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Health care, information needs, and outreach: reaching Ohio's rural citizens.

As a rural state, Ohio has a vital interest in addressing rural health and information needs. NetWellness is a Web-based consumer health information service that focuses on the needs of the residents of Ohio. Health sciences faculty from the state's three Carnegie Research I universities--University of Cincinnati, Case Western Reserve University, and The Ohio State University--create and evaluate content and provide Ask an Expert service to all visitors. Through partnerships at the state and local levels, involving public, private, commercial, and noncommercial organizations, NetWellness has grown from a regional demonstration project in 1995 to a key statewide service. Collaboration with public libraries, complemented by alliances with kindergarten through twelfth grade agencies, makes NetWellness Ohio's essential health information resource.

Health Education↗

Oral health status and access to dental care for ohio head start children.

PURPOSE: The purpose of this survey were to assess the dental caries prevalence rate among children enrolled in Ohio's Head Start programs and assess factors relating to their dental care access. METHODS: Oral screenings were conducted on 2,555 children, ages 3 through 5 years, at 50 Ohio Head Start centers using probability-proportional-to-size sampling. In addition, parental responses to 6 access-oriented questions on the consent form were analyzed. RESULTS: Overall, 38% of 3- to 5-year-old Head Start children screened had experienced dental caries, and 28% had at least 1 untreated decayed tooth. Of the children with caries experience, 73% had decayed teeth, while the remaining 27% had restorations only. Among children, there were no statistically significant differences associated with race or payment method. With regard to dental care access, 11% of Head Start parents reported they could not get wanted dental care for their children during the previous 12 months, most often due to cost of care/lack of insurance. Nine percent of children had a toothache in the previous 6 months. Although 85% of Head Start children had visited a dentist in the previous 12 months, another 10% had never visited a dentist. CONCLUSIONS: The significant prevalence rate of dental caries among Ohio Head Start children is consistent with other states' reports. Although almost 9 of 10 children visited a dentist during the year, three fourths of children with dental caries did not have their care completed by the time they were screened during the second half of the school year. Oral health disparities according to race and payment source were not found among Ohio Head Start children.

Child, Preschool↗

Dietary fluoride supplements for Ohio children--the role of the physician.

1. All children should receive one form of systemic fluoride and appropriate forms of topical fluoride. 2. If a child is not receiving optimally fluoridated water, the physician or dentist should prescribe dietary fluoride supplements (tablets or drops). 3. The correct dosage must be determined based on patient age and fluoride content of the patient's main water source(s). 4. Special attention is necessary concerning fluoride intake for children breast-feeding or consuming infant formula. 5. To determine the correct fluoride dose, these steps should be followed: A. Always have a sample of the main drinking water source (usually home water) analyzed for the fluoride content before prescribing a fluoride supplement, if you do not have other specific knowledge of water fluoride content. The Ohio Department of Health, Division of Laboratories can provide water fluoride-testing services. B. When the fluoride content of the water has been determined, the fluoride level and the child's age should be compared to the Supplemental Fluoride Dosage Schedule to identify the correct supplement dose. 6. The Division of Dental Health, Ohio Department of Health can provide a list of communities that are optimally fluoridated. Please contact: Ohio Department of Health Division of Dental Health 246 N. High Street Columbus, Ohio 43266-0588 (614) 466-4180

Administration, Oral↗

Selenium content of foods purchased or produced in Ohio.

Approximately 450 samples of about 100 types of foods consumed by rural and urban Ohioans were analyzed for selenium. Meat, dairy products, eggs, and grain products produced in Ohio have considerably lower selenium content than corresponding products produced in high selenium areas, such as South Dakota. Retail Ohio foods with interregional distribution tended to be higher in selenium content than corresponding foods produced in Ohio. Best sources of selenium in Ohio foods commonly consumed were meat and pasta products. Poor sources of selenium were fruits, most vegetables, candies, sweeteners, and alcoholic and nonalcoholic beverages. Establishment of an accurate data base for selenium depends on knowledge of the interregional distribution of foods, the selenium content of foods at their production site, and the selenium content of foods with wide local distribution.

