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At least 127 records · Page 7Linked to original sources
PubMed1976

The effect of narcotic and narcotic-antagonist drugs in the newborn rabbit.

The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping. When nalorphine was combined with pethidine the period of primary apnoea was still increased although the duration and number of gasps were restored to control values. Naloxone, in contrast, acted as a mild respiratory stimulant, shown as a longer phase of dyspnoea. Also it completely abolished the respiratory depression produced by pethidine. Naloxone may be preferable to nalorphine as a drug to reverse the effects of pethidine immediately after birth.

Animals↗
PubMed1992

[Use of narcotics by school children in Greenland. A nation-wide study of habits of school children concerning narcotics].

An attempt was made to describe the extent to which school pupils employ the intoxicants: tobacco, alcohol, hash and sniffing. The prophylactic committee, PAARISA, issues informative campaigns about intoxicants, the effects of which are assessed by means of investigations such as this. An anonymous questionnaire was employed. This was sent to 18 towns and seven villages distributed over all of Greenland. The questionnaire contained questions about social background, smoking habits, alcohol habits, sniffing and smoking of marihuana. The questionnaire was completed by the pupils in the schools under confidential conditions and was then returned to the author. The investigation was carried out during the period from 15.10. 1990- 15.11. 1990. All of the towns and the largest villages in all Greenland participated. The investigation was established on the initiative of the author in cooperation with PAARISA. A total of 1,934 school pupils aged from 12 to 19 years replied to the questionnaire. The percentage of replies was 88 of these questioned. Out of 1,557 pupils who spoke Greenlandic, 774 were boys and 783 girls. Out of 377 pupils who spoke Danish, 208 were boys and 169 girls. 26% of the Danish-speaking boys and 45% of the Greenlandic-speaking boys smoke, while 39% of the Danish-speaking girls and 61% of the Greenlandic-speaking girls smoke. Three quarters of the oldest age group smoke. Girls smoke more frequently than boys. 71% smoke more than three cigarettes daily. 87% of the Danish-speaking and 63% of the Greenlandic-speaking pupils had tried drinking alcohol.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Central action of narcotic analgesics. II. Locomotor activity and narcotic analgesics.

The effect of morphine, codeine, fentanyl and pentazocine on locomotor activity of rats and mice and open-field performance of rats were tested. All the analgesics tested produced a depressive action in the rat. In mice a depressive action was produced by pentazocine and codeine. Fentanyl increased the exploratory and basal locomotor activity of mice. Morphine increased the exploratory activity, but, given at doses of 2.5 and 10 mg/kg decreased the basal locomotor activity. The increase of locomotor activity in mice by morphine and fentanyl is caused by an indirect stimulation of catecholamine receptors.

Analgesics, Opioid↗