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At least 127 records · Page 7Linked to original sources
PubMed1977

[Quantitative interpretation of graphs from Stuart pantography. II. Geometrical bases].

In an experimental investigation, Stuart pantographic records are geometrically analyzed. The influence of the parameters' inclination and curving of condylar guidance, intercondylar distance, Bennett angle, distance of the plate, and position of the recording pencil are studied. Further quanitative analysis was not performed, as Stuart pantography is only meant for transmission to the respective articulator and is nto suitable for metric recording.

Dental Articulators↗
PubMedDate not supplied

[Graph method of analyzing the stationary kinetics of polyenzyme systems].

Methods based on the graphical representation of relations between metabolites concentrations were worked out for the description and analysis of the steady-state kinetics of the multienzyme systems. The properties of graphics characterizing various steady-state regimens were investigated. Relations relevant to the analysis of regulatory phenomena were derived for the concentration of non-adjacent metabolites. Rules are presented for the kinetical description of multienzyme systems posessing external inputs and outputs. Certain branchings occuring in multienzyme systems were considered. The developed methods allow generalization concerning multisubstrate multiproduct reactions as well as systems containing regulatory enzymes with non-michaelian kinetics. It is suggested that the generalized methods may be helpful for the analysis of the metabolic regulation.

Catalysis↗
PubMed1992

Judgments of change and proportion in graphical perception.

Subjects judged change and proportion when viewing graphs in two experiments. Change was judged more quickly and accurately with line and bar graphs than with pie charts or tiered bar graphs, and this difference was larger when the rate of change was smaller. Without a graduated scale, proportion was judged more quickly and accurately with pie charts and divided bar graphs than with line or bar graphs. Perception is direct when it requires simpler or fewer mental operations; we propose that perception of change is direct with line and bar graphs, whereas perception of proportion is direct with pie charts and divided bar graphs. The results are also consistent with the proximity compatibility principle. Suggestions for improving the design of graphical displays are given.

Adult↗
PubMed2026

ARISE: RNA-anchored shared-edge topology and hierarchical fusion for spatial multi-omics integration.

MOTIVATION: Spatial multi-omics technologies jointly profile transcriptomes, proteins and chromatin accessibility in situ, enabling integrative analysis of tissue organization across molecular layers. However, most existing graph-based integration methods rely on independently constructed modality-specific k-nearest-neighbor graphs. When auxiliary modalities are sparse or noisy, these graphs can become topologically discordant, propagate spurious edges, weaken cross-modal alignment, and reduce spatial domain resolution. RESULTS: We present Anchored RNA for Integrated Spatial Embedding (ARISE), an RNA expression anchored framework for spatial multi-omics integration. ARISE defines a shared-edge topology by intersecting RNA feature-similarity and spatial-proximity graphs, encodes auxiliary modalities on this common scaffold, and integrates them through inside-out hierarchical fusion. We further show theoretically that graph intersection minimizes false-positive edges within a broad class of k-of-r graph fusion rules, providing a principled basis for topology anchoring. Across various spatial multi-omics benchmarks spanning simulated and real datasets in bi-modal and tri-modal settings, ARISE improves spatial domain identification, cross-modal consistency, and preservation of tissue structure relative to existing methods. Furthermore, the learned representation supports biologically meaningful downstream analyses, including marker-based domain annotation, pathway enrichment, and cis-regulatory inference, indicating that ARISE yields a robust and interpretable framework for spatial multi-omics integration. AVAILABILITY AND IMPLEMENTATION: The source code is available at https://github.com/XiangxiangWang-code/ARISE. The archived version used in this study is available at https://doi.org/10.6084/m9.figshare.32686137.v2.

Multiomics↗
PubMed1976

[In vivo blood histamine during anesthesia].

Assays of overal histaminaemia were carried out, in 150 patients anaesthetised according to three different techniques, apart from any surgical act. 119 anaesthesias took place without any incident, 33 were disturbed by the appearance of rashes or of bronchospasm. The overall histaminaemia varied according to three types of graphs (a flat graph, an ascending graph, or a descending graph) without it being possible to evoke any relationship between this course and the clinical signs. It seems that the presence of a background predisposing to histamine-liberation is however responsible for greater frequency of the descending graphs, and that the method of administration of the anaesthetic product is a factor which can intervene in the genesis of the phenomena of histamine-liberation during anaesthesia. An interpretation of the variations in the graphs of histaminaemia is attempted by the authors.

Adolescent↗
PubMed1992

Schematic methods for probabilistic enzyme kinetics.

