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At least 127 records · Page 7Linked to original sources
PubMed1978

On the mechanism of the persistence of lymphocytic choriomeningitis virus in the continuous cell line Detroit-6.

A persistent lymphocytic choriomeningitis virus, noninfectious for mice, was revealed in the continuous human cell line, Detroit-6. The virus was detected in the cell monolayer by an indirect immunofluorescence test and in the cell homogenate by a complement-fixation test. Between 30 and 80% of the cells produced viral antigen in subsequent passages of the culture. Thymidine analogues (BrDU and IDU) stimulated the synthesis of antigen. DNA of the persistently infected cell line was transfected to the mouse lymphoid cell line, L1210, which became persistently infected with the virus.

Antigens, Viral↗
PubMed1994

Air pollution and hospital admissions for the elderly in Detroit, Michigan.

Several studies in recent years have suggested that exposure to airborne particles and to ozone are associated with increases in respiratory hospital admissions. Few of those studies have used inhalable particles as their measure of exposure, and the studies did not always examine both particle and ozone exposure. This study examined the association between both PM10 and ozone and respiratory hospital admissions for persons 65 yr of age and older in the Detroit, Michigan, metropolitan area during the years 1986 to 1989. After controlling for seasonal and other long-term temporal trends, temperature, and dew point temperature, both PM10 (RR = 1.012, 95% CI = 1.019-1.004) and 24-h ozone concentrations (RR = 1.026, 95% CI = 1.040-1.013) were associated with daily admissions for pneumonia. The relative risks are for a 10-microgram/m3 increase in PM10 and a 5-ppb increase in 24-h ozone concentration and from models including both pollutants. Admissions for COPD other than asthma were associated with PM10 (RR = 1.020, 95% CI = 1.032-1.009) and ozone (RR = 1.028, 95% CI = 1.049-1.007) as well. Asthma admissions were not associated with either pollutant. Controlling for one pollutant did not effect the magnitude of the association with the other pollutant. The magnitude of these relative risks are very similar to those recently reported in Birmingham, Alabama, Ontario, and New York State. This suggests that the associations with both pollutants are likely to be causal.

Aged↗
PubMed2002

The relationship between social support, stress, and health among women on Detroit's East Side.

A conceptual model of the stress process has been useful in examining relationships between numerous social determinants (e.g., chronic stress), protective factors (e.g., social support), and health status. In this article, the authors examine multiple sources of chronic stress, instrumental and emotional support, and health outcomes among a random sample (N = 679) of predominantly low-income African American women who reside on Detroit's east side. The findings suggest that a number of chronic stressors have an impact on depressive symptoms and general health and that even though instrumental and emotional support each have a significant effect over and above the effects of the stressors, when both are included in the model, instrumental support, and not emotional support, remains as a significant predictor of health outcomes. These findings suggest the need for health education interventions and policy strategies that strengthen social support and aim at macro-level changes necessary to reduce chronic stressful conditions.

Adult↗
PubMed1998

Detroit's East Side Village Health Worker Partnership: community-based lay health advisor intervention in an urban area.

In recent years, there have been few reports in the literature of interventions using a lay health advisor approach in an urban area. Consequently, little is known about how implementation of this type of community health worker model, which has been used extensively in rural areas, may differ in an urban area. This article describes the implementation of the East Side Village Health Worker Partnership, a lay health advisor intervention, in Detroit, Michigan, and notes how participatory action research methods and principles for community-based partnership research are being used to guide the intervention. Findings are presented on how the urban context is affecting the design and implementation of this intervention. Implications of the findings for health educators are also presented and include the utility of a participatory action research approach, the importance of considering the context and history of a community in designing a health education intervention, and the importance of recognizing and considering the differences between rural and urban settings when designing a health education intervention.

Adult↗
PubMed2006

Drawing from Freirian empowerment methods to develop and use innovative learning maps: increasing enrollment of uninsured children on Detroit's eastside.

In 2001, virtually every child on Detroit's eastside was eligible for health coverage, yet approximately 3,000 children remained uninsured. The primary aim of the Eastside Access Partnership (EAP), a community-based participatory research collaboration, was to increase enrollment of uninsured children in state programs. To achieve this aim, one of the approaches that EAP is using is the innovative Learning Map titled Choosing the Healthy Path, which was developed in collaboration with Root Learning, Inc. Although Learning Maps were originally developed to assist corporations in implementing strategic change, their integration of visualization and interactive dialogue incorporates Freirian principles of empowerment education, making them a viable option for providing meaningful learning opportunities for community residents. This article presents the collaborative process involving the University of Michigan, local community-based organizations, community members, and Root Learning consultants to develop a visual map that enables community residents to understand and overcome the barriers that prevent them from obtaining health insurance for their children.