Food Analysis↗

An analysis for temporal variation in Down syndrome births in Ohio, 1970-1979.

Our study investigates the epidemiology of Down syndrome (DS) in the state of Ohio during the 1970s. The occurrence of DS births was examined to learn if statistically significant temporal variation was present among these data. Both monthly and annual numbers of DS births, adjusted for changing numbers of live births, were tested for such variation; furthermore, the data were analyzed for cyclic variation by attempting to fit simple trigonometric functions to the data. Individuals with DS were ascertained using the records of cytogenetics laboratories and birth certificate records. Demographic data such as race, date of birth, and maternal age were collected on these individuals using their birth certificates as the data source. Appropriate parallel live-birth data were obtained from the Ohio Department of Health. The total number of affected individuals ascertained was 1,364, 66.7% of the total estimated population size. The data analysis was restricted to whites only (1,203 individuals) because they represented a more homogeneous sample than the total.Monthly and annual variation in the numbers of live births was removed by producing single-year maternal-age adjusted numbers of DS births using the total Ohio white live births as the reference population. Analysis of covariance using single-year maternal ages </= 16 and >/= 45 as the covariate was used to analyze the adjusted numbers of DS births for temporal variation. No significant differences were detected among the annual adjusted numbers of DS births (P = .24), nor were there differences among the monthly adjusted numbers of DS (P = .37). The modes of ascertainment were tested to learn if there were annual or monthly differences in the method of ascertainment. No significant differences were detected for these data (P = .82 and P = .85, respectively). Furthermore, the data were separated into the maternal-age categories < 35 and >/= 35, and annual and monthly adjusted DS births to these two maternal-age categories were examined for temporal variation. No significant differences were found among these data, P > .10 for all four of the tests. No simple cyclic functions were found to fit either the annual or monthly data. The Ohio study reported here showed that through the use of a large sample, controlling for variation in the numbers of live births, and the use of detailed statistical tests, no significant temporal variation in the occurrence of DS births existed during the 1970s.

Adult↗

Reservoir of St. Louis encephalitis virus in Ohio bats.

Inoculation of the big brown bat (Eptesicus fuscus) with a small dose of a St. Louis encephalitis (SLE) virus strain isolated in Ohio indicated that the big brown bat was susceptible to infection. The virus was maintained in the bats through hibernation (70 days), and the bats developed a viremia within 4 days of arousal from hibernation (105 days after inoculation). A field survey of 390 big brown bats and little brown bats (Myotis lucifugus) conducted in 5 regions of Ohio during 1979 to 1981 revealed a SLE virus-neutralizing antibody prevalence of 9%. Cohabitation of natural caves and abandoned mineshafts in Ohio by Culex pipiens mosquitoes, big brown bats, and little brown bats was also documented. Demonstration of a 9% prevalence rate of neutralizing antibody to SLE virus in big brown bats and little brown bats in Ohio during a nonepizootic period indicated that the bat may be involved in the maintenance of SLE virus in enzootic foci and could have a role in dissemination of SLE virus to epizootic foci.

Animals↗

Use of cocaine during the immediate prepartum period by childbearing women in Ohio.

Despite widespread concern about exposure of infants in utero to cocaine, population-based data regarding the prevalence of such exposures are limited. An official task force in Ohio called for studies to generate such data for that state. During three weeks in late 1990, urine was obtained within 48 hours of birth from 1,819 infants born in 25 Ohio hospitals randomly selected from a pool of hospitals accounting for over 80% of Ohio births. Maternal age, race/ethnicity, and residence information were collected so that results could not be linked to individual mothers or infants. Urines were screened for benzoylecgonine (BZE), a cocaine metabolite, using a commercially available immunoassay. The crude prevalence of BZE positivity was 2.0%. When adjusted for unequal cluster sizes and race/ethnicity, the prevalence was 1.4%. The adjusted prevalence for infants born to black mothers was 7.2%, for infants born to white mothers, 0.3%. Ninety-seven percent of the mothers whose infants tested positive were residents of a city of 20,000 or more people. The use of hospital maternity units as a basis for anonymous sampling, as demonstrated in this study, may be a useful model for other jurisdictions seeking population-based data concerning perinatal drug exposures. Such methods may be especially useful for trend studies and program evaluation. In this study, we found widely distributed prepartal cocaine usage in Ohio. Black newborns were significantly more likely than white newborns to show evidence of recent cocaine exposure.

