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[1801-2001: two centuries of dermatology and venereology in the Assistance Publique-Hôpitaux de Paris].

The specialization "Dermatology" was born at the Saint-Louis hospital in France in 1801, in the light of the revolutionary reforms that led to fundamental changes in the functioning of the hospitals in Paris. Hence, the Saint-Louis hospital occupies an eminent position in the history of dermatology in France, reinforced by the role of Jean-Louis Alibert, who founded the French school of Dermatology. Despite the place occupied by the physicians of the Saint-Louis Hospital in the creation and development of the French school of dermatology, other physicians in other hospitals contributed to the expansion of the dermatology school. The work of Pierre Rayer, in the nineteenth century, at the Saint-Antoine and subsequently the Charité hospitals, are within this scope. More recently, the re-organization of the Faculty of Medicine into University Hospital Centers has permitted the creation of various treatment, teaching and research centers within the structure of the public hospitals in Paris. From the start, syphilis was part of the Dermatology teaching and practice. In Paris, several so-called "specialized" hospitals were created to house patients presenting with syphilis. Later on, the existence of these hospitals was questioned notably because of the constraints that their functioning imposed on the patients. Anti-venereal care centers were developed in response to the request of the practitioners to facilitate the access to treatment.

Dermatology↗

[The adventures of doctor Jean Matuszinski, friend of Frédéric Chopin, from Warsaw in 1808 to Paris in 1842].

Jean Matuszinski, a Pole born in Warsaw, happened to be the student of a Frenchman who had emigrated to Poland: Nicolas Chopin. French was still widely spoken at that time in Matuszinski's native land. For a while, Matsuzinski was even a boarder in Warsaw, lived with this Franco-Polish family and became a close friend to Nicolas' son, Frederic Chopin. He was the only one who kept in touch with Chopin, despite the many international dramatic events of the time: an insurrection in Poland rapidly squashed by the Russians. Paris became the heart of the intellectual and artistic life for Polish citizens who took refuge there. After spending some time in Germany where Jean Matuszinski received a doctorate in medicine from the university of Tubingen in 1834, he went to Paris where he was delighted to meet again with Frederic Chopin, and received another doctorate from the Faculty of Medicine of Paris. During his short medical career, he was able to observe several forms of tuberculsis: an acute that killed Frederic's younger sister, and a chronic one that affected Frederic for more than fifteen years. But Matuszinski could take care of Chopin only during the first six years of the latter's illness because himself died from a severe subacute form of tuberculosis, when he was only 33 years old.

Famous Persons↗

[Future of premature infants of less than 33 weeks gestational age: results of an inquiry undertaken in 1985 in the Paris region].

Improvements in combining obstetrics and neonatology led to a trend to intervene earlier in premature babies born before the 33rd week of gestational age. The enquiry that was carried out in 1985 in the Paris geographical region had as its objective to assess on the one part how many premature deliveries occurred between the 25th and 33rd week of amenorrhea and on the other hand what happened in the short term to the infants born from these pregnancies, i.e., their mortality; and for those who survived, their quality of life. The study was carried out on a representative sample of the deliveries in 1985 in the four departments of the Paris region--Paris and the three departments of the Petite Couronne--where half of all deliveries were assessed. The enquiry covered 53,430 deliveries for which the overall prematurity rate was 4.5%, and those deliveries that occurred before 33 weeks of gestational age constituted 1.0% (539 babies). Twenty children were lost for follow-up after a year. This was 4.9% of the live births and 6.3% of the live children who left the neonatology centres. At 2 years of age, the numbers that were not followed up were eventually 24, which was 5.8% of live births and 7.6% of those that left the centres of neonatology. The results show a very high rate of antepartum mortality but also of mortality during and after labour. Only 379 infants out of the 539 (70%) were transferred into special care baby units. By 1 year of age, the survivors were 57% of the total number of deliveries and 75% of the live births and 82% of those transferred to the special units. As far as concerned those that were live born, the survival rate at the age of 1 year varied considerably according to the duration of the pregnancy. The number of those that survived a pregnancy of less than 27 weeks was low (31%). It was, at 28 weeks, 53%. This is the age where births have to be registered. It reached 87% of the live births that occurred at 32 weeks. One has to point out that there is no statistically significant difference between 27 and 28 weeks of gestation. Whereas there is a significant difference (p less than 0.05) with those delivered at 29 weeks (75%). 80% of those 291 infants that were examined at 1 year of age were considered to be normal as far as psychomotor and sensorial behaviour was concerned.(ABSTRACT TRUNCATED AT 400 WORDS)