The theory of steady-state enzyme processes which avoids using the mass action law of chemical kinetics and consistently describes catalytic mechanisms by probabilistic concepts has recently been proposed (Mazur, 1991, J. theor. Biol. 148, 229-242). To facilitate the analysis of complex reaction graphs by this theory the possibility of constructing schematic rules similar to those used in classical kinetics is studied. It is found that due to the similarity of algebraic procedures the popular method of King & Altman can be applied in probabilistic kinetics in addition to the earlier proposed rule based on enumeration of cycles of the reaction graph. This similarity also allows one to adapt many other shortcut methods of classical kinetics for probabilistic reaction graphs. The paper considers separately the possibility of transforming reaction mechanisms so that the initial graph is replaced by a simpler but equivalent one. It is shown that there are few cases when a group of states can be replaced by one united state, with earlier known rules such as the rule of Cha for equilibrium stages being particular cases of a more general procedure. In addition a novel method is proposed which performs step-by-step reduction of any reaction graph. All the new methods can be adapted for traditional kinetics as well. The results obtained demonstrate that many schematic rules of classical kinetics are of probabilistic origin.

Enzymes↗
PubMed1991

[The effect of synchronization on estrus and pregnancy in sheep and on levels of thyroxine, triiodothyronine, 17 beta-estradiol, progesterone and cholesterol].

Knowledge of pathogenesis of sexual dysfunctions at altered thyroid activity is limited by the knowledge of multiple and ubiquitous action of its hormones throughout the organism. One of the possibilities of modulatory influence of thyroid hormones on sexual functions can be realized through the participation of thyroxine and triiodothyronine in the synthesis and metabolism of primary substrate of steroid synthesis--cholesterol. The presented work is aimed at the study of simultaneous dynamic changes of concentrations of thyroxine (T4), triiodothyronine (T3), 17 beta-estradiol (E2), progesterone (P4) and cholesterol (Chol) during synchronization of the rutting period and gravidity at parallel correlative evaluation of mutual relations of the followed parameters in ten Merino sheep in the seasonal period. Synchronization was achieved by chlorsuperlutin (Agelin--vaginal swabs, Spofa; 20 mg of chlorsuperlutin/swab) and PMSG (500 I. U./animal). Blood was sampled by means of a jugular vein puncture at the time of swab insertion (-13th day) and after three (-10th day) and seven (-7th day) following days, at the removal of swabs and application of PMSG (-3rd day), on the day of insemination (zero day), on the 7th, 14th and 17th day and in the middle of the 2nd, 3rd, 4th and 5th month of gravidity. In the phase of oestrus synchronization a significant increase of E2 concentrations on days -7 and -3 of the experiment (0.47 +/- 0.079 and 0.542 +/- 0.177 nmol.l-1 of serum, P less than 0.001; P less than 0.001) was observed compared to the E2 values on day -13 (0.084 +/- 0.036 nmol.l-1 of serum). Parallel to these observations, marked intermittent changes of T4 (Tab. I, Graph 1) were recorded with the lowest values of this parameter observed on days -10 (41.75 +/- 20.23, P less than 0.05) and -3 (50.22 +/- 18.77, P less than 0.05) and the highest on day -7 (96.77 +/- 17.51 nmol.l-1, P less than 0.01) and day zero (85.40 +/- 19.59 nmol.l-1 of serum, P less than 0.05) in comparison with the -13th day (67.22 +/- 18.29 nmol.l-1 of serum). Concentrations of P4 (Tab. I, Graph 4) declined to the lowest values on day zero observation (0.09 +/- 0.08 nmol.l-1 of serum, P less than 0.05 vs 3.40 +/- 3.61 nmol.l-1 on day -13). No significant changes of concentrations of T3 (Tab. I, Graph 2) and Chol (Tab. I, Graph 5) were observed during oestrus synchronization. During gravidity, concentrations of E2 (Tab. I Graph 3) showed an increasing trend compared to the -13th day.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1978

Activation energy for RNA transport from isolated rat liver nuclei.

