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PubMedDate not supplied

[Cholinergizing treatment in hyperkinesis].

Hyperkineses are a clinical and pathogenetic counter-part of parkinsonism (MP). Their underlying cause is increased activity of the dopaminergic system or insufficiency of the cholinergic system. Treatment inhibiting the dopaminergic system, similarly as anticholinergic treatment is of little effectiveness in MP. A trial of substitutive treatment was undertaken activating the cholinergic system with a precursor of acetylcholine (dimethyl-amino-ethanol-deanol--Bimanol) with simultaneous inhibition of cholinesterase with prostigmin. The results of this treatment were compared with previously applied antidopaminergic treatment (Haloperidol) and with the effects of L-dopa. This treatment was given to 11 patients with Huntington's chorea (ChH), 4 with faciolingual dyskinesis (DFL), 3 with torticollis spasmodicus (TS), 3 with maladie des tics (MT) and 8 with dyskinesia following treatment with L-dopa (MP). Cholinergizing treatment gave better results than antidopaminergic treatment in TS and ChH, and worse in MT. In dyskinesia following L-dopa cholinergizing treatment gave also no effects reported by others. Differences in the results of cholinergizing and antidopaminergic treatment may indicate non-homogenous pathological mechanism of these hyperkineses. Cholinergizing treatment in hyperkineses is based on a similar principle as L-dopa treatment in MP and this approach seems to be proper but more effective preparations should be sought for.

Adult↗
PubMedDate not supplied

[The electromyographic analysis of trembling hyperkinesis in Wilson-Konovalov's hepatocerebral dystrophy].

Global electromyography was applied in the examination of 20 patients with Wilson-Konovalov's hepatocerebral dystrophy before and after stereotaxic operations. The origin of volley muscular activity is explained on the basis of segmental reflexes known in neurophysiology: indirect relief of alpha-motoneurons from the primary terminals of the spindle, autogenous, recurrent and reciprocal inhibition of alpha-motoneurons.

Adolescent↗
PubMed1988

Psychopharmacologic facilitation of psychosocial therapy of violence and hyperkinesis.

Experiments on naturally occurring hyperkinetic and violent dogs and cats demonstrated the usefulness of low dosages of amphetamine (0,2-1,0 mg/kg per os) in inhibiting these nonadaptive forms of behavior, permitting the development of discriminated Pavlovian and operant conditional responses. When amphetamine therapy was combined systematically with conditioning experiments and psychosocial therapy, for long enough periods of time (many weeks), the beneficial effects of this drug persisted in the nodrug state, i.e. the learning was not state-dependent. Amphetamine also ameliorated significantly conditional emotional visceral responses in dogs with low adaptation to psychologically stressful situations. The same low dosage of amphetamine which improved the behavior and learning of hyperkinetic and violent dogs disrupted the behavior and produced disorientation in normal dogs with previously stable conditional responses.

Amphetamine↗