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PubMed1997

Role of gustatory and postingestive actions of sweeteners in the generation of positive affect as evaluated by place preference conditioning.

Either an 18% sucrose or a 0.1% saccharin solution was used as reward in a conditioned place preference procedure. The respective solution was consumed immediately before the subject was confined to the non-preferred compartment of a place preference box. In this way only the affective reaction produced by the rewarding stimulus participated in place conditioning. Non-deprived rats consumed similar quantities of the two solutions, suggesting that they were equally rewarding. Yet only sucrose induced place preference. The lack of effect of saccharin may have been due to weaker positive affect or to an inability to induce an affective state that outlasted consummatory behavior. The first possibility was evaluated in the second experiment. Food-deprived rats were subjected to a discrimination learning task in a runway with plain water, sucrose or saccharin as reinforcer. Sucrose sustained running responses and produced improvement of discrimination behavior. Saccharin had a small effect at the first sessions only. It was concluded that saccharin is less rewarding than sucrose. In a final experiment, one group of rats was injected with glucose (2 g/kg) 17 min before being introduced in the non-preferred compartment of a place preference box. Another group was given the same dose of glucose just before drinking saccharin for 15 min. Immediately thereafter place conditioning was performed. Glucose alone had no effect, while a place preference was established when glucose injection was combined with saccharin drinking. These results show that the positive affect produced by sweet substances does not outlast consummatory behavior in the absence of postabsorptive actions.

Analysis of Variance↗
PubMed1999

Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. I. A correlational and factor analysis and the effects of ovarian hormones.

This study investigated measures of sexual behavior displayed by female rats in bilevel chambers, the statistical relationships among the measures, and their dependency on hormone priming. Normative data from a standard 35-min test of sexual behavior were gathered from 82 fully primed sexually experienced Long-Evans females and subjected to multiple correlational and factor analyses. Several consummatory measures of copulation were related significantly, whereas appetitive level changing was statistically independent of consummatory measures. Factor analyses were conducted using orthogonal rotations of correlational matrices derived either from (a) measures of female behavior alone or (b) measures of female and male behavior together. The first analysis revealed five factors that accounted for 84% of the intersubject variance: Receptivity, Pacing, Appetitive Level Changing, Lordosis Reflex, and Solicitation. The second factor analysis with male data included revealed seven factors that accounted for 95% of the intersubject variance: Pacing, Copulatory Rate, Mount Count, Receptivity, Appetitive Level Changing, Solicitation, and Lordosis Reflex. Subsequently, subsets of these females were maintained on different steroid priming regimens (oil, low estrogen, high estrogen, high estrogen and progesterone) prior to a standard test of sexual behavior. Although the expression of all sexual behaviors required estrogen priming, appetitive level changing, solicitation, and pacing required progesterone for their full expression. Finally, appetitive level changing developed following hormone treatment alone, regardless of whether the females received access to sexually active males, inactive castrated males, or other females. Use of bilevel chambers allows complex patterns of sexual behavior to be observed in female rats and may thus facilitate the identification of neurochemical or endocrine mechanisms associated with different aspects of female sexual motivation and performance.

Animals↗
PubMed1992

The distribution of catecholamines and beta-endorphin in the brains of three behaviorally distinct breeds of dogs and their F1 hybrids.

This study examines neurochemical and behavioral differences among three types of domestic dogs and F1 hybrids derived from them. Purebred dogs included Border Collies, representing herding dogs, Shar Plaininetz, representing livestock protecting dogs, and Siberian Huskies, representing Northern dogs. Composite behavioral scores were derived from frequency measures of various components of predatory behavior observed when the dogs were tested with mice. Catecholamine levels, including norepinephrine (NE), dopamine (DA), and epineprine (EPI), were determined in various brain regions by high-performance liquid chromatography (HPLC) with electrochemical detection. beta-endorphin levels were determined in the same regions by RIA. Collies showed the highest levels of non-consummatory behaviors and Huskies the highest levels of consummatory behaviors. Shars were found to have lower levels of NE and DA than Collies and Huskies in several brain regions, including those comprising the nigrostriatal DA system. Positive correlations between neurochemical and behavioral characteristics could be made between Shars and Collies. Comparisons of F1 hybrids with their respective parental breeds revealed no clear pattern of inheritance for these characteristics but suggested that multiple factors, both independent and epistatic, are involved. Based on previous studies on nigrostriatal DA and behavior, the levels of DA in this system may be causally related to the levels of predatory behavior expressed by Collies and Shars.

