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[The Italian Society of Nephrology Guidelines (3rd Edition): principles and methods].

Scientific Societies at both a local and international level are making big effort to prepare their clinical practice guidelines. The Italian Society of Nephrology has already published in two previous editions a series of guidelines relating to various aspects of management and diagnosis of different renal diseases. In this review we present the criteria of the 3(rd) edition of the Italian Society of Nephrology guidelines. This 3(rd) edition of guidelines will be based on the availability of scientific evidence in different areas of nephrology, dialysis and transplantation. Ten key intervention questions have been identified, based on the availability of systematic reviews of randomized trials or individual randomized address them. Systematic reviews and randomized trials are the optimal study design to address intervention questions. These have been summarized based upon rigid methodological criteria and strictly reflect the evidence basis. The different phases of development and publication of the 3(rd) edition of the Italian Society of Nephrology guidelines are presented.

Italy↗

Training in pediatric nephrology for developing countries.

During recent years, there has been an increasing demand for specialized care for children with kidney diseases, even in developing countries with limited resources. It is imperative to provide suitable facilities for appropriate and relevant training in pediatric nephrology to promote growth of pediatric nephrology in these areas. The training should give emphasis on preventive aspects, early diagnosis of common diseases and their optimum management with available resources. It should focus on locally prevalent renal diseases. The training programs should take into consideration the socioeconomic and cultural framework of the local community when designing curricula. To overcome the shortage of pediatric nephrology health professionals in the developing countries, the International Pediatric Nephrology Association has taken initiatives to support development of such training programs.

Developing Countries↗

Patterns of patient care reported by nephrologists: implications for nephrology training.

The recent estimate of the nephrology workforce indicates that more nephrologists must be trained to care for the increasing number of patients with end-stage renal disease (ESRD). This conclusion was based on a 1996 survey indicating that nephrologists devote an average of 35% of their activities caring for ESRD patients. We compared data in that survey with those from a 1991 survey of members of the American Society of Nephrology to determine similarities between the different periods. The 1,590 responders in the 1991 survey (35% of the American Society of Nephrology membership) indicated that 50% devoted more than 75% of their effort to patient care, predominately for patients with general nephrology and hypertension problems. Approximately 69% of respondents cared for fewer than 50 hemodialysis patients, and the majority of respondents felt the maximum number of dialysis patients for whom they could provide adequate medical care would be 50. Most respondents felt that there would be a deficiency of nephrologists in their community within 5 years. Results from both the 1991 and 1996 surveys indicate that practice patterns have not changed markedly; combining results from the two surveys makes it clear that more nephrologists are needed to care for the projected increase in dialysis patients. Because nephrologists should be involved in the management of the pre-ESRD patient, training programs will have to broaden the preparation of future nephrologists.

Adult↗

On the evolution of pediatrics and the emergence of pediatric nephrology.

Pediatrics is a relatively new discipline; it came into existence at the end of the nineteenth century, when the number practitioners of medicine interested in the study and teaching of pediatrics grew in proportion to research in diseases of children. The study of two childhood diseases was instrumental in the very emergence of nephrology. The first disease was diarrheal dehydration of infants, the study of which in the first decades of the twentieth century provided much of the body of knowledge of water and electrolyte metabolism that formed the foundations of renal physiology. The second disease was the nephrotic syndrome of children, the successful treatment of which became possible after the Second World War with the use of adrenal cortical tropic hormone and steroids. The prohibitive cost of obtaining these new miracle drugs then led to the foundation in 1948 of the Nephrosis Foundation, which became the National Kidney Foundation (NKF) in 1950-the first organization in the United States dedicated to the support and dissemination of knowledge on diseases of the kidney. The Scientific Advisory Board of the NKF was the nidus around which the discipline of nephrology then evolved and, after the availability of maintenance hemodialysis, flourished. Pediatric nephrology, which emerged from these beginnings, closes the circle that began with the emergence of nephrology from its foundations in pediatric studies of childhood diarrhea and treatment of the nephrotic syndrome.

Child↗

An evaluation of a shared primary and secondary care nephrology service for managing patients with moderate to advanced CKD.