Follow-Up Studies↗

[Creutzfeldt-Jakob disease in the Paris area: ethnic origin of the patients].

Twenty six (27 p. 100) of 96 patients dying from Creutzfeldt-Jakob disease in the Paris metropolitan area between 1968 and 1982 were born in foreign countries although the proportion of foreign-born residents account for only 15 p. 100 of the population. The annual mortality rate of Creutzfeldt-Jakob's disease in this group of foreign-born cases (1.33 per million) was twice that of French-born residents (0.64 per million). Twenty of the 26 foreign-born cases originated from countries surrounding the Mediterranean sea, and 5 of 7 familial cases belonged to 2 Tunisian families. There was no spatial clustering of foreign-born cases and no relationship between their Paris residence and the percent of foreign-born people living in the same area. The disproportionate frequency of Creutzfeldt-Jakob's disease among foreign-born residents thus seems to be a contributing factor to the higher prevalence of Creutzfeldt-Jakob's disease in Paris when compared to the rest of France. It further suggests that the prevalence of Creutzfeldt-Jakob's disease in Mediterranean countries may be greater than expected.

Creutzfeldt-Jakob Syndrome↗

Epidemiological features of Legionnaires' disease in the Paris area.

Although the first French case of Legionnaires' disease (LD) was diagnosed in 1979 and the first six serogroups of L. pneumophila and L. longbeachae serogroup 2 were demonstrated in environmental samples from the Paris area, the incidence of the disease has not yet been evaluated in France. Prevalence of antibodies, as detected by an immunofluorescent assay, in the Paris population of our study ranged from 0.9 to 2.2%. LD was demonstrated in 155 (4.4%) of 3502 patients investigated mainly by serology. In a prospective study in a respiratory intensive care unit 20 (7.8%) cases of pneumonia out of 257 were caused by L. pneumophila. 171 of the 175 cases of LD diagnosed in Paris during 33 months were caused by L. pneumophila serogroup 1. Risk factors and epidemiological features of patients are similar to those described in other countries.

Adult↗

[Registration of congenital malformations in Paris. Evaluation and perspectives of a study carried out under the auspices of the European Economic Community].

Since 1976 a registration of congenital malformations has been gradually set in Paris. At present it covers 95% of the births registered in this department which amount to 38,925 births in 1982. Since 1981, it has been extended to include malformations diagnosed during the first month of life in neonatal units in Paris, for residents in Paris, and also a register of therapeutic abortions for congenital abnormalities. It is part of the 17 registers which have been started on the initiative of the European Economic Community. The results of the frequency of different types of congenital malformation are given for the years 1978 to 1982. The value of this register as epidemiological information and the studies that have been carried out with a view to determining aetiology are discussed.

Congenital Abnormalities↗

[Mental disorders in Japanese living in Paris].

This paper relates the original work of a group of seven young Japanese psychiatrists during their residentship or their foreign assistant function in Paris. During approximately 3 years, they devoïd a part of their activity to assist their japanese copatriots who having developed some mental health accidents during they stay in the district of Paris. From the 28 patients, 15 have been hospitalized in different psychiatric wards of Paris but the french psychiatrists did not take part of the paper. The authors have divided their clinical material into 3 groups of japanese patients: tourists, permanent residents or temporary residents who represents 2/3 of the whole. In each group the incidence of nosographic diagnosis is precise and the transcultural problems are underlined. Finally, all the patients has been sent back to Japan.