Adolescent↗

Mental health and substance abuse parity: a case study of Ohio's state employee program.

BACKGROUND: In the United States, insurance benefits for treating alcohol, drug abuse and mental health (ADM) problems have been much more limited than medical care benefits. To change that situation, more than 30 states were considering legislation that requires equal benefits for ADM and medical care ("parity") in the past year. Uncertainty about the cost consequences of such proposed legislation remains a major stumbling block. There has been no information about the actual experience of implementing parity benefits under managed care or the effects on access to care and utilization. AIMS OF THE STUDY: Document the experience of the State of Ohio with adopting full parity for ADM care for its state employee program under managed care. Ohio provides an unusually long time series with seven years of managed behavioral health benefits, which allows us to study inflationary trends in a plan with unlimited ADM benefits. METHODS: Primarily a case study, we describe the implementation of the program and track utilization, and costs of ADM care from 1989 to 1997. We use a variety of administrative and claims data and reports provided by United Behavioral Health and the state of Ohio. The analysis of the utilization and cost effect of parity and managed care is pre-post, with a multiyear follow-up period. RESULTS: The switch from unmanaged indemnity care to managed carve-out care was followed by a 75% drop in inpatient days and a 40% drop in outpatient visits per 1000 members, despite the simultaneous increase in benefits. The subsequent years saw a continuous decline in inpatient days and an increased use of intermediate services, such as residential care and intensive outpatient care. The number of outpatient visits stabilized in the range of 500-550 visits per 1000. There was no indication that costs started to increase during the study period; instead, costs continued to decline. A somewhat different picture emerges when comparing utilization under HMOs with utilization under a carve-out with expanded benefits. In that case, the expansion of benefits led to a significant jump in outpatient utilization and intermediate services, while there was a small decrease in inpatient days. Insurance payments in 1996/1997 were almost identical to the estimated costs under HMOs in 1993. CONCLUSIONS: In contrast to the emerging inflation anxiety regarding overall health care costs, managed care can provide long-run cost containment for ADM care even when patient copayments are reduced and coverage limits are lifted. This may differentiate ADM care from medical care and reasons for this difference include the state of management techniques (more advanced for ADM care), complexity of treatments (much higher technology utilization in medical care) and demographic factors (medical, but not behavioral health, costs increase as the population ages). IMPLICATIONS FOR HEALTH POLICY: The experience of the state of Ohio demonstrates that parity level benefits for ADM care are affordable under managed care. It suggests that the concerns about costs that have stymied ADM policy proposals are unfounded, as long as one is willing to accept managed care. IMPLICATIONS FOR RESEARCH: The continuing decline in costs raises concerns that levels of care may become insufficient. While concerns about costs being too high dominate the policy hurdle for parity legislation at this moment, the next step in research is to address quality of care or health outcomes, areas about which even less is known than about costs.

Journal Article↗

Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.

Amino acid changes that influence activity and resistance to beta-lactams and beta-lactamase inhibitors were explored by constructing the Gly238Ser and Met69Ile-Gly238Ser mutants of the OHIO-1 beta-lactamase, a class A enzyme of the SHV family. The Km values of cefotaxime and ceftazidime for OHIO-1 and Met69Ile beta-lactamases were > or = 500 microM. The Km of cefotaxime for the Gly238Ser beta-lactamase was 26 microM, and that of ceftazidime was 105 microM. The Km of cefotaxime for the Met69Ile-Gly238Ser beta-lactamase was 292 microM, and that of ceftazidime was 392 microM. For the beta-lactamase inhibitors clavulanate and sulbactam, the apparent Ki values for the Met69Ile-Gly238Ser enzyme were 0.03 and 0.15 microM, respectively. Relative Vmax values indicate that the Met69Ile-Gly238Ser mutant of the OHIO-1 beta-lactamase possesses cephalosporinase activity similar to that of the Gly238Ser mutant but diminished penicillinase activity. In an Escherichia coli DH5alpha strain that possesses a Met69Ile beta-lactamase of the OHIO-1 family, the added Gly238Ser mutation resulted in a phenotype with qualities that confer resistance to expanded-spectrum cephalosporins and, to a lesser extent, beta-lactamase inhibitors.

