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At least 127 records · Page 7Linked to original sources
PubMed1981

[Use of ionizing radiation for sterilizing alginate dressings containing various antibacterial preparations].

The effect of various doses of ionizing radiation on activity of antibacterial drugs contained in polymer alginate coatings was studied. Sensitivity of P. aeruginosa, E. coli, Staph. aureus, Proteus and B. subtilis used as the test organisms to the drugs and their combinations after radiation sterilization was determined on liquid nutrient media with the method of serial dilutions and agar diffusion and the use of the respective reference antibiotics. The coatings were irradiated in an isotope unit with 60Co at a dose of 7 Krad/min. The data are indicative of the possible use of ionizing radiation for sterilization of pharmaceutical alginate coatings in trade packings. Combined effect of antimicrobial substances and ionizing radiation plays an important role in the efficiency of radiation sterilization. Sterility of the majority of the drugs was achieved after irradiation in doses of 0.5-1 Mrad. The bactericidal activity of gentamicin, mafenid, polymyxin M and neomycin contained in the alginate coatings sterilized with gamma-radiation in doses of 1-2.5 Mrad did not decrease immediately and 1 year after irradiation.

Alginates↗
PubMed1980

[Search for antimicrobial agents and their various combinations that are effective in relation to the main microfloral representatives in the burn wound].

Activity of 10 antibiotics, 6 surface active substances, 1 antioxidant and boric acid against P. aeruginosa, E. coli, Pr. vulgaris and Staph. aureus most frequently vegetating in burn wounds was studied. It was found that gentamicin had the highest antibacterial effect on the above organisms. Polymyxin M had a pronounced antimicrobial action on P. aeruginosa and E. coli. A significant antibacterial effect with respect to Staph. aureus, E. coli and Pr. vulgaris was observed with the use of the drugs of the nitrofuran line, i.e. salaful, furagin and furacillin. These drugs were not active against P. aeruginosa. A high antimicrobial effect with respect to all of the test-microbed used was recorded with methacyl, a surface active substance. To show the synergistic effect on the microbes most frequently vegetating in burn wounds, the antibacterial action of the drug combinations was studied. The synergistic effect (16 to 100 times) was observed with the use of polymyxin M combination with mafenide, carbenicillin with gentamicin, methacide with fenozan. The microorganisms tested were resistant to boric acid. On the basis of the study the most effective drugs and their combinations were chosen for their addition to the algipores (polymer coatings) used in treatment of burns infected with the above microbes.

Anti-Bacterial Agents↗
PubMed1979

Pharmacology of sulfadiazine silver. Its attachment to burned human and rat skin and studies of gastrointestinal absorption and extension.

The attachment of Ag110-labeled sulfadiazine silver (AgSU) to the burn wound of humans and full and partial thickness scald burns of rats was studied over time. The duration of Ag adherence to burned skin and the absorption and organ distribution of ingested AgSU was studied. Peak attachment to human burns was 1% of the administered dose in 24 hours. Rat wounds showed greater attachment. Dissections of the wounds showed 81% to 98.7% of this attachment to be in the most superficial layers of cells and no silver was observed in organs of surface-treated animals. Duration of attachment after one application was until wound slough with percent attachment dropping from 5% to 1.7% over that time. Oral ingestion resulted in substantial silver deposition, particularly in liver and lungs. Clearance occurs in three weeks. The basic function of AgSU may be through the slow release of silver into the superficial wound environment.

Animals↗
PubMed1991

Fungal burn wound infection. A 10-year experience.

To evaluate our experience with fungal burn wound infection, we performed a 10-year review for comparison with our experience with bacterial burn wound infection. During the study period, a marked decline occurred in bacterial wound infection but not in fungal wound infection. Patients with either bacterial or fungal burn wound infection had massive injury, with burn size averaging greater than 50% of the total body surface area. Factors that appear to have markedly reduced bacterial burn wound infection, including patient isolation, topical chemotherapeutic agents, and burn wound excision, do not appear to have had a similar effect on fungal wound infection. The mechanism of spread and colonization of fungi, and the lack of effective topical chemotherapeutic antifungal agents, may explain in part our findings.

