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At least 127 records · Page 7Linked to original sources
PubMed2000

[Chiral separation of glycerin monosulfides and bisulfides with a stationary phase of amylose-tris(3,5-dimethylphenylcarbamate)].

Amylose-tris(3,5-dimethylphenylcarbamate) (ADMPC) and aminopropylated silica gel(APS) were prepared after the reported methods. ADMPC was immobilized on APS from tetrahydrofuran solution with a coating amount of 15%. The chiral stationary phase was packed in a stainless-steel column(150 mm x 4.6 mm i.d.) by slurry method. The column was used for the enantioseparation of 6 glycerin monosulfides and 4 glycerin bisulfides. Mixtures of hexane and 2-propanol were used as mobile phases. The enantiomers of the monosulfides could be separated quite well, while those of the bisulfides could not at all. This phenomenon shows that the ether oxygen atom of the monosulfides plays a key role in the chiral discrimination process. The retention time of the solutes increases significantly as the amount of 2-propanol decreases. This shows the main interaction between the solutes and the chiral stationary phase is hydrogen bonding. A dynamic model is presented to account for the chiral discrimination mechanism.

Amylose↗
PubMed1958

Studies with dried and glycerinated smallpox vaccines of full and diminished potencies.

In a further vaccination and laboratory study with two dried smallpox vaccines (designated "P" and "Q") and one glycerinated vaccine, the potency of samples of each vaccine was deliberately lowered by exposure to heat. Groups of volunteers were vaccinated with the fully potent vaccines and with those of reduced potency. All subjects who developed a vesicular response were challenged one year later by revaccination with a potent vaccine, and the results obtained in the different groups were compared. No significant variation could be detected in the response of the different groups to the challenge vaccination. These findings indicate that if vesiculation is obtained with a vaccine, even though potency has been reduced to a point where it produces less than 50% successful primary vaccinations, satisfactory protection will result one year later. It also appears that successful vaccination with a dried vaccine confers as good immunity as that obtained from glycerinated lymph. Vaccines with a pock count of 10(6) infective units per millilitre will produce about 40% successes in primary vaccination.

Hot Temperature↗
PubMed1976

[Change in the ATPase activity of glycerinated muscle fibers under the influence of urethane].

The influence of uretane on ATPase activity and contractility of frog glycerinated muscle fibers was studied. Parallel decrease of contractility and ATPase activity of glycerinated muscles takes place upon toxic uretane concentration (1.01 M). A lower uretane concentration (0.34 M) inducing considerable increase of conservation time contractive reaction maintains a higher ATPase activity than does the control one; ATPase activity of the actomyosin from these models is the same as the control one.

Actomyosin↗
PubMed1991

[Neural blockage of phenol-glycerine for cancer pain].

Neural blocking of phenol-glycerine was used for the treatment of cancer pain originated from the esophagus, stomach, liver, lung, rectum, ovary, nasopharynx, head and neck. According to the dose difference, 148 cases were divided into three groups of 7-10% 4-5 ml (30 cases), 15-20% 3-4 ml (70 cases), and 25% 2-2.5 ml (48 cases). The result observed among the three groups as good or fair was 46.7%, 80% and 89.6% respectively, however, complications occurred too within the rate of 13.3%, 34.3% and 14.6% respectively. It is indicated that 2.5 ml of 15-25% phenol-glycerine seems better.

Adolescent↗
PubMed1989

[Ambulatory treatment of suppurative wounds with cooled glycerin].

Experiments were conducted on 106 albino rats under ether anesthesia. The effect of cooled glycerin, liquid nitrogen, ultrasonics, and their combinations on the course of an inflammatory process was studied. Cooled glycerin was used in the clinic in the treatment of 141 patients as the result of which the period of temporary incapacity reduced 1.4 times as compared to that in the traditional methods of wound cleansing.

Adolescent↗
PubMed1988

[Effect of detergent and glycerin on the efficacy of nasal immunotherapy with allergens and on the level of the lymphocyte subpopulation in the organs of local immunity].

Experimental mixed allergy to staphylococcal antigens in guinea pigs was treated by the intranasal administration of a staphylococcal allergen with a surfactant or glycerin added. The treatment was found to produce a hyposensitizing effect with respect to immediate and delayed hypersensitivity. The addition of glycerine enhanced this effect. At the same time the level of T-lymphocytes in the lungs and the lymph nodes of the respiratory tract returned to normal. Detergent used at a concentration of 2% abolished the hyposensitizing effect of the allergen, stimulated T-lymphocytes in the lymph nodes of the respiratory tract and the lungs; the number of T-suppressors decreased.

Administration, Intranasal↗
PubMed1977

[Characteristics of the virulence of a strain of S. typhimurium and its glycerin mutant in a HEp-2 cell line model].

