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Results for “LATHYRISM”

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At least 127 records · Page 7Linked to original sources
PubMed1979

Fine structural evidence of increased endothelial permeability in chronic lathyrism.

The endothelium of the thoracic aorta of Wistar rats intoxicated with Beta-Aminopropionitrile (BAPN) for 9 weeks was studied. The animals were sacrificed at intervals, from the first to the 9th week of the treatment and 1, 2 and 3 months after the end of the treatment. Changes in the endothelial cells were studied by electron microscopy after staining with uranyl acetate and lead citrate, after impregnation with lanthanum. BAPN increased endothelial permeability, pinocytosis was more active in treated rats than controls, the intercellular junctions widened and cytoplasmic lesions with cell necrosis occurred. These intimal changes were comparable to those observed in man during ageing and in arteriosclerosis.

Animals↗
PubMed1980

Long term lathyrism and atherogenic diet in the rat. Protective action of pyridinol carbamate.

In the rat, prolonged administration (7 months) of Beta-Aminopropionitrile in association with a hyperlipidic diet caused the formation of widespread pronounced atheroma. The addition of Pyridinol Carbamate during the treatment minimized and retarded the appearance of lipid overload lesions. The histological modifications were found together with an increase in the free cholesterol fraction. These two observations explain the protective role of Pyridinol Carbamate on the wall of the aorta.

Aminopropionitrile↗
PubMed1978

Chronic lathyrism and atheromatosis in the rat. Study of the V.L.D.L. and plasma and arterial wall lipids.

Temporary chronic administration of Beta-amino-propionitrile (B.A.P.N.) produced morphological and biochemical changes of the aortic wall of rat as well as abnormalities of the plasma lipid levels. A hyperlipidic diet resulted in the blood plasma lipid abnormalities as B.A.P.N. intoxication. Nine weeks of B.A.P.N. followed by 42 weeks of a hyperlipidic diet increased the aortic cholesterol level and induced an atheroma. The diet alone produced only an endothelial lipid overload. The structure of arterial wall played the decisive role in atherogenesis.

Aminopropionitrile↗
PubMed1982

The experimental study of scoliosis in bipedal rat in lathyrism.

Using Wister albino rats, bipedal rats were prepared; to which semicarbazide at a concentration of 0.075%, 0.05% and 0.025% were given as drinking water and the rats were divided into three groups A, B and C according to such concentrations. Osteolathyrism was caused in this way and the relations between doses as well as the dosing period and the progress of scoliosis were examined roentgenologically and histologically and the following conclusions were obtained. 1. The frequency of occurrence of scoliosis was 82% in the bipedal rats and 13% in the quadrupedal rats (level of significance alpha = 0.001% or less). 2. Primordial top vertebrae were located concentratively in the lower 1/3 of thoracic vertebra. 3. In the primordial curve, those cases showing a right side curve accounted for 76%. 4. After termination of administration of semicarbazide, spontaneous improvement took place only in those cases showing scoliosis of less than 40 degrees. 5. In the author's experimental scoliosis, the static and dynamic condition of posture nearly coincided with those of men in clinical studies. 6. Histological changes were especially marked in the cartilage layer on the vertebral epiphyseal line, being quite diversified.

Animals↗