Cephalosporin Resistance↗

Analysis of 16S rRNA and 51-kilodalton antigen gene and transmission in mice of Ehrlichia risticii in virgulate trematodes from Elimia livescens snails in Ohio.

Operculate snails (the family Pleuroceridae: Elimia livescens) were collected between June and October 1998 from a river in central Ohio where repeated cases of Potomac horse fever (PHF) have occurred. Of collected snails, consistently 50 to 80% carried a combination of cercariae and sporocysts of digenetic virgulate trematodes. The trematodes obtained from each snail were pooled and tested for Ehrlichia risticii, the agent of PHF, by nested PCR using primers specific to the 16S rRNA gene. Out of a total of 209 trematode pools, 50 pools were found to be positive by PCR. The DNA sequence of the 16S rRNA gene identified in one trematode pool was identical to that of the type strain of E. risticii, and the sequence of the gene identified in another pool differed from that of the type strain by 1 nucleotide. Comparison of the deduced amino acid sequence of the partial 51-kDa antigen gene from various sources revealed that Maryland, Ohio (except Ohio 081), and Kentucky strains are in a cluster distinct from the sequences obtained from sources in California and Oregon. Ohio 081 was shown previously by antigenic composition analysis to be distinct from other groups. However, all sequences examined were not segregated according to their sources: horse blood or infected trematodes. E. risticii was found to be transmittable from trematodes to mice and was subsequently passaged from infected mice to additional mice, as determined by PCR analysis. Our findings suggest the evolution of E. risticii in the natural reservoir in separate geographic regions and persistent infection of trematode populations with E. risticii during summer and early fall. The study also suggests that the mouse can be used to isolate E. risticii from the infected trematode.

Amino Acid Sequence↗

Ohio legal entanglement: A.W. Lensgraf, D.C.: 1927-1935.

The purpose of this paper is to illustrate the legal frustration of the early practice life during the late 1920s and 1930s in Ohio of Arthur William Lensgraf, D.C., a rank-and-file practicing Palmer graduate who, early on in his career, was an ardent supporter of B.J. Palmer and "the good ole P.S.C." At this time, B.J.'s influence on the profession was at an all time high; and he did not refrain from exerting it in Ohio. Attention will be paid to the arrest and constant threat of imprisonment since, during this time, the licensing laws present in Ohio were ambiguous at best. The Platt-Ellis law that was passed in 1915 and enacted in 1916 compromised medical and chiropractic forces into defining chiropractic as a "limited branch of medicine and surgery" placing it directly under the thumb of the Ohio state medical board.

Chiropractic↗

Multiresistant Salmonella ohio infections at the University Hospital of the West Indies.

During 1982-83 there was a substantial increase in the number of S. ohio infections at the University Hospital of the West Indies, which coincided with the appearance of strains resistant to chloramphenicol, cotrimoxazole, ampicillin, neomycin and carbenicillin. Multiresistant strains of S. ohio accounted for 19.3% of all salmonella isolates during this period and all of 40 strains tested were able to transfer resistance determinants to E. coli K12 J 53-2. S. ohio was cultured from stool (60), blood (5), wounds and abscesses (4) and postmortem material (2). Eighty-six per cent of S. ohio infections occurred in children of 3 years old or less. There was a high incidence of gastroenteritis in malnourished children, a 14% incidence of localizing infections and a 7% incidence of septicaemia. Two infants with severe gastroenteritis and bronchopneumonia died. There were a number of unusual infections including two cases of septicaemia in children receiving chloramphenicol for Haemophilus influenzae meningitis, a scrotal abscess secondary to extravasation of urine and infected scabies in a child with marasmic kwashiorkor.

Adolescent↗

Generalist physicians in nonmetropolitan countries in Ohio.

