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[Aroma and perfume allergy: anathema for some epicurean appeal?].

Aromas and fragrances are present in many cosmetics, some topical drugs, food and various hygiene, household and industrial products. They can be responsible for contact dermatitis. Multiple sensitizations can even involve in various combinations some fragrance compounds, a given degradation product or a contaminant. The diagnosis relies on clinical examination and oriented anamnesis. A histological examination is sometimes necessary. Specific path testing brings insight on the culprit chemical compounds.

Dermatitis, Contact↗

Perfume dermatitis.

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Dermatitis↗

Perfume dermatitis in children sensitized to balsam of Peru in topical agents.

Hjorth in his classic monogram "Eczematous Allergy to Balsams" emphasized that sensitization to balsam of Peru is most important since secondary allergens such as "fragrances" are ubiquitous. The application of a topical medication containing balsam of Peru to the skin of an infant, particularly in the occluded diaper area, seems a great way to sensitize the infant not only to balsam of Peru but also to our fragrant environment.

Administration, Topical↗

[Modification of Alcomat breath alcohol measurements by various substances of routine use (mouthwash, perfume, after-shave lotion etc].

This paper presents the reliability of the "BAC-values" (AAKB) at the application and consumption of substances of daily usage, ascertained with the help of the "Alcomat". Hereby it was found that especially at the application of preparations for the mouth- and throat-hygiene like toilet lotion values of max. 0.30% had to be taken into consideration, even if there was no "alimentary" alcohol existing in the blood.

Accidents, Traffic↗

Liquid chromatographic-fluorometric determination of cinnamyl alcohol in perfumes, colognes, and toilet waters.

A liquid chromatographic (LC) method is described for the determination of cinnamyl alcohol (3-phenyl-2-propen-1-ol) in fragrance compositions. The fragrance product is partially cleaned up by diluting the fragrance with a 95% ethanol-water mixture and passing it through a short column containing RP-8 packing. An aliquot of the effluent is then analyzed by LC using an RP-18 column interfaced to a spectrophotofluorometer equipped with double monochromators. The fluorescence emission intensity of the eluted cinnamyl alcohol is measured and compared with that of a standard to calculate the amount of cinnamyl alcohol present. Recoveries from fragrance products fortified with cinnamyl alcohol at levels ranging from 0.0020 to 0.060 mg/mL ranged from 85 to 105% with a mean of 94%. The lowest level of determination was 0.0005 mg/mL.

1-Propanol↗