LACTIC DEHYDROGENASE IN CANCER.
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The changes in the mandible and in its relationship to surrounding soft tissue structures after loss of the teeth are described; the regular presence of deficiencies in the cortical bone along the line of the occlusal ridge is emphasized. Resection specimens of squamous carcinoma of the oral cavity not treated by radiotherapy were examined where there was mandibular involvement by tumor, and showed that the main route of tumor entry into the bone was through the occlusal ridge. Subsequent perineural spread along the inferior alveolar nerve has been found to be a regular occurrence.
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Cases of mouth neoplasms were analysed in Instituto Arnaldo Vieira de Carvalho, São Paulo. The authors present a literature review about the topics carcinogenesis and co-carcinogenesis. It was shown that there is a relationship between the possible etiological factors and the appearance of these neoplasms. It was observed a interdependency between these factors and the accuracy of these lesions, despite of their real etiology be unknown.
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A series of 145 patients with tongue and floor of mouth neoplasms is presented. Age, sex, TNM classification, lymph node presence or absence at the time of first visit and management protocols have been studied in each case. Management protocols have been divided into primitive tumor treatment (iridium and/or surgery) and lymph node treatment (radical surgery and radiotherapy). Results have been assessed considering tumoral stage and management scheme.