Adult↗
PubMedDate not supplied

Burn of the auricle.

Silvadene cream and Sulfamylon make up the treatment regimen for one contributor (Dr. Crumley). No systemic antibiotics would be given. Any areas of obvious third-degree burns would be debrided and grafted. The tympanic membrane perforation would be treated with antibiotic/steroid drops. The second author concurs with use of Silvadene cream and would avoid any pressure on the area (Dr. Abemayor). While he agrees that systemic antibiotics should be avoided, he also would not prescribe ear drops. He recommends evaluation for a pulmonary or ophthalmologic injury. There is a disagreement regarding imaging studies. One expert would order a CT scan to rule out facial fractures (Dr. Crumley). His counterpart would not order a CT but would check a baseline chest x-ray if there were any sign of pulmonary compromise (Dr. Abemayor). Both experts would obtain an audiogram after the acute problems are treated. In the case of foul drainage, burn reconstruction would be delayed. In addition to treating the otorrhea with ear drops, one physician would add oral antibiotics (Dr. Abemayor). The other author believes tympanoplasty should be performed prior to reconstruction (Dr. Crumley). There were several procedures suggested for the reconstruction. Both authors discuss a method of creating a postauricular pocket, burying the ear pedicle, and using costal cartilage for an inlay helical graft. Another approach involves minimal debridement of the cartilage and letting the wound mature for 6 to 8 months. At that time the area would be debrided and the postauricular skin used for external coverage (Dr. Crumley). If the facial scar is a cosmetic problem 1 year after the injury, triamcinolone injections and local massage should be considered.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

The control of burn wound sepsis.

This presentation reviews the course of burn wound sepsis in a group of 621 acute patients treated at the Shriners Burns Institute, Cincinnati Unit, between 1970 and 1976. During this period of time, the overall mortality rate fell from 14% in 1970 to 3 and 5%, respectively, in 1975 and 1976. Staphylococcus aureus was the most commonly recovered organism from the burn wound, colonizing 85% of the burn patients. Beta hemolytic streptococcus represented a potential threat despite the fact that it was recovered from only 5 to 10% of the patients. Pseudomonas aeruginosa showed a decrease in colonization during the period of this study, from 50% of the wounds in 1970 to 21% in 1976. Candida albicans was the fungal organism most commonly recovered from the burn wound and from the blood stream. Fifteen deaths occurred in this group as a result of invasive infection, one from S. aureus, five from P. aeruginosa, two from Klebsiella-Enterobacter, and one from Escherichia coli, as well as six fungal deaths, five from Candida albicans and one from mucormycosis. Therapeutic measures used to control burn wound sepsis consisted of prevention of contamination from exogenous sources, control of burn wound pathogens, early recognition of invasive burn wound sepsis, aggressive management of the burn wound, and optimal nutritional support. During this period the extent of burn associated with a survival of 50% has risen from 50% in 1970 to 80% in 1976. This improvement in survival is directly related to progressive improvement in local and systemic measures available for the control of infection.

Burns↗
PubMed1984

Opportunistic infections in severely burned patients.

The risk of infection in burn patients, which is proportional to the extent of burn, reflects the combined effect of impairment of all aspects of the host defense system and microbial factors. The microbial flora colonizing the burn wound changes with time following injury and provides the organisms causing infections in burn patients. The temporal pattern of the predominant gram-negative organisms causing infections in a burn unit resembles that of a succession of mini-epidemics necessitating an active program of microbial surveillance to guide treatment of infections. Topical chemotherapy has significantly reduced the occurrence of invasive burn wound infections, but microbial control is imperfect and the burn wound, as well as the patient as a whole, must be closely monitored (using wound biopsies as indicated) to diagnose and treat infection in a timely manner. The treatment of burn wound infections is guided by extent and depth of microbial invasion, density of microorganisms, and systemic changes. As a manifestation of immunologic impairment, infection in sites other than the burn wound remains the most frequent cause of death in burn patients. The use of broad spectrum serologic agents to enhance immuno-competence in extensively burned patients may reduce the occurrence of life threatening opportunistic infections.