BACKGROUND: Chronic kidney disease (CKD) is common, and nephrology services may not cope with the comprehensive referral of patients with CKD. We evaluated a shared primary and secondary care nephrology scheme, hypothesizing that some patients with less progressive moderate to advanced CKD can be identified and safely managed without attending the renal unit. METHODS: A retrospective review of 949 new referrals with stages 3 to 5 CKD managed in either the hospital nephrology clinic (HC) or the shared care scheme (SCS), in which nephrologists review patients remotely by using regular biochemical tests and clinical data recorded in primary care. RESULTS: Two hundred sixty-six patients (28%) were enrolled in the SCS and 683 patients (72%) were managed solely in the HC. Median time to entering the SCS was 111 days (interquartile range, 0 to 328 days). Baseline factors independently predictive of enrollment in the SCS were increasing age, greater glomerular filtration rate (GFR) and serum albumin levels, and no diabetic nephropathy. Few SCS patients did not attend reviews. Forty-one patients (15%) required recall to the HC, mostly because of a decline in GFR. Beneficial changes were seen in blood pressure levels and prescribing of angiotensin-system inhibitors from first referral to 3 years in all patients. Those enrolled in the SCS had good prognosis, with a lower risk for death or renal replacement therapy than the HC group after adjustment for age, sex, GFR, diabetic nephropathy, and vascular disease (hazard ratio, 0.64; 95% confidence interval, 0.38 to 0.89; P = 0.003). CONCLUSION: In this setting, it was possible to select nearly 30% of patients with stages 3 to 5 CKD for management in the SCS. More than half enrolled within 4 months of nephrology referral. Systematic surveillance was effective, and most patients remained stable, with few progressing to renal replacement therapy or death.

Aged↗

Nephrology, dialysis and transplantation in Brazil.

The European Renal Association welcomes this opportunity and feels that European nephrologists should be informed about the state of nephrology in South America, with which particularly our Latin colleagues maintain close cultural relationships. The following report on Nephrology in Brazil is a welcome addition to a series of reports designed to provide to European nephrologists a global view of nephrology. It is hoped that this is not misconstrued as a violation of nephrological Monroe doctrine.

Acute Kidney Injury↗

Longer duration of predialysis nephrological care is associated with improved long-term survival of dialysis patients.

BACKGROUND: Late nephrological referral of chronic renal failure patients has been shown to be associated with high morbidity and short-term mortality on dialysis. However, the impact of predialysis nephrological care duration (PNCD) on the long-term survival of dialysis patients had not been evaluated. METHODS: We studied data from all 1057 consecutive patients who started dialysis treatment at the Necker Hospital from 1989 to 1998 (mean age at start of dialysis 53.8+/-17.2 years (range 18-91 years), excluding from analysis patients who presented with acute renal failure (n=60) or advanced malignancy (n=35). We evaluated the effects of PNCD and clinical risk factors on all-cause mortality after long-term follow-up on dialysis. RESULTS: Among the 1057 patients analysed (13.2% diabetics), PNCD was <6 months in 258 patients, 6-35 months in 267 patients, 36-71 months in 227 patients and >or=72 months in 307 patients. Cardiovascular (CV) morbidity, namely a history of myocardial or cerebral infarction, peripheral arteriopathy, and/or cardiac failure, before starting dialysis was 39.6% and 37.4%, respectively, in patients followed for <6 months or 6-35 months, compared with 24.4% in those followed for 36-71 months and 19.9% in those followed for >or=72 months (P<0.001). Five-year survival was significantly lower in patients with a PNCD of <6 months (59+/-4.1%) than for 36-71 months or >or=72 months (77.1+/-3.7 and 73.3+/-3.6%, respectively, P<0.001), but similar to those followed for 6-35 months (65.3+/-3.9%, NS). By Cox proportional hazard analysis, PNCD <6 months, age, diabetes and prior CV disease were independent predictive factors of all-cause death on dialysis. CONCLUSIONS: This study provides suggestive evidence that longer duration of regular nephrological care in the predialysis period, at least for several years prior to the start of dialysis, is associated with a better long-term survival on dialysis. Such data strongly support the argument for early referral and regular nephrological care of chronic renal failure patients.