Animals↗
PubMed1987

Relationship of type A behavior pattern in smokers to carbon monoxide exposure and smoking topography.

Stress-related physiological factors have been proposed to mediate the Type A behavior pattern (TABP) and coronary heart disease (CHD). However, collateral behavioral factors, such as the exaggerated consummatory response patterns of Type As, may also be involved. Study 1 examined this hypothesis by comparing exposure to cigarette smoke in 42 graduate and undergraduate student smokers assessed for the TABP. After controlling for smoking rate and Federal Trade Commission cigarette carbon monoxide yield, Type As' alveolar carbon monoxide (COa) levels were higher than Type Bs', and Jenkins Activity Survey scores were correlated with COa. To determine the source of this difference, we measured smoking topography in 10 Type As and 10 Type Bs in Study 2. Type As and Type Bs did not differ in number of puffs taken or puff volume, but Type As' inhalation duration was 70% longer than Type Bs'. These results suggest that consummatory behaviors of Type As may help account for the Type A-CHD relationship for smokers. Due to increased smoke exposure, Type A smokers may also be at greater risk for cancer and lung disease than Type B smokers.

Adolescent↗
PubMed1989

Two-stage model of memory trace formation: a role for "noisy" brain states.

Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities, while population synchrony of pyramidal cells is maximum during immobility, consummatory behaviors, and slow wave sleep associated with field sharp waves. Sharp waves reflect the summed postsynaptic depolarization of large numbers of pyramidal cells in the CA1 and subiculum as a consequence of synchronous discharge of bursting CA3 pyramidal neurons. The trigger for the population burst in the CA3 region is the temporary release from subcortical tonic inhibition. An overview of the experimentally explored criteria of synaptic enhancement (intensity, frequency, and pattern of postsynaptic depolarization, calcium influx, cooperativity, threshold) suggests that these requirements may be present during sharp wave-concurrent population bursts of pyramidal cells. Experimental evidence is cited showing that (a) population bursts in CA3 may lead to long-term potentiation in their postsynaptic CA1 targets, (b) tetanizing stimuli are capable of increasing the synchrony of the sharp wave-burst, and (c) activity patterns of the neocortical input to the hippocampus determine which subgroup of CA3 neurons will trigger subsequently occurring population bursts (initiator cells). Based on the experimental evidence reviewed a formal model of memory trace formation is outlined. During exploratory (theta) behaviors the neocortical information is transmitted to the hippocampus via the fast-firing granule cells which may induce a weak and transient heterosynaptic potentiation in a subgroup of CA3 pyramidal cells. The weakly potentiated CA3 neurons will then initiate population bursts upon the termination of exploratory activity (sharp wave state). It is assumed that recurrent excitation during the population burst is strongest on those cells which initiated the population event. It is suggested that the strong excitatory drive brought about by the sharp wave-concurrent population bursts during consummatory behaviors, immobility, and slow wave sleep may be sufficient for the induction of long-term synaptic modification in the initiator neurons of the CA3 region and in their targets in CA1. In this two-stage model both exploratory (theta) and sharp wave states of the hippocampus are essential and any interference that might modify the structure of the population bursts (e.g. epileptic spikes) is detrimental to memory trace formation.

Animals↗
PubMed1982

Drinking, but not feeding, is opiate-sensitive in hamsters.

