BIOLOGICAL ACTIVITY OF FORMYL DERIVATIVES OF DIGITALIS GLYCOSIDES.
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A computer programme for the digitalis therapy developed by us was tested in 282 patients with heart insufficiency. It helps to control the course of the therapy, to establish the optimum fully effective dose of the individually determined glycoside sensitivity and to decrease significantly the danger of an overdosage.
It appears well established that the inotropic effect of digitalis is due initially to inhibition of the sodium pump (Na-K-ATPase), initiating a cascade effect which in turn increases "diastolic" intracellular Ca2+, which then increases "systolic" intracellular Ca2+ responsible for the inotropic effect.
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