Adaptation, Psychological↗

[Epidemiological aspects of osteoarticular tuberculosis in adults. Retrospective study of 206 cases diagnosed in the Paris area from 1980 to 1994].

OBJECTIVES: The aim of this study was to determine the epidemiologic features of bone and joint tuberculosis in the Paris area from 1980 to 1994. METHODS: This retrospective study included 206 cases of confirmed bone and joint tuberculosis (in situ specimen) diagnosed from 1980 to 1994 in 7 hospital units (mainly rheumatology clinics) in Paris and suburban areas. RESULTS: The number of cases increased by a mean 12 per year from 1980 to 1989 then by 17 cases per year from 1990 to 1994. In both 1993 and 1994 there were 21 cases per year. The percentage of immigrant patients was 53% from 1980 to 1989 then reached 74% for 1990-1994, predominantly in subjects from black Africa. Only one patient in the series had human immunodeficiency virus (HIV) infection. A favoring factor was found in 23% of the immigrant and in 45% of the native French patients. Mean age was 37 years in immigrants and 58 years in French patients. Compared with French patients, immigrants had a higher rate of multifocal bone and joint tuberculosis, peripheral osteitis and spondylitus. CONCLUSION: Our findings suggest that the incidence of bone and joint tuberculosis has increased in Paris in 1993 and 1994. Two populations are especially susceptible: the elderly and/or immunodepressed French population and immigrants coming from endemic zones. The role or HIV infection was minimal in this predominantly rheumatology series.

Adult↗

Paris-Trousseau syndrome platelets in a child with Jacobsen's syndrome.

The thrombocytopenia in an infant with clinical features of Jacobsen's syndrome characterized by multiple congenital anomalies, cardiac defects, psychomotor retardation, and deletion of chromosome 11 at 11q23.3 has been evaluated. Study of his platelets in the electron microscope revealed giant alpha granules in his cells identical in appearance to those reported in the family with Paris-Trousseau syndrome. As a result, the Paris-Trousseau syndrome appears to be a variant of the Jacobsen syndrome, and the thrombocytopenia observed in all cases of chromosome 11q23.3 deletion due to dysmegakaryopoieses. Giant alpha granules are frequently observed in normal platelets during long-term storage and may form in Jacobsen and Paris-Trousseau platelets during prolonged residence in the bone marrow.

Abnormalities, Multiple↗

The various shapes of the paries jugularis and the frequency of additional ducts in the fossa jugularis as further factors influencing the spread of pathological processes.

We investigated 100 skulls and found in 8 cases a dehiscence of the paries jugularis. In 7 cases this was on the left side and in 1 case on the right. Thickness of the paries jugularis was estimated by means of a diaphanoscopic technique. We classified data according to four degrees of diaphaneity: 0 (hardly translucent), 1 (translucent), 2 (brightly translucent) and 3 (nearly transparent). The frequencies of these degrees were: 0, 38 cases (19%); 1, 122 cases (61%); 2, 35 cases (17.5%); and 3, 5 cases (2.5%). In investigating the frequency of additional ducts in the paries jugularis, we distinguished between three types of solum tympani: type I, no additional canals (18 cases); type II, 1-10 additional canals (172 cases); and type III, more than 10 additional canals (10 cases).

Adult↗

Hydroxyapatite/calcium carbonate (HA/CC) vs. plaster of Paris: a histomorphometric and radiographic study in a rabbit tibial defect model.