The long-lasting opiate antagonist, naltrexone (NTX), was examined for its effects on various types of consummatory behavior in male golden hamsters and rats. Rat, but not hamster, 24 hr food and water intakes were significantly decreased by four daily NTX (10.0 mg/kg) injections. Hamsters displayed a minimal night to day feeding ratio compared to rats. Hamsters increased food intake following insulin (50 U/kg) administration, but not after 24 hr food deprivation (FD) or 2-deoxy-D-glucose (2-DG; 800 mg/kg) injections. NTX (1.0 and 10 mg/kg) had no effect on feeding, but markedly attenuated hamster drinking induced by 48 hr water deprivation or hypertonic saline injection. Dexamethasone (DEX), a glucocorticoid which depletes pituitary beta-endorphin and produces anorexia in rats, had no effect on daily hamster intake. Since the normal feeding profile of the hamster is similar to that of naloxone and DEX-treated rats, hamsters appear to lack an opiate-sensitive feeding system. In contrast, stimulated drinking behavior of hamsters operates through an opiate-sensitive mechanism. Thus, there are marked species differences concerning the involvement of endogenous opioids in consummatory behavior.

Animals↗
PubMed1990

Brain stimulation-induced feeding alters regional opioid receptor binding in the rat: an in vivo autoradiographic study.

Although opioid antagonists block feeding behavior in a variety of animal models, the number and identity of CNS regions in which the inferred endogenous opioid activity mediates feeding have yet to be established. Furthermore, it is not yet clear whether the opioid activity that sustains feeding is a concomitant of the appetitive motivational state or the consummatory response. In an effort to address these issues, an in vivo autoradiographic method was used to visualize CNS regional changes in opioid release during appetitively motivating electrical stimulation in the lateral hypothalamus (ESLH) and during consummatory behavior elicited by such stimulation. Regional decreases in [3H]diprenorphine [(3H]Dpr) binding, suggesting increased release of an endogenous opioid peptide, were observed in the medial prefrontal cortex, medial septum, gustatory cortex, zona incerta, mediodorsal thalamus, and hippocampus of rats receiving ESLH. Decreased binding in the latter 4 structures did not appear when animals were allowed to eat during ESLH, suggesting that the inferred opioid release is associated with appetitive behaviors elicited by ESLH which are suppressed when food is available and consummatory behavior predominates. When animals were allowed to eat during ESLH, [3H]Dpr binding in anterior cingulate cortex decreased substantially, suggesting that feeding behavior specifically triggers opioid release in this region. ESLH and feeding were found to increase [3H]Dpr binding in a number of CNS regions. Alternative explanations for increased binding, including inhibition of tonic opioid release, changes in cerebral blood flow, and opioid receptor up-regulation are discussed.

Animals↗
PubMed1983

Influence of perinatal malnutrition on adult physiological and behavioral reactivity in rats.

A series of experiments examined the behavioral and pituitary-adrenal response to novelty of perinatally malnourished rats tested as adults after nutritional rehabilitation begun at weaning. Neither the behavioral measures of ambulation, rearing and defecation, nor the plasma corticosterone response to a brief exposure to an open field differentiated the previously malnourished subjects from controls. Similar to controls, previously malnourished subjects were also capable of displaying a graded corticoid elevation to environments increasingly different from the home cage. However, exploratory behavior, as measured by head-dip frequency and duration in the hole-board, was reduced in the previously malnourished rats. Although latency and amount of fluid consumed in a novel environment did not differ, previously malnourished rats were unable to use the cues associated with a consummatory behavior to modulate the pituitary-adrenal response to novelty. Thus, perinatal malnutrition does not influence either the behavioral or physiological activational response to novel stimulation but appears to alter the ability of the animal to use a consummatory behavior to modulate this response.

Animals↗
PubMed1988

The role of the hypothalamic-pituitary-adrenocortical axis in post-stress induced ethanol consumption by rats.

