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At least 127 records · Page 7Linked to original sources

Linear systems modeling of adaptive optics in the spatial-frequency domain.

Spatial-frequency domain techniques have traditionally been applied to obtain estimates for the independent effects of a variety of individual error sources in adaptive optics (AO). Overall system performance is sometimes estimated by introducing the approximation that these individual error terms are statistically independent, so that their magnitudes may be summed in quadrature. More accurate evaluation methods that account for the correlations between the individual error sources have required Monte Carlo simulations or large matrix calculations that can take much longer to compute, particularly as the order of the AO system increases beyond a few hundred degrees of freedom. We describe an approach to evaluating AO system performance in the spatial-frequency domain that is relatively computationally efficient but still accounts for many of the interactions between the fundamental error sources in AO. We exploit the fact that (in the limits of an infinite aperture and geometrical optics) all the basic wave-front propagation, sensing, and correction processes that describe the behavior of an AO system are spatial-filtering operations in the Fourier domain. Essentially all classical wave-front control algorithms and evaluation formulas are expressed in terms of these filters and may therefore be evaluated one spatial-frequency component at a time. Performance estimates for very-high-order AO systems may be obtained in 1 to 2 orders of magnitude less time than needed when detailed simulations or analytical models in the spatial domain are used, with a relative discrepancy of 5% to 10% for typical sample problems.

Journal Article↗

Sources of error in measuring cerebrospinal fluid formation by ventriculocisternal perfusion.

Ventriculocisternal perfusion is regarded as a precise method of measuring the rate of formation of cerebrospinal fluid (CSF) but it possesses inherent potential sources of error. Using the technique to measure CSF formation rate in the rhesus monkey, we have observed rate changes when none were expected. Most puzzling has been the steady decline of CSF formation rate at 4 percent each hour during the final five hours of a seven hour perfusion although variables known to affect CSF formation remained stable. In addition, alterations in rate caused by artefacts were observed in experiments in which craniospinal blood volume was changed by sudden changes of either PCO2 or central venous pressure. Mobilisation or sequestration of incompletely equilibrated CSF is believed responsible. In other experiments, a small increase of intracranial pressure produced by increasing outflow resistance was quickly followed by an apparent reduction of CSF formation. We have concluded that to assess accurately the effect a variable has on the rate of CSF formation, one must control perfusion time and craniospinal blood volume as well as intracranial pressure.

Animals↗

Two sources of error in pop-out localization.

An odd-one-out stimulus, such as a vertical bar among horizontals, pops out from the background and is easily detected, but its location may be slightly ambiguous. Four observers were asked to pinpoint these stimuli on thousands of trials, in 5 x 5 and 9 x 9 arrays of Gabor patches. We found they made frequent errors toward neighbors of the target. Over a range of performance from 41% to 96% correct, the frequency of neighbor errors was well described by a linear function of the total error frequency, a function that might result from mixing together two spatial distributions--one broad, the other narrow. We suggest that these represent two sources of error in pop-out localization; one might correspond to a higher visual area with imprecise retinotopic mapping, and the other to a more fine-grained localization process in primary visual cortex.

Depth Perception↗

Accuracy of end-tidal carbon dioxide tension analyzers.

Substantial mean differences between arterial carbon dioxide tension (PaCO2) and end-tidal carbon dioxide tension (PETCO2) in anesthesia and intensive care settings have been demonstrated by a number of investigators. We have explored the technical causes of error in the measurement of PETCO2 that could contribute to the observed differences. In a clinical setting, the measurement of PETCO2 is accomplished with one of three types of instruments, infrared analyzers, mass spectrometers, and Raman spectrometers, whose specified accuracies are typically +/- 2, +/- 1.5, and +/- 0.5 mm Hg, respectively. We examined potential errors in PETCO2 measurement with respect to the analyzer, sampling system, environment, and instrument. Various analyzer error sources were measured, including stability, warm-up time, interference from nitrous oxide and oxygen, pressure, noise, and response time. Other error sources, including calibration, resistance in the sample catheter, pressure changes, water vapor, liquid water, and end-tidal detection algorithms, were considered and are discussed. On the basis of our measurements and analysis, we estimate the magnitude of the major potential errors for an uncompensated infrared analyzer as: inaccuracy, 2 mm Hg; resolution, 0.5 mm Hg; noise, 2 mm Hg; instability (12 hours), 3 mm Hg; miscalibration, 1 mm Hg; selectivity (70% nitrous oxide), 6.5 mm Hg; selectivity (100% oxygen), -2.5 mm Hg; atmospheric pressure change, less than 1 mm Hg; airway pressure at 30 cm H2O, 2 mm Hg; positive end-expiratory pressure or continuous positive airway pressure at 20 cm H2O, 1.5 mm Hg; sampling system resistance, less than 1 mm Hg; and water vapor, 2.5 mm Hg. In addition to these errors, other systematic mistakes such as an inaccurate end-tidal detection algorithm, poor calibration technique, or liquid water contamination can lead to gross inaccuracies. In a clinical setting, unless the user is confident that all of the technical error sources have been eliminated and the physiologic factors are known, depending on PETCO2 to determine PaCO2 is not advised.