OBJECTIVE: To identify by specialty (family practice, general internal medicine, and general pediatrics) the number and ratios of generalist physicians per 100,000 population in nonmetropolitan counties in Ohio and to describe the trends in these data from 1975 through 1990. DESIGN: The data were compiled on a country basis by physician census takers residing in each county in Ohio. The US Office of Management and Budget's definition of nonmetropolitan counties formed the basis of the calculations. RESULTS: In nonmetropolitan counties of Ohio, generalist physician numbers and ratios improved between 1975 and 1990 in general internal medicine (from 5.9 to 10.2 per 100,000 population) and general pediatrics (from 2.6 to 4.9 per 100,000 population) but not in family practice, which experienced a decrease from 31.0 to 28.7 per 100,000 population. Eight counties with no hospitals were unable to attract general internists or general pediatricians. CONCLUSIONS: The results of this study indicate the importance of characterizing generalist physician workforce data by specialty and practice location on a state-wide basis and suggest that increasing the supply of physicians does not greatly improve the geographic distribution of the medical workforce. These findings should affect the development of local, state, and federal physician workforce policies aimed at addressing the problem of physician geographic maldistribution.

Family Practice↗

Evolution of the dentition in prehistoric Ohio Valley Native Americans: II. Morphology of the deciduous dentition.

In order to evaluate the microevolutionary dynamics of morphological features of the deciduous dentition, I collected data on the variation of 57 features (33 crown and 24 root) from prehistoric Ohio Valley populations. I sampled a total of 370 individuals from 26 populations representing a lineage that inhabited the middle and upper Ohio valley region from approximately 3000 to 350 BP. Evolutionary changes in the frequencies of morphological features of the deciduous teeth in this lineage were limited. Over 80% of the features show no significant differences among the populations. The relatively few features that show consistent differences separate pre- and postmaize agricultural populations. I discuss explanations for this change in terms of selection differences or gene flow. The general pattern of morphological trait expression in the deciduous teeth of this Ohio Valley lineage corresponds to what has been termed the Mongoloid dental complex (sinodonty in the permanent teeth). I suggest additional features that, with further study, may be added to this morphological complex.

Biological Evolution↗

Size and morphology of the permanent dentition in prehistoric Ohio Valley Amerindians.

Metric and morphological characterizations of the permanent teeth from a total of 155 prehistoric Amerindians are presented. The individuals represent samples from three Ohio Valley burial complexes (considered together as the Late Diffuse group): Glacial Kame, Adena and Ohio Hopewell. Metric data include common measures of central tendency and dispersion. From these measures estimates and analyses of the magnitude of sexual dimorphism and relative variability are presented as well as analyses of the patterns of these estimates. Forty morphological characters are also tabulated. The results indicate a number of provisional hypotheses: the generally larger tooth size of the Late Archaic Indian Knoll when compared to the Late Diffuse groups is consistent with the hypothesis of mitigated selective pressures in more technologically advanced groups; although tooth size is smaller in the Late Diffuse groups, dental morphology is as complex, or more so when compared to the Indian Knoll group. Since morphology and size do not covary exactly the biocultural forces resulting in smaller tooth size do not seem to act as strongly on dental morphology; odontological differences within the Late Diffuse arise primarily between the Glacial Kame-Adena and the Ohio Hopewell. These differences correspond to major biocultural changes in this area; although provisional hypotheses concerning odontological variability are erected, hypotheses concerning evolutionary trends must await the discovery of evolving lineages within these groups; similarities are noted among all compared groups including the pattern and magnitude of sexual dimorphism and relative variability. These parameters may be similar for all eastern Amerindians during this period; finally, the morphology of the deciduous dentition, which generally predicts that of the permanent teeth, is found to be less complex than the permanent teeth. This may be the result of a selective disadvantage for the individuals in the deciduous dentition sample which is reflected in the dentition.

Cuspid↗

Temporal changes in Ohio amniocentesis utilization during the first twelve years (1972-1983), and frequency of chromosome abnormalities observed.