1. Previous studies conducted in our laboratory demonstrated that rats given a choice between a 0.1% saccharin solution or 10% ethanol/0.1% saccharin solution and repeatedly exposed on an unpredictable basis to stressful stimuli, consumed increasing quantities of the ethanol solution following cessation of stressor presentation as compared to nonstressed control rats. 2. Stressful stimuli potently activate the hypothalamic-pituitary-adrenocortical (HPA) axis, thus a systematic investigation of the HPA axis and its involvement in post-stress induced ethanol consummatory behavior was undertaken. 3. Exposure to repetitive unpredictable stressful stimuli did not induce the free-choice consumption of ethanol in either hypophysectomized rats or chronic dexamethasone treated rats. 4. Adrenalectomized rats exposed to chronic unpredictable stressful stimuli consumed increased quantities of ethanol following cessation of stressful stimuli in both a quantitative and qualitative manner which mirrored that of intact animals. 5. Repeated intravenous administration of exogenous adrenocorticotropin (ACTH1-39) on an unpredictable basis also induced ethanol consuming behavior, following the discontinuation of its administration. 6. These results suggest that elimination of the pituitary or pharmacological antagonism of stress-induced HPA activation will prevent post-stress induced ethanol consummatory behavior. 7. Conversely, activation of a functional hypothalamic-pituitary system or repeated administration of exogenous ACTH1-39 will initiate ethanol consumption in rats. 8. Thus, hormones secreted from the pituitary, namely ACTH, appear to play a crucial role in the post-stress induced initiation of ethanol consuming behavior in rats.

Adrenalectomy↗
PubMed2005

Differential effects of removing the glucose or saccharin components of a glucose-saccharin mixture in a successive negative contrast paradigm.

When rats experience an unexpected decrease in reward value, e.g., from 32% sucrose to 4% sucrose, consummatory behavior abruptly decreases to a level below control subjects that only experience the lesser reward, a phenomenon known as Successive Negative Contrast (SNC). In food deprived rats experiencing downshifts in sucrose concentration, SNC dissipates in 3-4 days, as consummatory behavior in shifted rats recovers to the level of unshifted controls. In Experiment 1 food deprived rats that were given 5 min daily access to a 2% glucose-0.15% saccharin mixture, and subsequently shifted to 2% glucose alone, displayed a dramatic SNC effect relative to rats that only received 2% glucose. This SNC effect was primarily manifested as a decrease in the number of consummatory bursts initiated. Interestingly, intake failed to recover to control levels during eight daily postshift sessions. However, in Experiment 2 subjects that were shifted from the same glucose-saccharin mixture to 0.15% saccharin alone failed to show SNC rather, intake fell to the level of control animals which only received 0.15% saccharin. The data from Experiment 1, in conjunction with previous studies utilizing non-deprived rats, quinine adulteration, or shifts from sucrose to saccharin, show that reductions in taste value can produce contrast effects, but suggest that a threshold caloric value is necessary for recovery. The data from Experiment 2 may suggest that saccharin and glucose do not contribute equally to the enhanced palatability of the mixture.

Analysis of Variance↗
PubMed1982

Tail pinch behavior and analgesia in diabetic mice.

Mild tail pinch induced "consummatory" behaviors in mice. The major tail pinch behavior appeared to be chewing with food ingestion occurring possibly as an epiphenomenon. All tail pinch behaviors were obliterated by the dopamine antagonist haloperidol; and the opiate antagonist, naltrexone, decreased eating without altering chewing. The combination of dopamine blockade and tail pinch induced jumping behavior in mice. Diabetic mice showed increased tail flick latencies to radiant heat and to the induction of tail pinch behaviors, displaying these behaviors less commonly than their homozygote and heterozygote littermate controls.

Animals↗
PubMed1989

Effect of clonidine on sucrose intake and water intake varies as a function of dose, deprivation state, and duration of exposure.