Algorithms↗

Sources of error in the spike-triggered averaging method of motor unit number estimation (MUNE).

Motor unit number estimation (MUNE) is an electrophysical technique to estimate the number of motor units innervating a muscle or muscle group. MUNE may be useful as a measure of progression of lower motor neuron loss in amyotrophic lateral sclerosis (ALS). Several methods of MUNE have been developed. The spike-triggered averaging method can be readily performed on EMG machines with signal averaging capabilities and is suitable for estimating the number of motor neurons innervating proximal muscles. We have used MUNE as a measure of disease state in a drug efficacy trial for ALS. From our experience with this method we have identified sources of error which can affect MUNE accuracy. We have investigated these sources and report their effect on MUNE.

Action Potentials↗

The influence of distance on registration in ISO-C-3D navigation: a source of error in ISO-C-3D navigation.

Computer-assisted treatments have become increasingly common. Consequently, there is an increased desire for navigation methods with simplified workflow. Anatomic-based pair-point registration is often mentioned as a source of error. Alternatively, the use of preoperatively implanted markers for registration remains complex. The self-acting registration of Iso-C-3D at the moment of data acquisition can reduce essential errors. The aim of this study was to evaluate the effect of reference placement on accuracy, and to determine the maximum acceptable distance between the reference and a given isocentre. This study demonstrates the interdependence of the reference distance on the region of interest (ROI). The mean error of registration amounts to 0.04 mm (0.04-0.05 mm) up to a distance of 200 mm and beyond 0.25 mm (0.24-0.26) for distances beyond 200 mm. The accuracy was significantly lower (p<0.0001) with a distance more than 200 mm. For optimal accuracy when utilizing navigation for pelvic and long bone surgery, the reference base should not been placed at a distance more than 200 mm from the isocentre of interest.

Humans↗

[The risk of gastrostomy in childhood. Sources of error and prevention (author's transl)].

The indication for gastrostomy in childhood arises from the possibilities of decompression and enteral feeding. The demand for an operative procedure to children involves simple technique, safety, efficacy and uncomplicated nursing. The most important sources of error in the creation of a gastrostoma arise from the position and size of the catheter, atraumatic suture technique; on the other hand there is the threat of postoperative extension of the gastrostoma, local infection and sepsis. The results of our own procedure are described and the results given of 172 of our own cases.

Aftercare↗

Factors influencing the accuracy of the cardiac output monitoring and diagnostic unit for pneumatic artificial hearts.

The Cardiac Output Monitor and Diagnostic Unit (COMDU) has been the most widely used method to noninvasively determine cardiac output in pneumatic ventricles for the past 10 years. Clinical observation has suggested a discrepancy between the COMDU and expected cardiac outputs. In vivo tests verified and quantified this error. The error sources were examined using in vitro test conditions, with both the inflow and outflow, as well as COMDU flow readings, being analyzed. Transducer and calibration error sources were also identified, and the accuracy of the method for determining cardiac output for the in vitro test conditions was quantified. With a more accurate calibration scheme, the in vitro average error was reduced from -16.2% (range of 0.1% to -41.1%) to 0.1% (range 4.8% to -3.65). The major error sources were identified as missed inflow, transducer calibration and drift, and system variance.

Animals↗

Human factors as a source of error in peak Doppler velocity measurement.