Adolescent↗
PubMed2004

Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System.

PURPOSE: Population-based estimates of the incidence of brain metastases are not generally available. The purpose of this study was to calculate population-based incidence proportions (IPs) of brain metastases from single primary lung, melanoma, breast, renal, or colorectal cancer. PATIENTS AND METHODS: Patients diagnosed with single primary lung, melanoma, breast, renal, or colorectal cancer (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System (MDCSS) were used for analysis. IP of brain metastases by primary site and variable of interest (race, sex, age at diagnosis of primary cancer, and Surveillance, Epidemiology, and End Results [SEER] stage of primary cancer) was calculated with 95% CIs. RESULTS: Total IP percentage (IP%) of brain metastases was 9.6% for all primary sites combined, and highest for lung (19.9%), followed by melanoma (6.9%), renal (6.5%), breast (5.1%), and colorectal (1.8%) cancers. Racial differences were seen with African Americans demonstrating higher IP% of brain metastases compared with other racial groups for most primary sites. IP% was significantly higher for female patients with lung cancer, and significantly higher for male patients with melanoma. The highest IP% of brain metastases occurred at different ages at diagnoses: age 40 to 49 years for primary lung cancer; age 50 to 59 years for primary melanoma, renal, or colorectal cancers; and age 20 to 39 for primary breast cancer. IP% significantly increased as SEER stage of primary cancer advanced for all primary sites. CONCLUSION: Total IP% of brain metastases was lower than previously reported, and it varied by primary site, race, sex, age at diagnosis of primary cancer, and SEER stage of primary cancer.

Adult↗
PubMed2004

Validation of the Detroit Area Study Discrimination Scale in a community sample of older African American adults: the Pittsburgh healthy heart project.

This study examined the construct validity of the Detroit Area Study Discrimination Questionnaire (DAS-DQ) in 49 healthy African American adults, with respect to its association with global measures and daily experiences of psychological demand. Daily experiences of psychological demand were obtained using ecological momentary assessment (EMA) methods. Everyday Mistreatment, as measured by the DAS-DQ, was significantly related to global reports of perceived stress and depression but was unrelated to measures of hostility and social desirability. Everyday Mistreatment was significantly related to average EMA score measures of Negative Affect and Social Conflict but was unrelated to daily experiences of Task Demand or Decisional Control. Negative Affect mediated the relation between Everyday Mistreatment and global reports of perceived stress. In contrast, Lifetime History of Discrimination, as measured by the DAS-DQ, was unrelated to global measures or daily experiences of stress. Thus, this study lends support to the construct validity of the DAS-DQ.

Aged↗
PubMed1983

Alcohol problems among employed men and women in metropolitan Detroit.

A survey of employed adults in metropolitan Detroit showed that more men than women had alcohol problems but this was largely attributable to the higher percentage of alcohol-dependent drinkers among men. There was little difference between the percentages of men and women who could be identified as nondependent problem drinkers.

Adolescent↗
PubMed2006

Discrimination, symptoms of depression, and self-rated health among african american women in detroit: results from a longitudinal analysis.

OBJECTIVES: Our understanding of the relationships between perceived discrimination and health was limited by the cross-sectional design of most previous studies. We examined the longitudinal association of self-reported everyday discrimination with depressive symptoms and self-rated general health. METHODS: Data came from 2 waves (1996 and 2001) of the Eastside Village Health Worker Partnership survey, a community-based participatory survey of African American women living on Detroit's east side (n=343). We use longitudinal models to test the hypothesis that a change in everyday discrimination over time is associated with a change in self-reported symptoms of depression (positive) and on self-reported general health status (negative). RESULTS: We found that a change over time in discrimination was significantly associated with a change over time in depressive symptoms (positive) (b=0.125; P<.001) and self-rated general health (negative) (b=-0.163; P<.05) independent of age, education, or income. CONCLUSIONS: The results reported here are consistent with the hypothesis that everyday encounters with discrimination are causally associated with poor mental and physical health outcomes. In this sample of African American women, this association holds above and beyond the effects of income and education.

Adult↗
PubMed1982

Blood lead levels among high-risk children, Detroit, Michigan.

Since 1972, a federally funded lead screening program has been operational in Detroit, Michigan. Blood lead screening data (27,430 initial tests on Black children less than or equal to 6 years) were assigned by census tract of child's residence to one of the 15 socioeconomically similar areas in geographic proximity to one another. Higher blood lead levels were associated with lower education, lower income, and increased proportion of single parent families. This emphasizes the need to continue screening efforts in lower socioeconomic areas with older housing.

Black or African American↗
PubMed1997

An international comparison of cancer survival: Toronto, Ontario, and Detroit, Michigan, metropolitan areas.