The history of amniocentesis utilization in the seventh largest state of the United States is documented from its inception in 1972 through the first half of 1984. Amniocentesis utilization ratios for Ohio residents aged greater than or equal to 35 have increased from 0.21 per cent (19/9091) in 1972 to 23.4 per cent (1655/7531) in 1983, representing an average annual growth rate of 43.1 per cent. Of the amniocenteses performed from January 1, 1978-July 1, 1984, 71 per cent were referred for advanced maternal age (greater than or equal to 35), 15 per cent for maternal anxiety (30-34), 10 per cent for family history or previous child with a genetic defect, and 4 per cent for other reasons. Between 1978-1983 utilization by women 45 years of age was only 20 per cent higher than women 35 even though their risk of giving birth to a Down syndrome child was bout one order of magnitude higher. In addition, various factors were tested as to whether they affected utilization of amniocentesis by women greater than or equal to 35 during 1978-1983. A strong correlation of +0.89 existed between county population size and utilization ratios. No difference in utilization was found between whites and nonwhites, regardless of county population size. When utilization ratios were compared separately between Protestants, Catholics and other religions in Ohio's most populated county, no statistical differences were found. From 1978-July 1, 1984, the frequency of all cytogenetically abnormal chromosome results observed in Ohio amniocenteses to women greater than or equal to 35 was 2.48 per cent (187/7536). Of these, 2.15 per cent (162/7536) had unbalanced karyotypes. Future maximum amniocentesis utilization for women greater than or equal to 35 is estimated at 60-70 per cent.

Adult↗

Municipal sewage sludge application on Ohio farms: health effects.

A 3-year prospective epidemiologic study was conducted on 47 farms receiving annual applications of treated sludge (average of 2-10 dry metric tons/ha/year) and 46 control farms in three geographic areas of Ohio. On the sludge-receiving farms 164 persons (78 families) and on the control farms 130 persons (53 families) participated by cooperating with monthly questionnaires concerning their health and their animals' health, annual tuberculin testing, and quarterly blood sampling for serological testing. The estimated risks of respiratory illness, digestive illness, or general symptoms were not significantly different between sludge farm and control farm residents. Similarly, there were no observed differences between disease occurrence in domestic animals on sludge and on control farms. No conversions from negative to positive tine test results occurred after sludge had been applied to the farms. The frequency of serological conversions (fourfold or greater rise in antibody) to a series of 23 test viruses and the frequency of associated illnesses were similar among persons on sludge and control farms. The absence of observed human or animal health effects resulting from sludge application in this study of Ohio farms was associated with low sludge application rates which were in accordance with Ohio and U.S. Environmental Protection Agency guidelines. Caution should be exercised in using these data to predict health risks associated with sludges containing higher levels of disease agents and with higher sludge application rates and larger acreages treated per farm than used in this study.

Adolescent↗

Concurrent infections of Giardia and Cryptosporidium on two Ohio farms with calf diarrhea.

Giardia and Cryptosporidium infections were diagnosed by immunofluorescence assay on two Ohio dairy farms with calf diarrhea problems. On the first farm, all nine diarrheic calves sampled once in June had Giardia cysts in their feces. On the second farm, all five diarrheic calves examined at the beginning of the diarrhea outbreak in March had Giardia infection. When resampled, the overall infection rate of normal and diarrheic calves was 82.4% in April, and 40.0% in August after the diarrhea subsided. Positive calves ranged from 11 to 164 days of age, and 22.2% of them were as young as 1 to 3 weeks of age. Eight of nine diarrheic calves (88.8%) on the first farm had Cryptosporidium infection. Lower infection rates (< 30%) were found on the second farm. Six of 10 positive calves were 11-22 days old, three were 164-177 days old, and one was 71 days old. Five of these 10 positive calves were also positive for Giardia infection. Five diarrheic calves on the northern Ohio farm and one diarrheic calf on the central Ohio farm were treated with metronidazole after failing to respond to antibiotic therapy. Clinical improvement was observed in all calves within 48 h after the start of treatment. The high Giardia infection rates and intensities in calves of a wide age range and the clinical response to metronidazole suggest that Giardia infection contributed to the outbreaks of diarrhea.

Animals↗