Aged↗
PubMed1990

Partial amino acid sequence of erythrocyte carbonic anhydrase from tiger shark.

1. A partial primary structure (197 residues) of carbonic anhydrase from tiger shark (Galeocerdo cuvieri) erythrocytes has been determined. 2. The amino acid sequence of the enzyme is identical to those of human cytoplasmic carbonic anhydrases (CA I-III) by as much as 52-60%. 3. It is shown that tiger shark CA most closely resembles the CA II isoenzyme of amniotes. 4. Isoelectric focusing and inhibition studies on carbonic anhydrase from dogfish (Squalus acanthias) blood and muscle indicate the presence of the same isoenzyme in shark blood and muscle.

Alkylation↗
PubMed2006

Vibrational analyses of sulfamoyl halides NH2SO2X (X is F, Cl and Br).

The structural stability of sulfamoyl halides NH(2)-SO(2)X (X is F, Cl and Br) were investigated by DFT-B3LYP/6-311+G** and ab initio MP2/6-311+G** calculations. From the calculations the molecules were predicted to exist only in the anti (XS bond is anti with respect to nitrogen lone pair) conformation with the possibility of very low abundance of the syn (SO(2) and NH(2) groups eclipse each other) form of only the fluoride. The equilibrium constant for the syn<-->anti conformational conversion of sulfamoyl fluoride was calculated to be 0.0172 that corresponds to an equilibrium mixture of about 2% syn and 98% anti at 298.15K. The vibrational frequencies were computed at DFT-B3LYP level for the stable anti conformer of the d(0) and d(2) (ND(2)-SO(2)X) deuterated species of the three molecules. Normal coordinate calculations were then carried out and the potential energy distributions were calculated for the molecules.

Chemical Phenomena↗
PubMed2006

Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound.

BACKGROUND: Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process. METHODS: A partial thickness skin donor site wound was created on the back and indwelling catheters were placed in the carotid artery and jugular vein in rabbits under general anesthesia. Sulfamylon cream (8.5%, BERTEK Pharmaceuticals Inc., Morgantown, W Va) was applied on the wound, with either open or occlusive dressing. The control wound was covered with dressings only. On day 7 after injury, stable isotope tracers were infused to determine the fractional synthetic rate (FSR) of DNA, and FSR and fractional breakdown rate (FBR) of protein in the wound. RESULTS: In the Sulfamylon-open dressing group, the DNA FSR was 1.3 +/- 0.6%/day, the protein FSR was 8.0 +/- 3.5%/day, and the net protein deposition (FSR - FBR) was -0.3 +/- 3.7%/day. These values were lower (P < .01 to .05) than the corresponding values in the control group (DNA FSR: 2.9 +/- 0.9%/day; protein FSR: 20.5 +/- 8.4%/day; net protein deposition: 7.9 +/- 6.0%/day). Sulfamylon cream selectively inhibited DNA FSR from the de novo base synthesis pathway (2.3 +/- 1.2 vs 0.8 +/- 0.5%/day, P < .05 vs control). With the occlusive dressing Sulfamylon cream did not decrease wound DNA FSR due to a stimulation of the base salvage pathway, but still decreased protein FSR (11.5 +/- 5.1%/day, P < .05 vs control). Histologic slides indicated that Sulfamylon cream inhibited re-epithelialization, collagen formation, and angiogenesis in the wound. CONCLUSIONS: Topical Sulfamylon cream application inhibited DNA and protein synthesis in the wound, which would be expected to retard the healing process.

Administration, Topical↗