OBJECTIVE: The study was conducted to assess the error and variability that results from human factors in Doppler peak velocity measurement. The positioning of the Doppler sample volume in the vessel, adjustment of the Doppler gain and angle, and choice of waveform display size were investigated. We hypothesized that even experienced vascular technologists in a laboratory accredited by the Intersocietal Commission for Accreditation of Vascular Laboratories make significant errors and have significant variability in the subjective adjustments made during measurements. METHODS: Problems of patient variability were avoided by having the four technologists measure peak velocities from an in vitro pulsatile flow model with unstenosed and 61% stenosed tubes. To evaluate inaccurate angle and sample volume positioning, a probe holder was used in some of the experiments to fix the Doppler angle at 60 degrees. The effect of Doppler gain was studied at three settings--low, ideal, and saturated gains--that were standardized from the ideal level chosen by consensus amongst the technologists. Two waveform display sizes were also investigated. Peak velocity measurement was assessed by comparison with true peak velocities. For each variable studied, average peak velocities were calculated from the 10 measurements made by each technologist and used to find the percent error from the true value, and the coefficient of variation was used to measure the variability. RESULTS: Doppler angle, sample volume placement, and the Doppler gain were the most significant sources of error and variability. Inaccurate angle and placement increased the variability in measurements from 1% to 2% (range) to 4% to 6% for the straight tube and from 1% to 2% to 3% to 9% for the 61% stenosis. The peak velocity error was increased from 9% to 13% to 7% to 28% for the stenosis. Both measurement error and variability were strongly dependent on the Doppler gain level. At low gain, the error was approximately 10% less than the true value and at saturated gain, 20% greater. The display size only affected measurements from the stenosed tube, increasing the error from 9% to 13% to 15% to 24%. CONCLUSIONS: Major factors affecting Doppler peak velocity measurement error and variability were identified. Inaccurate angle and sample volume placement increased the variability. The presence of a stenosis was found to increase the measurement errors. The error was found to depend on the Doppler gain setting, with greater variability at low and saturated gains and on the display size with a stenosis. CLINICAL RELEVANCE: Doppler ultrasound peak velocity measurements are widely used for the diagnostic assessment of the severity of arterial stenoses. However, it is known that these measurements are often in error. We have identified subjective human factors introduced by the technologist and assessed their contribution to peak velocity measurement error and variability. It is to be hoped that by understanding this, improvements in the machine design and measurement methods can be made that will result in improved measurement accuracy and reproducibility.

Artifacts↗

Interactions with hemoglobin: a source of error in measurements of transketolase activity in hemolysates.

Measurements of the activity of transketolase in human erythrocyte lysates by an assay coupled to NADH oxidation indicate that interactions of assay substrates with hemoglobin can give rise to overestimations of transketolase activity. Three potential sources of error are identified. Thus, in lysates containing methemoglobin, NADH oxidation can be due firstly to methemoglobin reductase activity or secondly to the monooxygenase activity of methemoglobin, for which the substrate can be ribose 5-phosphate, a substrate also of transketolase. Thirdly, the addition of high concentrations of the transketolase cofactor, TDP, to an insufficiently buffered reaction mixture can cause the aggregation and precipitation of hemoglobin: a phenomenon that may be misconstrued as an enhanced increase in absorbance at 340 nm and hence as additional transketolase activity. Although the present study concentrates on these potential artefacts in assays of transketolase activity, the findings may well be relevant to the measurement of other enzyme activities in hemolysates by procedures based ultimately on the rate of consumption or production of NAD(P)H.

Chromatography, Gel↗

Sources of error in tissue and tumor measurements of 5-[18F]fluorouracil.

UNLABELLED: Central to the assessment of variability of pharmacokinetic parameters is knowledge of bias and variability of the measurement technique, preventing observed differences from being ascribed inappropriate significance. This article presents an evaluation of sources of error in the measurement of normal tissue and tumor pharmacokinetics using 18F-labeled 5-fluorouracil (FU) and PET. METHODS: A standard approach to data acquisition, processing and analysis was developed using a PET scanner, filtered backprojection reconstruction and region of interest analysis. Fourteen tracer 5-[18F]FU patient studies and a phantom study were completed, with 4 of the patient studies repeated 1 wk later. These data allowed evaluation of the overall reproducibility of the technique and the components of measurement variability due to tissue sampling. The effect of reconstruction technique and sampling region size on quantification was assessed using phantom data. RESULTS: All measured radioactivity versus time curves were tissue specific. Week-to-week variability in the area under this curve (representing combined physiological and measurement difference) was -3% to +15% for liver and -9% to -16% for spleen and kidney. Metastasis variability was greatest at -20%. Visual and computer realignment of the second paired study produced similar results. Interobserver effects were small compared to differences between studies. CONCLUSION: These results confirm the feasibility of using PET as a pharmacokinetic tool for 5-[18F]FU studies. Although overall experimental error (i.e., random variation in data acquisition, processing and analysis) was low, constraints in data interpretation emerged.

Adult↗

Switching donor cells as a major source of error in compatibility testing.