The search for an ideal bone substitute is ongoing. Multiple osteoconductive bone substitutes are available today. Plaster of Paris (POP) (calcium sulfate) has been used for more than 100 years for treatment of skeletal defects. This implant is compared to a new material, hydroxyapatite/calcium carbonate (HA/CC), in a rabbit tibia model. HA/CC is made from partial conversion of coralline calcium carbonate to hydroxyapatite and has an outer hydroxyapatite layer and an inner calcium carbonate core, a combination that leads to faster resorption than that of pure hydroxyapatite. This study compares the histomorphometric and radiographic properties of POP and HA/CC in a rabbit tibial defect. Both implants preferentially restore bone to the cortex relative to the canal. Plaster of Paris was fully resorbed by 6 weeks both radiographically and histometrically and HA/CC was substantially resorbed by 42 weeks. No significant difference was noted in volume fraction of bone between the two implants at 42 weeks postimplantation. Hydroxyapatite/calcium carbonate is a biocompatible bone graft substitute with a rate of resorption significantly slower than plaster of Paris.

Animals↗

A clinical evaluation of plaster-of-Paris and eight synthetic fracture splinting materials.

A number of new synthetic orthopaedic splinting materials, all claiming substantial advantages over the traditional plaster-of-Paris, have been introduced in recent years. However, although their properties have been extensively measured in the laboratory, little has been documented concerning their performance in clinical use. This study was therefore initiated as a comparative evaluation of the clinical characteristics and ease of use of these relatively expensive materials in the fabrication of below-knee weight-bearing casts. The study encompassed nine materials--seven based on water-activated polyurethanes, one thermoplastic and plaster-of-Paris, and involved a total of 203 patients. It was concluded that plaster-of-Paris should be used for all routine splinting applications, but that in cases in which cast weight, cast bulk, or the time to bearing weight is important, a synthetic material, chosen principally on the basis of cost, is indicated.

Adolescent↗

Heat generation in plaster-of-Paris and resulting hand burns.

Four female pupils at a technical school received hand burns while trying to make moulds of their hands using a dental plaster instead of ordinary plaster-of-Paris. In three cases the burns were so severe that several fingers had to be amputated due to irreversible tissue damage. The severity of the burns is explained on the basis of an experimental study where it was demonstrated that the temperature of hardening dental plaster rose to 70 degrees C and had a hardness that was 10-times greater than ordinary plaster-of-Paris. This should serve as a warning against the use of dental plaster in direct casting of living tissue. However, the technique used here is also considered dangerous, as ordinary plaster-of-Paris under certain circumstances could also cause severe burns.

Adolescent↗

Hydrocarbon pollution fixed to combined sewer sediment: a case study in Paris.

Over a period of two years (2000-2001), sediment samples were extracted from 40 silt traps (STs) spread through the combined sewer system of Paris. All sediment samples were analysed for physico-chemical parameters (pH, organic matter content, grain size distribution), with total hydrocarbons (THs) and 16 polycyclic aromatic hydrocarbons (PAHs) selected from the priority list of the US-EPA. The two main objectives of the study were (1) to determine the hydrocarbon contamination levels in the sediments of the Paris combined sewer system and (2) to investigate the PAH fingerprints in order to assess their spatial variability and to elucidate the PAH origins. The results show that there is some important inter-site and intra-site variations in hydrocarbon contents. Despite this variability, TH and PAH contamination levels (50th percentile) in the Parisian sewer sediment are estimated at 530 and 18 microg g(-1), respectively. The investigation of the aromatic compound distributions in all of the 40 STs has underlined that there is, at the Paris sewer system scale, a homogeneous PAH background pollution. Moreover, the study of the PAH fingerprints, using specific ratios, suggests the predominance of a pyrolytic origin for those PAHs fixed to the sewer sediment.

Cities↗

An evaluation of plaster of Paris barriers used under various materials to repair furcation perforations (in vitro study).