Lick frequency was monitored in five-minute intervals over a one-hour period in rats given access to 8% sucrose (Experiment 1) or water (Experiment 2). Prior to the session, the rats were administered either isotonic saline or clonidine (6.24, 12.5, or 25 micrograms/kg). In deprived rats (82%) clonidine led to a dose-related increase in consummatory behavior. Water intake in deprived rats was depressed by clonidine. In rats maintained on a free-feeding schedule, the higher clonidine doses led to a decrement in sucrose intake over the first 15 minutes of access; whereas the 6.25 micrograms/kg dose stimulated consummatory behavior, but only during the first five minutes of access. There were no reliable effects of clonidine on sucrose intake late in the access period for the free-feeding rats. Water intake in free-feeding rats tended to be enhanced by the low dose of clonidine, particularly late in the access period. In general, deprivation enhanced sucrose intake and depressed water intake and clonidine exaggerated both of these trends.

Animals↗
PubMed1982

Tail pinch-induced eating: is it the tail or the pinch?

Mildly pinching the tail of the rat results in a set of consummatory behaviors including eating, chewing and licking. This phenomenon has been characterized as one which is not causally dependent on induction of pain. In the present study we report that pinching the scruff of the neck, the ears, or the rear paw of rats also results in consummatory behaviors similar to those observed during tail pinch. We suggest that stress-induced eating caused by pressure applied to various regions of the rat involves the perception of noxious stimuli (nociception).

Animals↗
PubMed1992

Physiological function of granule cells: a hypothesis.

In this chapter we review the physiological properties of granule cells in vivo and in vitro. We conclude from the literature that in intact rats granule cells fire rhythmic bursts of action potentials concurrent with exploration-associated theta waves. The population discharge of granule cells coincides with the maximum probability of firing of CA3 pyramidal cells on the positive phase of focally recorded theta waves. During consummatory behaviors, immobility and anesthesia the firing rate of granule cells substantially decreases. We propose that the conjoint activity of the discharging CA3 cells and tetanization of these same cells by mossy fibers during exploratory (theta) behavior will temporarily increase synaptic efficacy among the active CA3 neurons even after the termination of exploration. As a result, the very same CA3 cells that carried information during exploration now become the burst-initiator cells of the sharp-wave associated population bursts during consummatory behaviors and sleep. The creation of new burst-initiator neurons is hypothesized to be essential for memory trace formation. From this perspective the main physiological function of granule cells is to 'tetanize' CA3 pyramidal neurons during exploratory behaviors and induce a meaningful reorganization of the functional connectivity of the CA3 network.

Animals↗
PubMed2005

Krox-20 gene expression: influencing hindbrain-craniofacial developmental interactions.

Krox-20 is a C(2)H(2)-type zinc-finger transcription factor that plays an essential role in hindbrain development. The Krox-20 null mutation results in hindbrain anomalies that result in neonatal death due to respiratory and feeding deficits. Here we review our studies of how the Krox- 20 null mutation impacts the development of motor and sensory systems critical for the production of consummatory behaviors (suckling/chewing). First, we demonstrated that Krox-20 null mutants suffer a selective loss of primary jaw-opening muscles during prenatal development. In vivo and in vitro studies are reviewed that highlight intrinsic defects in mutant jaw-opener muscles that contribute to muscle degeneration. Next we focus on the impact of the mutation on proprioceptive neurons activated during consummatory behaviors. Mesencephalic trigeminal (Me5) neurons are primary sensory neurons that relay jaw proprioception to the central nervous system. These cells are unique because their cell bodies are located in the central as opposed to the peripheral nervous system. Data are reviewed that demonstrate the impact of the mutation on Me5 neurons, a cell group traditionally thought to emerge from the mesencephalon. We show that Krox-20 null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL assays performed in each set of studies reveal that Krox-20 expression acts to protect both muscle and mesencephalic trigeminal neurons against apoptosis, suggesting that Krox-20, in addition to its role in hindbrain patterning, has a broader, long-lasting role in development.

