada↗

Unit dose radiopharmaceutical service as a component of total pharmacy practice.

A unit dose radiopharmaceutical distribution system as a component of total pharmacy services is discussed. The radiopharmacy functions of compounding, calibrating and distributing are rotated on a weekly basis among the staff pharmacists. The elution process and departmental policies and procedures are described. The pharmacist's unique expertise for preparing radiopharmaceutical doses is discussed.

Drug Compounding↗

Fundamentals of medication error research.

Types of medication errors are defined, error detection techniques are described, and the validity of several medication error studies is evaluated. A medication error is generally defined as a deviation from the physician's medication order as written on the patient's chart. In hospitals, medication errors occur at a rate of about one per patient per day. A dispensing error is one made by pharmacy staff when distributing medications to nursing units or directly to patients in an ambulatory-care pharmacy; the error rates for doses dispensed via the cart-filling process range from 0.87% to 2.9%. Categories of medication errors should be operationally defined before an investigation, and any allowable deviations from the physician's order should be clearly stated. Fourteen error category definitions are presented. Methods for detecting medication errors include anonymous self-reports (questionnaires), incident reports, the critical-incident technique (analyses of a large number of individual errors to identify common causal factors), and direct observation (including the disguised-observation and participant observer techniques). Observation is the best error detection method in terms of accuracy. Results of medication error studies were examined for validity and classified into one of four categories: (A) results should be accepted as reported, (B) results overestimate or underestimate the truth by a known amount, (C) results overestimate the truth by an unknown amount, and (D) results should not be accepted. All studies examined for validity used observation as the error detection technique. The following guidelines for observation-based medication error studies were established: The observer should follow the subject to the patient's bedside, the observer should witness patient consumption of each dose, the observer should not be familiar with patient drug regimens before observation, operational definitions must be used, and having an error validation committee can be advantageous. Future studies are needed that focus on the identification and testing of new error prevention methods that use the techniques described.

Data Collection↗

Equipment management guide. Improving the drug distribution process--do you need an automated decentralized pharmacy dispensing system?

In this Equipment Management Guide, we provide guidance to help hospitals determine whether implementing an automated decentralized pharmacy dispensing system (ADPDS) will be an effective way to improve their drug distribution process. We describe the ADPDSs themselves and then discuss factors that hospitals should consider before deciding on such a system. Specifically, we identify several areas that many pharmacies target for improvement and discuss whether and how an ADPDS can help the facility make the desired improvements. We also provide guidance for determining the cost-effectiveness of such a system, as well as for selecting a system that will most appropriately meet the hospital's needs. In the Evaluation that follows this Guide, we present our criteria for evaluating ADPDSs and the results of our testing of three such systems.

Accounting↗