OBJECTIVES: This study examined whether socioeconomic status has a differential effect on the survival of adults diagnosed with cancer in Canada and the United States. METHODS: The Ontario Cancer Registry and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program provided a total of 58,202 and 76,055 population-based primary malignant cancer cases for Toronto, Ontario, and Detroit, Mich, respectively. Socioeconomic data for each person's residence at time of diagnosis were taken from population censuses. RESULTS: In the US cohort, there was a significant association between socioeconomic status and survival for 12 of the 15 most common cancer sites; in the Canadian cohort, there was no such association for 12 of the 15 sites. Among residents of low-income areas, persons in Toronto experienced a survival advantage for 13 of 15 cancer sites at 1- and 5-year follow-up. No such between-country differentials were observed in the middle- or high-income groups. CONCLUSIONS: The consistent pattern of a survival advantage in Canada observed across various cancer sites and follow-up periods suggests that Canada's more equitable access to preventive and therapeutic health care services is responsible for the difference.

Health Services Accessibility↗
PubMed2001

An investigation of Gf-Gc theory in the older adult population: joint factor analysis of the Woodcock-Johnson-Revised and the Detroit Test of Learning Aptitude-Adult.

Researchers and clinicians are increasingly interested in the structure of intelligence among older adults. A joint factor analysis was conducted for 27 subtests of the Woodcock-Johnson Psycho-Educational Battery-Revised and the Detroit Tests of Learning Aptitude-Adult for a sample of 50 persons ranging in age from 55 to 84 years (M=65.16 yr.). The results provide evidence for the latent factors speci fied by Gf-Gc theory in older adults, indicate which Gf-Gc factors are measured by subtests of the two batteries, and illustrate the necessity of cross-battery assessment to identify the full complement of Gf-Gc factors.

Aged↗
PubMed1977

Incidence of leptospirosis in the detroit rat population.

The rat population (Rattus norvegicus) in the city of Detroit was surveyed to determine the incidence of leptospirosis. Four methods of survey were used--serological, direct examination of urine, culture of urine, kidney and brain, and histopathological examination. Of 358 sera tested by the microscopic-agglutination test, 277 (77.4%) had significant agglutinins for serotype icterohaemorrhagiae. Significant differences were found between adult and young animals in both incidence and antibody titers, titers of 1:50 or higher being present in 90.3% and 38.8%, respectively, of adult and young rats. Examination of freshly drawn urine by dark field microscopy revealed that 59.6% of the animals were shedding leptospirae. When stained with Steiner's silver stain, 91.9% of the kidney sections were positive for leptospirae, showing this to be the most sensitive test of those used. Leptospirae were isolated from one or more cultures of kidney, urine, or brain from 221 (59.2%) of the 358 rats examined.

Animals↗
PubMed1995

Teamwork at the Detroit Medical Center. Bridging the gap.

In 1992, Harper Hospital, a part of the Detroit Medical Center, initiated a Quality Enhancement and Clinical Resource Management (QE/CRM) program. The program was designed to be physician-driven and multidisciplinary. Its goal is to "look closely and critically at the appropriate use of clinical resources to affect the most desired outcomes." Through the use of teams for different clinical services, led by physicians and comprised mainly of physicians, quality of care and cost issues are identified and investigated. Changes to practice have occurred that have not only improved outcomes and saved the medical center money, but prepared it to go to managed care.

Cost Control↗
PubMed1997

Detroit health system steps up to the DM plate with health promotion center.

Detroit's Henry Ford Health System has opened the Center for Health Promotion and Disease Prevention in order to research prevention processes, encourage healthy lifestyle choices among its members, and assist its providers in incorporating prevention strategies into their delivery of services. Here is a profile of the center and the programs it is developing in pursuit of these goals.

Community Health Planning↗
PubMed1980

The making of an HMO city....a case study on the development of HMOs in Detroit.

As the option of participating in an HMO is extended in more and more cities, this case study of Detroit, prepared for the Office of Health Maintenance Organizations of the U.S. Public Health Service by ICF, Inc. of Washington, D.C. will provide many useful insights into the wide spectrum of HMO operational activity.

Health Benefit Plans, Employee↗
PubMedDate not supplied

Cardiovascular Fitness and Rehabilitation Program, Sinai Hospital of Detroit.

Rehabilitation of persons with cardiac disease involves restoring and maintaining optimal physical, psychologic, occupational, social, and recreational status. It is based on the belief that adequate physical fitness and reduction of psychologic symptoms, including depression and poor self-image, can be attained by physical conditioning and education. The hospital-based and extended community-center program of Sinai Hospital of Detroit provides the environment for this effort.

Electrocardiography↗