Adult↗

Evidenced based nephrology care.

This paper highlights the importance of evidenced-based practice (EBP) and its implications to patient and health professionals working within nephrology. The need to ensure that practice is based upon best evidence should be a concern for all health care professionals. Confusion sometimes surrounds the concept of EBP and the potential impact this may have upon patient outcomes. It is the intention of this paper to firstly demystify the process of EBP highlighting the important factors to be considered in moving towards EBP in nephrology care. Secondly, the paper draws upon a number of well-conducted research studies, which have important implications for nephrology care. These selected examples of best evidence will highlight further where ongoing work could be focused. Whilst there is much published within current literature concerning research within nephrology it is essential that practitioners are encouraged to develop the skills to critically search literature, appraise and evaluate its usefulness in developing appropriate and meaningful evidence to enhance practice and patient care.

Benchmarking↗

[The usefulness of hospital at home in nephrology].

BACKGROUND AND OBJECTIVE: The Hospital at Home Unit (HHU) is a medical care model effective in different fields of medical and surgical conditions. The objective of the study was to analyse the utility of moving acute nephrologic patients to a HHCU. PATIENTS AND METHOD: We review the Nephrology Service requests to move patients to the HHU the last 3 years. The results were compared with those obtained from the rest of patients admitted at the HHU during the same period. RESULTS: The requests number was 85 and 79 (93%) patients were included for the study. Patients had high comorbidity (Charlson index mean, 3.75) and acute medical problems. The length of stay at the HHU was 12.65 days. The total intervention rate was 1.23 interventions/day. In 71 cases (89.9%) the hospital discharge was at the patient's home. In 8 cases the readmission at the hospital was required to solve the medical process. Hospital readmissions after the HHCU discharge before 30 days was 6.3%. No statistical differences were found between nephrology patients and the rest of HHU patients when comparing the intervention rates, the percentage of home discharges and the hospital readmissions. CONCLUSIONS: The moving of nephrologic acute patients to a HHU is a save choice and well accepted by patients and their families.

Adolescent↗

Hippocratic medicine and nephrology.

The history of nephrology is a part of culture in general and should be treated not as a hobby or an isolated specialty of medical science, but as closely connected with medical education and everyday clinical practice. In the age of the apotheosis of renal biotechnology, medicine more than ever needs to combine Hippocratic messages with renal technologic achievements, in order both to restore quality of life in patients with renal disease and to bring harmony and balance to individuals impaired in body and soul. Indeed, Hippocratic medicine lies at the root of the development of clinical nephrology. Hippocratic writings have not lost their nephrologic interest, despite the enormous recent advances in renal technology. Today's practising nephrologist can still learn not only from Hippocratic clinical observations, but also from the prognostic thoughts, the ethical principles, the philosophic concepts and the humane messages of the 'father of clinical nephrology'.

Codes of Ethics↗

The changing face of nephrology.

Projected requirements for nephrology physicians indicate a need for an increase in the number of nephrology trainees. In addition, government regulations are creating the climate to diminish the entry of international medical graduates into all residency programs. To meet the needs of renal patients, especially those with end-stage renal disease, and such areas of growth as nephrology research, more US medical graduates, particularly women and members of minority groups, will have to select nephrology as a career. This article discusses issues that this challenge raises for the specialty, including the impact on patient care, mentoring, and the use of nonphysician clinicians.

Career Choice↗

International use of an academic nephrology World Wide Web site: from medical information resource to business tool.