The temperature dependence of ATP-enhanced RNA delivery from rat liver nuclei to a surrogate cytoplasm was investigated. Examination of linear-rate data on Arrhenius graphs of 1/T vs. log (% RNA delivered per min) revealed an activation energy of 12.5--13 kcal/mol. When data derived from longer incubation periods was displayed on Arrhenius graphs, we observed a discontinuous graph--two distinct linear segments with slopes of differing sign which intersected near 20 degrees C. It was demonstrated that this discontinuity was not due to lipid phase transition in the nuclear membranes and that its position depended upon treatment of the nuclei and upon additives to the incubation mixtures. The decline in transport apparent in the upper-temperature domain on 20-min Arrhenius graphs was shown to be based on the diffusion of transported macromolecular RNA back into the nucleus--a process greatly amplified by the rapidity of transport in this domain. The large net inward diffusion, in concert with significantly differing activation energies for RNA transport and passive diffusion, suggests that the process of nucleocytoplasmic RNA transport is not diffusion driven. Our data have established that an integral parameter of RNA transport (namely, the activation energy) remains unchanged in various in vitro manipulations.

Animals↗
PubMed1992

Choosing specifiers: an evaluation of the basic tasks model of graphical perception.

Effect sizes obtained from 39 experiments were used to evaluate the predictions of the basic tasks model of graphical efficacy. This model predicts that performance will be attenuated with graphical displays as a function of the particular specifier, or visual dimension, used to code data values. In this review the basic tasks model predicted performance more accurately than did Tufte's data-ink principle. In addition, variability in effect sizes across studies revealed that the model was more successful at predicting performance in local (focusing) tasks than in global information synthesis tasks. Furthermore, the model was better at predicting performance in tasks requiring the use of physically present rather than remembered graphs. Further differences in effect sizes resulted from variability in the exact specifiers used in experimental graphs. Minimal differences were obtained among graphs that used position, length, or angle as specifiers. However, graphs that used area or volume to represent quantitative values were associated with consistently worse performance than found with other formats.

Attention↗
PubMed1976

3-dimensional graphic display of electrocardiograms.

We developed a new method to display a potential distribution of the heart activity on the body surface. Electrocardiograms were recorded from many points distributed regularly on the precordial region. From these electrocardiograms three-dimensional graph of potential distribution was produced by a small digital computer and displayed on the CRT. This graph continuously changes with time according to change of potential distribution like an animation. An interpolation method that we had derived took a short execution time and give a smooth approximated curve. Three-dimentional graphs of electrocardiograms were produced for healthy male subjects. From these graphs a transmission of a wave front of the ventricular activation can be seen as if the wave moves over the picture.

Adult↗
PubMed2026

REAPER: a project-centric workflow layer for comparative repeatome analysis.

INTRODUCTION: Repeatome characterization from short-read sequencing data is widely performed using RepeatExplorer2/TAREAN. However, long-lived multisample projects and explicit comparative designs are often executed as ad hoc command sequences that are hard to version, rerun, and monitor on shared compute environments - a gap that motivates a project-centric workflow layer for repeatome analysis. METHODS: We present REAPER (Repeatome Extended Analysis Pipeline-Execution and Reporting), a project-centric workflow layer that couples a modular Snakemake pipeline with a Python project manager to enforce a stable on-disk layout and configuration-driven execution for single-sample and comparative repeatome analyses. REAPER does not implement a new repeat-discovery algorithm; it is an orchestration layer, and biological accuracy for clustering and satellite calling depends on the underlying RepeatExplorer2/TAREAN and satMiner methods it coordinates. REAPER standardizes: Read QC Deterministic subsampling and preparation RepeatExplorer2/TAREAN execution via seqclust, with satMiner-inspired iterative assembly Post-TAREAN BLAST-based annotation against curated repeat collections (optionally including taxon-scoped NCBI-derived resources with freshness checks) Optional graph-based comparative reports The pipeline makes comparative read allocation, prefix policy, and analysis-ready tables explicit; caching supports incremental reruns and structured logs support monitoring. Performance was assessed using a Triticeae short-read dataset (five samples), with rule-level logging of runtime and memory across pipeline stages. RESULTS: Rule-level performance logs show that graph-based clustering dominates runtime and memory, while QC and preparation steps are lightweight by comparison. Graph-report annotations for the Triticeae project additionally link high-ranking clusters to established repeat markers - including pTa794- and pSc119-class entries in curated databases. DISCUSSION: These findings illustrate biologically interpretable outputs (recovery of known Triticeae repeat markers) alongside quantitative performance metrics (identification of graph-based clustering as the dominant computational cost). By making comparative read allocation, prefix policy, and analysis-ready tables explicit - and by supporting caching and structured logging - REAPER supports reproducible comparative repeatome analysis in evolving multisample projects. As an orchestration layer rather than a discovery algorithm, REAPER's contribution lies in reproducibility, monitorability, and comparative-analysis infrastructure, with biological accuracy remaining contingent on the underlying RepeatExplorer2/TAREAN and satMiner methods.

TAREAN↗