Animals↗
PubMed2003

Ethanol and sucrose self-administration components: effects of drinking history.

Results of previous studies have shown that when rats consume higher concentrations of ethanol during initiation both the amount consumed and the pattern of consumption change with the return to a lower concentration. In this study, an across-sessions breakpoint procedure in the sipper-tube model was used to examine the effect that experience with drinking higher concentrations (a concentration manipulation) of both ethanol and sucrose had on appetitive and consummatory behaviors. A follow-up study was then conducted in the ethanol-consuming group with across-session breakpoint and intake examined before, during, and after a 3% sucrose/10% ethanol solution was presented in the sipper tube. As ethanol concentration increased, intake was not changed. Exposure to higher ethanol concentrations had no effect on the amount of 10% ethanol consumed when retested. The exposure tended to increase appetitive behavior (breakpoint), but this effect was not unique to ethanol, as rats self-administering 3% sucrose showed a similar increase. When the combined ethanol-sucrose solution was available, a significant increase in both intake and appetitive responding occurred; however, there was no change from prior intake or breakpoint when 10% ethanol was retested. That the addition of sucrose to the ethanol solution significantly increased appetitive and consummatory behaviors supports the suggestion that the composition of the alcoholic beverage can have a strong influence over the control of self-administration. Because most consumption of ethanol by human beings is in solutions that contain mixers that alter the taste of the solution, this taste factor needs to be considered in the regulation of ethanol drinking.

Alcohol Drinking↗
PubMed1997

Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain.

In the present study a detailed quantitative analysis was made using Fos as a marker for neural activation to define which subregions in the neural circuitry underlying male sexual behavior are involved in display of anogenital investigation versus copulation. Neural activity was differentially distributed following anogenital investigation versus mating and was restricted to specific subdivisions that form a heavily interconnected network. Chemosensory investigation increased neural activity in the posteromedial subdivision of the bed nucleus of the stria terminalis and the posterodorsal subdivision of the medial amygdala, brain regions that receive chemosensory signals processed through the olfactory bulbs, presumably reflecting the acquisition of chemosensory signals or the display of anogenital investigation. However, other sensory signals or sexual experience may also have contributed to the induction of neural activation in these brain areas. Moreover, consummatory behavior increased neural activity in the subparafascicular nucleus, a brain region that receives genital sensory inputs. In turn, this brain region projects to the medial preoptic nucleus and posterior nucleus of the amygdala, where neural activity was also abundant only following copulation. In addition, clusters of neurons were activated in the posteromedial subdivision of the bed nucleus of the stria terminalis and posterodorsal subdivision of the medial amygdala following consummatory behavior. The present study provides an anatomically detailed picture about the distribution of neural activation following sexual behavior in the rat, specifically in relation to differences following anogenital investigation versus mating.

Amygdala↗
PubMed1999

Neurotransmitter system interactions revealed by drug-induced changes in motivated behavior.

The present article reviews studies conducted either in collaboration with Jac Herberg, or in parallel with those studies that used consummatory behavior and responding for intracranial self-stimulation (ICSS) to investigate interactions between neurotransmitter systems. The studies reviewed include investigations of the role of dopamine in 8-OH-DPAT-induced feeding; the role of 5-HT3 receptors in the stimulant and depressant effects of nicotine on responding for ICSS; the interaction of D2 and 5-HT2 antagonists in sucrose consumption, and the differential contributions of alpha2-adrenoceptor and 5-HT2 antagonism to the rapid recovery of ICSS responding from depression produced by atypical neuroleptics. Further studies of the role of alpha2-adrenoceptor antagonism in the pattern of response decrements produced by neuroleptics on schedule-controlled responding for food confirm that the behavioral effects of monoamine interactions vary, depending on the specific receptor subtypes targeted and the behavioral paradigm employed. Consequently, the clinical relevance of findings will crucially depend on the choice of appropriate behavioral measures.

Animals↗