The present study was undertaken to evaluate the effect of plaster of Paris barriers on the sealing ability of various materials when used to repair furcation perforations. The study was conducted on 90 human permanent molars with well developed, nonfused roots. Access openings and furcation perforations were prepared in the pulp chamber floor. The teeth were divided into one control and five experimental groups of 15 teeth each. In the experimental group, plaster of Paris barriers were created in the perforations and then sealed with silver amalgam, glass ionomer (GI), self-cured composite resin, IRM, or AH26. Access openings were filled with composite resin. The teeth were submerged in a solution of 2% methylene blue dye for 2 wk. Finally, the samples were sectioned and evaluated for linear dye leakage and analyzed statistically. Maximum dye penetration was observed in amalgam followed in a decreasing order by GI, composite, IRM, and AH26. AH26 showed the best sealing ability in the presence of plaster of Paris barriers followed by IRM, composite resin, and GI. Amalgam showed the poorest sealing ability when used to repair furcation perforations.

Analysis of Variance↗

Detection of saponins in extracts from the rhizomes of Paris species and prepared Chinese medicines by high performance liquid chromatography-electrospray ionization mass spectrometry.

A highly sensitive and specific method, based on high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS), was developed for simultaneous detection of eleven steroidal saponins and one phytoecdysone in extracts from the rhizomes of thirteen PARIS species and four prepared Chinese medicines (PCMs). The HPLC experiments were performed by means of a reversed-phase C18 column (4.6 mm x 150 mm, 5 microm) and mobile phase system consisting of 0.1 % aqueous formic acid and acetonitrile under gradient elution conditions. The most intensive electrospray ionization signals were found in the negative ion spectra due to HCOO- adducts. The limits of detection (LODs) for the saponins were lower than 40 ng/mL in selected ion monitoring (SIM) mode. The identification of the saponins in the extracts of PARIS species and PCMs was confirmed using their retention times and mass spectral comparisons to standard compounds. The validated method was successfully applied for simultaneous detection of twelve standard compounds in the analytes so that it provided a new means for quality evaluation of Rhizoma Paridis and Chinese multiherb remedies that contain Rhizoma Paridis. The results showed that most species of PARIS contain steroidal saponins, which provided evidence for expanding the botanical origin of Rhizoma Paridis.

Chromatography, High Pressure Liquid↗

Description of the banding patterns of human chromosomes by acriding orange reverse banding (RFA) and comparison with the Paris banding diagram.

A reference diagram is presented which is comparable to the Paris banding diagram but which was based primarily on chromosomes studied by acridine orange reverse banding. Comparison with the Paris Conference (1971) banding diagram was made. Bands were combined in 13 instances and subdivided in 10 cases. The number of bands was found to depend primarily upon the length and quality of the chromosomes. No major differences between the present diagram and the Paris banding diagram were observed. Moreover, the results with acriding orange reverse banding were comparable to those previously reported with Giemsa R banding. In addition, sequential Q banding and R banding were carried out in the same cells. No significant differences in resolution of bands were observed when these two techniques were compared.

Acridines↗

Metabolic activity of Glomus intraradices in Arum- and Paris-type arbuscular mycorrhizal colonization.

Colonization of two plant species by Glomus intraradices was studied to investigate the two morphological types (Arum and Paris), their symbiotic interfaces and metabolic activities. Root pieces and sections were stained to observe the colonization and metabolic activity of all mycorrhizal structures. There were no growth responses observed in the plants caused by mycorrhizal symbiosis. The two morphological types had a similar percentage of root colonized, but the Arum-type had higher metabolic activity. Most of the mycorrhizal structures (88%) showed succinate dehydrogenase activity; about half showed acid phosphatase activity; and a small percentage showed alkaline phosphatase activity. Phosphatase activity was highest in arbuscules and low in intercellular hyphae in the Arum-type colonization. In the Paris-type, hyphal coils and arbusculate coils showed a similar intermediate percentage of phosphatase activity. We conclude that acid phosphatase is more important than alkaline phosphatase in both colonization types. We discuss the possibility that, whereas arbuscules in Arum-type are the main site for phosphorus release to the host plant, both the hyphal and arbusculate coils may be involved in the Paris-type.

Acid Phosphatase↗