Sensitivity of the HEp-2 cell culture to the infection with the virulent salmonella strains was shown; active penetration and multiplication of bacteria in the monolayer cells indicated this. Gly 90, a glycerine mutant defective by glycerokinase, obtained under the action of ethylmethanesulphonate, displayed a distinct difference from the initial virulent strains of salmonella by decreased invasive properties and the absence of any capacity to multiplication in the epithelial cells. The data on the avirulence of the glycerine mutant obtained on a model in vitro confirmed the observations carried out in vivo in intraperitoneal infection of albino mice (LD50 = 1-10(7) cells) and in keratoconjunctival infection of guinea pigs.

Animals↗
PubMedDate not supplied

[Hydroalcoholic, prophylenic, hydropropylenic and glycerinated solutions of PMCF. Their use in endodontics. "In vitro" and "in vivo" study].

This work aims to test the efficiency of hand instrumentation allied to paramonochlorophenol dressing in cases of pulp necrosis, when this substance is diluted in water and alcohol, propylenoglicol and glycerin. Superficial pression and pH were verified to test them afterwards facing to bacteria that could be found in infected root canals and avaible to study in our bacteria lab. Solution more effective "in vitro" and of less cytotoxicity "in vivo" were selected to be employed in patients from the Dental Clinics at School of Dentistry--Federal University of Minas Gerais. It was concluded that: 1. the relationship between cytotoxicity and bacterial activity was proportionally the reverse to superficial pression, except to Hydropropylenic solution of PMCF 5% and 10%; 2. in the study with patients (40 cases) the growth anaerobic microorganisms were present in 97.5% of examined teeth; 3. from solutions used for intracanal dressing hydroalcoholic solution of PMCF at 5% was the on which showed more effectiveness; 4. studies must be carried out on glycerin solution of PMCF, to turn viable its employment in Endodontia.

Adolescent↗
PubMed1985

[Na+ and K+ binding by glycerinated muscle fibers at equal concentrations of the chlorides of these cations in the medium].

The Na+ and K+ equilibrium distribution between the medium and glycerinated muscle fibres of the frog has been investigated under equal concentrations of NaCl and KCl in solutions. Concentrations of NaCl and KCl varied from 0.5-1.5 mkM till 50 mM. Ion strength (0.11) was constant owing to the imidazol--HCl buffer. The binding of Na+ and K+ by model fibres occurred in accordance with the Langmur equation. Two kinds of cation-binding sites were found. The one with a low limiting ion sorption (A infinity approximately 1.3 mmol/kg dry weight of fibres) and high affinities (-delta F0 approximately 4.3 kcal/mol) was saturated at 0.5 mM concentrations (Na+ = K+) in the medium, and the other--with A infinity exceeding the previous one by an order and low -delta F0 (2.5 kcal/mol) was discovered at Na+, K+-1-10 mM. At ion concentrations equal to 0.5-1 mM the Langmur-binding is disturbed. At Na+-K+ less than or equal to 1 mM Na+ bound:K+ bound approximately to 1:1. At higher concentrations of cations Na+ bound:K+ bound approximately equal to 3:2. It is concluded that at least part of the sites in model fibres is capable of interacting only with Na+, but not with K+. It is supposed that at equal concentrations of Na+ and K+ in the medium the cations are bound by Na+, K+-ATPase of glycerinated muscle fibres.

Animals↗
PubMedDate not supplied

[Effect of glycerin on several indices of intracranial hemodynamics and the electroencephalogram of wakeful cats with experimental intracerebral hemorrhage].

An intravenous infusion of glycerin to cats 24-48 hours after an intracerebral hemorrhage contributes to normalization of the EEG, Intensifies the local blood flow in the visual cortex, thalamus and reticular formation of the midbrain in both hemispheres (predominantly in the regions of the right affected hemisphere). The drug produces a fall in the absolute values of the intracranial pressure without its secondary rise after infusion is discontinued and causes a moderate rise of the perfusion pressure. The intravenous infusion of glycerin is more effective than its single injection.

Animals↗
PubMed1978

[Attempts at freezing bull semen in a yolk-raffinose medium without glycerin].

A new medium was produced, containing no glycerin but rich in raffinose, egg yolk, and mineral water, adequate for freezing bull semen. It was tested parallel to a control extender, consisting of yolk, lactose, and glycerine. The absolute survival rate of the spermatozoa kept at 0-4 degrees C in a raffinose medium proved by 24.25 h higher than that of the spermatozoa in the control medium. No other essential differences were established as to motility, heat resistance and percent of pathologic forms of freshly diluted and frozen semen between the test and the control medium. The biologic test on a total of 133 cows resulted in a 71.4% conception rate at first insemination. The semen frozen in the control medium showed 62.6% conception at the insemination of 123 cows. The difference of 8.8% was in favour of the new synthetic medium. The insufficient number of animals (133) used in the investigations made it necessary to test the new medium on a wider production basis.

Animals↗
PubMed1978

[Studies on the pharmacodynamic activity of several drug solvents. 2. Glycerin, N-(beta-hydroxyethyl)-lactamide, polyethylene glycol 400].