BACKGROUND: Studies of the use of the World Wide Web to obtain medical knowledge have largely focused on patients. In particular, neither the international use of academic nephrology World Wide Web sites (websites) as primary information sources nor the use of search engines (and search strategies) to obtain medical information have been described. METHODS: Visits ("hits") to the Walter Reed Army Medical Center (WRAMC) Nephrology Service website from April 30, 2000, to March 14, 2001, were analyzed for the location of originating source using Webtrends, and search engines (Google, Lycos, etc.) were analyzed manually for search strategies used. RESULTS: From April 30, 2000 to March 14, 2001, the WRAMC Nephrology Service website received 1,007,103 hits and 12,175 visits. These visits were from 33 different countries, and the most frequent regions were Western Europe, Asia, Australia, the Middle East, Pacific Islands, and South America. The most frequent organization using the site was the military Internet system, followed by America Online and automated search programs of online search engines, most commonly Google. The online lecture series was the most frequently visited section of the website. Search strategies used in search engines were extremely technical. CONCLUSIONS: The use of "robots" by standard Internet search engines to locate websites, which may be blocked by mandatory registration, has allowed users worldwide to access the WRAMC Nephrology Service website to answer very technical questions. This suggests that it is being used as an alternative to other primary sources of medical information and that the use of mandatory registration may hinder users from finding valuable sites. With current Internet technology, even a single service can become a worldwide information resource without sacrificing its primary customers.

District of Columbia↗

[Credentialing for diagnostic and interventional nephrology].

UNLABELLED: It is necessary to define the credentialing process that allows the nephrologist to achieve certification and accreditation in the following essential procedures of diagnostic and interventional nephrology: renal echography; renal and bone biopsies; the creation of vascular (arteriovenous fistula [FAV], grafts) or peritoneal access for permanent dialysis; the management and treatment of possible complications; and the implantation of central venous catheters for temporary or definitive hemodialysis. BACKGROUND: The acquisition of credentials for the interventional nephrologist includes the completion of training programs, the identification of appraisal indices, certification, possible recertification, and accreditation. The specialist validation allows the nephrologist to act as a tutor and supply the credentials for the interventional procedures in nephrology. The use of echography has remarkably simplified the procedure of percutaneous renal biopsy, a technical diagnostic invasive technique, practiced exclusively by the nephrologist the ecography-guided technique has reduced the risks of greater complications to less than 0.5%. However, guidelines are lacking on the training required to accredit a nephrologist in this technique. The initial placement of a shunt, vascular or peritoneal, to carry out dialysis treatment is usually performed by the nephrologist, radiologist, or surgeon. However, the successful long-term management of the dialysis patient generally demands a multidisciplinary approach. The poor management of the dialysis shunt can contribute to reduced patient life expectancy and increased costs of care. Therefore, it is essential that those who perform such interventional procedures must be certified and accredited according to strict protocol guidelines. In Italy (as opposed to the United States) most peritoneal shunt placements are performed by the nephrologist. However, international scientific society guidelines on this procedure, where they exist, are generic, allowing for the adaptation of particular techniques by various nephrologic centers. The criteria for the acquisition of credentials in one particular procedure must be uniform, logical, consistent, and applicable, comprising of a recognition of the basic procedure and a course of appropriate practical training. The criteria for training and credentialing in diagnostic and interventional nephrology should encompass the following points: The establishment of guidelines for the performance of all procedures that ensures suitable and effective treatment, including during emergencies, and considering the hospital context in which the procedures are performed. The recognition that scientific society guidelines for one specialty or procedure may not be appropriate or applicable to credentialing in another specialty or procedure. The ability of guidelines to adapt to improvements in technique and new technologies. The stipulations of insurance coverage and legal counselling must be taken into consideration whenever accreditation criteria are developed. CONCLUSIONS: An adequately certified and accredited background improves the quality of care, reduces costs and waiting list time, and reduces those complications that could increase the length of hospitalization.

Biopsy↗

Images of nephrology nursing practice: report of a survey.

The results of a survey designed to identify existing images of nephrology nursing practice are reported. The sample included 374 attendees at meetings sponsored by the American Nephrology Nurses' Association (ANNA). Content analysis revealed that the typical nephrology patient is elderly, has a chronic illness and negative affect, is not compliant, and is dependent on others. The typical nephrology nurse-patient interaction emphasizes teaching and support. The most common nursing activities are assessment, teaching, dialysis treatment, and psychological support.

Attitude of Health Personnel↗

[Development of nephrology in Lithuania].

