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Karyotypic conservatism in the genus Lepus (order Lagomorpha).

The G- and C-banded chromosomes of six species of hare (genus Lepus) are presented and compared. No variation in gross chromosome morphology or banding pattern was observed indicating that speciation in this widespread genus has not involved karyotypic change.

Animals↗

Localized primary amyloidosis of the genitourinary tract: does conservatism help?

Primary amyloidosis of the genitourinary tract is a rare clinical entity with an excellent prognosis in most cases. It is of interest to the urologist as it mimics malignancy. The definitive diagnosis is made on histologic examination and by excluding secondary causes of amyloidosis. We present 4 patients with primary localized amyloidosis of the genitourinary tract who were treated with transurethral resections alone with satisfactory outcome.

Adult↗

Karyotypic conservatism in the suborder Feliformia (Order Carnivora).

Multidirectional comparative chromosome painting was used to investigate the karyotypic relationships among representative species from three Feliformia families of the order Carnivora (Viverridae, Hyaenidae and Felidae). Complete sets of painting probes derived from flow-sorted chromosomes of the domestic dog, American mink, and human were hybridized onto metaphases of the spotted hyena (Crocuta crocuta, 2n = 40) and masked palm civet (Paguma larvata, 2n = 44). Extensive chromosomal conservation is evident in these two species when compared with the cat karyotype, and only a few events of chromosome fusion, fission and inversion differentiate the karyotypes of these Feliformia species. The comparative chromosome painting data have enabled the integration of the hyena and palm civet chromosomes into the previously established comparative map among the domestic cat, domestic dog, American mink and human and improved our understanding on the karyotype phylogeny of Feliformia species.

Animals↗

Interordinal conservatism of chromosome banding patterns in Gallus domesticus (Galliformes) and Melopsittacus undulatus (Psittaciformes).

Chromosome banding homologies were studied between the domestic chicken, Gallus domesticus (Galliformes), and the budgerigar, Melopsittacus undulatus (Psittaciformes). In spite of large karyological differences, the G-banding patterns were found to be conserved to a considerable extent between the two species. There were some differences in C- and Hoechst 33258/Q-banding patterns.

Animals↗

Serum albumin by dye-binding: bromocresol green or bromocresol purple? The case for conservatism.

Pooled patient's serum selected to have a wide range of albumin concentrations was analysed for albumin by bromocresol green with both long and short incubation times and also by bromocresol purple. Total protein, colloid osmotic pressure, calcium and magnesium were also measured. There were strong linear correlations between albumin measured by the three methods. Albumin values by bromocresol green with a short incubation time (1.5 min) averaged 5 g/L higher than those by bromocresol purple at all albumin concentrations. Colloid osmotic pressure correlated less strongly with total protein and with albumin by bromocresol purple than with albumin by the two bromocresol green methods. There were no significant differences between the correlation coefficients of calcium or magnesium with total protein and with albumin measured by the three methods. Bromocresol purple has no advantage over bromocresol green with a short incubation time for the clinical purposes for which albumin is measured: to detect abnormality, monitor change, predict colloid osmotic pressure and adjust calcium and magnesium for abnormal protein concentrations.

Bromcresol Green↗

Local recurrence after skin-sparing mastectomy: tumor biology or surgical conservatism?

BACKGROUND: Long-term follow-up of the use of skin-sparing mastectomy (SSM) in the treatment of breast cancer is presented to determine the impact of local recurrence (LR) on survival. METHODS: A total of 539 patients were treated for 565 cases of breast cancer by SSM and immediate breast reconstruction from January 1, 1989 to December 31, 1998. The American Joint Committee on Cancer pathological staging was stage 0 175 (31%), stage I 135 (23.9%), stage II 173 (30.6%), stage III 54 (9.6%), stage IV 8 (1.4%), and recurrent 20 (3.5%). The mean follow-up was 65.4 months (range, 23.7-86.3 months). Five patients were lost to follow-up. RESULTS: Thirty-one patients developed a LR during the follow-up including five who received adjuvant radiation. The distribution of LR stratified by cancer stage was stage 0 1, stage I 5, stage II 17, stage III 6, and recurrent 2. The overall LR was 5.5%. Twenty-four patients (77.4%) developed a systemic relapse and 7 (22.6%) patients remained free of recurrent disease at a mean follow-up of 78.1 months. The cancer stage of those remaining disease free was stage 0 1 (100%), stage I 4 (80%), and stage II 2 (11.8%). CONCLUSIONS: LR of breast cancer after SSM is not always associated with systemic relapse.

Breast Neoplasms↗

Insurance against germ theory: commerce and conservatism in late-Victorian medicine.

This article highlights the role played by commercial life insurance companies in determining the response to tuberculosis in Britain between 1865 and 1920. Late-Victorian life offices hired two sorts of physicians to help them screen out high-risk proposals: provincial medical examiners, who collected fees for examining candidates; and salaried medical advisors, who developed guidelines for the medical examination and interpreted the examiners' findings for the head office. The latter set of physicians, many of whom worked at specialist consumption hospitals in London, established an orthodoxy among life offices that privileged hereditarian explanations for the cause of tuberculosis. The provincial examiners resisted that orthodoxy, arguing that advances in public health and treatment rendered irrelevant any apparent correlation between family history and tuberculosis. In adjudicating this internal dispute, life offices stood by their salaried advisors, but in the process pushed them away from viewing disease in terms of specific causes and toward viewing disease in terms of statistical correlation. This victory of statistics over etiology preserved, at least for the rest of the twentieth century, the institutional prominence of insurance as a technique for coping with medical uncertainty.

Attitude of Health Personnel↗