The drug solvents glycerin, N-(beta-hydroxyethyl)-lactamide, and polyethylene glycol 400 (Lutrol 9) were examined for their pharmacodynamic properties in the following tests: i.p. toxicity, "sign pattern", inclined screen test, balance rod test, and potentiation of hexobarbitone sleeping time in mice, spasmolytic activity in the guinea pig isolated ileum, and cardiovascular studies in anaesthetized rats, cats, and dogs including the i.v. toxicity. In mice and rats glycerin exhibited the highest tocicity as well as the greatest activity in potentiating hexobarbitone sleeping time. In the isolated ileum the solvents showed unspecific spasmolytic activities with histamine, carbachol, and BaCl2 as spasmogens. After i.v. administration in rats, cats, and dogs the solvents caused cardiovascular effects even in very low doses. Based on the pharmacodynamic properties, doses are recommended for each solvent which should not be exceeded without control experiments in the laboratory routine. These tolerable doses do not only depend on the species but also on the test concerned.

Animals↗
PubMed1983

Effect of antibodies to light meromyosin on glycerinated muscle fibres and on actomyosin adenosinetriphosphatases.

The conformation change of light meromyosin influences the myosin and actin interaction, the myosin ATPase activity [22]. Starting from these data the specificity of the phenomenon has been investigated. The effect of LMM1, LMM- and LMM1-antibodies was studied on the isometric tension and relaxation of glycerol extracted muscle fibres. LMM1 was found to relax the fibres isometrically contracted by ATP-Ca2+; anti-LMM and anti-LMM1 markedly accelerated the development of isometric tension and inhibited the relaxation of ATP contracted glycerinated muscle fibres; in the presence of anti-LMM the ATPase rate of glycerinated myofibrils was slightly augmented. These results seem to indicate that LMM1 governs the actin binding site function of myosin and controls its affinity to actin. It is supposed that the reaction of myofibrils with specific LMM antibodies induced a transconformation in the myosin head increasing the affinity to actin of myosin.

Actins↗
PubMed1980

[Energy exchange in mitochondria and contractility of bundles of glycerinated myocardial fibers in traumatic shock].

The state of energy exchange on the basis of respiratory chain reactions of myocardial mitochondria and contractility of bundles of glycerinated muscle fibers in traumatic shock, were investigated. The mitochondria isolated from animal myocardium at the terminal stage of traumatic shock were found to be capable to carry out oxidative phosphorylation at the level typical for healthy animal mitochondria. Parallel tensometric analyses of contractility of bundles of glycerinated muscle fibers showed that in rats and dogs with traumatic shock the most pronounced changes occur in isometric tension and specific power. At the same time relative fiber shortening under isotonic conditions is insignificantly reduced.

Animals↗
PubMed1993

[Effect of glycerin-based multicomponent solution on blood parameters in its continuous intravenous administration].

A multicomponent solution for replacement of acute blood loss, consisting of 4.5% protein, 15% glycerin, 0.9% sodium chloride, 0.03% potassium chloride, 79.57% of water for injections, is suggested. The solution is used at the first hours after blood loss for prevention of shock by means of fluid redistribution between the aqueous sectors of the organism. In prolonged intravenous administration (every day within 30 days), the solution has no unfavourable effect on the organism. Selection of the components permits to eliminate the unfavourable effect of glycerin on the erythrocytes. It is recommended to use the multicomponent solution as a dehydrating and diuretic substance.

Animals↗
PubMedDate not supplied

[Glycerin as one of the components of a solution for treating acute blood loss].

Multicomponent formulation on the basis of glycerin due to a good selection of components contributes to a high survival of animals under replacement of an acute life-threatening blood loss by redistribution of fluid between the water sectors of the organism early after administration; besides, it stimulates biological processes in the organism. The component percentage tends to neutralize the hemolytic action of glycerin during the intravenous administration.

Acute Disease↗
PubMedDate not supplied

Use of a glycerin-based gel sheeting in scar management.

Management of hypertrophic and keloid scars can be difficult. This article presents an initial report on use of a glycerin-based gel sheeting to manage or prevent these scars. The results were comparable to those achieved with silicone sheeting, a typical treatment. Clinically, the glycerin-based sheeting was well tolerated, appeared to be effective, and was less expensive than the silicone sheeting. A prospective study will be done to confirm these findings.

Adolescent↗
PubMed1965

GLYCERINATED SKELETAL AND SMOOTH MUSCLE: CALCIUM AND MAGNESIUM DEPENDENCE.

Contractions of glycerinated skeletal (striated) and vascular (smooth) muscles are similar in their calcium dependence but differ in their magnesium dependence. The threshold concentration of free Ca(++) for contraction of either muscle was 1.8 x 10(-7)M; maximum tension developed when the concentration of free Ca(++) was slightly greater than 10(-6)M. The Mg concentration required for contraction of smooth muscle was at least ten times as great as that for skeletal muscle.

Buffers↗