This article reviews the development of nephrology in the different regions of Lithuania. History of Lithuanian nephrology started in Vilnius in 1969 when the first hemodialysis was performed in the oldest hospital of Lithuania. In 1969 the clinics of Kaunas Medical University started hemodialysis service, in 1977-Panevezys hospital, in 1991-Siauliai hospital and in 1993-Klaipeda hospital. In 1965 Assoc. Prof. S. Markovicius began to give a course in nephrology at the Faculty of Medicine of Vilnius University. In 1967 the first department of nephrology in Lithuania was opened at Vilnius City Hospital.

Adult↗

[Historical Archives of Italian Nephrology. Gabriele Monasterio (1903-1972) and the School of Pisa].

Gabriele Monasterio (1903-1972), a clinician with numerous medical interests, contributed remarkably to the development of the Italian nephrology of his time. His main scientific contributions were: - Investigation of the causes of normoglycaemic glycosuria. Of this condition he collected, from 1939 on, a large series of patients whom he also investigated - for the first time in the world - with renal biopsy and - thanks to a collaboration with Jean Oliver - the microdissection of the nephron. - Introduction, in the early 1960s, of a low protein diet for the patients with chronic renal failure. This, thanks to the stud-ies published by Monasterio co-workers Quirino Maggiore and Sergio Giovannetti, was largely used in Italy and abroad. - Classification of the nephropathies. This was described in the monograph Le Nefropatie Mediche (1954 and 1970), which had a large impact and today represents a classic of the Italian nephrological literature. Monasterio served remarkably the Italian Society of Nephrology: in 1957 as a member of the founding committee; from 1959 to 1962 and from 1964 to 1968 as President; in 1958, 1962, and 1964 as organizer of the National Congress; from 1962 to his death as the Editor-in-Chief of the official journal of the Society, Minerva Nefrologica. Finally, Monasterio was also a member of the first council of the International Society of Nephrology.

History, 20th Century↗

Mapping the literature of nephrology nursing.

OBJECTIVES: A bibliometric investigation was done to identify characteristics of the literature that nephrology nurses utilize. It is one component of a broader study, "Mapping the Literature of Nursing," by the Medical Library Association's Nursing and Allied Health Resources Section Task Force to Map the Literature of Nursing. METHODS: Following a standard protocol, this project utilized Bradford's Law of Scattering to analyze the literature of nephrology nursing. Citation analysis was done on articles that were published from 1996 to 1998 in a source journal. Cited journal titles were divided into three zones, and coverage in major article databases were scored for Zones 1 and 2. RESULTS: During the three-year period, journals were the most frequently cited format type. Eighty-one journals were cited in Zones 1 and 2. As Bradford's Law of Scattering predicted, a small number of the cited journals accounted for the most use. Coverage is most comprehensive for cited journals in Science Citation Index, PubMed/ MEDLINE, and EMBASE. When looking just at cited nursing journals, CINAHL and PubMed/MEDLINE provide the best indexing coverage. CONCLUSION: This study offers understanding of and insights into the types of information that nephrology nurses use for research. It is a valuable tool for anyone involved with providing nephrology nursing literature.

Abstracting and Indexing↗

The role of the ERA-EDTA in organizing continuing medical education in Europe for nephrology, dialysis and renal transplantation.

Continuing medical education (CME) is a process not to be ignored by the medical profession of nephrology. Each country has already organized or is going to organize a national CME system providing individual modalities of credit distribution and control. The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) has considered the need to work together with the European Union of Medical Specialists (UEMS) to study and to promote a unified CME system in Europe with the aim of defending the quality of a comparably high level of specialist care given to patients in the EU. To this aim, the ERA-EDTA has created a European Accreditation Council for CME in nephrology, dialysis and renal transplantation (ERA-EDTA EACCME). It acts not on-ly by accrediting European meetings providing great educational value, but aims to expand the commitment of the ERA-EDTA in educational activities everywhere in Europe. Continuous medical education activity started in 2004 with a series of residential courses. Finally, the ERA-EDTA entered the newly formed Board of Nephrology for CME, which will work to homogenize the training level of nephrologists in Europe aimed at CME, as well as continuing professional education (CPE) for nephrologists. The new ERA-EDTA activities for CME in nephrology, dialysis and renal transplantation will renew the role of this scientific society for all European nephrologists (www.era-edta.org/era-courses.asp).

Education, Medical, Continuing↗