The most likely cause of fatality in blood transfusion is transfusion of the wrong unit of blood to a patient. This type of error is usually attributed to improper patient identification at the time of sample collection or transfusion. A retrospective analysis of the results of an external proficiency testing program identified a common source of error occurring during laboratory testing that has not been previously reported. Results were analyzed when major errors were assigned to laboratories for obviously switching donor units in compatibility testing and/or subsequent investigation. In 24 surveys sent to extended testing (Level A) laboratories and 18 sent to basic testing (Level B) laboratories, the antigenic composition of the two donor cells made it possible to determine whether the cells had been switched. Seven errors were assigned to Level A participants for switching donor units during testing, constituting 38.9 percent of the 18 major errors assessed. Level B participants were assigned eight errors for switching donor units, 26.7 percent of the 30 major errors assessed. Approximately one-third (31.3 percent) of major errors committed on 42 proficiency testing surveys were caused by switching of donor cells during compatibility testing. This type of error may result in transfusion of an incompatible donor unit.

Journal Article↗

Measurement of blood flow by ultrasound: accuracy and sources of error.

Doppler ultrasound has now developed to the point where the rate of flow of blood in a given vessel can be measured with appropriate instrumentation. The theoretical basis of Doppler flow measurement is reviewed in this paper, with particular emphasis on the potential and actual sources of error. Three distinct approaches are identified, and the strengths and weaknesses of each discussed. The separate errors involved in estimating the vessel cross-sectional area, the angle of approach, and the Doppler shift are analyzed, together with the question of the uniformity of scattering from the blood. In vivo and in vitro tests of the accuracy obtained using a number of Doppler flow measuring instruments are then reviewed. It is concluded that the Doppler methods are capable of good absolute accuracy when suitably designed equipment is used in appropriate situations, with systematic errors of 6% of less. There are, however, considerable random errors, attributable primarily to errors in measuring the cross-sectional area and the angle of approach. Repeating the measurement of flow several times and averaging the results can reduce these random errors to an acceptable level.

Blood Flow Velocity↗

Tissue sampling as a potential source of error in experimental studies of cartilage.

Although it might seem trite to point out that tissue sampling is a potential source of experimental error, this survey disclosed that even experienced investigators in fact often work with cartilage that is contaminated by non-cartilaginous tissue of which they were unaware. Twenty-two specimens ranging from chick embryo sternum to bovine nasal septum were studied by serial sectioning. Eighteen of the 22 contained extraneous tissue comprising from 3 to 50% of the cross-sectional area. The impact of the contamination depends on the use being made of the material and probably is greatest in cell culture studies because chondrocytes and fibroblasts have large differences in population doubling time. Several approaches for minimizing the error are suggested by the findings. Histological examination of specimen material is thus a desirable quality control procedure in the design and interpretation of experiments on cartilage as well as other tissues.

Animals↗

Guidewire-induced coronary pseudostenosis as a source of error during physiological guidance of stent deployment.

Coronary pseudostenoses are a known result of the interaction between tortuous vessels and guidewires and are generally handled by the interventionalist as inocuous side effects of intracoronary instrumentation. The present report demonstrates that pseudostenosis may have hemodynamic relevance and may constitute an important source of error when physiological guidance of percutaneous procedures is performed using sensor-tipped guidewires.

Aged↗

[Instrumentation for blood pressure measurements: historical aspects, concepts and sources of error].

According to the International Council of Nurses the measurement of blood pressure is the procedure most performed by nurses in all the world. The aim of this study is to analyse the polemical aspects of instruments used in blood pressure measurement. Considering the analyses of the literature and the American Heart Association Recommendations, the main source of errors when measuring blood pressure are discussed.

American Heart Association↗

A source of error in self-reports of pap test utilization.

The prevention and early detection of cervical cancer is achieved through women's regular use of Pap tests. Ascertaining adherence to Pap screening guidelines is often based on self-report, which may be unreliable. This study examined the reliability of Pap test self-reports and one potential source of error in them. We predicted that women having any gynecological examination (other than Pap tests) would falsely report having had a Pap test more often than women who had not experienced gynecological procedures. We compared self-reported Pap test utilization with medical records among 161 low-income women. Women with no Pap test in their medical record but who had experienced other gynecological procedures falsely reported a Pap test significantly more often than those women who actually received a Pap test or who had not received any gynecological procedure. Confusion over what type of gynecological procedures these women received could result in their under-utilization of Pap tests. Further, these findings question the validity of study findings based only on self-reported outcomes.

Adolescent↗

Sources of error in heparin therapy of thromboembolic disease.

We observed a series of patients with thromboembolic disease treated intravenously with heparin sodium and monitored by the activated coagulation time (ACT) of whole blood. When patients responded slowly, had dangerous hemorrhage, or had ACTs well outside our target range, we analyzed infusion records to determine actual infusion rates. We found the following sources of error: (1) lack of pump precision, (2) interruption of infusion, (3) errors in making up solutions, and (4) failure of infusion or charting techniques.

Adult↗